Category: 616-47-7

《Microscopic structural and dynamic features in triphilic room temperature ionic liquids》 was written by Celso, Fabrizio Lo; Appetecchi, Giovanni B.; Simonetti, Elisabetta; Zhao, Man; Castner, Edward W. Jr.; Keiderling, Uwe; Gontrani, Lorenzo; Triolo, Alessandro; Russina, Olga. Safety of 1-Methyl-1H-imidazoleThis research focused onX ray neutron scattering viscosity diffusion relaxation fragility; fluorinated methylimidazolium ionic liquid microstructure; fluorous tail; ionic liquid; molecular dynamics (MD); neutron scattering; triphilic. The article conveys some information:

Here we report a thorough investigation of the microscopic and mesoscopic structural organization in a series of triphilic fluorinated room temperature ionic liquids, namely [1-alkyl,3-methylimidazolium][(trifluoromethanesulfonyl)(nonafluorobutylsulfonyl)imide], with alkyl = Et, Bu, octyl ([Cnmim][IM14], n = 2, 4, 8), based on the synergic exploitation of X-ray and Neutron Scattering and Mol. Dynamics simulations. This study reveals the strong complementarity between X-ray/neutron scattering in detecting the complex segregated morphol. in these systems at mesoscopic spatial scales. The use of MD simulations delivering a very good agreement with exptl. data allows us to gain a robust understanding of the segregated morphol. The structural scenario is completed with determination of dynamic properties accessing the diffusive behavior and a relaxation map is provided for [C2mim][IM14] and [C8mim][IM14], highlighting their natures as fragile glass formers. The experimental process involved the reaction of 1-Methyl-1H-imidazole(cas: 616-47-7Safety of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Safety of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,Journal of Photochemistry and Photobiology, A: Chemistry included an article by Park, Jumi; Shanmugasundaram, Kanagaraj; John, Jino C.; Choe, Youngson. Safety of 1-Methyl-1H-imidazole. The article was titled 《Aggregation induced emission small molecules for blue light-emitting electrochemical cells》. The information in the text is summarized as follows:

Two blue aggregation induced emission (AIE) luminogens containing phenanthroimidazole and tetraphenylethylene were designed and synthesized. The optical properties, thermal stability, electronic properties, electrochem. properties and electroluminescence of both the derivatives were studied. The phenanthroimidazole derivatives show good thermal stability and AIE properties. The non-doped light-emitting electrochem. cell devices were fabricated using these luminogens as light-emitting materials. The LEC devices show blue color emission centered at 474 nm with good performances. The results came from multiple reactions, including the reaction of 1-Methyl-1H-imidazole(cas: 616-47-7Safety of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Safety of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Binding selectivity and separation of p-functionalized toluenes with a metallo-cavitand in water》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Rahman, Faiz-Ur; Yang, Ji-Min; Wan, Yun-Hui; Zhang, Hui-Bin; Petsalakis, Ioannis D.; Theodorakopoulos, Giannoula; Rebek, Julius; Yu, Yang. Formula: C4H6N2 The article mentions the following:

A metallo-cavitand (1-2Pd) showed unprecedented binding selectivity and sequestration of p-functionalized toluene isomers in water. The host-guest complexation was studied using 1H and COSY NMR methods and xylene-isomer complexes were examined by using DFT calculations A liquid-liquid extraction scheme was developed for the separation of p-functionalized toluenes. In the experimental materials used by the author, we found 1-Methyl-1H-imidazole(cas: 616-47-7Formula: C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Formula: C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Product Details of 616-47-7In 2019 ,《Heterogeneous PS-Fe-NHC catalysed N-alkylation of amide and amine with alcohol as alkylating agent through dehydrative C-N bond formation reaction》 appeared in Journal of Applicable Chemistry (Lumami, India). The author of the article were Khairnar, Bhikan J.; Girase, Pravinsing S.; Chaudhari, Bhata R.. The article conveys some information:

An efficient, high-yielding and rapid protocol has been developed the N-alkylation reactions of amides and amines through dehydrative C-N bond formation processes by using PS-Fe-NHC as green reusable heterogeneous catalyst. Absence of unwanted products, general applicability, reusability of the catalyst, green synthesis avoiding toxic reagents and improved and operational simplicity make this protocol a useful, greener, cost effective and practical for both academic as well as industrial purposes.1-Methyl-1H-imidazole(cas: 616-47-7Product Details of 616-47-7) was used in this study.

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Product Details of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2019,International Journal of Biological Macromolecules included an article by Noguchi, Seiichiro; Sato, Koki; Yamamoto, Kazuya; Kadokawa, Jun-ichi. Reference of 1-Methyl-1H-imidazole. The article was titled 《Preparation of composite and hollow particles from self-assembled chitin nanofibers by Pickering emulsion polymerization》. The information in the text is summarized as follows:

This study investigated Pickering emulsion polymerization of styrene using self-assembled chitin nanofibers (CNFs) as stabilizers to produce CNF-based composite particles, which were further converted into hollow particles. Previously, we reported that regeneration from a chitin/1-allyl-3-methylimidazolium bromide ion gel using methanol fabricated self-assembled CNFs. Prior to the emulsion polymerization, CNFs were maleylated by reaction with maleic anhydride in the presence of perchloric acid. After styrene was added to a dispersion of the produced anionic CNFs in ammonia aqueous, a mixture was ultorasonicated to give an emulsion, in which styrene droplets were stably surrounded by CNFs. Radical polymerization was then conducted in the presence of potassium persulfate as an initiator to produce the composite particles. Particle sizes became smaller as the amounts of CNFs increased. The hollow particles were prepared by solubilizing out the polystyrene cores with toluene. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Reference of 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Reference of 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2022,Dai, Yue; Wu, Xiaopei; Yin, Yihua; Dai, Honglian published an article in International Journal of Pharmaceutics (Amsterdam, Netherlands). The title of the article was 《GSH/enzyme-responsive 2-sulfonyl-1-methylimidazole prodrug for enhanced transdermal drug delivery and therapeutic efficacy against hyperthyroidis》.HPLC of Formula: 616-47-7 The author mentioned the following in the article:

Novel GSH/enzyme-responsive anti-hyperthyroidism prodrugs designed for transdermal delivery of 2-sulfonyl-1- methylimidazole (MMI) were synthesized by a Michael addition reaction of MMI with propiolic acid (PA) followed by esterification with three long chain fatty alcs. and their structures were characterized by 1H NMR, 13C NMR and mass spectrometry. Their maximum steady state flux through rat skin in the PG/W solution was found to be more than 37-times faster than that of MMI. The result may be attributed to the improved lipophilicity of prodrug and rapid bioconversion. The prodrugs were hydrolyzed by esterase on passing through the skin and appeared mainly as intermediate MMI-PA in the receiver compartment and accompanied by a small amount of MMI and intact prodrug. The prodrugs did not release any MMI in the media without GSH or with 100 μM GSH, while the obvious MMI release could be observed within 6.4 h in the media containing 2 mM and 10 mM GSH, and their maximum cumulative release rates reached 95.07% for lauryl alc. ester prodrug (MMI-PA-OLa). MMI-PA-OLa exhibited a significant inhibition effect on lactoperoxidase (LPO) after being incubated in millimolar GSH media, whose inhibition rate was very similar to that of free MMI with an equivalent dose. These results suggested that MMI-PA-OLa could pass efficiently through the skin and release MMI in response to the intracellular environment. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7HPLC of Formula: 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.HPLC of Formula: 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Rapid Ultrasensitive Gel-Free Immunoblotting with Magnetic Labels》 was written by Shlyapnikov, Yuri M.; Kanev, Igor L.; Shlyapnikova, Elena A.. Product Details of 616-47-7 And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020. The article conveys some information:

Immunoblotting is widely used for the detection of proteins using specific antibodies. We present here a new immunoblotting method, which is characterized by exceptional sensitivity, rapidness, and low consumption of antibodies. A thin conductive layer between touching hydrophilic cellulose membranes instead of polyacrylamide gel is used for the electrophoretic separation of proteins. Contrary to common Western blotting, the separation occurs in nondenaturing conditions. The membrane surface is smoothed by deposition of the cellulose layer and modified with azidophenyl groups, allowing for the photochem. in situ immobilization of proteins, which are carried out after the electrophoresis. Thus, the addnl. step of transferring the protein from the gel onto the membrane is eliminated. Specific protein bands are then visualized by decoration with magnetic beads. The limit of detection of interleukin IL-1β reaches 0.3 fg or ∼104 mols., whereas the total blotting time is about 5 min. The application of the technique is demonstrated by the detection of IL-1β, total IgA, and IgA specific to Mycobacterium tuberculosis antigen in the exhaled breath samples, obtained from healthy subjects and tuberculosis patients. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Product Details of 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Product Details of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Preparation of 1-methyl-2,4,5-trinitroimidazole from derivatives of 1-methylimidazole and its oxidation under nitration conditions》 was written by Lian, Peng-Bao; Chen, Jian; Chen, Li-Zhen; Zhao, Chong-Yang; Wang, Jian-Long; Shen, Fen-Fen. Synthetic Route of C4H6N2 And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. The article conveys some information:

1-Methylimidazole, 1-methyl-4-nitroimidazole, 1-methyl-5-nitroimidazole, or 1-methyl-4,5-dinitroimidazole gave a mixture of 1-methyl-4,5-dinitroimidazole and 1-methyl-2,4,5-trinitroimidazole under the volume ratio of HNO3 to H2SO4 of 1:3 at 80° temperature for 2.5 h, and the highest unisolated yield of 1-methyl-2,4,5-trinitroimidazole was 2.4%. 1-Methyl-2,4,5-trinitroimidazole was prepared from 1-methyl-2-nitroimidazole, 1-methyl-2,4-dinitroimidazole, or 1-methyl-2,5-dinitroimidazole under the same conditions, and the yields were 65, 76, and 82%, resp. However, when the ratio of HNO3 to H2SO4 was 1:5 and reaction was carried out at 120° for 2.5 h, only 1-methyl-4,5-dinitroimidazole was obtained from 1-methylimidazole, 1-methyl-4-nitroimidazole, or 1-methyl- 5-nitroimidazole in yields 43, 64, and 81%, resp. 1-Methyl-2-nitroimidazole, 1-methyl-2,4-dinitroimidazole, or 1-methyl- 2,5-dinitroimidazole gave 1-methylimidazolidine-2,4,5-trione under the same conditions, the yields were 61, 63, and 65%, resp. Meanwhile, 1-methylimidazolidine-2,4,5-trione was obtained from 1-methyl-2,4,5-trinitroimidazole. Under strong nitration conditions, the nitro group at the C-2 position is a key substituent to promote oxidation of the imidazole ring. The possible reaction mechanism for the formation of 1-methylimidazolidine-2,4,5-trione from 1-methyl-2,4,5-trinitroimidazole is given. The structure of 1-methylimidazolidine-2,4,5-trione was further confirmed by single crystal X-ray diffraction. In the experimental materials used by the author, we found 1-Methyl-1H-imidazole(cas: 616-47-7Synthetic Route of C4H6N2)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Synthetic Route of C4H6N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Detection of miRNAs by tissue printing and dot blot hybridization》 were Nunez, Marcelino Martinez; de Folter, Stefan; de Fatima Rosas-Cardenas, Flor. And the article was published in Methods in Molecular Biology (New York, NY, United States) in 2019. Application of 616-47-7 The author mentioned the following in the article:

Tissue printing and dot blot are simple techniques to detect miRNA expression and localization, allowing a better understanding of the function of a miRNA. The authors describe a tissue printing and a dot blot hybridization protocol for miRNA detection and localization in plant tissues, which opens the possibility of analyzing spatiotemporal expression patterns of miRNAs. After reading the article, we found that the author used 1-Methyl-1H-imidazole(cas: 616-47-7Application of 616-47-7)

1-Methyl-1H-imidazole(cas: 616-47-7) is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate.Application of 616-47-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Synthesis and biological evaluation of some novel 1-alkyl-3-methylimidazolium carboxylate ionic liquids as potential antifungal agents》 was published in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. These research results belong to Perez, Ser John Lynon P.; Atayde, Eduardo C. Jr.; Arco, Susan D.. Name: 1-Methyl-1H-imidazole The article mentions the following:

In an effort to discover lead compounds that may be of importance as potent antifungal agents, a series of novel 1-alkyl-3-methylimidazolium carboxylate ionic liquids were efficiently synthesized through a solvent-free ultrasound-assisted quaternization reaction of 1-methylimidazole and alkyl bromides RBr (R = hexyl, octyl) followed by an anion exchange process with selected carboxylate anions (cinnamate, salicylate, crotonate, and oxalate). Quant. yields obtained were in the range of 86-94%. Structure characterization was done using FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques. All the synthesized compounds showed in vitro antifungal activity against the fungus Candida albicans with the min. inhibitory concentrations found to be less than or equal to 1%. Preliminary cytotoxicity assays (trypan blue exclusion and MTT) were performed on all ionic liquids and findings revealed higher lymphocyte viability in 1-hexyl-3-methylimidazolium carboxylate ionic liquids than in 1-octyl-3-methylimidazolium counterparts. No extensive toxicity effect was observed with the carboxylate anion variation. Among the tested compounds, 1-hexyl-3-methylimidazolium crotonate and 1-hexyl-3-methylimidazolium oxalate exhibited the lowest cytotoxicity in the trypan blue exclusion and MTT assays, resp. Together, our results highlight the potential of carboxylate-based ionic liquids in the development of next-generation antifungal drugs. In the experiment, the researchers used 1-Methyl-1H-imidazole(cas: 616-47-7Name: 1-Methyl-1H-imidazole)

1-Methyl-1H-imidazole(cas: 616-47-7) is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Name: 1-Methyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem