Category: 4857-06-1

The author of 《Aggregation-induced emission: lighting up herg potassium channel》 were Zhang, Xiaomeng; Liu, Tingting; Li, Qi; Li, Minyong; Du, Lupei. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2019. Category: imidazoles-derivatives The author mentioned the following in the article:

Based on the scaffold of astemizole and E-4031, four AIE light-up probes (L1-L4) for Human Ether-a-go-go-Related Gene (hERG) potassium channel were developed herein using AIE fluorogen(TPE). These probes showing advantages such as low background interference, superior photostability, acceptable cell toxicity, and potent inhibitory activity, which could be used to image hERG channels at the nanomolar level. These AIE light-up probes hoped to provide guidelines for the design of more advanced AIE sensing and imaging hERG channels to a broad range of applications. In the experiment, the researchers used many compounds, for example, 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Category: imidazoles-derivatives)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Qian, Ping; Deng, Yu; Mei, Haibo; Han, Jianlin; Pan, Yi published 《Metal-free nitroxyl radical-mediated β-C(sp3)-H amination of saturated ketones with heteroaryl halides: multiple roles of TEMPO》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 2-Chloro-1H-benzo[d]imidazole The information in the text is summarized as follows:

The first metal-free nitroxyl-radical-mediated β-amination of saturated ketones by using heteroaryl halides as amide precursors has been developed. This reaction proceeds through a cascade α-aminoxylation/Cope-like elimination/aza-Michael addition sequence to afford β-amino ketone derivatives with excellent yields. TEMPO plays multiple roles in the current β-amination process, including those of an oxidant, an α-aminoxylation reagent, a β-hydrogen acceptor, an in situ base, and an oxygen source. In the experiment, the researchers used many compounds, for example, 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Recommanded Product: 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Recommanded Product: 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Selective C-H trifluoromethylation of benzimidazoles through photoredox catalysis》 was written by Gao, Guo-Lin; Yang, Chao; Xia, Wujiong. Category: imidazoles-derivativesThis research focused ontrifluoromethyl benzoimidazole preparation; benzimidazole trifluoromethylation photoredox catalyst togni reagent. The article conveys some information:

A new strategy for the preparation of trifluoromethyl benzimidazoles I (R = H, 5,6-di-Me, 5-Cl, etc.; R1 = H, CH3, C6H5CH2, etc.; X = H, CH2OCH3, pyridin-2-yl, etc.) via visible light induced C-H trifluoromethylation at C4 of benzimidazoles II using Togni’s reagent in the presence of fac-Ir(ppy)3 has been presented. Its advantages are operational simplicity, mild reaction conditions, low catalyst loading and wide substrate scope, in which electron-withdrawing, electron-donating groups and different protecting groups are tolerated. After reading the article, we found that the author used 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Category: imidazoles-derivatives)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

V., Paleri Sandhya; V., Kakkotakath Muhammad Niyas; R., Karickal Haridas published their research in Research Journal of Chemistry and Environment in 2021. The article was titled 《Microwave assisted synthesis of benzimidazole derivatives using tetra butyl ammonium chloride as phase transfer catalyst, characterization, biological activities and molecular docking studies》.HPLC of Formula: 4857-06-1 The article contains the following contents:

Benzimidazole and its derivatives are of wide interest because of their diverse biol. activity and clin. applications. The heterocyclic imidazole core is a common moiety in a large number of natural products and pharmacol. active compounds and because of that they are possessing inhibitory activity as well as favorable selectivity ratio. Benzimidazoles exhibit significant activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous antioxidants, anti-parasitic, anti-helmintics, antiproliferative, anti-HIV, anti-convulsant, anti-inflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. The synthesis of benzimidazole derivatives remains a focus of medicinal research. Here benzimidazole derivatives were synthesized using two phase system under microwave conditions using the phase transfer catalyst tetra Bu ammonium chloride (10% mol) in good yield. The mol. docking study against 4GQQ protein with synthesized benzimidazole derivatives was performed to see the necessary interactions responsible for anti-bacterial activity. The experimental process involved the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1HPLC of Formula: 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.HPLC of Formula: 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Ru(II)-Catalyzed and acidity-controlled tunable [5+1]/[5+2] annulation for building ring-fused quinazolines and 1,3-benzodiazepines》 was written by Yang, Yurong; Zhang, Kaixin; Yang, Jian; Zhu, Guoxun; Chen, Weijie; Zhang, Chao; Zhou, Zhi; Yi, Wei. Related Products of 4857-06-1 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The Ru(II)-catalyzed tunable [5+1]/[5+2] annulation of N-benzo[d]imidazole indolines with propargyl carbonates was realized for the divergent synthesis of ring-fused quinazolines and 1,3-benzodiazepines bearing various functional groups. These transformations represented an efficient and practical strategy in constructing complex heterocycles via diversified C-H functionalization. A distinctive acidity-controlled reaction manner was clarified to account for the chemoselectivity. In the experiment, the researchers used many compounds, for example, 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Related Products of 4857-06-1)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Related Products of 4857-06-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Mishra, Shashank Shekher; Sharma, C. S. published their research in Indian Journal of Heterocyclic Chemistry in 2021. The article was titled 《Design, synthesis, cytotoxicity, and molecular docking studies of new benzimidazole hybrids as possible anticancer agents》.Safety of 2-Chloro-1H-benzo[d]imidazole The article contains the following contents:

A new anticancer agents, benzimidazole-based morpholine, thiomorpholine and piperazine hybrid compounds I [R = 4-HOC6H4CH2, 4-MeOC6H4CH2, 4-MeC(O)OC6H4CH2, 4-B(OH)2C6H4CH2, 1-[(4-pyrrol-1-ylphenyl)methyl], (4-pyrazol-1-ylphenyl)methyl; R1 = morpholino, thiomorpholino, 4-methylpiperazin-1-yl] were designed and synthesized. The structures of the synthesized compounds were confirmed by Proton NMR, Carbon-13 NMR and mass spectroscopy. The title compounds were screened for cytotoxicity against breast and lung cancer cell lines. Compound I [R = 4-B(OH)2C6H4CH2; R1 = morpholino] was found most active against lung cancer cell line with IC50 value of 2.11μM and compound I [R = 4-B(OH)2C6H4CH2; R1 = 4-methylpiperazin-1-yl] was found most active against breast cancer cell line with IC50 of 2.23μM. The mol. docking anal. was also carried out to explore binding pattern of compound with the target protein. All synthesized compounds showed excellent binding affinity toward target protein. In the experimental materials used by the author, we found 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Safety of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Safety of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Imidazolium-benzimidazolates as convenient sources of donor-functionalized normal and abnormal N-heterocyclic carbenes》 were Kureja, Kunal; Zinke, Julian; Bruhn, Clemens; Siemeling, Ulrich. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Computed Properties of C7H5ClN2 The author mentioned the following in the article:

Imidazolium-benzimidazolates are readily available conjugated mesomeric betaines, whose carbenic tautomers can form C,Nimine-metal chelates containing amino-functionalized normal or abnormal NHC ligands, depending on the degree of steric congestion. Deprotonation of the amino moiety gives rise to imine-functionalized C,Namido-metal chelates, whose Nimine atom can be easily utilized for the construction of heteronuclear complexes. In the experiment, the researchers used many compounds, for example, 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Computed Properties of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Computed Properties of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2018,Bente, Stefanie; Kampert, Florian; Tan, Tristan T. Y.; Hahn, F. Ekkehardt published 《Site-selective metallation of dicarbene precursors》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C7H5ClN2 The information in the text is summarized as follows:

An imidazolium/2-chlorobenzimidazole bis-NHC precursor was reacted with Ag2O followed by transmetalation with [AuCl(THT)] to give the Au-NHC complex via metalation of the imidazolium site, while the reaction of the same bis-NHC precursor with [Pd(PPh3)4] yields exclusively the azolato complex by oxidative addition of the C2-Cl bond to Pd0. Both complexes were converted into the heterobimetallic Au/Pd-complex by reaction with [Pd(PPh)3]4 (for the NHC complex) or Ag2O/[AuCl(THT)] (for the azolato complex), resp. The experimental part of the paper was very detailed, including the reaction process of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Formula: C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) binds to monoclonal antibodies, inhibiting their binding to their corresponding antigens. This activity may be due to its ability to bind covalently with amino groups on proteins and other molecules.Formula: C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2017,Jeyaleela, G. Dayana; Monisha, S. Irudaya; Vimala, J. Rosaline; Immaculate, A. Anitha published 《Isolation of 2-chlorobenzimidazole from Melia dubia leaf extract and its structural characterisation》.International Journal of Pharmacy and Pharmaceutical Sciences published the findings.Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole The information in the text is summarized as follows:

Objective: Natural products from medicinal plants, either as isolated compounds or as standardized plant extracts exhibit promising source of medicinal activity against various diseases. The aim of the present work was to make an attempt of isolation of bioactive principle and characterization of the isolated compound, from the medicinal plant Melia dubai Methods: The extraction was done by a cold percolation method and the compound was separated and isolated by chromatog. technique such as a thin layer chromatog. (TLC), column chromatog. and high-performance liquid chromatog. (HPLC). The isolated compound was crystallized and the structural characterization of the isolated compound was made using UV-Visible, FT-IR, 1H-NMR, GC-MS and MS techniques which confirmed the structure of the isolated compound Results: The separated and isolated compound was characterized by both phys. and spectral methods like UV-Visible spectroscopy (UV-Visible), Fourier transform IR spectroscopy (FT-IR), Proton NMR Spectroscopy (1H-NMR), Gas chromatog.-mass spectrometry (GC-MS), and Mass spectrometry(MS). Based on the studies, organizational characteristics of one bioactive principle were deciphered. The results revealed that the isolated species is 2-chlorobenzimidazole and it agreed well with the reported value and spectra for 2-chlorobenzimidazole. Conclusion: The above results obtained in this research work clearly indicated the promising occurrence of 2-chlorobenzimidazole in Media dubia plant leaves. The future scope of these studies may guide us to view the biol. activity of the isolated compound In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Application In Synthesis of 2-Chloro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Dioxothietanylation of heterocycles 2*. Imidazoles and benzimidazoles》 were Makarova, Nadezhda N.; Klen, Elena E.; Khaliullin, Ferkat A.. And the article was published in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2019. Synthetic Route of C7H5ClN2 The author mentioned the following in the article:

The 1-(1,1-dioxidothietan-3-yl)-1H-benzimidazoles I (R = H, Cl, CH3, C6H5CH2, CH3S, CH3CH2S) and 1-(1,1-dioxidothietan-3-yl)-1H-imidazoles II (R1 = H, CH3; R2 = H, NO2) were synthesized in the reaction of 3,5-dibromo-1-(1,1-dioxidothietan-3-yl)-1H-1,2,4-triazole with the sodium salts of benzimidazoles III and imidazoles IV. The reaction involves addition of azoles to thiete 1,1-dioxide formed in situ, which acts as a Michael acceptor. The effect of pKa values of benzimidazoles III and imidazoles IV on their reactivity is shown. The results came from multiple reactions, including the reaction of 2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1Synthetic Route of C7H5ClN2)

2-Chloro-1H-benzo[d]imidazole(cas: 4857-06-1) is an analog of benzimidazole that has been synthesized by Langmuir adsorption isotherm. It is a white crystalline solid that can be dissolved in water and hydrochloric acid. 2-Chloro-1H-benzo[d]imidazole inhibits the growth of herpes simplex virus by acting as a competitive inhibitor for the viral enzyme thymidine kinase, which catalyzes the conversion of thymine to thymidine.Synthetic Route of C7H5ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem