Category: 60-56-0

Electric Literature of 60-56-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows.

Step 4: {2-[4-(1-Methyl-imidazol-2-ylsulfanylmethyl)-benzoylamino]-phenyl}-carbamic acid tert-butyl ester (Compound 138) To a solution of N-methyl-2-mercaptoimidazole (28 mg, 0.25 mmol) in THF (1 mL), at r.t. under N2 atmosphere were successively added 137 (70 mg, 0.20 mmol), triphenylphosphine (70 mg, 0.27 mmol) followed by dropwise addition of diethyl azodicarboxylate (48 muL, 0.31 mmol). The mixture was stirred for 2 h and the solvent was removed in vacuo. Purification by flash chromatography using MeOH/CHCl3 (5:95) as the eluent afforded the title compound 138 (81 mg), in 91% yield, which was found to contain some diethyl hydrazodicarboxylate residus. The compound was used as is without further purification.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-imidazole-2(3H)-thione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MethylGene, Inc.; US6897220; (2005); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, A new synthetic method of this compound is introduced below., Recommanded Product: 60-56-0

2-Mercapto-l-methylimidazole (84 mg, 0.73 mmol) was added neat to a solution of 2- bromo-l-[l-(4-chloro-phenyl)-cyclopropyl]-ethanone (200.5 mg, 0.73 mmol) in CH3CN (5 mL) at room temperature, then Et3N (0.203 mL, 1.46 mmol) was added neat to the mixture and the reaction was stirred over night. The reaction was then quenched by addition of a small spatula of resin 2-chlorotrityl chloride, stirred for IH then the mixture was filtered and concentrated under vacuum. The crude mixture was purified by flash chromatography (hexane/EtOAc gradient 0-50%) to afford the title compound (216.5 mg, 97%) as cream-yellow solid. TLC single spot at R/ 0.13 (hexane/EtOAc 7:3); Mp = [95.5- 97.0 0C]; 1H NMR (270 MHz, CDCl3): delta 1.19 (q, J = 3.7 Hz, 2H), 1.63 (q, J = 3.2 Hz, 2H), 3.62 (s, 3H), 3.86 (s, 2H), 6.87 (d, J = 1.2 Hz, IH), 6.98 (d, J = 1.2 Hz, IH), 7.32 (d, J = 0.7 Hz, 4H); LC/MS (APCI) m/z 307 (M++H); HPLC tr = 1.88 min (100%) in 10% water-acetonitrile.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; STERIX LIMITED; WO2009/106817; (2009); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Application of 60-56-0, The chemical industry reduces the impact on the environment during synthesis 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, I believe this compound will play a more active role in future production and life.

Bleach (12% w/w aq, 110 ml) was cautiously added dropwise to a solution of 2-mercapto-1-methylimidazole (2.0 g) in conc. [H2SO4] (50 ml) cooled to [0C.] After stirring 30 minutes at [0C] the mixture was diluted with [H20] (30 ml) and dichloromethane (30 ml). The aqueous layer was re-extracted with dichloromethane and the combined organic layers dried [(MGS04)] and evaporated to give the product as an oil (730 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/31139; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60-56-0, Application In Synthesis of 1-Methyl-1H-imidazole-2(3H)-thione

Aroyl chloride (1 mmol) was added to a stirred solution of ammonium thiocyanate (1 mmol) in 10 mL MeCN. The mixture was stirred at room temperature (r.t.) for 30 min. Then, 2-mercapto-1-methylimidazole (1 mmol) was added and the reaction mixture was stirred for 2 h at r.t. The solvent was removed under reduced pressure and the resulting precipitate was collected and washed with 10 mL ofcold diethyl ether to afford the pure title compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-Methyl-1H-imidazole-2(3H)-thione

Reference Example 98 2-Cyano-6-(1-methyl-1H-imidazol-2-yl)thiopyridine 2-Mercapto-1-methyl-1H-imidazole (0.91 g, 7.94 mmol) and sodium hydride (60 % in oil, 0.35 g, 8.66 mmol) were dissolved in DMF (30 ml), and 2-chloro-6-cyanopyridine (1.05 g, 3.00 mmol) was added thereto.. The reaction mixture was stirred at 70 C for 18 hrs and combined with ethyl acetate and water.. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate.. The solvent was evaporated, and the residue was recrystallized from n-hexane-ethyl acetate to give the titled compound (1.71 g, ca. 100 %) as pale yellow crystals.1H-NMR (CDCl3) delta: 3.79 (3H, s), 7.21-7.23 (1H, m), 7.63-7.66 (1H, m), 8.85 (1H, t, J = 4.8 Hz), 8.25 (1H, d, J = 7.6 Hz), 8.56 (1H, d, J = 4.8 Hz). IR(KBr): 2231, 1570, 1550, 1433, 1373, 1167, 1152, 1086, 983, 798 cm-1.

According to the analysis of related databases, 60-56-0, the application of this compound in the production field has become more and more popular.

Application of 60-56-0, A common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A vial charged with 1 (0.25 g, 0.753 mmol), KF/Al2O3 (0.7 g) thiol (1.1 mmol), and 18-crown-6 (0.05 g, 0.225 mmol) in 5 mL of acetonitrile was heated for 20 h at 80 C. Then solvent was evaporated under reduced pressure and crude product was purified by flash chromatography on silica gel using the mixture petroleum ether – ethylacetate as eluent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 60-56-0, These common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 281; 2,5-dimethyl-N-{6-[(1-methyl-1H-imidazol-2-yl)thio]imidazo[1,2-b]pyridazin-2-yl}-3-furamide; [Show Image] A mixture of N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2,5-dimethyl-3-furamide (29 mg, 0.1 mmol), 2-mercapto-1-methylimidazole (23 mg, 0.2 mmol), potassium carbonate (27 mg, 0.2 mmol) and N,N-dimethylformamide (2 mL) was stirred with heating at 180C for 500 sec in a microwave reaction apparatus. The reaction mixture was filtered, and the filtrate was purified by preparative HPLC to give the title compound (23.3 mg, 63%). LC-MS 369(M+H).

The synthetic route of 60-56-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 60-56-0,Some common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of pyridine (1 mmol) in 3 mL dichloromethane was added dropwise to a magnetically stirred solution of 2-mercapto-1-methylimidazole or 5-mercapto-1-methyltetrazole (1 mmol) and acetylenic esters (1 mmol) in 15 mL dichloromethane. The reaction mixture was then stirred for 2 h at room temperature. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography using hexane-ethyl acetate as eluent. The solvent was removed under reduced pressure to afford the product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-2(3H)-thione, its application will become more common.

Reference:
Article; Asgharian-Sheykhi, Fahimeh; Hassanabadi, Alireza; Akhgar, Mohammad Reza; Karbalaei-Harofteh, Mina; Khajehpour, Ehsan; Journal of Chemical Research; vol. 37; 9; (2013); p. 523 – 525;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C4H6N2S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 60-56-0, Name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S. In an article, author is Gulevich, Anton V.,once mentioned of 60-56-0.

The first example of a diastereoselective thio-Ugi reaction: A new synthetic approach to chiral imidazole derivatives

The first example of a diastereoselective thio-Ugi reaction with chiral a-methylbenzylamine is described. The reaction results in formation of two diastereomers of thioamides, the major of which was isolated. We have found that under similar conditions stereochemical results of the thio-Ugi reaction are opposite to stereochemical results of the Ugi reaction. Several chiral thioamides were synthesized. The reaction of thioamides with ammonia results in substituted amidines, which can be cyclized to imidazole derivatives in aqueous HC1. The synthesis of chiral imidazole derivatives was elaborated. Using certain approaches, both isomers of a key synthon in the synthesis of SB203386 (an orally bioactive HIV-1 protease inhibitor) were prepared. The scope, limitations, and stereochemistry of the approach are discussed.

If you¡¯re interested in learning more about 60-56-0. The above is the message from the blog manager. Formula: C4H6N2S.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, SDS of cas: 60-56-0, 60-56-0, Name is 1-Methyl-1H-imidazole-2(3H)-thione, SMILES is S=C1NC=CN1C, belongs to imidazoles-derivatives compound. In a document, author is Oh, Keimei, introduce the new discover.

Biological evaluation of imidazole derivatives as inhibitors of hydroperoxide lyase, a key enzyme in plant volatile biosynthesis

Fatty acid hydroperoxide lyase (HPL) is a key enzyme in the biosynthesis of plant volatiles involved in defense responses to mechanical or herbivore-induced wounding. We report here the synthesis of imidazole derivatives and their inhibitory activities on the tomato 13-HPL subfamily. Among 1l newly synthesized compounds, we found that 1-[2-benzyloxy-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole (3) exhibits inhibitory activity against recombinant 13-HPL with an IC(50) value of approximately 39 mu M. Optical difference spectroscopy analysis of compound 3 and HPL interaction indicated that this compound induces a type II binding spectra with a K(d) value of approximately 13.5 mu M. (C) Pesticide Science Society of Japan

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 60-56-0. SDS of cas: 60-56-0.