Category: 3724-19-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3724-19-4, is researched, Molecular C8H9NO2, about Topological and luminescent properties of two coordination polymers constructed from 3-pyridinepropionic acid, the main research direction is zinc cadmium pyridinepropionate polymer complex preparation crystal structure luminescence.HPLC of Formula: 3724-19-4.

Two coordination polymers, [Zn(PPA)2(H2O)2]n (1) and [Cd(PPA)2]n (2) (HPPA = 3-pyridinepropionic acid), were hydrothermally synthesized. Both 1 and 2 crystallize in P1̅ space group. Zn(II) centers in 1 are extended by PPA ligands to form the 1-dimensional chains, which are consolidated by hydrogen bonding to construct a 3-dimensional supramol. network. The structure of 2 represents a rare binodal (3,6)-connected 2-dimensional layer with kgd topol. The luminescent properties of 1 and 2 in the solid state are discussed.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Isoquinolines. III. The nitration of 3,4-dihydro- and 1,2,3,4-tetrahydroisoquinolines》. Authors are McCoubrey, A.; Mathieson, DavidW..The article about the compound:3-Pyridinepropionic acidcas:3724-19-4,SMILESS:OC(=O)CCC1=CC=CN=C1).Quality Control of 3-Pyridinepropionic acid. Through the article, more information about this compound (cas:3724-19-4) is conveyed.

cf. C.A. 45, 1137i. 3,4-Dihydroisoquinoline(600 mg.) in 2.5 cc. H2SO4 (d. 1.84), added to 500 mg. KNO3 in 2.5 cc. H2SO4 at 0° and the mixture allowed to warm to room temperature (2 hrs.) and warmed 4 hrs. at 60° gives 700 mg. of a brown compound (presumably the 7-NO2 derivative), m. 88-90°; dehydrogenation by refluxing 2 hrs. with 200 mg. Pd black in 10 cc. tetrahydronaphthalene gives 170 mg. 7-nitroisoquinoline, m. 177-8°. Tetrahydroisoquinoline (10.5g.) converted into the sulfate by solution in the calculated amount of 5 N H2SO4, evaporated to dryness, the residue added to 10 g. KNO3 in 50 cc. concentrated H2SO4 at 0° kept overnight at room temperature, poured on ice, the mixture neutralized with aqueous NH3, the base extracted with CHCl3, the CHCl3 evaporated, and the residue extracted with petr. ether, gives the unstable 1,2,3,4-tetrahydro-7-nitroisoquinoline, analyzed as the HCl salt (I), in. 261° (12.5 g.); picrate, brown, m. 190-2°; 2-(p-nitro-benzoyl) derivative, yellow, m. 209-10°; 2-Bz derivative (IA), yellow, in. 125° I (5 g.) in 150 cc. EtOH, reduced over 300 mg. Pt oxide, gives 2.35 g. 7-amino-1,2,3,4-tetrahydroisoquinoline, m. 120-1°. IA (4.3 g.) in 100 cc. EtOH, reduced over Raney Ni (3 hrs.), gives 3.8 g. 7-amino-2-benzoyl-1,2,3,4-tetrahydroisoquinoline (II), cream, m. 129°; 1 g. II and 500mg. LiAlH4 in 100 cc. ether, refluxed overnight, give 900 mg. 2-benzyl analog (III), cream, m. 88°. 5,2-O2N(ClCH2CH2)C6H3CH2Cl (2.5 g.) and 3.5 g. PhCH2NH2 in 25 cc. EtOH, refluxed 1 hr., give 3 g. 2-benzyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline-HCl (IV), m. about 248°; reduction of 1 g. IV over Raney Ni (10 hrs.) gives 500 mg. III. Isoquinoline (5 g.) and 5 g. PhCH2Cl in 10 cc. EtOH, refluxed 6 hrs. and the product in H2O treated with excess KI, give 14 g. 2-benzylisoquinolinium iodide (V), yellow, in. 178°; 10 g. V in 100 cc. MeOH, reduced (6 hrs.) over 300 mg. Pt oxide, gives 6.2 g. 2-benzyl-1,2,3,4-tetrahydroisoquinoline, b20 200-5°; HCl salt, m. 204°; nitration gives IV. 2-Butyl-1,2,3,4-tetrahydroisoquinoline and KNO3 in concentrated H2SO4 give the 7-NO2 derivative (HCl salt, m. 234-5°).

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Imidazole – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.Recommanded Product: tert-Butyl 2-oxoindoline-1-carboxylate. The article 《A manganese coordination polymer and a palladium molecular compound of 3-pyridinepropionic acid (HL): [MnL2(H2O)2]∞ and trans-[Pd(HL)2Cl2]》 in relation to this compound, is published in Bulletin of the Korean Chemical Society. Let’s take a look at the latest research on this compound (cas:3724-19-4).

Three coordination polymers, [ML2(H2O)2] (M = Co (1), Ni (2), Mn (3)), were prepared from metal acetates (M(CH3COO)2·4H2O) and 3-pyridinepropionic acid (HL = (3-py)-CH2CH2COOH) by solvent-layer methods. By contrast, a discrete mol. compound, trans-[Pd(HL)2Cl2] (4), was synthesized by replacing benzonitrile (PhCN) ligands in trans-[Pd(PhCN)2Cl2] with HL under microwave-heating conditions. Compounds 1-3 have a 2D framework, and compound 4 contains a square-planar Pd metal.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organic Chemistry Frontiers called A general and efficient Mn-catalyzed acceptorless dehydrogenative coupling of alcohols with hydroxides into carboxylates, Author is Shao, Zhihui; Wang, Yujie; Liu, Yaqian; Wang, Qian; Fu, Xiaoling; Liu, Qiang, which mentions a compound: 3724-19-4, SMILESS is OC(=O)CCC1=CC=CN=C1, Molecular C8H9NO2, Quality Control of 3-Pyridinepropionic acid.

Herein, a sustainable method was developed for the synthesis of carboxylic acids RCO2H [R = Me, Ph, 3-pyridyl, etc.] via manganese-catalyzed acceptorless dehydrogenation of alcs. generating H2 as the sole byproduct. A wide range of carboxylic acids were synthesized with high yields and excellent functional group tolerance. The reaction proceeded selectively in the presence of a well-defined manganese pincer complex at a very low catalyst loading. Mechanistic studies including control experiments, NMR spectroscopy and X-ray crystallog. identified the resting state and key intermediates in the catalytic cycle.

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Imidazole – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Pyridinepropionic acid(SMILESS: OC(=O)CCC1=CC=CN=C1,cas:3724-19-4) is researched.HPLC of Formula: 86404-63-9. The article 《Discovery of Potent Hexapeptide Agonists to Human Neuromedin U Receptor 1 and Identification of Their Serum Metabolites》 in relation to this compound, is published in ACS Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:3724-19-4).

Neuromedin U (NMU) and S (NMS) display various physiol. activities, including an anorexigenic effect, and share a common C-terminal heptapeptide-amide sequence that is necessary to activate two NMU receptors (NMUR1 and NMUR2). On the basis of this knowledge, the authors recently developed hexapeptide agonists, which are highly selective to human NMUR1 and NMUR2, resp. However, the agonists are still less potent than the endogenous ligand, hNMU. Therefore, the authors performed an addnl. structure-activity relationship study, which led to the identification of a more potent hexapeptide I that exhibits similar NMUR1-agonistic activity as compared to hNMU. Addnl., the authors studied the stability of synthesized agonists, including I, in rat serum, and identified two major biodegradation sites: Phe2-Arg3 and Arg5-Asn6. The latter was more predominantly cleaved than the former. Moreover, substitution with 4-fluorophenylalanine, as in I, enhanced the metabolic stability at Phe2-Arg3. These results provide important information to guide the development of practical hNMU agonists.

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Imidazole – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Influence of H-Bond Strength on Chelate Cooperativity, the main research direction is ether phenol intramol hydrogen bond zinc porphyrin pyridine complex; zinc porphyrin phenol association constant pyridyl ether.Reference of 3-Pyridinepropionic acid.

Intermol. complexes formed between metalloporphyrins and pyridine ligands equipped with multiple H-bond donors and acceptors were used to measure the free energy contributions due to intramol. ether-phenol H-bonding in the 24 different supramol. architectures using chem. double mutant cycles in toluene. The ether-phenol interactions are relatively weak, and there are significant populations of partially bound states where between zero and four intramol. H-bonds are made in addition to the porphyrin-ligand coordination interaction. The complexes were analyzed as ensembles of partially bound states to determine the effective molarities for the intramol. interactions by comparison with the corresponding intermol. ether-phenol H-bonds. The properties of the ether-phenol interactions were compared with phosphonate diester-phenol interactions in a closely related ligand system, which has more powerful H-bond acceptor oxygens positioned at the same location on the ligand framework. This provides a comparison of the properties of weak and strong H-bonds embedded in the same 24 supramol. architectures. When the product of the intermol. association constant and the effective molarity KEM > 1, there is a linear increase in the free energy contribution due to H-bonding with log EM, because the intramol. interactions contribute fully to the stability of the complex. When KEM < 1, the H-bonded state is not significantly populated, and there is no impact on the overall stability of the complex. Intermol. phosphonate diester-phenol H-bonds are 2 orders of magnitude stronger than ether-phenol H-bonds in toluene, so for the phosphonate diester ligand system, 23 of the 24 supramol. architectures make intramol. H-bonds. However, only 8 of these architectures lead to detectable H-bonding in the ether ligand system. The other 15 complexes have a suitable geometry for formation of H-bonds, but the ether-phenol interaction is not strong enough to overcome the reorganization costs associated with making intramol. contacts, i.e., KEM < 1 for the ether ligands, and KEM > 1 for the phosphonate diester ligands. The values of EM measured for two different types of H-bond acceptor are linearly correlated, which suggests that EM is a property of the supramol. architecture. However, the absolute value of EM for an intramol. phosphonate diester H-bond is ∼4 times lower than the corresponding value for an intramol. ether-phenol interaction embedded in the same supramol. framework, which suggests that there may be some interplay of K and EM.

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Imidazole – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-Pyridinepropionic acid( cas:3724-19-4 ) is researched.Quality Control of 3-Pyridinepropionic acid.Li, Yuqi; Sharma, Savita K.; Karlin, Kenneth D. published the article 《New heme-dioxygen and carbon monoxide adducts using pyridyl or imidazolyl tailed porphyrins》 about this compound( cas:3724-19-4 ) in Polyhedron. Keywords: preparation pyridyl imidazolyl tailed iron porphyrin; carbon monoxide adduct pyridyl imidazolyl tailed iron porphyrin; dioxygen adduct pyridyl imidazolyl tailed iron porphyrin; 1,2H-NMR spectroscopy; Base tethered heme complexes; Heme-FeIII-superoxo complexes; Reduced Heme-FeII complexes; heme-FeII-carbonyl complexes. Let’s learn more about this compound (cas:3724-19-4).

Inspired by the chem. relevant to dioxygen storage, transport and activation by metalloproteins, in particular for heme/copper oxidases, and carbon monoxide binding to metal-containing active sites as a probe or surrogate for dioxygen binding, a series of heme derived dioxygen and CO complexes have been designed, synthesized, and characterized with respect to their phys. properties and reactivity. The focus of this study is in the description and comparison of three types heme-superoxo and heme-CO adducts. The starting point is in the characterization of the reduced heme complexes, [(F8)FeII], [(PPy)FeII] and [(PIm)FeII], where F8, PPy and PIm are iron(II)-porphyrinates and where PPy and PIm possess a covalently tethered axial base pyridyl or imidazolyl group, resp. The spin-state properties of these complexes vary with solvent. The low temperature reactions between O2 and these reduced porphyrin FeII complexes yield distinctive low spin heme-superoxo adducts. The dioxygen binding properties for all three complexes are reversible, via alternate argon or O2 bubbling. Carbon monoxide binds to the reduced heme-FeII precursors to form low spin heme-CO adducts. The implications for future investigations of these heme O2 and CO adducts are discussed.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3724-19-4, is researched, Molecular C8H9NO2, about Poly[trans-diaquabis[μ-3-(3-pyridyl)propionato-κ2N,O]cadmium(II)], the main research direction is mol structure cadmium aqua pyridylpropionato polymeric complex; crystal structure cadmium aqua pyridylpropionato polymeric complex; hydrogen bond cadmium aqua pyridylpropionato polymeric complex.Quality Control of 3-Pyridinepropionic acid.

[Cd(L)2(H2O)2]n (L = 3-pyridinepropionic acid, C8H8NO2), is a two-dimensional coordination polymer in which the CdII ion lies on an inversion center and is coordinated in a slightly distorted octahedral environment. The aqua H atoms are involved in intermol. O-H…O H bonds, which extend the two-dimensional structure to a three-dimensional architecture. The Cd…Cd separation within a layer is 9.0031(1) Å. Crystallog. data and at. coordinates are given.

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Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Inhibition of Human Neutrophil Elastase with Peptidyl Electrophilic Ketones. 2. Orally Active PG-Val-Pro-Val Pentafluoroethyl Ketones.Product Details of 3724-19-4.

Valylprolylvalyl pentafluoroethyl ketones with different N-protecting groups were evaluated in vitro and in vivo as inhibitors of human neutrophil elastase (HNE). Several of these compounds were found to be orally active in HNE-induced rat and hamster lung hemorrhage models. The morpholinylcarbonylbenzoyl derivative I (MDL 101,146), was studied in greater detail. Hydration and epimerization studies were performed on I and related compounds in various media, including human blood serum. High-performance liquid chromatog. studies on a reversed-phase system as a measure of the lipophilicity of I and related compounds revealed that the orally active compounds fell in a small range of relative retention times. The Ki value determined for I vs HNE was 25 nM.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 3724-19-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Pyridinepropionic acid, is researched, Molecular C8H9NO2, CAS is 3724-19-4, about Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands. Author is Akhtar, Muhammad Nadeem; Shahid, Muhammad; Sadakiyo, Masaaki; Ikram, Muhammad; Rehman, Sadia; Ahmed, Irshad.

Compounds [CuII2(benz)4(Hbenz)2] (I) and [CuII(ppa)2(H2O)2]n (II), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound II showed IC50 = 31.22±0.45 μM, as compared to compound I with IC50 = 36.52±0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound I exhibited selective antiurease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.

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Reference:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem