Category: 852445-84-2

Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)On March 27, 2013, Visbal, Renso; Ospino, Isaura; Lopez-de-Luzuriaga, Jose M.; Laguna, Antonio; Gimeno, M. Concepcion published an article in Journal of the American Chemical Society. The article was 《N-Heterocyclic Carbene Ligands as Modulators of Luminescence in Three-Coordinate Gold(I) Complexes with Spectacular Quantum Yields》. The article mentions the following:

The first three-coordinate gold(I) N-heterocyclic carbene (NHC) complexes have been prepared with the nido-carborane diphosphine. The complexes are brightly luminescent and present very high quantum yield values. The carbene ligand is able to modulate the energy of the emissions and, depending upon the substituent, the luminescence changes from blue to green. Theor. calculations corroborate that the emissions are phosphorescence and arise from charge transfer (LML’CT) transitions from nido-carborane ligand (L) to metal/ligand group “”gold(I)-NHC ligand”” (ML’).Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2012,European Journal of Inorganic Chemistry included an article by Landers, Brant; Navarro, Oscar. Recommanded Product: 852445-84-2. The article was titled 《Microwave-Assisted Synthesis of (N-Heterocyclic carbene)MCl Complexes of Group 11 Metals》. The information in the text is summarized as follows:

The use of microwave heating for the synthesis of (N-heterocyclic carbene)-bearing complexes of Cu, Ag and Au allows for a drastic reduction of the reaction times required by conventional heating, while affording comparable or better yields of the desired complexes. In addition to this study using Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I), there are many other studies that have used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Recommanded Product: 852445-84-2) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 852445-84-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

《Modulating the Bonding Properties of N-Heterocyclic Carbenes (NHCs): A Systematic Charge-Displacement Analysis》 was published in Chemistry – A European Journal in 2017. These research results belong to Gaggioli, Carlo Alberto; Bistoni, Giovanni; Ciancaleoni, Gianluca; Tarantelli, Francesco; Belpassi, Leonardo; Belanzoni, Paola. Product Details of 852445-84-2 The article mentions the following:

In view of their intensive use as ligands in many reactions catalyzed by transition-metal complexes, modulation of the bonding properties of N-heterocyclic carbenes (NHCs) on a rational basis is highly desirable, which should enable optimization of current applications or even promote new functions. In this paper, we provide a quant. anal. of the chem. bond between a metal fragment AuCl and a series of 29 different NHCs in [(NHC)AuCl] complexes. NHCs electronic properties are modified through: (i) variation of the groups attached to the NHC nitrogen atoms or backbone; (ii) change of unsaturation/size of the NHC ring; (iii) inclusion of paracyclophane moieties; or (iv) heteroatom substitution on the NHC ring. For evaluating the donation and back-donation components of the Dewar-Chatt-Duncanson (DCD) model in the NHC-AuCl bond, we apply the charge-displacement (CD) anal. within the NOCV (natural orbitals for chem. valence) framework, a methodol. that avoids the constraint of using symmetrized structures. We show that modulation of the NHC bonding properties requires substantial modification of their structure, such as, for instance, insertion of two ketone groups into the NHC backbone (which enhances the π back-donation bond component and introduces an effective electronic communication within the NHC ring) or replacement of a nitrogen atom in the ring with an sp3 or sp2 carbon atom (which increases and decreases the π back-donation bond component, resp.). We extend our investigation by quant. comparing the NHC electronic structures for a subset of 13 NHCs in [(NHC)PPh] adducts, the 31P NMR chem. shift values of which are exptl. available. The latter have been considered as a suitable tool for measuring the NHCs π acceptor properties [Bertrand et al., Angew. Chem. Int. Ed. 2013, 52, 2939-2943]. We show that information obtained using the metal fragment can be transferred to the PPh moiety and vice versa. However, the 31P NMR chem. shift values only qual. correlate with the π acceptor properties of the NHCs, with the stronger π acidic carbenes as the most outliners. The results came from multiple reactions, including the reaction of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Product Details of 852445-84-2)

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. Product Details of 852445-84-2 In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)On March 27, 2013, Visbal, Renso; Ospino, Isaura; Lopez-de-Luzuriaga, Jose M.; Laguna, Antonio; Gimeno, M. Concepcion published an article in Journal of the American Chemical Society. The article was 《N-Heterocyclic Carbene Ligands as Modulators of Luminescence in Three-Coordinate Gold(I) Complexes with Spectacular Quantum Yields》. The article mentions the following:

The first three-coordinate gold(I) N-heterocyclic carbene (NHC) complexes have been prepared with the nido-carborane diphosphine. The complexes are brightly luminescent and present very high quantum yield values. The carbene ligand is able to modulate the energy of the emissions and, depending upon the substituent, the luminescence changes from blue to green. Theor. calculations corroborate that the emissions are phosphorescence and arise from charge transfer (LML’CT) transitions from nido-carborane ligand (L) to metal/ligand group “”gold(I)-NHC ligand”” (ML’).Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In 2012,European Journal of Inorganic Chemistry included an article by Landers, Brant; Navarro, Oscar. Recommanded Product: 852445-84-2. The article was titled 《Microwave-Assisted Synthesis of (N-Heterocyclic carbene)MCl Complexes of Group 11 Metals》. The information in the text is summarized as follows:

The use of microwave heating for the synthesis of (N-heterocyclic carbene)-bearing complexes of Cu, Ag and Au allows for a drastic reduction of the reaction times required by conventional heating, while affording comparable or better yields of the desired complexes. In addition to this study using Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I), there are many other studies that have used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Recommanded Product: 852445-84-2) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine. In addition, imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies. Recommanded Product: 852445-84-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)On September 22, 2010 ,《C-C Coupling Reactivity of an Alkylgold(III) Fluoride Complex with Arylboronic Acids》 was published in Journal of the American Chemical Society. The article was written by Mankad, Neal P.; Toste, F. Dean. The article contains the following contents:

Previously, alkylgold(III) fluorides are proposed as catalytic intermediates that undergo C-C coupling with reagents such as arylboronic acids in Au(I)/Au(III) cross-coupling reactions. Here is reported the first exptl. evidence for this elementary mechanistic step. Complexes of the type (NHC)AuMe (NHC = N-heterocyclic carbene) were oxidized with XeF2 to yield cis-(NHC)AuMeF2 products, which are in equilibrium with their fluoride-dissociated, dimeric [(NHC)AuMe(μ-F)]2[F]2 forms. In one case, a monomeric cis-(NHC)AuMeF2 complex was favored exclusively in solution, and it reacts with a variety of ArB(OH)2 reagents to yield Ar-CH3 products. In the experimental materials used by the author, we found Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I))

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

HPLC of Formula: 852445-84-2On June 10, 2021, Vanden Broeck, Sofie M. P.; Nelson, David J.; Collado, Alba; Falivene, Laura; Cavallo, Luigi; Cordes, David B.; Slawin, Alexandra M. Z.; Van Hecke, Kristof; Nahra, Fady; Cazin, Catherine S. J.; Nolan, Steven P. published an article in Chemistry – A European Journal. The article was 《Synthesis of Gold(I)-Trifluoromethyl Complexes and their Role in Generating Spectroscopic Evidence for a Gold(I)-Difluorocarbene Species》. The article mentions the following:

Readily prepared and bench-stable [Au(CF3)(NHC)] compounds were synthesized by using new methods, starting from [Au(OH)(NHC)], [Au(Cl)(NHC)] or [Au(L)(NHC)]HF2 precursors (NHC = N-heterocyclic carbene). The mechanism of formation of these species was investigated. Consequently, a new and straightforward strategy for the mild and selective cleavage of a single carbon/fluorine bond from [Au(CF3)(NHC)] complexes was attempted and found to be reversible in the presence of an addnl. nucleophilic fluoride source. This straightforward technique has led to the unprecedented spectroscopic observation of a gold(I)-NHC difluorocarbene species. The results came from multiple reactions, including the reaction of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2HPLC of Formula: 852445-84-2)

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.HPLC of Formula: 852445-84-2 Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The author of 《Acid, silver, and solvent-free gold-catalyzed hydrophenoxylation of internal alkynes》 were Richard, Marcia E.; Fraccica, Daniel V.; Garcia, Kevin J.; Miller, Erica J.; Ciccarelli, Rosa M.; Holahan, Erin C.; Resh, Victoria L.; Shah, Aakash; Findeis, Peter M.; Stockland, Robert A. Jr.. And the article was published in Beilstein Journal of Organic Chemistry in 2013. Application In Synthesis of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) The author mentioned the following in the article:

A range of (aryl)gold compounds were synthesized and investigated as single-component catalysts for a hydrophenoxylation of un-activated internal alkynes. Both carbene and phosphine-ligated compounds were screened as part of this work and the most efficient catalysts contained either JohnPhos or IPr/SIPr. Phenols bearing either electron-withdrawing or electron-donating groups were efficiently added using these catalysts. No silver salts, acids, or solvents were needed for the catalysis, and either microwave or conventional heating afforded moderate to excellent yields of the vinyl ethers. The title compounds thus formed included 1-[[(1Z)-1,2-diphenylethenyl]oxy]-4-nitrobenzene (I) and related substances, such as 1-nitro-4-[[(1Z)-1-phenyl-1-hexen-1-yl]oxy]benzene. The synthesis of the target compounds was achieved by a reaction of alkynes, such as 1,2-diphenylethyne, 5-decyne, (1-hexynyl)benzene with phenol derivatives, such as 4-nitrophenol, methylphenol, [1,1′-biphenyl]-4-ol. In the experiment, the researchers used many compounds, for example, Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Application In Synthesis of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I))

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
However, the application of imidazoles is not limited to the field of peptides and peptidomimetics. Application In Synthesis of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)On October 16, 2013 ,《Gold-Mediated Expulsion of Dinitrogen from Organic Azides》 was published in Journal of the American Chemical Society. The article was written by Dash, Chandrakanta; Yousufuddin, Muhammed; Cundari, Thomas R.; Dias, H. V. Rasika. The article contains the following contents:

Organoazides and their nitrogen expulsion chem. have attracted the attention of many scientists because they serve as a useful source of nitrene fragments and interesting nitrene rearrangement products. Gold-mediated reactions are also of significant current interest. This manuscript describes several important discoveries based at the intersection of these fields. In particular, the authors report the first isolable gold organoazides ([(SIPr)-AuN-(1-Ad)-NN][SbF6], [(SIPr)-AuN-(2-Ad)-NN][SbF6] and [(SIPr)-AuN-(Cy)-NN][SbF6]; SIPr = a N-heterocyclic carbene; 1-AdNNN = 1-azido-adamantane; 2-AdNNN = 2-azidoadamantane; CyNNN = azidocyclohexane), and their gold-mediated nitrogen expulsion chem., and the isolation of formal nitrene rearrangement products of 1-AdN, 2-AdN and CyN (including the elusive 4-azahomoadamant-3-ene) as their gold complexes. The authors have also performed a computational study to understand and explain the observed structure of gold-coordinated 1-AdNNN and 2-AdNNN and their nitrogen elimination pathways, which implies that the conversion of the organoazide complex to the imine is a concerted process without a nitrene/nitrenoid intermediate. Kinetic studies of [(SIPr)-AuN-(2-Ad)-NN][SbF6] from 30 to 50 °C indicate that nitrogen elimination is a first-order process. The exptl. determined activation parameters are in good agreement with the calculated values. The experimental part of the paper was very detailed, including the reaction process of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I))

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are also present in imidazole ring alkaloids, which are potential therapeutics for thrombosis, cancer and inflammatory diseases.Reference of Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I) Although other azole heterocycles are ubiquitous in a wide range of biologically active natural products, imidazole rings occur predominantly in the natural amino acid histidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Akana, Jennifer A.; Bhattacharyya, Koyel X.; Mueller, Peter; Sadighi, Joseph P. published an article in Journal of the American Chemical Society. The title of the article was 《Reversible C-F Bond Formation and the Au-Catalyzed Hydrofluorination of Alkynes》.Computed Properties of C27H38AuClN2 The author mentioned the following in the article:

The gold(I) fluoride complex [(SIPr)AuF] [SIPr = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene] reacts reversibly with 3-hexyne to form a (β-fluorovinyl)gold(I) species. The more stable fluorovinyl complex trans-{(SIPr)Au[(Ph)C:C(F)CH3]}, formed by addition of [(SIPr)AuF] across 1-phenyl-1-propyne, has been characterized crystallog. Both the protonolysis of a (fluorovinyl)gold complex and the reaction of a cationic (alkyne)gold(I) complex with the mild HF source Et3N•3HF result in fluoroalkene formation. Electrophilic gold(I) complexes, supported by N-heterocyclic carbene ligands and generated in situ, catalyze the trans-hydrofluorination of internal alkynes at room temperature This catalysis represents a new, selective, and potentially versatile method for the synthesis of fluoroalkenes. In addition to this study using Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I), there are many other studies that have used Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2Computed Properties of C27H38AuClN2) was used in this study.

Chloro{1,3-bis[2,6-bis(1-methylethyl)phenyl]-4,5-dihydroimidazol-2-ylidene}gold(I)(cas: 852445-84-2) belongs to imidazoles.Imidazole rings are part of unnatural cyclic peptides and are used as ester isosteres in peptidomimetic studies.
Computed Properties of C27H38AuClN2 However, the application of imidazoles is not limited to the field of peptides and peptidomimetics.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem