Category: 51-17-2

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 51-17-2, Name is 1H-Benzo[d]imidazole, SMILES is C12=CC=CC=C1N=CN2, in an article , author is Du, Li-Hua, once mentioned of 51-17-2, Application In Synthesis of 1H-Benzo[d]imidazole.

Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from Thermomyces lanuginosus/K2CO3 in a continuous-flow microreactor

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K2CO3 in a continuous-flow microreactor was described. The effects of the mixed catalysts, molar ratio and the structure of reactants on the reaction performance were experimentally studied. The attractive features of this process are shorter reaction times (30 min) and excellent yields compared to that in shaker reactors.

Interested yet? Read on for other articles about 51-17-2, you can contact me at any time and look forward to more communication. Application In Synthesis of 1H-Benzo[d]imidazole.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 51-17-2, Name is 1H-Benzo[d]imidazole, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is DEMEO, M, Quality Control of 1H-Benzo[d]imidazole.

EVALUATION OF THE MUTAGENIC AND GENOTOXIC ACTIVITIES OF 48 NITROIMIDAZOLES AND RELATED IMIDAZOLE DERIVATIVES BY THE AMES TEST AND THE SOS CHROMOTEST

The mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives have been evaluated by using modified versions of the Ames test and the SOS Chromotest. Salmonella typhimurium tester strain TA 100 was used with and without metabolic activation in the Ames test and Escherichia coli tester Strain PQ 37 was used with and without metabolic activation in the SOS Chromotest. Including metronidazole and dimetridazole, 45 derivatives were mutagenic and genotoxic. The mutagenic potencies (MP) ranged from 0.127 to 53,717 revertants/nmol while the SOS induction powers (SOSIP) ranged from 0.00131 to 107 IF/nmol. The overall correlation between MP and SOSIP was r = 0.845 (n = 84) as calculated by linear regression analysis. A higher correlation was observed between MP and SOSIP without the S9 mix than with it. Among the imidazole derivatives, the 5-nitroimidazoles with a lactam ring at the 2-position showed the highest MP and SOSIP. The presence of a nitro group at the 5-position was critical for the mutagenicity and the genotoxicity of the derivatives. Substituents at the 1- and 2-positions were also found to modulate these activities.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 51-17-2, in my other articles. Quality Control of 1H-Benzo[d]imidazole.

Related Products of 51-17-2, A common heterocyclic compound, 51-17-2, name is 1H-Benzo[d]imidazole, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Put 30 g of water into the reaction kettle, turn on the stirring, and sequentially add 0.06 g of Fe (NO3) 3.9H2O, 15 g of 96% sulfuric acid, 0.03 g of tetrabutylamine bromide, 2.5 g of benzimidazole, and raise the temperature;(2) When the reaction temperature reaches 80 C, 20 g of oxone is added in batches, and the reaction is incubated for 8 hours after the addition.(3) After the reaction is completed, the temperature is lowered to -10 to 10 C, and concentrated ammonia is slowly added dropwise under stirring to adjust the pH value to 0.6 to 1, and then stirring is continued for 1 hour for crystallization, suction filtration, and drying to obtain 4,5-imidazole di Carboxylic acid, the filtrate can be used for further product recovery, yield 73%.

The synthetic route of 51-17-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Changshu Institute of Technology; Yang Yang; Fu Renzhong; Wang Xin; Fang Zhengjiao; Lu Zhengyi; Zeng Xiaojun; (11 pag.)CN110818628; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51-17-2, name is 1H-Benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H6N2

To a stirred solution of 1H-benzo[d]imidazole (2 g, 16.94 mmol) in acetic acid (25 mL) under an inert atmosphere was added 10% Pd/C (50% wet, 600 mg) at room temperature. The reaction mixture was stirred at 90-95 C. under a hydrogen atmosphere (75 PSI) for 24 h. After consumption of starting material (by TLC), the reaction mixture was filtered through a pad of celite and the pad was washed with EtOAc (100 mL). The filtrate was basified with saturated sodium bicarbonate solution (100 mL) and extracted with EtOAc (2*100 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain 4,5,6,7-tetrahydro-1H-benzo[d]imidazole (800 mg, 6.55 mmol, 40%) as an off white solid. 1H NMR (400 MHz, DMSO-d6): delta 11.52 (brs, 1H), 7.35 (s, 1H), 2.45 (brs, 4H), 1.74-1.67 (m, 4H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 51-17-2.

Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; (93 pag.)US2018/186773; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem