Category: 5465-29-2

Related Products of 5465-29-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5465-29-2 as follows.

Step 3) Methyl 2-[4-[(2-Propyl-1H-benzimidazol-1-yl)methyl]phenyl]-3-pyridinecarboxylate To a solution of 2-propyl-1H-benzimidazole (67 mg, 0.42 mmol) in DMF (1.5 mL) was added NaH (60% dispersion in mineral oil; 17 mg, 0.42 mmol). After 20 min, a solution of methyl 2-[(4-chloromethyl)phenyl]-3-pyridinecarboxylate (100 mg, 0.38 mmol) in DMF (3 mL) was added. After 20 h, the mixture was cooled (0 C.) and water (10 mL) and brine (5 mL) were added. The mixture was extracted with EtOAc, and the combined extracts were washed with brine, dried, and concentrated. Purification by flash chromatography (30% EtOAc/hexane) gave 138 mg (94%) of product as a colorless oil. 1 H NMR (CDCl3) delta 0.96 (t, J=7.3 Hz, 3H), 1.81 (m, 2H), 2.77 (t, J=7.9 Hz, 2H), 3.61 (s, 3H), 5.32 (s, 2H), 7.05 (d, J=8.3 Hz, 2H), 7.14 (m, 3H), 7.26 (dd, J=7.8, 4.8 Hz, 1H), 7.42 (d, J=8.3 Hz, 2H), 7.71 (d, J=7.6 Hz, 1H), 8.03 (dd, J=7.8, 1.8 Hz, 1H), 8.68 (dd, J=4.8, 1.8 Hz, 1H).

According to the analysis of related databases, 5465-29-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Home Products Corporation; US5283242; (1994); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 5465-29-2, name is 2-Propylbenzimidazole, molecular formula is C10H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives

Step 4) Methyl 2-[4-[(2-Propyl-1H-benzimidazol-1-yl)methyl]phenyl]-1-cyclopentene-1-carboxylate To a cooled (0 C.), stirred partial solution of 2-propyl-1H-benzimidazole (0.79 g, 4.96 mmol) in DMF (4 mL) was added NaH (60% dispersion in mineral oil; 0.20 g, 4.96 mmol). After 1.5 h, a solution of methyl [2-[(4-chloromethyl)phenyl]-1-cyclopentene]-1-carboxylate (1.13 g, 4.51 mmol) in DMF (1.5 mL) was added and the resultant mixture was stirred at room temperature for 18 h. Water was added and the mixture was extracted with EtOAc. The combined extracts were washed with brine, dried, and concentrated. Purification by flash chromatography (30% EtOAc/hexane) gave 1.63 g (96%) of product as a yellow oil. 1 H NMR (CDCl3) delta 1.00 (t, J=7.5 Hz, 3H), 1.86 (m, 2H), 1.95 (m, 2H), 2.79 (m, 6H), 3.59 (s, 3H), 5.33 (s, 2H), 6.99 (d, J=8.2 Hz, 2H), 7.28 (m, 5H), 7.77 (d, J=7.5 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5465-29-2, its application will become more common.

Reference:
Patent; American Home Products Corporation; US5283242; (1994); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem