Category: 94084-75-0

Morita, Kunihiko published the artcileOzagrel hydrochloride monohydrate, a thromboxane synthase inhibitor, and its metabolites as inhibitors of hepatic microsomal drug metabolism, Computed Properties of 94084-75-0, the main research area is ozagrel metabolite liver microsome drug metabolism.

The change in the hepatic oxidative drug-metabolizing capacity in humans treated with ozagrel hydrochloride (I; OZA), an imidazole derivative and a new thromboxane A2 synthase inhibitor, was studied and the inhibitory potencies of the metabolites of OZA (M-1 and M-2) on the mouse hepatic microsomal monooxygenase system in vitro were compared with that of OZA. In vitro, M-1 and M-2, which are the β-oxidized form and the reduced form of OZA, resp., inhibited aminopyrine N-demethylation, aniline hydroxylation and testosterone hydroxylations in mouse hepatic microsomes and produced type II difference spectra in the same manner as OZA. The kinetic data indicated that the inhibitory potencies and the affinities of these compounds for cytochrome P 450 were decreased in the order of M-2 > OZA > M-1. The ratio of 6β-hydroxycortisol to cortisol in urine, used as an indicator of oxidative drug-metabolizing capacity in humans, did not change significant during oral treatment with 400 mg/day of OZA, while the ratio decreased to 80-85% of the original level during treatment with 800 mg/d of OZA. Although the participation of the metabolites of OZA in the reduction of drug-metabolizing capacity in vivo is not yet clear, the results suggest that hepatic oxidative drug-metabolizing enzyme activities in humans are inhibited by treatment with a relatively high dose of OZA.

Chemical & Pharmaceutical Bulletin published new progress about Drug-metabolizing enzymes Role: PROC (Process). 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Computed Properties of 94084-75-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Xu, Yan-Hong published the artcileSelf-assembly of zinc polymers based on a flexible linear ligand at different pH values: Syntheses, structures and fluorescent properties, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid, the main research area is zinc imidazolylmethylbenzonitrile imidazolylmethylbenzoate terephthalate complex polymer preparation structure fluorescence; crystal structure zinc imidazolylmethylbenzonitrile imidazolylmethylbenzoate terephthalate complex polymer.

Five novel coordination polymers, [Zn(imbz)2]n (1), {[Zn(imbz)2]·H2O}n (2), [Zn(imbz)(μ2-OH)]n (3), [Zn3(imbt)2(p-bdc)3]n (4), [Zn4(μ3-OH)2(imbt)2(p-bdc)3]n (5), (imbt = 4′-(imidazol-1-ylmethyl)benzonitrile, imbz- = 4′-(imidazol-1-ylmethyl)benzoate and p-bdc = terephthalate) were hydrothermally prepared through systematically changing the pH values of reaction mixture, and structurally characterized by elemental anal., IR spectroscopy and single-crystal x-ray crystallog. Compounds 1 and 2 exhibit similar 2-dimensional (4,4) grid structures, whereas compound 2 contains a right-handed helix along b-axis. Compound 3 has a distorted diamond framework which was constructed via imbz- ligands and μ2-OH groups linking metal atoms. Compound 4 shows a 2-dimensional 6-connected network with trinuclear zinc clusters as secondary building units (SBUs), whereas 5 shows a distorted α-Po with tetranuclear zinc clusters as SBUs, in which p-bdc ligands act as bridges. Also, compounds 1-5 all exhibit strong blue photoluminescence in the solid state at room temperature

Solid State Sciences published new progress about Crystal structure. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem