Category: 359860-27-8

Han, Gyeongyeop published the artcileProtein-patterning on functionalized, non-biofouling poly[N-acryloxysuccinimide-co-oligo(ethylene glycol) methyl ether methacrylate] film-coated PET surfaces, Related Products of imidazoles-derivatives, the publication is Macromolecular Research (2018), 26(3), 263-269, database is CAplus.

We successfully fabricated poly(ethylene terephthalate) (PET) surfaces through a perfluoroaryl azide-based photochem. reaction, and subsequently formed an intrinsically activated, non-biofouling poly[N-acryloxysuccinimide-co-oligo(ethylene glycol) Me ether methacrylate] on the surface through surface-initiated, controlled radical polymerization The grafted copolymer film on PET facilely generated a protein pattern using a microcontact printing technique without employing both an activation step to introduce an active functional group (e.g., succinimidyl ester) and a passivation process for minimizing non-specific adsorption. Consequently, we characterized the functionalized PET surfaces by using various methods including contact angle measurement, XPS, scanning probe microscopy (SPM), field-emission SEM (FE-SEM). In addition, we evaluated the non-biofouling efficacy of the protein-patterned copolymer film on PET by confocal laser scanning microscopy.[Figure not available: see fulltext.].

Macromolecular Research published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yun, Je-Moon published the artcilePhotosensitive polymer brushes grafted onto PTFE film surface for micropatterning of proteins, COA of Formula: C18H34N4O5S, the publication is Journal of Materials Chemistry (2010), 20(10), 2007-2012, database is CAplus.

Surface grafting of photosensitive polymer brushes on a flexible polymer surface was performed using Ar ion irradiation, which generated peroxides on the polymer surface upon exposure to air. These peroxides were utilized as initiators for graft polymerization of a photosensitive diazoketo-functionalized methacrylate monomer. Upon UV light exposure, the diazoketo group was converted into the carboxylic acid group which was used to covalently immobilize amine-functionalized biotin in a patterned fashion. Successful binding of streptavidin to the biotin-linked regions proved the potential of the platform for biomol. patterning applications on com. polymer substrates.

Journal of Materials Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C6H8N2O2S, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cho, Woo Kyung published the artcileChemical modification of Si nanowires for bioconjugation, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Bulletin of the Korean Chemical Society (2005), 27(1), 111-114, database is CAplus.

The authors report the chem. modification of SiNWs (Si nanowires) by a combination of the formation of covalently bonded, organic monolayers on the surface of SiNWs and successive surface organic reactions. Self-assembled monolayers (SAMs) of 10-undecenyltrichlorosilane were formed on the surface of SiNWs. The terminal vinyl groups on the surface of SiNWs were oxidized to carboxylic acid groups by KMnO₄, K₂CO₃, and NaIO₃. The carboxylic acid groups were then activated with N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC) and pentafluorophenol (PFP). The formation of the SAMs on SiNWs and the successive reactions were confirmed by polarized IR external reflectance spectroscopy (PIERS). After the PFP activation, any mols. with amine functional groups can be anchored onto the surface of SiNWs through an amide bond. The PFP-activated SiNWs were washed carefully with EtOH several times. The sample was then immersed in a solution of biotin-amine (10 mM in EtOH) for 30 min and washed carefully with EtOH several times. Attachment of the biotin to the SiNWs was verified PIERS and fluorescence confocal microscopy. By sonication, the SiNWs were then separated from the Si wafer and dispersed in EtOH. The dispersed SiNWs were spun off by using centrifugation.

Bulletin of the Korean Chemical Society published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Punna, Sreenivas published the artcileA bioorthogonal immobilization method for affinity chromatography, Related Products of imidazoles-derivatives, the publication is American Biotechnology Laboratory (2007), 25(1), 20-21, database is CAplus.

Affinity chromatog. is a powerful and generally applicable process of purifying biomols. such as antibodies, carbohydrates, and enzymes by taking advantage of the affinity of these mols. toward appropriate ligands. The immobilization of ligands to an agarose support is challenging and critical to follow a method that is not detrimental to the functional groups present in the ligand, which are necessary for the binding of the mol. to be purified. For that, the ligand should contain a functional group for immobilization to the support that is not vital to its binding property. This paper reports on the use of click reaction as a highly selective and convenient immobilization method for affinity chromatog.

American Biotechnology Laboratory published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Punna, Sreenivas published the artcile“Clickable” agarose for affinity chromatography, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Bioconjugate Chemistry (2005), 16(6), 1536-1541, database is CAplus and MEDLINE.

Successful purification of biol. mols. by affinity chromatog. requires the attachment of desired ligands to biocompatible chromatog. supports. The Cu(I)-catalyzed cycloaddition of azides and alkynes, i.e., the premier example of “click chem.”, is an efficient way to make covalent connections among diverse mols. and materials. Both azide and alkyne units are highly selective in their reactivity, being inert to most chem. functionalities and stable to wide ranges of solvent, temperature, and pH. The authors show that agarose beads bearing alkyne and azide groups can be easily made and are practical precursors to functionalized agarose materials for affinity chromatog.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shuvaev, Vladimir V. published the artcileEndothelial Targeting of Antibody-Decorated Polymeric Filomicelles, Formula: C18H34N4O5S, the publication is ACS Nano (2011), 5(9), 6991-6999, database is CAplus and MEDLINE.

The endothelial lining of the lumen of blood vessels is a key therapeutic target for many human diseases. Polymeric filomicelles that self-assemble from polyethylene oxide (PEO)-based diblock copolymers are long and flexible rather than small or rigid, can be loaded with drugs, and-most importantly-they circulate for a prolonged period of time in the bloodstream due in part to flow alignment. Filomicelles seem promising for targeted drug delivery to endothelial cells because they can in principle adhere strongly, length-wise to specific cell surface determinants. In order to achieve such a goal of vascular drug delivery, two fundamental questions needed to be addressed: (i) whether these supramol. filomicelles retain structural integrity and dynamic flexibility after attachment of targeting mols. such as antibodies, and (ii) whether the avidity of antibody-carrying filomicelles is sufficient to anchor the carrier to the endothelial surface despite the effects of flow that oppose adhesive interactions. Here we make targeted filomicelles that bear antibodies which recognize distinct endothelial surface mols. We characterize these antibody targeted filomicelles and prove that (i) they retain structural integrity and dynamic flexibility and (ii) they adhere to endothelium with high specificity both in vitro and in vivo. These results provide the basis for a new drug delivery approach employing antibody-targeted filomicelles that circulate for a prolonged time yet bind to endothelial cells in vascular beds expressing select markers.

ACS Nano published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C11H12O4, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kanso, Hussein published the artcileChemiluminescence immunoassays for estradiol and ethinylestradiol based on new biotinylated estrogen derivatives, SDS of cas: 359860-27-8, the publication is Analytical Biochemistry (2017), 63-68, database is CAplus and MEDLINE.

New chemiluminescence-based immunoassays for sensitive detection of 17-β estradiol (E2) and ethinylestradiol (EE2) are described on the basis of the use of biotinylated estrogen derivatives Estrogen derivatives bearing a carboxylic group (E2-COOH and EE2-COOH) on C-3 position were synthesized, covalently bound to aminated biotin and subsequently immobilized on avidin-coated microtiter plates. The assay principle was based on competition between free and immobilized estrogens for their binding to primary antibodies, with subsequent revelation using horseradish peroxidase (HRP)-labeled secondary antibodies. Under optimized conditions, the chemiluminescence immunoassays showed a highly sensitive response to E2 and EE2, with resp. detection limits of 0.5 and 1.2 ng L^-1. The LOD achieved using biotinylated E2 was in the same order of magnitude as those obtained using com. available E2-bovine serum albumin conjugate (E2-BSA). The developed devices were successfully applied to anal. wastewater treatment plants effluents (WWTP) with negligible matrix effect.

Analytical Biochemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zerressen, Andreas published the artcileToward the Selection of Ribozymes for 1,3-Dipolar Cycloaddition Reactions, Application In Synthesis of 359860-27-8, the publication is Journal of Molecular Evolution (2005), 61(2), 236-244, database is CAplus and MEDLINE.

In vitro selection from combinatorial RNA libraries has repeatedly been used to study the catalytic and binding potential of nucleic acids. These selections not only led to RNA sequences catalyzing transformations known from metabolic pathways but also generated novel ribozymes for typical organic reactions. We were interested in 1,3-dipolar cycloaddition reactions, which are important tools for the formation of heterocyclic systems in organic chem. and might also be found in the hypothetic RNA world. Here we describe our strategy and experiments to isolate RNA mols. catalyzing a 1,3-dipolar cycloaddition between nitrile oxides and an acrylate conjugated to RNA. We used direct selection with linker-coupled reactants, which has previously allowed the generation of true trans-acting catalysts for bimol. reactions. A photocleavable linker was introduced to provide for a more stringent selection criterion. The 1,3-dipolar cycloaddition reaction was established in aqueous solution using a modified dinucleotide that was tethered to the dipolarophilic substrate. Two selection protocols were established, namely, a low-stringency affinity-based selection protocol, and a high-stringency procedure using the photocleavable moiety. In neither case was an increased activity toward the desired reaction obtained after 15 and 11 selection rounds, resp. The resulting pools of RNA from several rounds were investigated both in cis and in trans. The limitations of this selection methodol. are discussed in comparison with other catalysts for dipolar cycloadditions and, also, with respect to the unconventional substrates used.

Journal of Molecular Evolution published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C13H10N2S, Application In Synthesis of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dolgosheina, Elena V. published the artcileRNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking, Formula: C18H34N4O5S, the publication is ACS Chemical Biology (2014), 9(10), 2412-2420, database is CAplus and MEDLINE.

Because RNA lacks strong intrinsic fluorescence, it has proven challenging to track RNA mols. in real time. To address this problem and to allow the purification of fluorescently tagged RNA complexes, the authors have selected a high affinity RNA aptamer called RNA Mango. This aptamer binds a series of thiazole orange (fluorophore) derivatives with nanomolar affinity, while increasing fluorophore fluorescence by up to 1100-fold. Visualization of RNA Mango by single-mol. fluorescence microscopy, together with injection and imaging of RNA Mango/fluorophore complex in C. elegans gonads demonstrates the potential for live-cell RNA imaging with this system. By inserting RNA Mango into a stem loop of the bacterial 6S RNA and biotinylating the fluorophore, the aptamer can be used to simultaneously fluorescently label and purify biol. important RNAs. The high affinity and fluorescent properties of RNA Mango are therefore expected to simplify the study of RNA complexes.

ACS Chemical Biology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kam, Nadine Wong Shi published the artcileNanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells, Formula: C18H34N4O5S, the publication is Journal of the American Chemical Society (2004), 126(22), 6850-6851, database is CAplus and MEDLINE.

The interactions between various functionalized carbon nanotubes and several types of human cancer cells are explored. We have prepared modified nanotubes and have shown that these can be derivatized in a way that enables attachment of small mols. and of proteins, the latter through a novel noncovalent association The functionalized carbon nanotubes enter nonadherent human cancer cells as well as adherent cell lines (CHO and 3T3) and by themselves are not toxic. While the fluoresceinated protein streptavidin (MW ≈ 60 kD) by itself does not enter cells, it readily enters cells when complexed to a nanotube-biotin transporter and exhibits dose-dependent cytotoxicity. The uptake pathway is consistent with adsorption-mediated endocytosis. The use of carbon nanotubes as mol. transporters could be exploited for various cargos. The biocompatibility and unique phys., elec., optical, and mech. properties of nanotubes provide the basis for new classes of materials for drug, protein, and gene delivery applications.

Journal of the American Chemical Society published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem