Category: imidazoles-derivatives

Zaouak, Amira published the artcileDegradation mechanism of losartan in aqueous solutions under the effect of gamma radiation, Product Details of C8H13ClN2O, the publication is Radiation Physics and Chemistry (2021), 109435, database is CAplus.

In this paper, the impact of gamma radiation on one of emerging pharmaceutical pollutant was investigated. Deriving from sartan class, losartan, one of the most consumed antihypertensive drug was irradiated at doses of 0.5-4 kGy in aqueous solutions The removal of COD (COD) and total organic carbon (TOC) during the irradiation process reflects that the mineralization efficiency increases with increasing radiation dose. During the mineralization process some aromatic intermediates such as 4-[2-(1H-1,2,3,4-tetrazol-5-yl) phenyl] phenol, 2-butyl-4-chloro-5-(hydroxymethyl) imidazole-1-ol, 2,4prime-dihydroxybiphenyl, tetrazole, 1,2,4 benzentriol, 1,4-hydroxyquinone and quinone were identified by LC/MS. These results show that degradation process starts with cleavage of the starting mol. by hydroxyl radicals, which are generated by the radiolysis of water. Based on these observations, a mechanistic schema of losartan was proposed. At the end, losartan kinetic study was performed indicating a pseudo first order degradation process.

Radiation Physics and Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C14H10O4, Product Details of C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcilePhysicochemical stability and bioavailability of antazoline hydrochloride suppositories, Quality Control of 2508-72-7, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1977), 14(2), 239-49, database is CAplus.

Antazoline-HCl (I) [2508-72-7] suppositories formulated in 1:1 Witepsol H15 [18348884-L]-Witepsol E75 [18348884-L] base remained stable for 1 yr, while compositions in carbowax [25322-68-3] and cocoa butter preparations showed discoloration, crystallization, and other deterioration indications during storage. Bioavailability of I was good from Witepsol and cocoa butter formulations. I was rapidly absorbed from the rectum as indicated by protection of guinea pigs against injected histamine.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kassem, A. A. published the artcileFormulation and stabilization of antazoline hydrochloride nasal drops, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1978), 15(2), 161-76, database is CAplus.

The influence of storage and various stabilizers on the degradation of antazoline-HCl (I) [2508-72-7] nasal drops was investigated. The degradation reaction of I was 1st order with half life of 162.8 days. Addition of stabilizers increased the stability of the drug. A mixture of 20% propylene glycol [57-55-6] with 0.1% w/v Na metabisulfite was relatively better than other stabilizers tested and the half life of the drug is protracted to 1995 days.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wysokowski, Marcin published the artcileIonic liquid-assisted synthesis of chitin-ethylene glycol hydrogels as electrolyte membranes for sustainable electrochemical capacitors, Related Products of imidazoles-derivatives, the publication is Scientific Reports (2022), 12(1), 8861, database is CAplus and MEDLINE.

A novel chitin-ethylene glycol hybrid gel was prepared as a hydrogel electrolyte for elec. double-layer capacitors (EDLCs) using 1-butyl-3-methylimidazolium acetate [Bmim][Ac] as a chitin solvent. Examination of the morphol. and topog. of the chitin-EG membrane showed a homogeneous and smooth surface, while the thickness of the membrane obtained was 27μm. The electrochem. performance of the chitin-EG hydrogel electrolyte was investigated by cyclic voltammetry and galvanostatic charge/discharge measurements. The specific capacitance value of the EDLC with chitin-EG hydrogel electrolyte was found to be 109 F g^-1 in a potential range from 0 to 0.8 V. The tested hydrogel material was electrochem. stable and did not decompose even after 10,000 GCD cycles. Addnl., the EDLC test cell with chitin-EG hydrogel as electrolyte exhibited superior capacitance retention after 10,000 charge/discharge cycles compared with a com. glass fiber membrane.

Scientific Reports published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C6H4ClNO2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Huang, Zhen published the artcileGlobal Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is ACS Chemical Biology (2019), 14(2), 192-197, database is CAplus and MEDLINE.

Clin. investigation of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 resulted in serious adverse neurol. events. Structurally unrelated FAAH inhibitors tested in humans have not presented safety concerns, suggesting that BIA 10-2474 has off-target activities. A recent activity-based protein profiling (ABPP) study revealed that BIA 10-2474 and one of its major metabolites inhibit multiple members of the serine hydrolase class to which FAAH belongs. Here, we extend these studies by performing a proteome-wide anal. of covalent targets of BIA 10-2474 metabolites. Using alkynylated probes for click chem.-ABPP in human cells, we show that des-methylated metabolites of BIA 10-2474 covalently modify the conserved catalytic cysteine in aldehyde dehydrogenases, including ALDH2, which has been implicated in protecting the brain from oxidative stress-related damage. These findings indicate that BIA 10-2474 and its metabolites have the potential to inhibit multiple mechanistically distinct enzyme classes involved in nervous system function.

ACS Chemical Biology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Eom, Young Woo published the artcileCytotoxicity of substituted benzimidazolyl curcumin mimics against multi-drug resistance cancer cell, Quality Control of 7467-35-8, the publication is Bulletin of the Korean Chemical Society (2013), 34(4), 1272-1274, database is CAplus.

Recently, we discovered that introduction of benzimidazole groups to the feruloyl scaffold through aldol condensation greatly improved the cytotoxicity of synthetic curcumin mimics against various cancer cells. Because the benzimidazole mols. exhibit a variety of biol. properties such as anticancer, antiviral, and anti-hypertensive activity, we can expect their novel cytotoxic properties come from benzimidazolyl groups attached to the feruloyl structure. Our goal was to evaluate the cytotoxicity of novel curcumin mimics with structurally diverse benzimidazol moieties against multidrug resistance (MDR) cancer cells. A novel curcumin mimics library has been synthesized with the purpose of discovering novel anticancer drug candidates that inhibit a proliferation both MDR cancer cells and non-MDR cancer cells at the same time. We confirmed that our novel curcumin mimics inhibit the growth of MDR cancer cells more strongly than our previous inhouse curcumin mimic libraries and curcumin; among the tested derivatives, 13b, 14b, and 14h are the strongest candidates inhibiting multidrug resistance cancer cells.

Bulletin of the Korean Chemical Society published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Quality Control of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mizuhara, Tsukasa published the artcileDesign and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182, SDS of cas: 359860-27-8, the publication is Bioorganic & Medicinal Chemistry (2013), 21(7), 2079-2087, database is CAplus and MEDLINE.

To investigate the mechanism of action of the potent antiviral compound PD 404182, three novel photoaffinity probes equipped with a biotin or alkyne indicator were designed and synthesized based on previous structure-activity relationship studies. These probes retained the potent anti-HIV activity of the original pyrimidobenzothiazine derivatives In photoaffinity labeling studies using HIV-1-infected H9 cells (H9IIIB), eight potential proteins were observed to bind PD 404182.

Bioorganic & Medicinal Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Handy, Scott T. published the artcileImidazolium ionic liquids: C2 substitution and acidity, Related Products of imidazoles-derivatives, the publication is Proceedings – Electrochemical Society (2006), 548-555, database is CAplus.

Although imidazolium room temperature ionic liquids (RTILs) have found considerable application, they are not the “inert” solvents that they are frequently considered to be. In particular, the 2 position is prone to deprotonation to form a stabilized carbene. Although this can be beneficial, it can also result in unwanted side reactions under basic conditions. We have studied the acidity of this position in substituted and unsubstituted imidazolium RTILs and discovered that even simple Me substitution does not avoid reasonably facile deprotonation at this site.

Proceedings – Electrochemical Society published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Handy, Scott T. published the artcileThe 2-Position of Imidazolium Ionic Liquids: Substitution and Exchange, Synthetic Route of 45533-87-7, the publication is Journal of Organic Chemistry (2005), 70(5), 1915-1918, database is CAplus and MEDLINE.

The 2-position of imidazolium cations is known to be relatively acidic, leading to the useful Arduengo-type carbenes. At the same time, the acidity of this site can lead to undesired side reactions when using imidazolium-based ionic liquids as solvents. In this note, we describe the surprisingly facile deuterium exchange at this position and also the synthesis and exchange under modestly basic conditions (triethylamine) of a series of 2-methyl-substituted compounds

Journal of Organic Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Synthetic Route of 45533-87-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Dazhi published the artcileMechanism studies of oxidation and hydrolysis of Cu(I)-NHC and Ag-NHC in solution under air, Product Details of C27H39ClN2, the publication is Journal of Organometallic Chemistry (2020), 121025, database is CAplus.

The decomposition of copper(I)-NHC and silver-NHC complexes in solution under air was studied. The Cu(I)-NHCs were oxidized into urea derivatives and hydrolyzed into imidazoliums or benzimidazoliums. The decomposition of Ag-NHC with a saturated backbone led to ring-opening product, while the Ag-NHC with an unsaturated backbone led to imidazolium and Ag-bisNHC complex. The effects of steric property, hydrophilicity, and binding energy of NHC to O₂ and H₂O on the decomposition of Cu(I)-NHC were studied using theor. calculations Steric hindrance played an important role on the stability of Cu(I)-NHC. Pathways for the decomposition of Cu(I)-NHC and Ag-NHC were proposed.

Journal of Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Product Details of C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem