Category: imidazoles-derivatives

Formulation development and evaluaation of Candesartan Cilexetil immediate release tablets was written by Challa, Yellareddy;Banavath, Sujatha.;Swathi, Alle.;Eslavath, Ragya;Ramakrishna, Ubbani;Suthakaran, R.;Jyothirmai, Kalyankar Manasvi. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2018.Electric Literature of C33H34N6O6 This article mentions the following:

The tablets were prepared and evaluated using wet granulation technique. In order to optimize the product, different formulations were developed. And pre compression and post compression were evaluated. To check the compatibility of drug with various polymers,. FTIR spectra of Candesartan Cilexetil were recorded, The IR spectral anal. of Candesartan Cilexetil pure drug alone showed that principal peaks were observed at wave numbers 2939.13 cm-1, 1752.03 cm-1, 1546.56 cm-1, 1713.38 cm-1 and 1573.01 cm the major peaks were observed at 2937.48 cm-1, 1752.22 cm-1, 1546.30 cm-1, 1713.10 cm-1 and 1573.28 cm-1.. All the formulations were evaluated for phys. characteristics, Disintegration, in-vitro Dissolution and Stability studies. The Formulation F8 showed fair flow properties when compared to the reference product.From the obtained in vitro results of the above formulation Trials, We selected F – 8 as the optimized formulation because it showed total drug release with in 30 min than all other formulations and reference product. In the experiment, the researchers used many compounds, for example, 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5Electric Literature of C33H34N6O6).

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (cas: 145040-37-5) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C33H34N6O6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Estimation of the saturation pressure of pure ionic liquids using MLP artificial neural networks and the revised isofugacity criterion was written by Hekayati, Javad;Rahimpour, Mohammad Reza. And the article was included in Journal of Molecular Liquids in 2017.Computed Properties of C18H31F6N3O4S2 This article mentions the following:

Despite the long-held misconception surrounding pure ionic liquids (ILs), recent exptl. investigations have unequivocally established that several ILs could boil at temperatures sufficiently low to avoid the risk of decomposition Nonetheless, the exptl. complexity combined with the high costs incurred for the measurement of the saturation pressure of ILs, with typical values below 0.1 (Pa), make the development of predictive models for this important thermophys. property of great importance. In the current study, utilizing 325 exptl. vapor pressure data points belonging to 26 ILs with mol. weights spanning 205.265-629.763 (g·mol^– 1), a robust multilayer perceptron (MLP) feedforward artificial neural network (ANN) has been constructed. The weights and biases of the proposed network, which is comprised of only one hidden layer with nine neurons, have been optimized using the Bayesian regularization approach. The input parameters of the ANN include the critical temperature, critical pressure, acentric factor, as well the mass connectivity index of the IL of interest, which are easily calculable using a modified Lydersen-Joback-Reid group contribution method. In addition, comprehensive comparisons have been made with two thermodynamically rigorous treatments for the prediction and correlation of the vapor pressure of pure substances, namely the zero-pressure liquid fugacity approach as well as the revised isofugacity criterion. According to the results obtained, the proposed ANN can satisfactorily be employed for the prediction of the saturation pressure of pure ILs with an overall AARD below 1%. In the experiment, the researchers used many compounds, for example, 3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5Computed Properties of C18H31F6N3O4S2).

3-Dodecyl-1-methyl-1H-imidazol-3-ium bis((trifluoromethyl)sulfonyl)amide (cas: 404001-48-5) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C18H31F6N3O4S2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A convenient route to the imidazo[4,5-b]pyridines was written by Harada, Kenichi;Choshi, Tominari;Sugino, Eiichi;Sato, Koichi;Hibino, Satoshi. And the article was included in Heterocycles in 1996.Related Products of 3034-41-1 This article mentions the following:

The reaction of acroleins possessing a leaving group, derived from alkenyl sulfides by Vilsmeier reaction, with 4-amino-1-methylimidazole provided a new and convenient route to the imidazole[4,5-b]pyridines, the reaction mechanisms of which were examined by a deuterium labeled experiment In the experiment, the researchers used many compounds, for example, 1-Methyl-4-nitroimidazole (cas: 3034-41-1Related Products of 3034-41-1).

1-Methyl-4-nitroimidazole (cas: 3034-41-1) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 3034-41-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Iron-Mediated Electrophilic Amination of Organozinc Halides using Organic Azides was written by Grassl, Simon;Singer, Johannes;Knochel, Paul. And the article was included in Angewandte Chemie, International Edition in 2020.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

A wide range of alkyl-, aryl- and heteroarylzinc halides were aminated with highly functionalized alkyl, aryl, and heterocyclic azides. The reaction proceeded smoothly at 50 °C within 1 h in the presence of FeCl₃ (0.5 equiv) to furnish the corresponding secondary amines such as RNHR¹ [R = 4-MeOC₆H₄, 3,5-di-MeC₆H₃, 6-chloro-3-pyridyl, etc.; R¹ = cyclopropyl, 4-FC₆H₄, 4-ClC₆H₄, etc.] in good yields. This method was extended to peptidic azides and provided the arylated substrates with full retention of configuration. To demonstrate the utility of this reaction, prepared two amine derivatives of pharmaceutical relevance using this iron-mediated electrophilic amination as the key step. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Copper-Catalyzed Aminoheteroarylation of Unactivated Alkenes through Distal Heteroaryl Migration was written by Kwon, Yungeun;Zhang, Wei;Wang, Qiu. And the article was included in ACS Catalysis in 2021.Application In Synthesis of 1-Methylbenzimidazole This article mentions the following:

A copper-catalyzed aminoheteroarylation of unactivated alkenes to access valuable heteroarylethylamine motif. was reported. The developed reaction features a copper-catalyzed intermol. electrophilic amination of the alkenes followed by a migratory heteroarylation. The method applies to alc.-, amide-, and ether-containing alkenes, overcoming the common requirement of a hydroxyl motif in previous migratory difunctionalization reactions. This reaction was effective for the introduction of diverse aliphatic amines and has good functional group tolerance, which was particularly useful for rich functionalized heteroarenes. This migration-involved reaction was found well suited as a powerful ring-expansion approach for the construction of medium-sized rings that were in great demand in medicinal chem. In the experiment, the researchers used many compounds, for example, 1-Methylbenzimidazole (cas: 1632-83-3Application In Synthesis of 1-Methylbenzimidazole).

1-Methylbenzimidazole (cas: 1632-83-3) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application In Synthesis of 1-Methylbenzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Transformation of Epoxidized Natural Rubber into Ionomers by Grafting of 1H-Imidazolium Ion and Development of a Dynamic Reversible Network was written by Mandal, Subhradeep;Hait, Sakrit;Simon, Frank;Ghosh, Anik;Scheler, Ulrich;Arief, Injamamul;Tada, Toshio;Hoang, Tung X.;Wiessner, Sven;Heinrich, Gert;Das, Amit. And the article was included in ACS Applied Polymer Materials in 2022.Safety of 1-Methyl-1H-imidazol-3-ium chloride This article mentions the following:

Epoxidized natural rubber (ENR) was grafted with imidazolium ions, giving the materials self-healing and reprocessing properties. These imidazolium ions in the form of neutral ionic repeating units transformed the polyisoprene-based polymer chains into ionomers. Fourier transform IR (FTIR) spectroscopy and solid-state NMR analyses were carried out to confirm various interactions between ENR and 1H-imidazole. In particular, dynamic hydrogen bonding and the formation of ionic aggregates led to superior mech. strength (tensile strength, ~4.5 MPa; elongation at break, ~700%), self-healing efficiency (90% in terms of elongation), and reprocessability of the resulting compound Furthermore, the material exhibited excellent transparency with a normalized transparency of 90 ± 0.7% at a typical thickness of 0.5 mm. The visualization and the stability of the healing processes were confirmed by SEM and confocal microscopy analyses. Finally, temperature scanning stress relaxation (TSSR) studies were carried out to identify the different types of stress relaxation behavior of the material and the effects of various noncovalent interactions on the high-temperature stability of the compounds These studies could assist to gain significant insight into natural rubber-based advanced materials for sustainable development. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Safety of 1-Methyl-1H-imidazol-3-ium chloride).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Safety of 1-Methyl-1H-imidazol-3-ium chloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic enantioselective syn hydration of enones in water using a DNA-based catalyst was written by Boersma, Arnold J.;Coquiere, David;Geerdink, Danny;Rosati, Fiora;Feringa, Ben L.;Roelfes, Gerard. And the article was included in Nature Chemistry in 2010.Reference of 85692-37-1 This article mentions the following:

The enantioselective addition of water to olefins in an aqueous environment is a common transformation in biol. systems, but was beyond the ability of synthetic chemists. Here, we present the first examples of a non-enzymic catalytic enantioselective hydration of enones, for which we used a catalyst that comprises a copper complex, based on an achiral ligand, non-covalently bound to (deoxy)RNA, which is the only source of chirality present under the reaction conditions. The chiral β-hydroxy ketone product was obtained in up to 82% enantiomeric excess. Deuterium-labeling studies demonstrated that the reaction is diastereospecific, with only the syn hydration product formed. So far, this diastereospecific and enantioselective reaction had no equivalent in conventional homogeneous catalysis. In the experiment, the researchers used many compounds, for example, 1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1Reference of 85692-37-1).

1-(1-Methyl-1H-imidazol-2-yl)ethanone (cas: 85692-37-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 85692-37-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of [¹⁸F]fluoroetanidazole: a potential new tracer for imaging hypoxia was written by Tewson, T. J.. And the article was included in Nuclear Medicine and Biology in 1997.Recommanded Product: 2-(2-Nitro-1H-imidazol-1-yl)acetic acid This article mentions the following:

[¹⁸F]fluoroetanidazole is prepared by an active ester coupling reaction between the 2,3,5,6-tetrafluorophenyl ester of 2-nitroimidazoleacetic acid and [¹⁸F]fluoroethylamine. [¹⁸F]Fluoroethylamine is prepared from N-[2-(toluene-4-sulfonyloxy)ethyl]phthalimide and [¹⁸F]fluoride and purified by distillation The overall reaction takes about 90 min and gives a yield, uncorrected, of about 25%. Purification on a reversed-phase column is straightforward. In the experiment, the researchers used many compounds, for example, 2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7Recommanded Product: 2-(2-Nitro-1H-imidazol-1-yl)acetic acid).

2-(2-Nitro-1H-imidazol-1-yl)acetic acid (cas: 22813-32-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: 2-(2-Nitro-1H-imidazol-1-yl)acetic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

N-Trifluoromethylthio-dibenzenesulfonimide: A Shelf-Stable, Broadly Applicable Electrophilic Trifluoromethylthiolating Reagent was written by Zhang, Panpan;Li, Man;Xue, Xiao-Song;Xu, Chunfa;Zhao, Qunchao;Liu, Yafei;Wang, Haoyang;Guo, Yinlong;Lu, Long;Shen, Qilong. And the article was included in Journal of Organic Chemistry in 2016.Related Products of 25045-82-3 This article mentions the following:

The super electrophilicity of a shelf-stable, easily prepared trifluoromethylthiolating reagent N-trifluoromethylthio-dibenzenesulfonimide I was demonstrated. Consistent with the theor. prediction, I exhibits reactivity remarkably higher than that of other known electrophilic trifluoromethylthiolating reagents. In the absence of any additive, I reacted with a wide range of electron-rich arenes and activated heteroarenes under mild conditions. Likewise, reactions of I with styrene derivatives can be fine-tuned by simply changing the reaction solvents to generate trifluoromethylthiolated styrenes or oxo-trifluoromethylthio or amino-trifluoromethylthio difunctionalized compounds in high yields. In the experiment, the researchers used many compounds, for example, 6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3Related Products of 25045-82-3).

6-Nitroimidazo[1,2-a]pyridine (cas: 25045-82-3) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 25045-82-3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Improvement in the diffraction efficiency of a polymer using an ionic liquid was written by Kim, Sung Ho;Attri, Pankaj;Kim, In Tae. And the article was included in Journal of the Serbian Chemical Society in 2018.Synthetic Route of C4H7ClN2 This article mentions the following:

In this paper, photosensitive materials for information storage devices are presented. The polymers were prepared using surface relief-grating (SRG) fabrication with a diode-pumped solid-state (DPSS) laser of 532 nm, and the diffraction efficiency (DE) of the polymers were assessed with a low-power DPSS laser at 633 nm. However, the diffraction efficiency of the azo-functionalized epoxy-based polymer was low, even after 15 min of exposure. To improve the efficiency and reduce the time it takes for the DE measurements of the photosensitive polymer, tbe polymer was combined ionic liquids (1Ls). Various ILs, i.e., 1-methylimidazolium chloride ([Mim]CI) from the imidazolium family of TLs and diethylammonium dihydrogen phosphate (DEAP), triethylammonium 4-aminotoluene-3-sulfonic acid (TASA) and tributylmethylammonium Me sulfate (TBMS) from the ammonium family of ILs, were investigated. For the first time, it was observed that DE dramatically increased the DEAP-polymer mixture in 4 min compared to the polymer (alone) and other polymer-IL mixtures Therefore, DEAP lL could help improve the efficiency of DE measurements in a shorter time. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3Synthetic Route of C4H7ClN2).

1-Methyl-1H-imidazol-3-ium chloride (cas: 35487-17-3) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C4H7ClN2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem