Category: 288-32-4

These common heterocyclic compound, 288-32-4, name is 1H-Imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 288-32-4

To a DMF (20 mL) solution of 3-chloro-4-fluorobenzaldehyde (500 mg), potassium carbonate (1.20 g) and imidazole (275 mg) were added one by one, and the reaction solution was agitated at 80 C. overnight. Water and ethyl acetate were added to the reaction solution, and the organic layer was partitioned. After the obtained organic layer was washed with a saturated saline solution, it was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (elution solvent:ethyl acetate?ethyl acetate_methanol=10:1), and 548 mg of the title compound was obtained. The physical properties of the compound are as follows. 1H-NMR (CDCl3) delta (ppm): 10.0 (s, 1H), 8.09 (d, J=2.0 Hz, 1H), 7.91 (dd, J=2.0, 8.0 Hz, 1H), 7.80 (s, 1H), 7.54 (d, J=8.0 Hz, 1H), 7.24-7.27 (m, 2H).

The synthetic route of 1H-Imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; US2006/4013; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2

a. 4-(1H-Imidazol-1-yl)-nitrobenzene To a solution of 4-fluoronitrobenzene (25 g; ~ 0.18 mol) in 250 ml N,N-dimethylformamide was added imidazole (50 g; ~ 0.74 mol). The reaction mixture was stirred at 140C for 2 h, and then poured into ice-water to give the title compound as a precipitate. Yield: 32 g (~ 94%). M.p. 199-202C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; NOVO NORDISK A/S; EP698024; (1997); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 288-32-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-32-4, name is 1H-Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step A. 1-Methoxymethyl-1H-imidazole To a solution of 1.06 g of imidazole (15.56 mmol) in 20 ml of THF at 0 C. was added 658 mg (16.45 mmol) of NaH (40% dispersion in oil) and the mixture was stirred at 0 C. for 30 mins.After this time, 1.2 ml (15.7 mmol) of chloromethyl methyl ether were added and the mixture was allowed to warm to room temperature and stirred for 14 h.After this time the reaction was quenched by the addition of a saturated aqueous solution of ammonium chloride, allowed to warm to room temperature, and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered and the filtrate was concentrated.The residue was purified by chromatography on silica gel (hexanes:EtOAc, 1:1) to give the title compound. 1H-NMR (CDCl3) delta 3.21 (s, 3H), 5.18 (s, 2H), 7.00 (d, J=19 Hz, 2H0, 7.54 (s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tularik Inc.; US2003/229093; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 1000 ml flask were added 108.3 g (1.59 mol) of imidazole and 630 g of tetrahydrofuran. After the atmosphere of the system was replaced with nitrogen, the imidazole was dissolved under stirring. Thereto was added dropwise 39.3 g (0.2 mol) of diphosgene at room temperature over a period of 2 hours. After completion of the dropwise addition, the stirring was continued at room temperature for 1 hour and then the whole was heated to 55C, followed by continuous stirring for another 1 hour. Imidazole hydrochloride yielded as a by-product was filtrated with heat and was then washed with 100 g of tetrahydrofuran. The imidazole hydrochloride filtrated off was dried under reduced pressure at 40C to obtain 83.2 g (0.796 mol) of imidazole hydrochloride (recovery of 100%). A filtrate containing CDI was concentrated and subjected to toluene-crystallization, and CDI was filtrated off under a nitrogen atmosphere. The CDI filtrated off was dried under reduced pressure at 40C to obtain 58.0 g (0.358 mol) of CDI as white crystals (yield 90%). M.p. 111.2 to 118.6C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Imidazole, its application will become more common.

Reference:
Patent; Hodogaya Chemical Co., Ltd.; EP1731510; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 288-32-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-32-4, name is 1H-Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

1. To a solution of 1 (20 g, 108.1 mmol) in dry DMF (200 mL) were added lH-imidazole (8.1 g, 118.9 mmol), Cs2C03 (38.7 g, 118.9 mmol), Cul (2 g), 18-Crown-6 (2 g). The resulting solution was stirred at 80 C for 24 h. The mixture was cooled to RT, treated with water and extracted with EA. The combined extracts were washed with water, brine, dried over anhydrous Na2S04, filtered and concentrated to give a crude oil. The crude product was purified by recrystallization to afford 2 (1 1 g, 59.2 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; CHIANG, Lillian W.; MURPHY, Eain Anthony; KAYSER, Frank; SUN, Qun; FINK, Sarah Jocelyn; (128 pag.)WO2019/79519; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 288-32-4,Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Benzoyl chloride (4.99 g, 35.5mmol) wasadded dropwise to a solution of imidazole (4.83 g, 7.1mmol)in dichloromethane (25 mL). The reaction mixture wasstirred for 3 h, and the resulting precipitate was removedby filtration. The filtrate was washed with cold water (<=5 C,10mL x 3) and concentrated under reduced pressure. Theresidue was purified by bulb-to-bulb distillation (heatertemperature: 160 C, 80 mmHg) to yield 1c (4.33 g, 71%yield) as colorless liquid. 1HNMR (400 MHz, CDCl3,26 C): /ppm 8.07 (t, J = 1.0 Hz, 1H, f ), 7.817.79(m,2H, a), 7.69 (tt, J1 = 7.4 Hz, J2 = 1.8 Hz, 1H, c), 7.587.54(m, 3H, b and d), 7.16 (dd, J1 = 1.8 Hz, J2 = 1.0 Hz, 1H, e). The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings. Reference:
Article; Kohsaka, Yasuhiro; Homma, Kazumasa; Sugiyama, Susumu; Kimura, Yoshikazu; Chemistry Letters; vol. 47; 1; (2018); p. 100 – 102;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 288-32-4, A common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Comparative Example 1; Preparation of 2-(1H-imidazol-1-yl)acetic acid (Process Related to WO2005/063717)Reaction flask was charged with imidazole (50 g), dimethylformamide (20 ml), toluene (200 ml), potassium carbonate (90 g) and potassium iodide (5 g). The mixture was stirred for 10 min and methyl chloroacetate (120 g, 97 ml) was added at 25-30 C. over 1.5 hr. The mixture was stirred for 1 hour at 25-30 C., heated to 60-65 C. and was stirred at this temperature for additional 3 hours. The mixture was cooled down to room temperature and ethyl acetate (100 ml) was added. The mixture was stirred for 20 min and upper organic layer was decanted. Ethyl acetate (100 ml) was added to the residue and the mixture was stirred for 20 min. Upper organic layer was decanted and combined with the first one. Water (100 ml) was added to the residue and the mixture was stirred for 30 min. Inorganic salts were filtered off to give after drying 72.6 g of dry cake (content of diacid in dry inorganic cake was 5.8 g (represents 4.3% of theoretical yield). The filtrate was extracted with ethyl acetate (2×100 ml). Aqueous phase 152 ml contain 24.1 g of the diacid (represents 17.8% of theoretical yield). The ethyl acetate layers were combined with previous extracts. Combined ethyl acetate extracts were evaporated to give 50.5 g of brownish oil.

The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kas, Martin; Benes, Michal; Pis, Jaroslav; US2010/130746; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-32-4, name is 1H-Imidazole, A new synthetic method of this compound is introduced below., Safety of 1H-Imidazole

To a solution of 1H-imidazole (42 g, 617 mmol) in dichloromethane (1 L) was added cyanogen bromide (22.5,212 mmol) and the mixture was heated to reflux for 30 minutes,allowed to cool to room temperature and the white solid was filtered off. The filtrate was concentrated to 100 ml andstored in the refrigerator for 3 days. The precipitated solid wasfiltered off to obtain 8 g di(1H-imidazol-l-yl)methanimine(49.6mmol, 8%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 288-32-4, name is 1H-Imidazole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 288-32-4

To a mixture of toluene and imidazole was added triethyl amine followed by chloroacetonitrile.The reaction mixture was heated and maintained for 7 to 8 hrs. The reaction mass was cooledand the toluene layer was separated. To the reaction mass methylene dichloride was added, stined and filtered. The filtrate was distilled under vacuum. To the residue tetrahydrofuran was added and the reaction mixture is further distilled to obtain the title product. The product thus obtained was recrystallized in isopropyl alcohol. HPLC purity> 99.0 % Chiral purity>99.0%

According to the analysis of related databases, 288-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLENMARK PHARMACEUTICALS LIMITED; BHIRUD, Shekhar Bhaskar; BHUSHAN, Kumar Hari; ZHOPE, Sunil Sudhakar; GHADIGAONKAR, Shailesh Govind; SINGH, Pardeep; DESHMUKH, Shekhar Ashok; CHAND, Prem; (35 pag.)WO2016/92478; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-32-4, SDS of cas: 288-32-4

To a stirred solution of imidazole (6.80 g, 100 mmol) in anhydrous dichloromethane (500 mL) was added BrCN (3.70 g, 33 mmol) and stirring was continued at reflux for 30 min. The mixture was cooled to room temperature and concentrated to afford di(imidazole-1-yl)methanimine (4.05 g, 72 %) as a pale yellow solid which was used without further purification.H NMR (DMSO-d6): 10.21 (br s, 1 H, NH), 8.09 (s, 2 H, 2 * CH), 7.57 (s, 2 H, 2 * CH), 7.12 (s, 2 H, 2 * CH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Imidazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SHIRE, LLC; FRANKLIN, Richard; TYSON, Robert G; GOLDING, Bernard T; WO2012/85586; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem