Category: imidazoles-derivatives

Li, Dazhi published the artcileSynthesis of Imidazolidinone, Imidazolone, and Benzimidazolone Derivatives through Oxidation Using Copper and Air, Quality Control of 258278-25-0, the publication is Organic Letters (2019), 21(10), 3572-3575, database is CAplus and MEDLINE.

A new synthetic method of urea derivatives using copper and air was developed. These mild conditions provided moderate to very good yields for 15 examples (53-93%), while low yields were obtained with sterically hindered substrates (3 examples). The reaction was found to go through an in situ generated copper-N-heterocyclic carbene, which was then oxidized into cyclic urea derivatives possessing alkyl, benzyl, aryl, hydroxy, Boc-protected, and tertiary amine groups.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Baca, Kalin R. published the artcilePhase Equilibria and Diffusivities of HFC-32 and HFC-125 in Ionic Liquids for the Separation of R-410A, Synthetic Route of 79917-90-1, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(2), 816-830, database is CAplus.

Current legislation calling for the phase out of hydrofluorocarbon (HFC) refrigerants is driving a global market shift that has prompted industry and research institutions to investigate new refrigerant mixtures and sustainable separation techniques for recycling refrigerants. The recent American Innovation and Manufacturing (AIM) Act of 2020 requires an 85% phase down of HFC production over the next 15 years. To achieve this goal, azeotropic refrigerant mixtures, such as R-410A composed of 50 wt % HFC-32 (difluoromethane, CH₂F₂) and 50 wt % HFC-125 (pentafluoroethane, CHF₂CF₃), will have to be separated to recycle the lower global warming HFC-32 component. The present work investigates the solubility of HFC-32 and HFC-125 in six ionic liquids (ILs) with halogen anions for the purpose of developing the thermophys. property data required for designing extractive distillation recycling processes and understanding the choice of cation and anion type. A gravimetric microbalance was used to collect isothermal vapor-liquid equilibrium data for each of the ILs at 298.15 K and pressures from 0.05 to 1.0 MPa. The Peng-Robinson equation of state was used to model the solubility of the HFCs in the ILs. The solubility of HFC-32 in the ILs showed small differences, while the solubility of HFC-125 had significant variations with respect to the anion type and the cation alkyl chain length. Fick’s law was applied to calculate diffusion coefficients for each HFC/IL system. HFC-32 has a greater diffusivity than HFC-125 based on the smaller mol. size. The 1-n-hexyl-3-methylimidazolium chloride and the trihexyl(tetradecyl)phosphonium chloride ILs have the highest HFC-125/HFC-32 selectivity at 298.15 K. Based on both the mass uptake and selectivity ratio, these two ILs are potential entrainers for the separation of R-410A using extractive distillation

ACS Sustainable Chemistry & Engineering published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Issa, I. M. published the artcilePolarographic estimation of antazoline hydrochloride, Computed Properties of 2508-72-7, the publication is Pharmazie (1978), 33(8), 513-15, database is CAplus and MEDLINE.

Antazoline-HCl (I-HCl) [2508-72-7] was estimated polarog. at a dropping Hg electrode in KCl-HCl supporting electrolyte (pH 3.2). Two waves were produced with E_1/2 values of -1.35 V and -1.65 V. As revealed from the study of the effect of Hg column height, pH of the medium, and concentration of the depolarizer, the polarog. reduction of the antazolinium cation was preceded by a catalytic H-wave. The diffusion-controlled nature of the electrode process allowed I determination at â‰?.0 × 10^-4 M. The procedure is simple, accurate, and sensitive and could be used in the presence of tablet additives.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Computed Properties of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hirohata, R. published the artcileSynthesis of ophidine, Name: (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Proceedings of the International Congress of Biochemistry (1955), 20, database is CAplus.

Ophidine is an anserine-like compound from cobra muscle. Kendo (C.A. 45, 3438c) reported that it is β-alanyl-2-methylhistidine. To confirm this structure, 2-methyl-4(5)-hydroxymethylimidazole (I), m. 114°, was synthesized from NH₄OH, fructose, and AcH. I was converted to the chloromethyl compound (II), m. 125°. AcNHCH(CO₂Et)₂ was condensed with II, yielding Et α-acetamido-α-carbethoxy-2-methyl-4(5)-imidazolepropionate (III), m. 122°. III was hydrolyzed and decarboxylated to 2-methylhistidine (IV), m. 231°, which was acetylated and resolved by means of acylase 1. The resulting L-IV with phthaloyl-β-alanyl chloride in the presence of NEt₃ at -10° yielded phthaloyl-β-alanyl-2-methylhistidine (V), m. 240°. By treating V with N₂H₄.H₂O solution 2 days, the phthaloyl group was detached, and β-alanyl-2-methylhistidine, m. 249°, was obtained. It gave no depression in m.p. when mixed with natural ophidine. Few exptl. details are given.

Proceedings of the International Congress of Biochemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Name: (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chakrabarty, Manas published the artcileA Keggin heteropoly acid as an efficient catalyst for an expeditious, one-pot synthesis of 1-methyl-2-(hetero)arylbenzimidazoles, Application In Synthesis of 2622-67-5, the publication is Tetrahedron Letters (2007), 48(30), 5239-5242, database is CAplus.

The Keggin heteropoly acid, silicotungstic acid, H₄SiW₁₂O₄₀, was demonstrated to be highly efficient for an expeditious, one-pot synthesis of arylbenzimidazoles, e.g., I, from N-methyl-1,2-benzenediamine and arylaldehydes in Et acetate at room temperature The catalyst worked equally well for N-phenyl-1,2-benzenediamine.

Tetrahedron Letters published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bachhav, Rishikesh S. published the artcileAssay Test procedure as a CPP at Bulk-Solution stage – Esomeprazole Sodium Injection 40MG, Category: imidazoles-derivatives, the publication is World Journal of Pharmaceutical Research (2020), 9(5), 1565-1580, database is CAplus.

A review. To develop & validate the anal. Assay Test procedure as a Critical Processing Parameters at the Bulk-Solution stage during manufacturing of Esomeprazole Sodium Injection 40mg. As per current available literature and the references, Esomeprazole active substance is available in market in five forms, i.e. Esomeprazole as Plan active [Tablet]; Esomeprazole Magnesium Trihydrate [Tablet, Capsule Delayed Release]; Esomeprazole Potassium [Tablet & Capsule]; Esomeprazole Strontium [Capsule Delayed Release] and Esomeprazole Sodium [Injectable]. Assay test for Active & other dosage forms [Tablet, Capsule] were available. Available Test procedure are based on either Potentiometory Titration or HPLC basis. Esomeprazole Sodium Injection 40mg Dosage form is not in any pharmacopeia. As per available reference & literature assay test method for intermediate testing & finished product is based on HPLC. Intermediate testing [In-Process Testing] require as Critical Process Parameters [CPP] to ensure the quality i.e. appropriate bulk-solution purity, before to proceed for filling of Bulk-solution in unit dosage form [Vials]. To test the bulk solution purity approx. 5-6 h required. Which leads to hold the Bulk solution, further it impact & may risk bio-burdon of bulk solution Also it impact & reduce the productivity of line by 5-6 h. HPLC testing required special skilled manpower & cost. Considering all above concerns of current available test methods; this article project is selected to develop & validate the anal. Assay Test procedure as a Critical Processing Parameters at the Bulk-Solution stage during manufacturing of Esomeprazole Sodium Injection 40mg.

World Journal of Pharmaceutical Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kitamura, Mitsuru published the artcileDirect Azidation of Phenols, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is European Journal of Organic Chemistry (2019), 2019(33), 5824-5827, database is CAplus.

Direct azidation of phenols was developed. By treating chloroimidazolinium chloride I and sodium azide with phenol in the presence of a secondary amine in methoxyethanol, ortho-azidation of phenol was achieved.

European Journal of Organic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sieron, Leslaw published the artcileTrityl losartan, Synthetic Route of 79047-41-9, the publication is Acta Crystallographica, Section C: Crystal Structure Communications (2004), C60(11), o821-o823, database is CAplus and MEDLINE.

The title compound (systematic name: {2-butyl-4-chloro-1-[2′-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazol-5-yl}methanol), C₄₁H₃₇ClN₆O, crystallizes in the centrosym. space group P1̅ with two independent mols. in the asym. unit. Crystallog. data are given. These mols. differ significantly only in the relative orientations of the rings in the biphenylyltetrazole moieties. One of the mols. shows disorder for three C atoms in the Bu group. H bonds link the mols. in an infinite chain along the a axis.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C14H26O2, Synthetic Route of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gaber, Abd El-Aal M. published the artcileThermal fragmentation and rearrangement of 3-phenyl-4-aryl-5-phenylimino-1,2,4-oxadiazoline derivatives, Category: imidazoles-derivatives, the publication is Afinidad (2009), 66(541), 252-257, database is CAplus.

Thermal fragmentation of 3-phenyl-4-aryl-5-phenylimino-1,2,4-oxadiazolines I and II (Ar = Ph, p-tolyl) in a sealed tube under nitrogen gives rise to benzonitrile, arylamines, anilides, phenols, arylureas, and benzimidazole derivatives In the presence of naphthalene as solvent, I gave a- and P-naphthols beside the previous products. Also, heating of I under reflux in boiling anhydrous tetraline leads to the formation of 1-hydroxytetraline, α-tetralone and 1,1′-bi-tetralyl as the major products. The isolated products have been interpreted in terms of a free radical mechanism involving the homolysis of N-O and/or C-N bond.

Afinidad published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Islam, Mohammad Shahidul published the artcileMizoroki-Heck Cross-Coupling of Acrylate Derivatives with Aryl Halides Catalyzed by Palladate Pre-Catalysts, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is European Journal of Inorganic Chemistry (2019), 2019(43), 4695-4699, database is CAplus.

The Mizoroki-Heck (MH) reaction involving aryl halides with various acrylates and acrylamide was studied using air and moisture-stable imidazolium-based palladate pre-catalysts for the synthesis of internal alkenes RHC=CH(R¹)(C(O)R²) [R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, Me, 4-MeOC₆H₄CH₂, etc.; R² = OMe, On-Bu, NH₂, etc.]. These pre-catalysts were converted into Pd-NHC species (NHC = N-heterocyclic carbene) under catalytic conditions and were capable of facilitating the Mizoroki-Heck reaction of aryl halides with various acrylates. The effects of solvent, catalyst loading, temperature and bases on the reaction outcome were investigated. Various coupling partners were tolerated under the optimal reaction conditions catalyzed by palladate [SIPr·H][Pd(η³-2-Me-allyl)Cl₂]. The efficiency of the optimized synthetic methodol. was tested on various aryl halides and substituted acrylates as well as acrylamides. The MH reaction yielded the coupled products in good to excellent isolated yields (up to 98%).

European Journal of Inorganic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem