Category: 5036-48-6

On December 31, 2020, Jiang, Long; Lei, Xiang; Wang, Kaijie; Zhang, Zhijie; Wang, Fang; Lu, Sheng; Chen, Xiaoqiang published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Colorimetric and fluorometric detection of NADPH using imidazolium functionalized polydiacetylenes with high sensitivity and selectivity. And the article contained the following:

The NAD derivatives (NADPH, NADP+, NADH, and NAD+) are important redox cofactors that involve in many biol. activities, and their concentration levels are associated with a variety of diseases. In this work, an imidazolium functionalized polydiacetylenes sensing system (IM-PDAs) is reported to selectively detect the reduced form of NADP (NADPH). Depending on the electrostatic attraction between the pos. charged imidazolium heads and the neg. charged phosphate groups, the sensing system exhibits colorimetric and fluorescent responses when exposed to NADPH and its oxidized form (NADP+); while the system does not respond to the less neg. charged NADH and NAD+ at the concentration range tested in this study. Owing to the pos. charged nicotinamide of NADP+, the detection sensitivity of IM-PDAs towards NADP+ is much lower than that towards NADPH, successfully differentiating NADPH from the rest three cofactors. Furthermore, IM-PDAs loaded paper-based sensor is constructed and demonstrates the potentials of IM-PDAs based sensing device for practical applications in NADPH detection. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to colorimetry fluorometry nadph imidazolium functionalized polydiacetylene, Biochemical Methods: Spectral and Related Methods and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 15, 2020, Rios-Gomez, Julia; Garcia-Valverde, Maria Teresa; Lopez-Lorente, Angela Inmaculada; Toledo-Neira, Carla; Lucena, Rafael; Cardenas, Soledad published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Polymeric ionic liquid immobilized onto paper as sorptive phase in microextraction. And the article contained the following:

A new planar sorptive phase based on the simple immobilization of polymeric ionic liquids on paper is proposed. The sorptive phase can develop hydrophobic or mixed-mode (combining hydrophobic and ion exchange) interactions with the target analytes. The polymer is prepared by the Radziszewski reaction, which takes place in aqueous media, and it has been thoroughly characterized by different techniques including IR spectroscopy, matrix-assisted laser desorption/ionization coupled to high-resolution mass spectrometry and proton NMR. Three different strategies aimed to immobilize the polymeric ionic liquid on paper have been evaluated. Among them, simple thermal curing at 120°C was selected. The as-prepared paper has been evaluated for the extraction of several non-steroidal anti-inflammatory drugs from urine, the analytes being finally determined by liquid chromatog. with tandem mass spectrometry. The method detection limits were 3.8, 7.2, 6.8, 9.4, 15.7, and 5.1μg/L for indomethacin, diclofenac, tolmetin, ketoprofen, naproxen, and ibuprofen, resp. Calibration models were linear (R2 > 0.9949) up to 1000μg/L. The intra-day precision, expressed as relative standard deviation and calculated at three different concentrations levels (limit of quantification, 250μg/L, and 1000μg/L), varied between 1.1 and 13%. The accuracy, calculated as relative recovery, was in the range from 72 to 95%, thus being considered appropriate. The easiness of polymeric ionic liquid paper synthesis and the multi-sample extraction protocol designed allows the processing of a high number of samples at the same time. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to polymeric ionic liquid paper microextraction drug, bioanalysis, microextraction, paper substrate, polymeric ionic liquids, radziszewski reaction, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

War, Javeed Ahmad; Srivastava, Santosh Kumar published an article in 2020, the title of the article was Rationale design and synthesis of some novel imidazole linked thiazolidinone hybrid molecules as DNA minor groove binders.Application In Synthesis of N-(3-Aminopropyl)-imidazole And the article contains the following content:

A new series of imidazole linked thiazolidinone hybrid mols. was designed and subsequently synthesized through a feasible, three step reaction protocol. The structures of these mols. were established using FT-IR, 1H NMR, 13C NMR and HRMS techniques. In vitro susceptibility tests against some Gram pos. (Staphylococcus aureus and Bacillus subtilis) and Gram neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) exhibited broad spectrum potency of the mols. The most potent mol. (S2A7) amongst the screened mols., showed min. inhibitory concentration (MIC) value not less than 2.0μg/mL which was at par with the reference drug Streptomycin. Structure activity relationships revealed nitro and chloro groups being crucial for bioactivity when present at meta position of arylidene ring in 3-(3-(imidazol-1-yl)propyl)-5-(benzylidene)-2- (phenylimino)thiazolidin-4-one. DNA (DNA)and bovine serum albumin (BSA) binding studies for S2A7 under simulated physiol. pH were probed using UV Visible, fluorescence quenching, gel electrophoresis and mol. docking techniques. These studies established that S2A7 has strong binding affinity towards DNA and binds at the minor groove of DNA with binding constant (Kb) of 0.1287×102 L/mol. Mol. docking simulations of S2A7 with DNA and BSA predicted binding affinity of -9.2 and -7.2 kcal/mol, resp. Van der Waals forces and hydrogen bonding interactions were predicted as the main forces of interaction. With DNA, S2A7 exhibited specific binding affinity towards adenine-thiamine base pairs. The compound S2A7 forms a stable complex with BSA by binding at subdomain IIIA implying high bio-distribution of the compound The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole

The Article related to imidazole thiazolidinone antibiotic dna minor groove binder bacterial infection, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 21, 2020, Billeci, Floriana; D’Anna, Francesca; Feroci, Marta; Cancemi, Patrizia; Feo, Salvatore; Forlino, Antonella; Tonnelli, Francesca; Seddon, Kenneth Richard; Gunaratne, H. Q. Nimal; Plechkova, Natalia V. published an article.COA of Formula: C6H11N3 The title of the article was When functionalization becomes useful: Ionic liquids with a “sweet” appended moiety demonstrate drastically reduced toxicological effects. And the article contained the following:

The growing number of applications of ionic liquids (ILs) in industry have brought attention to the green credentials of synthesis, as well as their cytotoxicities and ecotoxicities both for their use and accidental leakage into the environment. With the abovementioned properties in mind, we designed a class of ILs with either cations bearing a gluconamide motif and aliphatic side chains or the anion incorporating a gluconic acid (derived from food waste) moiety. An IL with an imidazolium cation with an appended gluconic amide (bearing five hydroxyl groups) moiety was also synthesized for a useful comparison. Different structural features were considered, placing emphasis on the nature and length of the alkyl chain and the nature of the anion. For comparison, two ILs, one with a hydroxyl group and another without any hydroxyl groups, were prepared Apart from the typical characterization of ILs, such as differential scanning calorimetry, thermogravimetric anal., conductivity, and viscosity measurements, the main focus was placed on the evaluation of their cytotoxicities and ecotoxicities, performing tests with three cancer cell lines (HeLa, HTC-116, and MCF-7) and fish embryos (zebrafish). Data obtained have shed light on the relationship working between the physicochem. properties and the structural features of the ILs. Interestingly, these ILs are able to inhibit cell growth only at very high concentrations (IC50 ≈ 10-3 M) and they do not affect the vitality of fish embryos, allowing them to be classified as harmless solvents. To our surprise, the data collected show that derivatization with the “sweet” residue on the imidazolium cation completely removes the well-known toxicity effects of imidazolium ILs. “Sweet” ionic liquids incorporating a moiety derived from food waste were obtained. They show good physicochem. properties and drastically reduced toxicity. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3

The Article related to ionic liquid functionalization reducing toxicity sweet moiety appending, Toxicology: Chemicals (Household, Industrial, General) and other aspects.COA of Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 15, 2020, Demarteau, Jeremy; O’Harra, Kathryn E.; Bara, Jason E.; Sardon, Haritz published an article.Computed Properties of 5036-48-6 The title of the article was Valorization of Plastic Wastes for the Synthesis of Imidazolium-Based Self-Supported Elastomeric Ionenes. And the article contained the following:

Imidazolium-based ionenes are known to be high-performance materials for a great variety of applications. The preparation of these polymers requires the use of bis-imidazole starting monomers, which are commonly prepared by using toxic chloride reagents. In this study, bis-imidazole monomers are synthesized by organocatalytic chem. recycling of discarded plastics through chem. depolymerization By using poly(ethylene terephthalate) and bisphenol A polycarbonate as starting materials, different monomers containing amide or urea functionalities are prepared to produce high-mol.-weight ionic polymers. These novel ionenes show excellent elastomeric and self-healing behavior, serving as a promising means to expand the exploration of plastic wastes as a source of new materials. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Computed Properties of 5036-48-6

The Article related to valorization plastic waste imidazolium self supported elastomeric ionene, ionenes, organocatalysis, plastics, recycling, waste valorization, Plastics Fabrication and Uses: Fabricating Techniques and other aspects.Computed Properties of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 24, 2020, Kilic, Ahmet; Beyazsakal, Levent; Findik, Bahar Tuba; Incebay, Hilal published an article.Application In Synthesis of N-(3-Aminopropyl)-imidazole The title of the article was Synthesis and electrochemical investigation of chiral amine bis(phenolate)-boron complexes: In vitro antibacterial activity screening of boron compounds. And the article contained the following:

A new class of low-cost, easily-synthesizable and modifiable chiral amine bis(phenolate) ligand (L), its chiral boron complex (LB), and five different salen groups (1-(3-Aminopropyl) imidazole (LB1), N,N-Diethyl-p-phenylenediamine (LB2), 2-Picolylamine (LB3), 4′-Aminoacetophenone (LB4), and 4-Amino-2,2,6,6-tetramethyl piperidine (LB5)) containing chiral boron complexes were synthesized. These newly synthesized chiral compounds were fully characterized by 1H and 13C NMR, FTIR, UV-visible, and LC-MS/MS spectroscopy, m.p., elemental anal., and cyclic voltammetry techniques. The in vitro antibacterial activity of the synthesized different chiral boron complexes was tested against four pathogenic bacteria strains using the resazurin-based broth microdilution method, and the MIC values of each boron complex were determined Based on the overall results, the N, N-Diethyl-p-phenylenediamine group containing chiral boron complex (LB2) showed the highest activity against all bacterial strains, with the lowest MIC value of 4μg/mL which is nearly in the range of values for com. antibacterial drugs. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole

The Article related to preparation boron chiral amine phenolate complex, cyclic voltammetry boron chiral amine phenolate complex, antimicrobial activity boron chiral amine phenolate complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 28, 2021, Cao, Yue; Zhou, Xiaoying; Luan, Lindong; Zeng, Hongmei; Zou, Guohong; Lin, Zhien published an article.Quality Control of N-(3-Aminopropyl)-imidazole The title of the article was Organically templated metal phosphate-oxalates: Solvent-free synthesis, crystal structure, and proton conduction. And the article contained the following:

Two new metal phosphate-oxalates, namely, H2api·Mn2(H2PO4)2(C2O4)2 (1) and H2mpip·Sc(H2PO4)2(C2O4)·0.5C2O4·1.5H2O (2), were prepared under solvent-free conditions, where api = 1-(3-aminopropyl)imidazole and mpip = 1-methylpiperazine. Compound 1 has a honeycomb-like structure with 12-ring windows. Compound 2 has a one-dimensional structure with scandium phosphate ladders decorated with oxalate ligands. The proton-conducting behaviors of this compound under 95% relative humidity were investigated. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to manganese scandium phosphate oxalate preparation crystal mol structure proton, proton conduction metal manganese scandium phosphate oxalate, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 31, 2022, Kohlgruber, Tsuyoshi A.; Perry, Samuel N.; Sigmon, Ginger E.; Oliver, Allen G.; Burns, Peter C. published an article.Application of 5036-48-6 The title of the article was Hydrogen bond network and bond valence analysis on uranyl sulfate compounds with organic-based interstitial cations. And the article contained the following:

Seven new uranyl sulfate compounds with organic charge-balancing cations were synthesized and structurally characterized. The structural unit topologies of the two chains and five sheets were previously reported in uranyl sulfate crystal chem., although they were synthesized using different organic mols. With the inclusion of six of these structures to the 48 previously published uranyl sulfate compounds, a total of 54 known uranyl sulfate compounds with organic charge-balancing cations were compiled and analyzed. A graphical approach was used to compare the structural unit topologies, and a bond valence approach was used to quantify the H bond networks that exist between the interstitial cationic and solvent species to the uranyl sulfate anionic structural units. This anal. helped elucidate which O atoms in the structural unit receive H bonds and how the organic cations stabilize the overall crystal structures in this subclass of U(VI) materials. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application of 5036-48-6

The Article related to uranyl sulfate anion preparation hydrogen bond network, crystal structure uranyl sulfate interstitial organic cation, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 5, 2022, Slassi, Siham; Aarjane, Mohammed; Amine, Amina published an article.Synthetic Route of 5036-48-6 The title of the article was Synthesis, spectroscopic characterization (FT-IR, NMR, UV-Vis), DFT study, antibacterial and antioxidant in-vitro investigations of 4,6-bis((E)-1-((3-(1H-imidazol-1-yl)propyl)imino)ethyl)benzene-1,3-diol. And the article contained the following:

A new bis-Schiff base, I derived from N-(3-aminopropyl)imidazole and 4,6-diacetylresorcinol was obtained. The bis Schiff base I was characterized through mass spectrometry, elemental anal., IR, UV-Vis, 1H and 13C NMR spectroscopy. The B3LYP method was used to calculate the optimized structure of the mol. through d. functional of theory (DFT) using the 6-31G (d, p) basis set. The 1H and 13C NMR chem. shifts with respect to TMS were calculated using the (GIAO) method in DMSO-d6 and compared with the exptl. data. In addition, the frontier MOs, electronic properties and the mol. electrostatic potential (MEP) of RS were investigated using DFT calculations The compound showed significant antibacterial activity against Staphylococcus aureus. The DPPH free radical scavenging assay was used to evaluate the antioxidant activity. The effective concentration (EC50) showed that the compound has a good antioxidant activity. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to bis imidazolyl propyl imino ethyl benzenediol preparation schiff base, antibacterial antioxidant surface electrostatic potential, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 1, 2020, Hilton-Proctor, J. P.; Ilyichova, O.; Zheng, Z.; Jennings, I. G.; Johnstone, R. W.; Shortt, J.; Mountford, S. J.; Scanlon, M. J.; Thompson, P. E. published an article.Formula: C6H11N3 The title of the article was Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors. And the article contained the following:

The synthesis of a 4-Ph substituted analog – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives I (R = H, Br, Ph, 2-phenylethyl, etc.; R1 = 2-Br, 4-Ph, morpholine-4-sulfonyl, etc.) were described. Ultimately, this has led to structurally complex, chiral compounds (R/S)-II (R2 = H, Me; R3 = H, 3,4-dimethoxyphenyl; R4 = H, N,N-diethylsulfamoyl) with progressively improved affinity as inhibitors of bromodomain-containing protein 4. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Formula: C6H11N3

The Article related to methyl phenylpyrrolidinone preparation bromodomain inhibitor, brd4, bromodomain, epigenetics, fragment-based drug design, k-ac, Heterocyclic Compounds (One Hetero Atom): Pyrroles and Pyrrolizines and other aspects.Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem