Category: imidazoles-derivatives

Improvement of the chromatographic separation performance of an imidazolium ionic liquid functionalized silica column by in situ anion-exchange with dodecyl sulfonate and dodecylbenzene sulfonate anions was written by Sun, Min;Feng, Juanjuan;Chen, Wenjie;Li, Leilei;Duan, Huimin;Luo, Chuannan. And the article was included in Journal of Separation Science in 2014.Product Details of 79917-89-8 This article mentions the following:

The anionic part of ionic liquids can provide addnl. interactions during chromatog. separations The chromatog. separation performance of a silica column functionalized with 1-propyl-3-methylimidazolium chloride ionic liquid was improved by in situ anion-exchange from chloride anions to dodecyl sulfonate anions and dodecylbenzene sulfonate anions. The separation performances of these ionic liquid functionalized phases were studied and compared with each other using polycyclic aromatic hydrocarbons, phthalates, parabens, and phenols as model compounds The new columns presented a better chromatog. separation than the original one. This was ascribed retention mechanism from organic anions. The introduction of dodecyl sulfonate anions increased the hydrophobicity of stationary phase. Also, the Ph groups of dodecylbenzene sulfonate anions could provide an enhanced selectivity to aromatic compounds such as polycyclic aromatic hydrocarbons by π-π interactions. Anal. repeatability of the new columns was satisfactory (relative standard deviation of retention time, 0.10-0.40%; relative standard deviation of peak area, 0.66-0.84%). In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Product Details of 79917-89-8).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 79917-89-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hexahalometallate salts of trivalent scandium, yttrium and lanthanum: cation-anion association in the solid state and in solution was written by Champion, Martin J. D.;Levason, William;Pugh, David;Reid, Gillian. And the article was included in New Journal of Chemistry in 2016.Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride This article mentions the following:

The hexahalide salts, [NBu₄]₃[LaCl₆] (1), [BMPYRR]₃[LaCl₆] (2, BMPYRR = 1-butyl-1-methylpyrrolidinium), [EMIM]₃[MX₆] (EMIM = 1-ethyl-3-methylimidazolium; M = La, X = Cl (3), Br (4), I (5); M = Sc (6), Y (7), Ce (8), X = Cl) and [EDMIM]₃[MX₆] (EDMIM = 1-ethyl-2,3-dimethylimidazolium; M = Y (9), X = Cl; M = La, X = Cl (10), I (11)) were prepared and x-ray crystal structures determined for several of them, with a view to probing the effect of varying the trivalent metal ion, the halide and the countercation on the structures adopted in the solid state. The crystal structures of the EMIM and EDMIM salts show extensive H-bonding between the halide ligands and organic cations; based upon the H-bonding distances, this appears to be strongest for the [EMIM]₃[MCl₆] salts, becoming progressively weaker for heavier metal ion or halide. In terms of the cations, changing from EMIM to EDMIM also reduces the strength of the H-bonding. The strength of the cation-anion pairing in solution also was probed in solution via NMR spectroscopy where possible (⁴⁵Sc, ⁸⁹Y and ¹⁸⁹La) and, for the EMIM salts, via the shift of δ(H2) relative to [EMIM]Cl at a standard concentration The trends observed in solution mirror those determined in the solid state. In the experiment, the researchers used many compounds, for example, 1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride).

1-ethyl-2,3-dimethylimidazolium chloride (cas: 92507-97-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 1-ethyl-2,3-dimethylimidazolium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Simple protic ionic liquid [Et₃NH][HSO₄] as a proficient catalyst for facile synthesis of biscoumarins was written by Patil, Sandip K.;Awale, Deepak V.;Vadiyar, Madagonda M.;Patil, Suryakant A.;Bhise, Sagar C.;Kolekar, Sanjay S.. And the article was included in Research on Chemical Intermediates in 2017.HPLC of Formula: 35487-17-3 This article mentions the following:

Abstract: We have explored a number of protic ionic liquids (PILs) as a catalyst for the synthesis of biscoumarins by condensation of 4-hydroxycoumarin with an aromatic aldehyde. Methylimidazolium- and triethylammonium-based PILs were synthesized by simple neutralization reaction with protic acids. Triethylammonium hydrogen sulfate [Et₃NH][HSO₄] was found to be the best among the studied PILs concerning the yield of products and reaction time period. Different biscoumarin derivatives were synthesized based on 4-hydroxycoumarin and various substituted aromatic aldehydes at optimum reaction conditions. Obtained products were separated just by simple filtration. The facile method does not require addnl. purification for formed products. The catalyst has shown better yields along with outstanding recyclability, providing an environmental benign protocol for the synthesis of biscoumarin derivatives Graphical Abstract: Screening of simple protic ionic liquids as a catalyst in the synthesis of biscoumarins, out of which [Et₃NH][HSO₄] was found to be best among the studied PILs. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3HPLC of Formula: 35487-17-3).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 35487-17-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Filling environmental data gaps with QSPR for ionic liquids: Modeling n-octanol/water coefficient was written by Rybinska, Anna;Sosnowska, Anita;Grzonkowska, Monika;Barycki, Maciej;Puzyn, Tomasz. And the article was included in Journal of Hazardous Materials in 2016.Electric Literature of C7H13ClN2 This article mentions the following:

Ionic liquids (ILs) form a wide group of compounds characterized by specific properties that allow using ILs in different fields of science and industry. Regarding that the growing production and use of ionic liquids increase probability of their emission to the environment, it is important to estimate the ability of these compounds to spread in the environment. One of the most important parameters that allow evaluating environmental mobility of compound is n-octanol/water partition coefficient (K_OW). Exptl. measuring of the K_OW values for a large number of compounds could be time consuming and costly. Instead, computational predictions are nowadays being used more often. The paper presents new quant. structure-property relationship (QSPR) model that allows predicting the logarithmic values of K_OW for 335 ILs, for which the exptl. measured values had been unavailable. We also estimated bioaccumulation potential and point out which group of ILs could have neg. impact on environment. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors was written by Costales, Abran;Mathur, Michelle;Ramurthy, Savithri;Lan, Jiong;Subramanian, Sharadha;Jain, Rama;Atallah, Gordana;Setti, Lina;Lindvall, Mika;Appleton, Brent A.;Ornelas, Elizabeth;Feucht, Paul;Warne, Bob;Doyle, Laura;Basham, Stephen E.;Aronchik, Ida;Jefferson, Anne B.;Shafer, Cynthia M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Electric Literature of C7H5BrN2 This article mentions the following:

2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Mol. modeling and medicinal chem. techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochem. properties. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-benzoimidazole (cas: 83741-35-9Electric Literature of C7H5BrN2).

4-Bromo-1H-benzoimidazole (cas: 83741-35-9) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Electric Literature of C7H5BrN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

K₂S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles was written by Zhu, Xiaoming;Zhang, Fuxing;Kuang, Daizhi;Deng, Guobo;Yang, Yuan;Yu, Jiangxi;Liang, Yun. And the article was included in Organic Letters in 2020.Reference of 1632-83-3 This article mentions the following:

A three-component reaction of o-iodoanilines with K₂S and DMSO that provided 2-unsubstituted benzothiazoles in moderate to good isolated yields with good functional group tolerance. Electron-rich aromatic amines and o-phenylenediamines instead of o-iodoanilines provided 2-unsubstituted benzothiazoles and 2-unsubstituted benzimidazoles with and without K₂S under similar conditions. Notably, DMSO plays three vital roles: carbon source, solvent and oxidant. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Reference of 1632-83-3).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 1632-83-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems was written by Duchemin, Nicolas;Aubert, Sidonie;de Souza, Joao V.;Bethge, Lucas;Vonhoff, Stefan;Bronowska, Agnieszka K.;Smietana, Michael;Arseniyadis, Stellios. And the article was included in JACS Au in 2022.COA of Formula: C6H8N2O This article mentions the following:

By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asym. catalysis, many challenges still remain to be faced, in particular when it comes to designing a ′universal′ catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asym. catalysis. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1COA of Formula: C6H8N2O).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C6H8N2O

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides was written by Makosza, Mieczyslaw;Bia-lecki, Maciej. And the article was included in Journal of Organic Chemistry in 1998.Recommanded Product: 1-Methyl-4-nitroimidazole This article mentions the following:

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of amination. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Recommanded Product: 1-Methyl-4-nitroimidazole).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 1-Methyl-4-nitroimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supported ionic-liquid-phase-stabilized Au(III) catalyst for acetylene hydrochlorination was written by Zhao, Jia;Gu, Shanchuan;Xu, Xiaolong;Zhang, Tongtong;Yu, Yi;Di, Xiaoxia;NI, Jun;Pan, Zhiyan;Li, Xiaonian. And the article was included in Catalysis Science & Technology in 2016.Safety of 1-Methyl-3-propylimidazolium Chloride This article mentions the following:

A stable and catalytically active Au(III) complexes was obtained using Supported Ionic Liquid Phase (SILP) technol. The resulting heterogeneous Au-IL/AC catalysts combined the advantages of the catalytic species being stabilized in the Au(III) form by forming a Au(III)-IL complex and the need for a less expensive metal catalyst because the active component could be better developed in a homogeneous reaction medium. When used in acetylene hydrochlorination reaction, this catalyst displayed an excellent specific activity and superior long-term stability. Under the same reaction conditions, the Au(III)-IL/AC catalyst showed higher activity and stability towards the vinyl chloride monomer (VCM) than IL-free Au/AC (C₂H₂ conversion = 72.1% at 180° compared to 16.1% without IL). It also delivered stable performance within the conversion of acetylene, reaching more than 99.4%, and there was only a 3.7% C₂H₂ conversion loss after running for 300 h under the reaction conditions of a temperature of 180° and a C₂H₂ hourly space velocity of 30 h^-1. Its exceptional ability to maintain the high activity and stability further demonstrated the potential for the replacement of Hg-based catalysts for acetylene hydrochlorination. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Safety of 1-Methyl-3-propylimidazolium Chloride).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Methyl-3-propylimidazolium Chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ionic liquids-coordinated Au catalysts for acetylene hydrochlorination: DFT approach towards reaction mechanism and adsorption energy was written by Xu, Hao;Meng, Shijun;Luo, Guohua. And the article was included in Catalysis Science & Technology in 2018.Electric Literature of C7H13ClN2 This article mentions the following:

The addition of various ILs to a Au catalytic system for acetylene hydrochlorination reaction was explored via d. functional theory (DFT) calculations The most common IL cations including imidazolium IL cations, quaternary ammonium IL cations and quaternary phosphonium IL cations were selected and compared. The reaction pathways were explored and the corresponding activation energies were obtained. Adsorption energies of each reactant and product were calculated, which was crucial for predicting the performance of the catalysts. IL addition can significantly change the energy profiles in the reaction pathways and the adsorption energies of each reactant and product, indicating the capacity of ILs for tuning the catalytic properties of Au catalysts in this reaction. Exptl. activation energies were obtained and the data were compared with DFT results. The consistency of computational and exptl. results provides valuable instructions for the design and preparation of high performance non-Hg catalysts for acetylene hydrochlorination. In the experiment, the researchers used many compounds, for example, 1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8Electric Literature of C7H13ClN2).

1-Methyl-3-propylimidazolium Chloride (cas: 79917-89-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C7H13ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem