Category: imidazoles-derivatives

Syntheses of substituted 2-(1-methyl-2-imidazolyl)quinolines was written by Khazan, Minoo;Hadizadeh, Farzin;Shafiee, Abbas. And the article was included in Journal of Heterocyclic Chemistry in 1997.Recommanded Product: 85692-37-1 This article mentions the following:

Reaction of methyllithium with 1-methyl-2-imidazolecarboxaldehyde afforded the corresponding alc. Oxidation of the alc. with manganese dioxide gave 2-acetyl-1-methylimidazole (I). I reacted with isatins to give quinoline-4-carboxylic acids, which were converted to amides, carbamates, and amines. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Recommanded Product: 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Heterocyclic analogs of pleiadiene. XXVIII. Reaction of 1,8-naphthalenediamine with aromatic and heteroaromatic aldehydes. Synthesis of 2-substituted derivatives of perimidine and 2-R-2,3-dihydroperimidines was written by Pozharskii, A. F.;Starshikov, N. M.;Pozharskii, F. T.;Mandrykin, Yu. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1977.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde This article mentions the following:

Perimidines I (R = furyl, substituted furyl, pyrrolyl, thienyl, quinolyl, substituted phenyl, etc.) (20 compounds) were prepared in 60-96% yields by cyclizing II with RCHO. Dehydrogenation of I with Pd/C in xylene, nitrobenzene, etc. gave 30-90% III. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde).

1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde (cas: 3012-80-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of 1-Methyl-1H-benzo[d]imidazole-2-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

POSS-Based Electrolyte for Efficient Solid-State Dye-Sensitized Solar Cells at Sub-Zero Temperatures was written by Lv, Kai;Zhang, Wei;Zhang, Lu;Wang, Zhong-Sheng. And the article was included in ACS Applied Materials & Interfaces in 2016.Application In Synthesis of 1-Octyl-1H-imidazole This article mentions the following:

To expand the application of solid-state dye-sensitized solar cells (ssDSSCs) to low temperatures, it is necessary to develop new solid electrolytes with low glass transition temperature (T_g). The T_g is regulated by varying the length of alkyl chain that is connected with the nitrogen atom in the imidazolium ring linked to the polyhedral oligomeric silsesquioxane (POSS). The T_g as low as -8.8 °C is achieved with the POSS grafted with methyl-substituted imidazolium. The effect of alkyl group on the conductivity, T_g, and photovoltaic performance has also been investigated. The conductivity and power conversion efficiency increase with the alkyl length, while the T_g first increases and then decreases with the alkyl length. Among the synthesized POSS-based ionic conductors, the POSS grafted with the methyl-substituted imidazolium yields the highest power conversion efficiency of 6.98% at RT due to its highest conductivity, and the efficiency (6.52%) is still good at -4 °C, as its T_g (-8.8 °C) is lower than the working temperature (-4 °C). This finding suggests that the POSS-based solid electrolyte is promising for subzero-temperature applications of ssDSSCs. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Application In Synthesis of 1-Octyl-1H-imidazole).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Octyl-1H-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrochemical behavior of 4-nitroimidazole and 2-methyl-5-nitroimidazole. Autoprotonation of anion radical and redox-catalyzed reduction of the supporting electrolyte cation was written by Roffia, S.;Gottardi, C.;Vianello, E.. And the article was included in Journal of Electroanalytical Chemistry and Interfacial Electrochemistry in 1982.Safety of 1-Methyl-4-nitroimidazole This article mentions the following:

The electrochem. behavior of the title imidazoles (HRNO₂) was studied in DMF and MeCN by polarog., cyclic voltammetry and controlled-potential electrolysis and coulometry. The above nitroimidazoles present similar behavior, displaying 2 reduction waves paralleled by 2 reduction peaks in linear sweep voltammetry. The 1st peak is irreversible up to a sweep rate of 250 V s^-1, while the 2nd one appears voltammetry. The exptl. data in the 1st process are consistent with the hypothesis that the irreversibility of the 1st wave is due to a rapid decay of the primary anion radical of HRNO₂ because of a fast protonation reaction by the starting nitroimidazole, with the formation of the conjugate base RNO₂^– and of the neutral radical of HRNO₂H. This last radical gives rise, as final reduction product, to the hydroxylamino derivative, the necessary protons being supplied by the starting HRNO₂. The 2nd process is attributable to the reduction of RNO₂^– to radical dianion of RNO₂. The complete mechanism is discussed in detail. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Safety of 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cell Permeable Imidazole-Desferrioxamine Conjugates: Synthesis and In Vitro Evaluation was written by Pramanik, Shreya;Chakraborty, Saikat;Sivan, Malavika;Patro, Birija S.;Chatterjee, Sucheta;Goswami, Dibakar. And the article was included in Bioconjugate Chemistry in 2019.Reference of 21252-69-7 This article mentions the following:

Desferrioxamine (DFO), a clin. approved iron chelator used for iron overload, is unable to chelate labile plasma iron (LPI) because of its limited cell permeability. Herein, alkyl chain modified imidazolium cations with varied hydrophobicities have been conjugated with DFO. The iron binding abilities and the antioxidant properties of the conjugates were found to be similar to DFO. The degree of cellular internalization was much higher in the octyl-imidazolium-DFO conjugate (IV) compared with DFO, and IV was able to chelate LPI in vitro. This opens up a new avenue in using N-alkyl imidazolium salts as a delivery vector for hydrophilic cell-impermeable drugs. In the experiment, the researchers used many compounds, for example, 1-Octyl-1H-imidazole (cas: 21252-69-7Reference of 21252-69-7).

1-Octyl-1H-imidazole (cas: 21252-69-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 21252-69-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Revealing the roles of hydrogen bond and Al₂Cl^–7 anion species and kinetics for ionic liquid catalyzed transesterification of ethylene carbonate with methanol was written by Wang, Gang;Zhao, Shirun;Yao, Haoyu. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2023.Category: imidazoles-derivatives This article mentions the following:

The co-production of di-Me carbonate (DMC) and ethylene glycol (EG) from the transesterification of ethylene carbonate (EC), which is synthesized from CO₂ and ethylene oxide, with methanol has received researchers′ attention. The interaction between cation and methanol via hydrogen bond and activation of carbonyl group in EC (or 2-hydroxyethyl Me carbonate, HEMC) by metal chloride-contained anion were identified to show synergistic effects on catalytic transesterification. Not AlCl₄^– but Al₂Cl₇^– anion species in AlCl₃-based IL exhibited activity in this transesterification, and the content of Al₂Cl₇^– species was observed to show linear relationship with the transformative rates of both EC and HEMC. The kinetic studies also elucidated that the rates of both EC (or HEMC) and methanol are first-order dependent on their concentrations, and the formation of HEMC intermediate was the kinetic-relevant step with the activation barrier of 92 kJ/mol. As a result, the yield and selectivity of DMC (or EG) could reach up to around 95 % and 97 % with catalysis of [MDMIM]Cl/AlCl₃ with AlCl₃ molar fraction of 0.67 after 12 h reaction at 140 °C, which showed higher performance than any other tested metal chloride-based IL. Besides, no decay in catalytic activity and selectivity of this IL was observed after 10 times′ recycling. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Category: imidazoles-derivatives).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Controlling the outcome of S_N2 reactions in ionic liquids: from rational data set design to predictive linear regression models was written by Schindl, Alexandra;Hawker, Rebecca R.;Schaffarczyk McHale, Karin S.;Liu, Kenny T.-C.;Morris, Daniel C.;Hsieh, Andrew Y.;Gilbert, Alyssa;Prescott, Stuart W.;Haines, Ronald S.;Croft, Anna K.;Harper, Jason B.;Jager, Christof M.. And the article was included in Physical Chemistry Chemical Physics in 2020.Product Details of 404001-48-5 This article mentions the following:

Rate constants for a bimol. nucleophilic substitution (S_N2) process in a range of ionic liquids are correlated with calculated parameters associated with the charge localization on the cation of the ionic liquid (including the mol. electrostatic potential). Simple linear regression models proved effective, though the interdependency of the descriptors needs to be taken into account when considering generality. A series of ionic liquids were then prepared and evaluated as solvents for the same process; this data set was rationally chosen to incorporate homologous series (to evaluate systematic variation) and functionalities not available in the original data set. These new data were used to evaluate and refine the original models, which were expanded to include simple artificial neural networks. Along with showing the importance of an appropriate data set and the perils of overfitting, the work demonstrates that such models can be used to reliably predict ionic liquid solvent effects on an organic process, within the limits of the data set. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Product Details of 404001-48-5).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 404001-48-5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Production of silk fibroin nanoparticles using ionic liquids and high-power ultrasounds was written by Abel Lozano-Perez, Antonio;Montalban, Mercedes Garcia;Aznar-Cervantes, Salvador David;Cragnolini, Francesca;Cenis, Jose Luis;Villora, Gloria. And the article was included in Journal of Applied Polymer Science in 2015.Reference of 79917-89-8 This article mentions the following:

Biopolymeric nanoparticles have attracted great research interest in the last few years due to their multiple applications. This article describes how high-power ultrasounds are capable of enhancing the dissolution process of silk proteins in ionic liquids (ILs) and how silk fibroin nanoparticles (SFNs) can be obtained directly from the silk/ionic liquid solution (SIL) by rapid desolvation in polar organic solvents. The silk fibroin integrity is highly preserved during the dissolution process, as confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of the SIL. These regenerated SFNs are insoluble in water and other common organic solvents and are indistinguishable from the classical SFNs with respect to their diameter (180 ± 5 nm), Zeta potential (-25 ± 3 mV), high degree of β-sheet and low cytotoxicity. Large amounts of silk can be turned into biomaterials directly from the SIL solution for use in a wide range of applications, while the ILs can be recovered from the coagulant solution under reduced pressure and reused without loss of their solvent properties. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41702. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Reference of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A new mononuclear Cd(II) complex CdL₂I₂ (L = 6-nitro-imidazo(1,2-a)pyridine) made up by a novel in situ reaction was written by Liu, Dao-Fu;Zhou, Wei-Wei;Zhao, Wang;Wang, Feng-Wu;Wei, Yi-Jun;Zhao, Xing;Wu, Yu-Jie;Chen, Ying;Qin, Nan-Nan. And the article was included in Inorganic and Nano-Metal Chemistry in 2017.Recommanded Product: 6-Nitroimidazo[1,2-a]pyridine This article mentions the following:

A novel in situ cyclocondensation reaction of anp (anp = 2-amino-5-nitropyridine) and ethanol into L (L = 6-nitro-imidazo(1,2-a)pyridine) under solvothermal conditions was observed for the first time. Crystal structure of a metal complex, CdL₂I₂ (1), was obtained. Complex 1 was synthesized from a solvothermal reaction of anp with CdI₂ in anhydrous ethanol and water. Complex 1 crystallizes in orthorhombic space group Pnma with a 13.662(9), b 16.734(11), c 8.767(5) Å. The structure of 1 shows mononuclear units. Weak hydrogen bonds and π···π stacking intermol. interactions assemble units to form a 3-dimensional supramol. network of 1. In the experiment, the researchers used many compounds, for example, 6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3Recommanded Product: 6-Nitroimidazo[1,2-a]pyridine).

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 6-Nitroimidazo[1,2-a]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Influence of Ionic Liquid on Recombination and Regeneration Kinetics in Dye-Sensitized Solar Cells was written by Li, Feng;Jennings, James Robert;Wang, Xingzhu;Fan, Li;Koh, Zhen Yu;Yu, Hao;Yan, Lei;Wang, Qing. And the article was included in Journal of Physical Chemistry C in 2014.Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

Nonvolatile electrolyte solutions are necessary for dye-sensitized solar cells (DSCs) with good long-term stability. Such electrolytes usually contain room-temperature ionic liquids (RTILs) and consequently possess higher viscosity and ionic strength than the volatile electrolytes used in current champion cells. In this study, we systematically investigated the effect of an RTIL additive on the performance of DSCs employing either a classical Ru-complex dye or a recently developed organic D-A-π-A dye, in combination with either I^–/I₃^– or [Co(bpy)₃]^2+/3+ as redox mediator. Using impedance spectroscopy and transient absorption measurements under various background illumination intensities, recombination and regeneration kinetics were examined Recombination is accelerated in the I^–/I₃^– devices upon addition of RTIL, regardless of the dye used, but it is retarded in the [Co(bpy)₃]^2+/3+ devices. Addition of RTIL slowed regeneration in I^–/I₃^– devices for both sensitizers, marginally accelerated it for [Co(bpy)₃]^2+/3+ with the Ru-complex dye, and did not significantly affect it for [Co(bpy)₃]^2+/3+ with the D-A-π-A dye. We show that these findings cannot be explained by diffusion limitations caused by increased solution viscosity or by a shift in the TiO₂ conduction band relative to the electrolyte redox level. These findings should be useful for future optimization of RTIL-based DSCs. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem