Category: 7098-07-9

These common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Ethyl-1H-imidazole

To the dry 100 mL three-necked flask was added 6.3 g (10 mmol) of M2 ‘, 0.96 g (10 mmol) of 1-ethyl terephthalate, 50 mL of acetonitrile, reacted at room temperature for 4 days and TLC was used to monitor the reaction end. Washed with petroleum ether (100 mL x 3) to give a viscous liquid which was washed with ether (100 mL x 3), dried in vacuo for 24 h, To give 7.2 g of the title compound (B5) as a brown oily liquid in a yield of 99percent.

The synthetic route of 1-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Central China Normal University; Zhang Aidong; Zhang Tiejiang; Duan Jiang; Tu Haiyang; (22 pag.)CN107188869; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 7098-07-9, name is 1-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7098-07-9, SDS of cas: 7098-07-9

General procedure: A solution of N-alkylimidazole (10 mmol, 2 equivalents) and Dibromoalkane (5 mmol, 1 equivalent) was refluxed in toluene (20 mL) for 24?30 h. The reaction mixture was allowed to cool and toluene was decanted leaving a sticky solid behind. The sticky solid was washed three times with dry THF and finally with diethyl ether once. Solvent was removed under vacuum to get a white amorphous hygroscopic powder (88?94 percent yield). NMR spectra were recorded in D2O and/or DMSO-d6.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Aher, Sainath Babaji; Bhagat, Pundlik Rambhau; Research on Chemical Intermediates; vol. 42; 6; (2016); p. 5587 – 5596;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Some common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Ethyl-1H-imidazole

Step 1: 341 parts of 1-ethylimidazole (manufactured by Tokyo Chemical Industry Co., Ltd.), 319 parts of dimethyl carbonate (manufactured by Tokyo Chemical Industry Co., Ltd.) and 340 parts of methanol (Tokyo Chemical Industry Co., Ltd.) were charged in a stainless steel autoclave equipped with a reflux condenser, And dissolved. Then, the temperature was raised to 140 ° C. The reaction was carried out at a pressure of 0.8 MPa for 30 hours. 1 H-NMR analysis of the reaction product revealed that 1-ethyl-3-methylimidazolium monomethyl carbonate was formed.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7098-07-9, its application will become more common.

Reference:
Patent; SANYO CHEMICAL INDUSTRIES LIMITED; SATOU, YOSHIMI; MURATA, SHINICHI; SEIKE, HIDEO; (20 pag.)JP5848690; (2016); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adding a certain compound to certain chemical reactions, such as: 7098-07-9, name is 1-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7098-07-9, category: imidazoles-derivatives

A mixture of CoCl26H2O (0.1705 g, 0.8 mmol), NH4VO3(0.1404 g, 0.8 mmol), eIM (0.8 mL), and H2O (8 mL) was heated at about 120 °C for 72 h. After the mixture was cooled to room temperature, dark purple crystals were isolated from the mixture. Yield: 62percent (based on NH4VO3); Anal. Calcd. for C30H52Co2N12O14V4(percent): C, 31.96; H, 4.61; N, 14.91. Found: C, 31.71; H, 4.42; N, 14.58.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Ethyl-1H-imidazole, and friends who are interested can also refer to it.

Reference:
Article; Niu, Yan-Hong; Yang, Song; Li, Ji-Kun; Xu, Yan-Qing; Hu, Chang-Wen; Chinese Chemical Letters; vol. 27; 5; (2016); p. 649 – 654;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 7098-07-9, A common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 100 mL three-necked flask, TMEDA (2.86 g, 3.72 ml, 24.7 mmol, Eq: 2.37) was combined with pentane (10 ml) to give a colorless solution. N-BuLi 1.6M in hexane (15.6 ml, 25.0 mmol, Eq: 2.4), followed by 1-ethyl-1H-imidazole (1 g, 10.4 mmol, Eq: 1.00) were added dropwise at -25° C. for 30 min. The reaction mixture was stirred at RT for 1 h (light yellow suspension). Afterwards, the suspension was cooled to -65° C. and THF anhydrous (30 ml) was added (-65° C. to -48° C.). A solution of iodine (3.83 g, 15.1 mmol, Eq: 1.45) in THF anhydrous (20 ml) was added dropwise to the reaction mixture (internal temperature remained below -55° C.)=>brown suspension. Stirring was continued as the reaction was gradually warmed to 0° C. during 1.3 hours (brown milky solution). Eventually, the reaction was quenched by adding 4 mL of methanol. Work up: The reaction mixture was poured into 50 mL sat. Na2SO3 and extracted with EtOAc (2*100 mL). The organic layers were combined, washed with brine, dried over Na2SO4, and concentrated i. V. Purification: The crude material was purified by flash chromatography (silica gel, 50 g, 20percent to 100percent EtOAc in heptane) to provide in the more polar fractions 417 mg of the desired title compound as yellow oil. MS (ESI): 222.9 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; HOFFMANN-LA ROCHE INC.; Aebi, Johannes; Amrein, Kurt; Hornsperger, Benoit; Kuhn, Bernd; Maerki, Hans P.; Mayweg, Alexander V.; Mohr, Peter; Tan, Xuefei; US2014/128429; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electric Literature of 7098-07-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7098-07-9, name is 1-Ethyl-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of N-alkylimidazole (10 mmol, 2 equivalents) and Dibromoalkane (5 mmol, 1 equivalent) was refluxed in toluene (20 mL) for 24?30 h. The reaction mixture was allowed to cool and toluene was decanted leaving a sticky solid behind. The sticky solid was washed three times with dry THF and finally with diethyl ether once. Solvent was removed under vacuum to get a white amorphous hygroscopic powder (88?94 percent yield). NMR spectra were recorded in D2O and/or DMSO-d6.

The chemical industry reduces the impact on the environment during synthesis 1-Ethyl-1H-imidazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Aher, Sainath Babaji; Bhagat, Pundlik Rambhau; Research on Chemical Intermediates; vol. 42; 6; (2016); p. 5587 – 5596;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthetic Route of 7098-07-9, A common heterocyclic compound, 7098-07-9, name is 1-Ethyl-1H-imidazole, molecular formula is C5H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 750 mL three-necked flask, 1-ethyl-1H-imidazole (3 g, 3.13 ml, 31.2 mmol, Eq: 1.00) was combined with DCM (140 ml) to give a colorless solution. 1,3-Dibromo-5,5-dimethylimidazolidine-2,4-dione (4.55 g, 15.9 mmol, Eq: 0.51), dissolved in DCM (140 ml), was added dropwise at 0° C. during 20 min. to give a dark green solution. The reaction mixture was stirred at 0° C. for another 2 h. Work up: The reaction mixture was poured into 125 mL sat Na2SO3, extracted with DCM (2*100 mL) and washed with H2O/brine (20 ml). The organic layers were combined, washed with brine, dried over Na2SO4, and concentrated i. V. Purification: The crude product was purified by flash chromatography (silica gel, 400 g, 5percent MeOH in DCM) go give 1.66 g of pure title compound as yellow liquid. MS (ESI): 175.0, 177.0 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 7098-07-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of Zn(CH3COO)22H2O (0.1705 g, 0.8 mmol), NH4VO3(0.1404 g, 0.8 mmol), eIM (0.3 mL), and H2O (8 mL) was heated at about 120 ¡ãC for 72 h. After the mixture was cooled to room temperature, yellow crystals were isolated from the mixture.Yield: 76percent (based on NH4VO3); Anal. Calcd. for C30H48Zn2N12V4O12(percent): C, 32.63; H, 4.35; N, 15.23. Found: C, 32.76; H, 4.41; N, 15.21.

The synthetic route of 1-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Niu, Yan-Hong; Yang, Song; Li, Ji-Kun; Xu, Yan-Qing; Hu, Chang-Wen; Chinese Chemical Letters; vol. 27; 5; (2016); p. 649 – 654;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Related Products of 7098-07-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7098-07-9, name is 1-Ethyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 2.5 equiv. of the corresponding N-imidazole in 5 mL THF in an ACE-pressure tube, 1 equiv. of the dibromo alkyl compound [32] was added. The solution was heated at 100 ¡ãC for 72 h. The solution was filtered and the precipitate was washed with 2 x 5 mL THF and dried under vacuum to yield a white powder.

The synthetic route of 1-Ethyl-1H-imidazole has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jokic?, Nadez?da B.; Zhang-Presse, Mei; Goh, Serena L.M.; Straubinger, Claudia S.; Bechlars, Bettina; Herrmann, Wolfgang A.; Ku?hn, Fritz E.; Journal of Organometallic Chemistry; vol. 696; 24; (2011); p. 3900 – 3905;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

7098-07-9, name is 1-Ethyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 7098-07-9

(1) in the equipped with a stirrer,thermometer,Calcium chloride drying tube and dropping funnel500 ml four-necked flask6.10 g (0.05 mol) of 1,3-propanesultone and150 mL of ethyl acetate was added and the mixture was stirred1,3-propane sultone dissolved,The flask was heated in an oil bath equipped with methyl silicone oil70 ¡ã C,Slowly drop dissolved(0.065 mol) of N-ethylimidazole50 mL of ethyl acetate was added dropwise(Dropwise addition time: 30 min)Insulation reaction 2h,Pressure filtration,The residue was washed with ethyl acetate,Vacuum drying,To give 1- (3-sulfopropyl) -3-ethylimidazolium salt (EIm-PS)10.20 g,The yield was 93.6percent.

Statistics shows that 7098-07-9 is playing an increasingly important role. we look forward to future research findings about 1-Ethyl-1H-imidazole.

Reference:
Patent; Guangxi Kemao Forest Chemical Co., Ltd.; Jiangxi Jinan Forest Products Industrial Co., Ltd.; Guangdong Komo Co., Ltd.; Weng, Liang; Xu, Sheyang; Chen, Jiuji; (16 pag.)CN104926664; (2016); B;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem