Category: 85330-50-3

Adding a certain compound to certain chemical reactions, such as: 85330-50-3, name is 4-Nitro-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 85330-50-3, HPLC of Formula: C7H5N3O3

Preparation of 4-amino-1H-benzo[d]imidazol-2(3H)-one 1a (scheme 2) To compound 4a (2g, 11.6mmol) dissolved in a mixture of 4/1 MeOH/THF (100ml) was added C/Pd 10% (500mg) and the reaction was hydrogenated at 60 psi overnight. (TLC AcOEt 9 / MeOH 1) The reaction was filtrated through a pad of Celite and the filtrate was evaporated under vacuum. The crude solid was crystallized from ether giving 1,5g of a white solid. Yield = 88%. 1HNMR (DMSO, 200 MHz) delta 4.84 (2H, bs), 6.22 (2H, m), 6.65 (1H, t, J = 8 Hz), 9.98 (1H, bs), 10.33 (1H, bs)

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Reference:
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 85330-50-3 as follows. Application In Synthesis of 4-Nitro-1H-benzo[d]imidazol-2(3H)-one

b)Preparation of 4-amino-benzimidazolin-2-one To a solution of 4-nitro-benzimidazolin-2-one (700 mg, 3.9mmol) in methanol(50 ml) and acetic acid (10 ml) was added 10% Pd/C (200 mg). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 ain. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (10%MeOH/CH2C2) gave the desired product (500 mg, 86%). 1H NMR (CD3SO2CD3): delta10.34 (s, 1H), 10.01 (s, 1H), 6.66 (t, 1H), 6.24 (d,1H), 6.22 (d, 1H), 5.15 (bs, 2H).

According to the analysis of related databases, 85330-50-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SmithKline Beecham Corporation; US6300325; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem