Category: 5036-48-6

On March 31, 2021, Murphy, Manoharan; Theyagarajan, K.; Thenmozhi, Kathavarayan; Senthilkumar, Sellappan published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Direct electrochemistry of covalently immobilized hemoglobin on a naphthylimidazolium butyric acid ionic liquid/MWCNT matrix. And the article contained the following:

Monitoring the concentration levels of hydrogen peroxide (H2O2) is significant in both clin. and industrial applications. Herein, we develop a facile biosensor for the detection of H2O2 based on direct electron transfer of Hb (Hb), which was covalently immobilized on a hydrophobic naphthylimidazolium butyric acid ionic liquid (NIBA-IL) over a multiwalled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) to obtain an Hb/NIBA-IL/MWCNT/GCE. Highly water-soluble Hb protein was firmly immobilized on NIBA-IL via stable amide bonding between the free -NH2 groups of Hb and -COOH groups of NIBA-IL via EDC/NHS coupling. Thus fabricated biosensor showed a well resolved redox peak with a cathodic peak potential (Epc) at -0.35 V and anodic peak potential (Epa) at -0.29 V with a formal potential (E°’) of -0.32 V, which corresponds to the deeply buried FeIII/FeII redox center of Hb, thereby direct electrochem. of Hb was established. Further, the modified electrode demonstrated very good electrocatalytic activity towards H2O2 reduction and showed a wide linear range of detection from 0.01 to 6.3 mM with a limit of detection and sensitivity of 3.2μM and 111μA mM-1 cm-2, resp. Moreover, the developed biosensor displayed high operational stability under dynamic conditions as well as during continuous potential cycles and showed reliable reproducibility. The superior performance of the fabricated biosensor is attributed to the effective covalent immobilization of Hb on the newly developed highly conducting and biocompatible NIBA-IL/MWCNT/GCE platform. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to hydrogen peroxide naphthylimidazolium butyric acid mwcnt hb immobilization, biosensor, direct electrochemistry, hemoglobin, hydrogen peroxide, ionic liquid, Biochemical Methods: Electrical and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 20, 2021, Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Marimuthu, Kalisvar; De, Partha Pratim; Ng, Oon Tek; Li, Peng; Zhu, Yabin; Pethe, Kevin; Chan-Park, Mary B. published an article.Synthetic Route of 5036-48-6 The title of the article was Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics. And the article contained the following:

Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with min. inhibitory concentrations (MICs) of 8-32μg/mL against clin. relevant and multidrug-resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, 2,6-DAC shows an excellent synergistic effect with various clin. relevant antibiotics proved by decreasing the MICs of the antibiotics against MDR A. baumannii and methicillin-resistant Staphylococcus aureus to <1μg/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via oral administration and 25 mg/kg compound via i.p. injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers or the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log10 reduction of A. baumannii in murine i.p. and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as a biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to antimicrobial chitosan derivative synergistic antibiotic, antibacterial, biocompatible, chitosan derivatives, nanoparticle, synergistic effect with antibiotics, Industrial Carbohydrates: Nonsugars and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 15, 2020, Kundu, Biswajit; Sarkar, Dipayan; Chowdhuri, Srijita Paul; Pal, Sourav; Das, Subhendu K.; Das, Benu Brata; Talukdar, Arindam published an article.Product Details of 5036-48-6 The title of the article was Development of a metabolically stable topoisomerase I poison as anticancer agent. And the article contained the following:

We have recently reported a new chemotype of a potent topoisomerase I poison with compound 1 as a potential anticancer chemotherapeutic agent. During further optimization, it has been observed that compound 1 suffers from high intrinsic clearance in human liver microsomes. To overcome the metabolic instability of compound 1, we report design and synthesis of metabolically stable Top1 poison 3. Newly identified Top1 poison 3 exhibits t1/2 of 69.1 min in human liver microsomes in comparison to compound 1 with t1/2 of 9.9 min. Mol. dynamic study of the newly optimized Top1 poison 3 was performed to get the insight into the stability of the binding pose in the active site. Compound 3 was able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line as compared to compound 1. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to preparation stable topoisomerase i inhibitor cancer, camptothecin, in vitro pharmacokinetics, metabolic stability, molecular dynamics, poison, topoisomerase 1, Pharmacology: Structure-Activity and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Li, Yang; Niu, Yimin; Zhu, Jianhua; Gao, Cuicui; Xu, Qunwei; He, Zhiyu; Chen, Dawei; Xu, Ming; Liu, Yang published an article in 2020, the title of the article was Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:

Legumain enzyme is a well-conserved lysosomal cysteine protease and is over-expressed in many tumor cells and tumor stromal cells and exhibits higher protease activity under acidic conditions, such as in lysosomes and endosomes. Legumain enzyme-triggered drug delivery systems have demonstrated potential therapeutic values in cancer targeted therapy. In tumor cells, DS-NA could disassemble rapidly in acidic environments, and then release doxorubicin through legumain digestion. Except as a drug vector, the drug release process from DS-NA could also be dynamically monitored by CLSM as the DOX was released from the surface of CDs through the AANL peptide linker digested by legumain, then transferred into the cell nucleus and exerted cytotoxicity, while the CDs themselves remained in the cytoplasm. As a control, the CDs-C9-DOX, which did not contain the AANL peptide linker, also still resided in the cytoplasm. Furthermore, in vivo studies show that DS-NA had a stronger inhibitory effect on tumor tissue with attenuated side effects to normal tissues than control nanoparticles or free drugs, which may be due to comprehensive effects including pH/legumain dual-triggered drug release, long blood circulation periods, and EPR effects. Together, a combination strategy of acid sensitivity and legumain enzyme sensitivity used for site-specific controlled release of drugs provides a novel method for enhanced and precise antitumor chemotherapy. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to ductal breast cancer legumain ph doxorubicin release nanoparticle anticancer, Pharmaceuticals: Pharmacognostic Products and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 19, 2020, Pirez, Cyril; Nagashima, Hiroki; Dumeignil, Franck; Lafon, Olivier published an article.Product Details of 5036-48-6 The title of the article was Probing Functionalities and Acidity of Calcined Phenylene-Bridged Periodic Mesoporous Organosilicates Using Dynamic Nuclear Polarization NMR, Diffuse Reflectance Infrared Fourier Transform Spectroscopy, and X-ray Photoelectron Spectroscopy. And the article contained the following:

Owing to their high surface area, their high stability, and their hydrophobicity, periodic mesoporous organosilica (PMO) materials represent promising catalytic support for environmentally friendly chem. processes in water. We investigate here how the calcination of PMO material with benzene linkers (PMOB) allows its functionalization. Conventional and dynamic nuclear polarization (DNP)-enhanced NMR spectroscopy, diffuse reflectance IR Fourier transform spectroscopy, and XPS prove that calcination at 450°C results in the oxidation of phenylene bridges into (poly)phenols but also into carboxylic acids. Ketone, aldehyde, as well as allyl and aliphatic alc. functionalities are also observed, but their amount is much lower than that of carboxylic acids. The calcination also cleaves the Si-C bonds. Nevertheless, N2 adsorption-desorption measurements, powder X-ray diffraction, and transmission electron microscopy indicate that the PMOB materials calcined up to 600°C still exhibit ordered mesopores. We show that the phenol and carboxylic acid functionalities of PMOB calcined at 450°C protonate the NH2 group of 1-(3-aminopropyl)imidazole (API) in water at room temperature, but no formation of a covalent bond between API and the calcined PMOB functionalities has been detected. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to organosilica surface acidity calcination, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 19, 2020, Pirez, Cyril; Nagashima, Hiroki; Dumeignil, Franck; Lafon, Olivier published an article.Product Details of 5036-48-6 The title of the article was Probing Functionalities and Acidity of Calcined Phenylene-Bridged Periodic Mesoporous Organosilicates Using Dynamic Nuclear Polarization NMR, Diffuse Reflectance Infrared Fourier Transform Spectroscopy, and X-ray Photoelectron Spectroscopy. And the article contained the following:

Owing to their high surface area, their high stability, and their hydrophobicity, periodic mesoporous organosilica (PMO) materials represent promising catalytic support for environmentally friendly chem. processes in water. We investigate here how the calcination of PMO material with benzene linkers (PMOB) allows its functionalization. Conventional and dynamic nuclear polarization (DNP)-enhanced NMR spectroscopy, diffuse reflectance IR Fourier transform spectroscopy, and XPS prove that calcination at 450°C results in the oxidation of phenylene bridges into (poly)phenols but also into carboxylic acids. Ketone, aldehyde, as well as allyl and aliphatic alc. functionalities are also observed, but their amount is much lower than that of carboxylic acids. The calcination also cleaves the Si-C bonds. Nevertheless, N2 adsorption-desorption measurements, powder X-ray diffraction, and transmission electron microscopy indicate that the PMOB materials calcined up to 600°C still exhibit ordered mesopores. We show that the phenol and carboxylic acid functionalities of PMOB calcined at 450°C protonate the NH2 group of 1-(3-aminopropyl)imidazole (API) in water at room temperature, but no formation of a covalent bond between API and the calcined PMOB functionalities has been detected. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to organosilica surface acidity calcination, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 31, 2020, Nazir, Ahsan; Yu, Haojie; Wang, Li; Liu, Jinhua; Li, Songbiao; Ul Amin, Bilal; Naveed, Kaleem-ur-Rahman; Ullah Khan, Rizwan; Khan, Amin; Usman, Muhammad; Elshaarani, Tarig; Uddin, Alim Md. published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Electromagnetic interference shielding effectiveness of ferrocene-based polyimidazole/carbon material composites. And the article contained the following:

Ferrocene-based polyimidazole (PPIFc) composites containing multiwalled carbon nanotube (MWCNT), reduced graphene oxide (RGO), and carbon black (CB) were prepared by chem. oxidative polymerization, resp. The prepared PPIFc/MWCNT, PPIFc/RGO, and PPIFc/CB composites were characterized by scanning electron microscope, transmission electron microscope, Fourier transform IR, X-ray diffraction, XPS, and thermogravimetric anal. The elec. conductive property of the PPIFc/MWCNT, PPIFc/RGO, and PPIFc/CB composites was tested by a four-probe method. The electromagnetic interference (EMI) shielding properties of the composites were measured by a coaxial method in the 1 to 4.5 GHz. These PPIFc/MWCNT, PPIFc/RGO, and PPIFc/CB composites showed good EMI shielding performance and total shielding effectiveness (SET) for PPIFc/CB was -11.2 dB, PPIFc/RGO was -13.1 dB, and PPIFc/MWCNT was -25.4 dB by using 50 wt% of the composite in the paraffin wax. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to ferrocene based polyimidazole mwcnt graphene oxide carbon black composite, electromagnetic interference shielding oxidative polymerization, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 1, 2020, Xu, Zhaozan; Tang, Hongying; Li, Nanwen published an article.Application In Synthesis of N-(3-Aminopropyl)-imidazole The title of the article was Enhanced proton/iron permselectivity of sulfonated poly(ether ether ketone) membrane functionalized with basic pendant groups during electrodialysis. And the article contained the following:

High permselectivity of cation exchange membrane for H+ and divalent metallic ions is essential for waste acid recovery by electrodialysis. Basic tertiary amine and imidazole groups were introduced into sulfonated poly(ether ether ketone) (SPEEK) membrane via a facile and controllable reaction, named as TA-x and IM-x (x was the basic group content), to construct acid-base pairs and reduce the swelling degree of membranes. 1H NMR confirmed the chem. structure of the as-obtained materials and protonation of tertiary amine and imidazole groups. As expected, all TA-x and IM-x membranes showed lower Fe2+ fluxes than pristine SPEEK membrane during electrodialysis because of their lower swelling degree and the electrostatic repulsion of protonated tertiary amine and imidazole groups. Remarkably, their H+ fluxes were kept similar to that of pristine SPEEK membrane. Therefore, the H+/Fe2+ permselectivity of membrane was improved considerably. Among them, IM-30 membrane showed the highest H+/Fe2+ permselectivity of 65.4, which was over three times that of pristine SPEEK membrane (19.1). Therefore, the introduction of basic groups into cation exchange membrane could reduce the swelling degree of membrane and improve the permselectivity between H+ and divalent metallic ions. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole

The Article related to sulfonated peek electrodialysis proton permselective membrane waste acid reclamation, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 15, 2021, Shahid, Salman; Baron, Gino V.; Denayer, Joeri F. M.; Martens, Johan A.; Wee, Lik H.; Vankelecom, Ivo F. J. published an article.COA of Formula: C6H11N3 The title of the article was Hierarchical ZIF-8 composite membranes: Enhancing gas separation performance by exploiting molecular dynamics in hierarchical hybrid materials. And the article contained the following:

Mixed matrix membranes (MMM) incorporating metal-organic framework (MOF) fillers have gained increasing attention in addressing environmental and sustainability challenges. Hierarchical materials combining pore sizes of different length scales are expected to facilitate mol. diffusion and mass transfer for the optimization of catalysis and separation processes. Herein, a novel preparation method for hierarchical ZIF-8 (H-ZIF-8) particles is presented for the synthesis of polyimide (PI)-based MMMs with good compatibility between filler and polymer. Gas permeability measurements of polyimide-Matrimid/H-ZIF-8 MMMs showed 4-fold improvements in permeability of both CO2 and CH4 coupled with a marked increase in selectivity and plasticization resistance for MMM with 30 wt% H-ZIF-8 loading. Gas transport anal. in these MMMs revealed that the enhanced gas separation performance of the MMMs can be related to the imidazolate modification of the PI structure and the hierarchical structure of H-ZIF-8, as confirmed by N2, Ar, mercury porosimetry, SEM, TEM anal. CO2 permeability for all MMMs increases with increasing CO2 concentration and by decreasing temperature The proof of concept, as demonstrated in this study, could be extended for the preparation of other hierarchical ZIFs and related MMMs. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3

The Article related to hierarchical zif8 composite membrane gas separation mol dynamic, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.COA of Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 1, 2021, Nayim, Sk; Jana, Gopal Chandra; Aktara, Mt Nasima; Khatun, Munira; Dhal, Asima; Beg, Maidul; Sahoo, Nandan Kumar; Maji, Anukul; Hossain, Maidul published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was 9-N-substituted novel berberine derivative for selective and sensitive nanomolar level fluorometric detection of human hemoglobin: A synthesis, sensing and interaction study. And the article contained the following:

Quant. determination of Hb (Hb) level is an obligatory part of diagnostic proceedings and an undisputed health index for a number of chronic diseases. In this study, we have tried to introduce a new 9-N-substituted berberine analog (BR-N) as a triumphant fluorescent sensor for aptly selective and extremely sensitive nanomolar detection of Hb. The probe was found to endure a rampant quenching in its highly intensified inherent fluorescence emission with successive addition of Hb. Though, the other available proteins and biomols. were proved to be failure in causing any significant change in fluorescence of BR-N under equivalent exptl. condition. Again, the sensitivity of the probe was such that it provided an astonishing detection limit of 0.41 nM having linearity range 1-70 nM. Noteworthy, the presence of Hb caused significant alternation in the nature of the intrinsic fluorescence curve of the probe which was also a differentiating aspect during Hb identification. Experiments revealed that ground state probe-protein complex formation was behind the reduction of fluorescence intensity through static quenching mechanism. The interaction study unearthed the binding constant value to be 2.8 × 105 M-1. Moreover, the probe was also successful when applied in real samples for quant. Hb determination which spoke for its reliable practical utility in the field of clin. diagnosis from today onwards. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to substituted berberine derivative sensitive nanomolar fluorometric sensor hb human, Biochemical Methods: Spectral and Related Methods and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem