Category: 5036-48-6

Pinyakit, Yuwaporn; Palaga, Tanapat; Kiatkamjornwong, Suda; Hoven, Voravee P. published an article in 2020, the title of the article was Sequential post-polymerization modification of a pentafluorophenyl ester-containing homopolymer: a convenient route to effective pH-responsive nanocarriers for anticancer drugs.Recommanded Product: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Recently, pH-responsive polymeric micelles have gained significant attention as effective carriers for anti-cancer drug delivery. Herein, pH-responsive polymeric micelles were constructed by a simple post-polymerization modification of a single homopolymer, poly(pentafluorophenyl acrylate) (PPFPA). The PPFPA was first subjected to modification with 1-amino-2-propanol yielding the amphiphilic copolymer of poly(pentafluorophenyl acrylate)-ran-poly(N-(2-hydroxypropyl acrylamide)). A series of amphiphilic random copolymers of different compositions could self-assemble into spherical micelles with a unimodal size distribution in aqueous solution Then, 1-(3-aminopropyl)imidazole (API), a reagent to introduce charge conversional entities, was reacted with the remaining PPFPA segment in the micellar core resulting in API-modified micelles which can encapsulate doxorubicin (DOX), a hydrophobic anti-cancer drug. As monitored by dynamic light scattering, the API-modified micelles underwent disintegration upon pH switching from 7.4 to 5.0, presumably due to imidazolyl group protonation. This pH-responsiveness of the API-modified micelles was responsible for the faster and greater in vitro DOX release in an acidic environment than neutral pH. Cellular uptake studies revealed that the developed carriers were internalized into MDA-MB-231 cells within 30 min via endocytosis and exhibited cytotoxicity in a dose-dependent manner. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole

The Article related to pentafluorophenyl ester ph responsive nanocarrier anticancer drug, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 2020, Feng, Jingxian; Xu, Minjun; Wang, Jiahao; Zhou, Songlei; Liu, Yipu; Liu, Shanshan; Huang, Yukun; Chen, Yu; Chen, Liang; Song, Qingxiang; Gong, Jingru; Lu, Huiping; Gao, Xiaoling; Chen, Jun published an article.Product Details of 5036-48-6 The title of the article was Sequential delivery of nanoformulated ä¼?mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer. And the article contained the following:

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease exhibiting the poorest prognosis among solid tumors. The efficacy of conventional therapies has been hindered largely due to the insufficient chemotherapeutic delivery to the dense desmoplastic tumor stroma, and the extremely high or toxic dose needed for chemotherapy. Traditional Chinese Medicine (TCM) contains effective components that can effectively regulate tumor microenvironment and kill tumor cells, providing promising alternatives to PDAC chemotherapy. In this study, two active drug monomers of TCM were screened out and a sequentially targeting delivery regimen was developed to realize the optimized combinational therapy. Transforming growth factor-å°?(TGF-å°? plays an indispensable role in promoting cancer-associated fibroblasts (CAFs) activation and proliferation, and CAFs have caused major phys. barriers for chemotherapeutic drug delivery. Herein, CAFs-targeting biodegradable polymer nanoparticle (CRE-NP(ä¼?M)) coated with CREKA peptide and loaded with TCM ä¼?mangostin (ä¼?M) was developed to modulate tumor microenvironment by interfering of TGF-å°?Smad signaling pathway. Low pH-triggered micelle modified with CRPPR peptide and loaded with another TCM triptolide was constructed to increase the therapeutic effect of triptolide at the tumor sites and reduced its damage to main organs. As expected, CRE-NP(ä¼?M) effectively inactived CAFs, reduced extracellular matrix production, promoted tumor vascular normalization and enhanced blood perfusion at the tumor site. The sequentially targeting drug delivery regimen, CRP-MC(Trip) following CRE-NP(ä¼?M) pretreatment, exhibited strong tumor growth inhibition effect in the orthotopic tumor model. Hence, sequentially targeting delivery of nanoformulated TCM offers an efficient approach to overcome the permeation obstacles and improve the effect of chemotherapy on PDAC, and provides a novel option to treat desmoplastic tumors. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to mangostin triptolide pancreatic cancer drug nanoformulation, acid-triggered micelles, pancreatic cancer, tgf-å°? traditional chinese medicine, triptolide, ä¼?mangostin, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Venkata Mallavadhani, Uppuluri; Vanga, Nagi Reddy; Balabhaskara Rao, Kancharana; Jain, Nishanth published an article in 2020, the title of the article was Synthesis and antiproliferative activity of novel (+)- usnic acid analogues.Name: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Twenty one novel (+)- usnic acid-based analogs belonging to three classes such as enamines, imines, and pyrazoles were synthesized. All the synthesized compounds were characterized by their spectral data (1H NMR, 13C NMR, IR, and HRMS). The synthesized compounds were evaluated for their antiproliferative activity against a panel of four human cancer cell lines including HeLa (cervix), MDA-MB-231 (breast), A549 (lung), and MiaPaca (pancreas) by employing SRB cell proliferation assay. Screening results indicated that all synthesized compounds showed enhanced activity than the parent compound Most significantly, compounds and showed potent antiproliferative activity against all the cancer cell lines tested. Compounds and arrested the cell cycle in G2/M phase and induced apoptosis in HeLa cells. In view of significant antiproevaliferative activity, compounds and can be considered as lead mols. for further development. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to cervical lung breast pancreatic cancer antiproliferative usnic acid, (+)- usnic acid, antiproliferative activity, apoptosis, cell cycle arrest, enamine, pyrazole, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 5, 2021, Qiu, Xiang; Wang, Shushu; Miao, Shanshan; Suo, Hongbo; Xu, Huajin; Hu, Yi published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Co-immobilization of laccase and ABTS onto amino-functionalized ionic liquid-modified magnetic chitosan nanoparticles for pollutants removal. And the article contained the following:

This work aims to achieve the co-immobilization of laccase and 2,2-binamine-di-3-ethylbenzothiazolin-6-sulfonic acid (ABTS) to improve removal capability of the biocatalyst for pollutants while avoiding potential pollution caused by ABTS. The laccase was immobilized on magnetic chitosan nanoparticles modified with amino-functionalized ionic liquid containing ABTS (MACS-NIL) based on Cu ion chelation (MACS-NIL-Cu-lac). The carrier was characterized by Fourier transform IR spectroscopy, thermogravimetric anal., x-ray diffraction and etc., and ESR confirmed the mediator mol. ABTS on the carrier could also play the role of electron transmission. MACS-NIL-Cu-lac presented relatively high immobilization capacity, enhanced activity (1.7-fold that of free laccase), improved pH and temperature adaptability, and increased thermal and storage stability. The removal performance assay found that MACS-NIL-Cu-lac had a good removal efficiency with 100.0 % for 2,4-dichlorophenol in water at 25 掳C, even when the concentration reached 50 mg/L. Reusability study showed that after six catalytic runs, the removal efficiency of 2,4-dichlorophenol by MACS-NIL-Cu-lac could still reach 93.2 %. Addnl., MACS-NIL-Cu-lac exhibited higher catalytic efficiencies with 100.0 %, 70.5 % and 93.3 % for bisphenol A, indole, and anthracene, resp. The high catalytic performance in pure water system obtained by the novel biocatalyst co-immobilizing laccase and electron mediator ABTS showed greater practical application value. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to laccase abts immobilization magnetic chitosan nanoparticle pollutant removal, abts, ionic liquid, laccase, magnetic chitosan nanoparticles, pollutants removal, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 16, 2020, Guo, Dandan; Yang, Chenxi; Qiu, Ruchen; Huang, Shaohua published an article.Application of 5036-48-6 The title of the article was A novel imidazolium bonding stationary phase derived from N-(3-aminopropyl)-imidazole for hydrophilic interaction liquid chromatography. And the article contained the following:

A novel imidazolium bonding method is proposed for the synthesis of hydrophilic interaction liquid chromatog. (HILIC) stationary phases. One obtained stationary phase (SilprAprImCl) was derived from direct reaction between N-(3-aminopropyl)-imidazole and 3-chloropropylated silica gel. Other two materials (SilprAprImBF4 and SilprAprImTf2N) were obtained from SilprAprImCl by ion exchange reaction, resp. FTIR spectroscopy and elemental anal. afforded the proofs of successful imidazolium immobilization and satisfied bonding efficiency. Various polar compounds such as saccharides, nucleosides, and nucleobases were used to evaluate the retention behaviors of these materials in HILIC mode. Different effects from mobile composition, column temperature, imidazolium unite and paired anions (Cl-, BF4-, and Tf2N-) in imidazolium were proved and discussed. Separation mechanism and the role of the imidazolium ions were also studied in mobile phases with different pH. Moreover, chromatog. stability was evaluated by consecutive injections. Finally, the reliability of these stationary phases was demonstrated by the separation of oligosaccharides in real fructooligosaccharides samples. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application of 5036-48-6

The Article related to imidazolium stationary phase aminopropylimidazole hilic, hilic, imidazolium group, polar compounds, retention mechanism, stationary phase, Placeholder for records without volume info and other aspects.Application of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 28, 2020, Rizzo, Carla; Cancemi, Patrizia; Mattiello, Leonardo; Marullo, Salvatore; D’Anna, Francesca published an article.HPLC of Formula: 5036-48-6 The title of the article was Naphthalimide Imidazolium-Based Supramolecular Hydrogels as Bioimaging and Theranostic Soft Materials. And the article contained the following:

1,8-Naphthalimide-based imidazolium salts differing for the alkyl chain length and the nature of the anion were synthesized and characterized to obtain fluorescent probes for bioimaging applications. First, their self-assembly behavior and gelling ability were investigated in water and water/dimethyl sulfoxide binary mixtures Only salts having longer alkyl chains were able to give supramol. hydrogels, whose properties were investigated by using a combined approach of fluorescence, resonance light scattering, and rheol. measurements. Morphol. information was obtained by SEM. In addition, conductive properties of organic salts in solution and gel state were analyzed. Imidazolium salts were successfully tested for their possible application as bioimaging and cytotoxic agents toward three cancer cell lines and a nontumoral epithelial cell line. Characterization of their behavior was performed by MTT and cell-based assays. Finally, the biol. activity of hydrogels was also investigated. Collectively, our findings showed that naphthalimide-based imidazolium salts are promising theranostic agents and they were able to preserve their biol. properties also in the gel phase. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).HPLC of Formula: 5036-48-6

The Article related to naphthalimide imidazolium pharmaceutical hydrogel bioimaging fluorescent probe, bioimaging, fluorescence, imidazolium salts, naphthalimide, supramolecular hydrogels, Pharmaceuticals: Formulation and Compounding and other aspects.HPLC of Formula: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 6, 2020, Kim, Da Hye; Seo, Jeongdeok; Na, Kun published an article.Electric Literature of 5036-48-6 The title of the article was pH-Sensitive Carbon Dots for Enhancing Photomediated Antitumor Immunity. And the article contained the following:

Recent cancer immunotherapy has attracted much attention due to high specificity and recurrence prevention of tumor. Nevertheless, its therapeutic effects are still challenging in solid cancer. To establish superior antitumor immunity, chlorin e6 (Ce6)-loaded pH sensitive carbon dots were investigated (Ce6@IDCDs). At tumoral pH 6.5, Ce6 was released four times compared with the release at physiol. pH 7.4 due to an imbalance between hydrophilic and hydrophobic forces via protonation of imidazole groups in Ce6@IDCDs. This result led to the superior singlet oxygen generating activity of Ce6@IDCDs without Ce6 quenching. The maturation effects of dendritic cells after co-incubation with supernatant media obtained from Ce6@IDCDs with laser-treated cells at pH 6.5 were much higher than at physiol. pH. Furthermore, Ce6@IDCDs following a laser at pH 6.5 significantly promoted calreticulin exposure and high-mobility group box 1 release, as major immunogenic cell death markers. In bilateral CT-26-bearing mice model, the Ce6@IDCDs elicited significant antitumoral effects at laser treated-primary tumor regions via therapeutic reactive oxygen species. Furthermore, Ce6@IDCDs upon laser irradiation induced a large amount of activated CD8+ T cells, natural killer cells, and mature dendritic cells recruitment into tumoral tissue and hampered tumor growth even at untreated sites approx. four-fold compared with those of others. Overall, this pH-sensitive immunoinducer can accomplish primary and distant tumor ablation via photomediated cancer immunotherapy. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to ph carbon dot photomediated antitumor immunity, cancer immunotherapy, carbon dot, immunoinducer, ph sensitive, photomediated immunotherapy, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ryder, Alison S. H.; Cunningham, William B.; Ballantyne, George; Mules, Tom; Kinsella, Anna G.; Turner-Dore, Jacob; Alder, Catherine M.; Edwards, Lee J.; McKay, Blandine S. J.; Grayson, Matthew N.; Cresswell, Alexander J. published an article in 2020, the title of the article was Photocatalytic ä¼?Tertiary Amine Synthesis via C-H Alkylation of Unmasked Primary Amines.Related Products of 5036-48-6 And the article contains the following content:

A practical, catalytic entry to ä¼?ä¼?ä¼?trisubstituted (ä¼?tertiary) primary amines by C-H functionalization has long been recognized as a critical gap in the synthetic toolbox. The authors report a simple and scalable solution to this problem that does not require any in situ protection of the amino group and proceeds with 100% atom-economy. The authors’ strategy, which uses an organic photocatalyst in combination with azide ion as a hydrogen atom transfer (HAT) catalyst, provides a direct synthesis of ä¼?tertiary amines, or their corresponding çº?lactams. The authors anticipate that this methodol. will inspire new retrosynthetic disconnections for substituted amine derivatives in organic synthesis, and particularly for challenging ä¼?tertiary primary amines. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Related Products of 5036-48-6

The Article related to photocatalyst alpha tertiary amine preparation alkylation, c鈭抙 activation, amines, photocatalysis, radicals, spiro compounds, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 2, 2020, McCann, Scott D.; Reichert, Elaine C.; Arrechea, Pedro Luis; Buchwald, Stephen L. published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability. And the article contained the following:

The authors have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room temperature The reaction development was guided by the idea that the productivity of catalysts employing BrettPhos-like ligands is limited by their lack of stability at room temperature Specifically, it was hypothesized that primary amine and N-heteroaromatic substrates can displace the phosphine ligand, leading to the formation of catalytically dormant palladium complexes that reactivate only upon heating. This notion was supported by the synthesis and kinetic study of a putative off-cycle Pd complex. Consideration of this off-cycle species, together with the identification of substrate classes that are not effectively coupled at room temperature using previous catalysts, led to the design of a new dialkylbiaryl monophosphine ligand. An Ot-Bu substituent was added ortho to the dialkylphosphino group of the ligand framework to improve the stability of the most active catalyst conformer. To offset the increased size of this substituent, the authors also removed the para i-Pr group of the non-phosphorus-containing ring, which allowed the catalyst to accommodate binding of even very large ä¼?tertiary primary amine nucleophiles. In comparison to previous catalysts, the GPhos-supported catalyst exhibits better reactivity both under ambient conditions and at elevated temperatures Its use allows for the coupling of a range of amine nucleophiles, including (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) ä¼?tertiary primary amines, each of which previously required a different catalyst to achieve optimal results. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to dialkylbiaryl monosphosphine ligand preparation amination coupling catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kang, Xiaoxu; Wang, Yushu; Chen, Zhigang; Wu, Yixin; Chen, Hao; Yang, Xi; Yu, Changyuan published an article in 2020, the title of the article was Imidazole modified Pt(IV) prodrug-loaded multi-stage pH responsive nanoparticles to overcome cisplatin resistance.Quality Control of N-(3-Aminopropyl)-imidazole And the article contains the following content:

An imidazole modified Pt(IV) prodrug with a long lipid tail can assemble into multi-stage pH responsive nanoparticles via electrostatic complexation with a neg. charged hydrophilic polymer. This strategy could overcome cisplatin resistance significantly. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to imidazole platinum prodrug ph responsive nanoparticle antitumor resistance, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem