Category: 359860-27-8

Chi, Young Shik published the artcileAsymmetrically functionalized, four-armed, poly(ethylene glycol) compounds for construction of chemically functionalizable non-biofouling surfaces, Synthetic Route of 359860-27-8, the publication is Chemistry – An Asian Journal (2009), 4(1), 135-142, database is CAplus and MEDLINE.

Asym. functionalized, four-armed, Tween20 derivatives that formed stable monomol. films on solid substrates were designed and synthesized. Thiol-modified Tween20 was used for forming self-assembled monolayers (SAMs) on gold, and maleimide-modified Tween20 was introduced onto SiO₂ surfaces with SAMs of (3-mercaptopropyl)trimethoxysilane through Michael addition These structurally modified Tween20 compounds gave the original characteristics of Tween20, non-biofouling (from ethylene glycol groups) and functionalizable (from OH groups) properties, to each substrate. The non-biofouling properties of the Tween20-coated gold and SiO₂ surfaces were investigated by surface plasmon resonance spectroscopy and ellipsometry, and these surfaces showed strong resistance against nonspecific adsorption of proteins. In addition, the biospecific binding of streptavidin was achieved after coupling of (+)-biotinyl-3,6,9-trioxaundecanediamine onto the non-biofouling surfaces through amide-bond formation.

Chemistry – An Asian Journal published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jeong, Seung Pyo published the artcileBinding behaviors of protein on spatially controlled poly[oligo(ethylene glycol) methacrylate] brushes grafted from mixed self-assembled monolayers on gold, Category: imidazoles-derivatives, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(40), 5291-5293, database is CAplus and MEDLINE.

Binding behaviors of streptavidin were studied with different lateral packing densities of biotin-functionalized, nonbiofouling pOEGMA brushes, synthesized by surface-initiated polymerization from mixed SAMs with different mole fractions of the polymerization initiator on Au surfaces.

Chemical Communications (Cambridge, United Kingdom) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jung, Chan-Hee published the artcileA study on the immobilization of biomolecules on poly(acrylic acid)-grafted MWCNTs prepared by radiation-induced graft polymerization, HPLC of Formula: 359860-27-8, the publication is Polymer (Korea) (2010), 34(2), 150-153, database is CAplus.

In this research. biomol.-immobilized multi-walled carbon nanotubes (MWCNTs) were prepared by using radiation-induced graft polymerization For the immobilization of biomols., the surface of MWNCTs was functionalized by radiation-induced graft polymerization of acrylic acid. Based on the results of TGA and Raman spectroscopy it was found that acrylic acid was effectively graft-polymerized on the MWCNTs. Biomols. such as DNA and proteins were immobilized onto the resultant poly(acrylic acid)-grafted MWCNTs. The results of the XPS and fluorescence microscopy confirmed that the biomols. were successfully immobilized on the poly(acrylic acid)-grafted MWCNTs.

Polymer (Korea) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ganesan, Ramakrishnan published the artcilePhotoactive Diazoketo-Functionalized Self-Assembled Monolayer for Biomolecular Patterning, Category: imidazoles-derivatives, the publication is Langmuir (2009), 25(16), 8888-8893, database is CAplus and MEDLINE.

A diazoketo-functionalized alkoxysilane compound was synthesized, and its self-assembled monolayer (SAM) formation was studied on glass and silicon substrates. IR spectroscopy was employed to follow the photoreaction in this system, which proved that carboxylic groups were generated from diazoketo groups in the surface of the substrate. Photopatterning of biotin/streptavidin on the diazoketo-functionalized SAM shows the potential of this novel platform for biomol. patterning.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jang, Kwang-Suk published the artcileBiolabeling and binding evaluation of amphiphilic nanocrystallopolymers, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Nanomaterials (2016), 7416532/1-7416532/7, database is CAplus.

Surfactant-like inorganic-organic hybrid mols. named as nanocrystallopolymers were designed by conjugation of the hydrophilic synthetic poly(amino acid), poly-α,β-(N-(2-hydroxyethyl)l-aspartamide), with hydrophobic inorganic nanoparticles. In aqueous media, amphiphilic nanocrystallopolymers form self-aggregates with unique morphologies. Here, a simple biolabeling method of nanocrystallopolymers was developed. Biotin was selected as a model biomol. The specific binding of biotin-labeled nanocrystallopolymers to the targeted surface was evaluated with a surface plasmon resonance sensor.

Journal of Nanomaterials published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hyun, Jinho published the artcileMicrostamping on an activated polymer surfaces: Patterning biotin and streptavidin onto common polymeric biomaterials, Synthetic Route of 359860-27-8, the publication is Langmuir (2001), 17(20), 6358-6367, database is CAplus.

Microstamping on an activated polymer surface (MAPS) is a methodol. that enables biomols. to be patterned on polymers with micrometer spatial resolution MAPS combines homogeneous surface derivatization of a polymer to introduce a reactive functional group followed by reactive microcontact printing (μCP) of a biol. ligand of interest, linked to an appropriate reactive group. We demonstrate here that polyethylene, polystyrene, poly(Me methacrylate), and poly(ethylene terephthalate) films can be successfully modified to introduce COOH groups on their surfaces, which can be subsequently patterned by reactive μCP of amine-terminated biotin after derivatization of the COOH groups with pentafluorophenol. XPS and time-of-flight secondary ion mass spectrometry (TOF-SIMS) confirmed the chem. of MAPS at each stage of the derivatization of the polymer surfaces and reactive μCP of biotin. Micropatterned biotin surfaces fabricated by MAPS were patterned with streptavidin by exploiting mol. recognition between biotin and streptavidin. The formation of streptavidin patterns was examined by fluorescence microscopy of Alexa488-labeled streptavidin and by TOF-SIMS imaging of ¹⁵N-labeled recombinant streptavidin, bound to biotin patterns. The contrast in the streptavidin micropatterns was optimized by examining the effect of blocking agents and streptavidin incubation time. Maximum contrast was obtained for binding of 0.1 μM streptavidin from a buffer containing 0.02% (volume/volume) Tween 20 detergent for an incubation time of 1 min.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pampalakis, G. published the artcile“Activography”: a novel, versatile and easily adaptable method for monitoring enzymatic activities in situ, Product Details of C18H34N4O5S, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(22), 3246-3248, database is CAplus and MEDLINE.

We developed “activog.” to map enzymic activities on tissue sections using activity-based probes. The assay was validated using a new protease-activity probe on skin biopsies to provide proof-of-concept. Activog. is more selective and tech. easier than the established in situ zymog., thus, adaptable in routine running clinico-chem. laboratories

Chemical Communications (Cambridge, United Kingdom) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Product Details of C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Vineberg, Jacob G. published the artcileDesign, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid-Camptothecin Combination Chemotherapy, Quality Control of 359860-27-8, the publication is Journal of Medicinal Chemistry (2014), 57(13), 5777-5791, database is CAplus and MEDLINE.

Novel tumor-targeting dual-warhead camptothecin conjugates with SB-T-1214, (two warheads), self-immolative disulfide linkers for drug release, biotin as the tumor-targeting moiety, and 1,3,5-triazine as the tripod splitter module, were designed and synthesized. The potency of these conjugates were evaluated against MX-1, MCF-7, ID8, L1210FR (BR+, biotin receptor overexpressed) and WI38 (BR-, normal) cell lines in the absence and presence of glutathione (GSH), which is an endogenous thiol that triggers drug release inside the cancer cells. With the GSH and resuspension protocol, one of them exhibited IC₅₀ values of 3.22-9.80 nM against all BR+ cancer cell lines, and 705 nM against WI38. Thus, there was a two orders of magnitude higher selectivity to cancer cells. Also, a clear cooperative effect was observed for the taxoid-camptothecin combination when two drugs were delivered to the cancer cells specifically in the form of a dual-warhead conjugate.

Journal of Medicinal Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C8H8O2, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lin, Lei published the artcileHigh-throughput method for in process monitoring of 3-O-sulfotransferase catalyzed sulfonation in bioengineered heparin synthesis, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Analytical Biochemistry (2019), 113419, database is CAplus and MEDLINE.

Bioengineered heparin (BEH) offers a potential alternative for the preparation of a safer pharmacol. heparin. Construction of in-process control assays for tracking each enzymic step during bioengineered heparin synthesis remains a challenge. Here, we report a high-throughput sensing platform based on ELISA (ELISA) and enzymic signal amplification that allows the rapid and accurate monitoring of the 3-OST sulfonation in BEH synthesis process. The anticoagulant activity of target BEH was measured to reflect the degree of sulfonation by testing its competitive antithrombin (AT) binding ability. BEH samples with different sulfonation degrees show different AT protein binding capacity and thus changes the UV response to a different extent. This BEH-induced signal can be conveniently and sensitively monitored by the plate sensing system, which benefits from its high sensitivity brought in by the enzymic signal amplification. Furthermore, modification convenience and mech. robustness also ensure the stability of the test platform. This proposed strategy exhibits excellent anal. performance in both BEH activity anal. and 3-OST sulfonation evaluation. The simple and sensitive plate system shows great potential in developing on-chip, high-throughput methods for fundamental biochem. process research, drug discovery, and clinic diagnostics.

Analytical Biochemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chuh, Kelly N. published the artcileChanges in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification, SDS of cas: 359860-27-8, the publication is Journal of the American Chemical Society (2014), 136(35), 12283-12295, database is CAplus and MEDLINE.

Metabolic chem. reporters (MCRs) of glycosylation are analogs of monosaccharides that contain bioorthogonal functionalities and enable the direct visualization and identification of glycoproteins from living cells. Each MCR was initially thought to report on specific types of glycosylation. The authors and others demonstrated that several MCRs are metabolically transformed and enter multiple glycosylation pathways. Therefore, the development of selective MCRs remains a key unmet goal. The authors demonstrate here that 6-azido-6-deoxy-N-acetyl-glucosamine (6AzGlcNAc) is a specific MCR for O-GlcNAcylated proteins. Biochem. anal. and comparative proteomics with 6AzGlcNAc, N-azidoacetyl-glucosamine (GlcNAz), and N-azidoacetyl-galactosamine (GalNAz) revealed that 6AzGlcNAc exclusively labels intracellular proteins, while GlcNAz and GalNAz are incorporated into a combination of intracellular and extracellular/lumenal glycoproteins. Notably, 6AzGlcNAc cannot be biosynthetically transformed into the corresponding UDP sugar-donor by the canonical salvage-pathway that requires phosphorylation at the 6-hydroxyl. In vitro experiments showed that 6AzGlcNAc can bypass this roadblock through direct phosphorylation of its 1-hydroxyl by the enzyme phosphoacetylglucosamine mutase (AGM1). Taken together, 6AzGlcNAc enables the specific anal. of O-GlcNAcylated proteins, and these results suggest that specific MCRs for other types of glycosylation can be developed. Addnl., the authors’ data demonstrate that cells are equipped with a somewhat unappreciated metabolic flexibility with important implications for the biosynthesis of natural and unnatural carbohydrates.

Journal of the American Chemical Society published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem