Category: imidazoles-derivatives

Xue, Yang published the artcileNovel hypoglycemic compound-synthesis of glycine derivatives and research on the role of PPARs, SDS of cas: 4760-35-4, the publication is Jiefangjun Yaoxue Xuebao (2009), 25(1), 5-10, database is CAplus.

The aim of this paper is to synthesize five novel hypoglycemic glycine-type drugs and research the role of PPARs. The synthesis started with the reaction between 4-hydroxybenzaldehyde and 3-[4-phenoxyphenoxy] propanol, 2-(4-phenoxyphenoxy) ethanol, benzimidazole derivatives The resulting compounds were condensed with proper aldehyde to give Schiff bases. The imine derivatives reacted with 4-methoxyphenyl carbonochloridate, followed by hydrolysis, to give the desired glycine analogs. The target’s role in the activation of PPARs was determined The results showed that the 5 novel compounds were synthesized and characterized by ¹HNMR. Targets show varying degrees of activation of PPARs. The bioassay indicated that five target compounds 6a, 6b, 6c, 6’a, 6’b were capable of activating PPARs. Among them, 6a, 6b, 6c are more effective. They can be good candidates for the therapy of insulin resistance and high blood sugar.

Jiefangjun Yaoxue Xuebao published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H7ClN2S, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chen, Hong published the artcileNew efficient copper(II)-catalyzed direct access to primary amide from aldehyde under solvothermal condition and related crystal structure study, Computed Properties of 7467-35-8, the publication is Chinese Journal of Structural Chemistry (2016), 35(5), 796-804, database is CAplus.

Two 1-methyl-1H-benzo[d]imidazole derivatives, C₁₈H₁₄CuN₄O₄·C₄H₈O₂ (1) and C₉H₉N₃O (2), were synthesized and characterized by NMR, MS, FT-IR, elementary anal. and x-ray single-crystal diffraction. Compound 1 crystallizes in monoclinic, space group P2₁/n with a = 9.6888(3), b = 7.3772(2), c = 14.3277(4) Å, β = 95.819(3)°, V = 1018.81(5) ų, M_r = 501.98, Z = 2, D_c = 1.636 g/cm³, F(000) = 518, μ = 1.123 mm^-1, MoKα radiation (λ = 0.71073 Å), the final R = 0.0325 and wR = 0.0859 for 1821 observed reflections with I > 2σ(I). Compound 2 crystallizes in monoclinic, space group C2/c with a = 14.2908(14), b = 14.4268(13), c = 8.4802(6) Å, β = 108.513(9)°, V = 1657.9(3) ų, M_r = 175.19, Z = 8, D_c = 1.404 g/cm³, F(000) = 736, μ = 0.097 mm^-1, MoKα radiation (λ = 0.71073 Å), the final R = 0.0563 and wR = 0.1531 for 1231 observed reflections with I > 2σ(I). Intermol. (N-H···N, N-H···O) and intramol. (N-H···N, C-H···O) hydrogen bonds, as well as C-H···π and π-π stacking interactions, help to stabilize the crystal structure of compound 2.

Chinese Journal of Structural Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Computed Properties of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jianming published the artcileEnvironmental Friendly Azide-Alkyne Cycloaddition Reaction of Azides, Alkynes, and Organic Halides or Epoxides in Water: Efficient “Click” Synthesis of 1,2,3-Triazole Derivatives by Cu Catalyst, SDS of cas: 4760-35-4, the publication is Chinese Journal of Chemistry (2012), 30(3), 644-650, database is CAplus.

An efficient click synthesis of 1,2,3-triazole derivatives from benzyl halides or alkyl halides, epoxides, terminal alkynes, and sodium azides in the presence of copper salts and relative benzimidazole salts have been developed. This procedure eliminates the need to handle potentially organic azides, which are generated in situ. A broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Chinese Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jianming published the artcileConstruction of the flavones and aurones through regioselective carbonylative annulation of 2-bromophenols and terminal alkynes, Synthetic Route of 4760-35-4, the publication is Tetrahedron Letters (2013), 54(14), 1802-1807, database is CAplus.

The easily available and efficient catalyst containing a benzimidazolium ligand and PdCl₂(PPh₃)₂ demonstrated excellent catalytic activity to construct the flavones and aurones, resp. This reaction can be operated under mild conditions, affording the desired products in moderate to good yields. This protocol was used to prepare the flavones and aurones by a slight modification of amines.

Tetrahedron Letters published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Synthetic Route of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Bong Soo published the artcileSurface-Initiated, Atom Transfer Radical Polymerization of Oligo(ethylene glycol) Methyl Ether Methacrylate and Subsequent Click Chemistry for Bioconjugation, Quality Control of 359860-27-8, the publication is Biomacromolecules (2007), 8(2), 744-749, database is CAplus and MEDLINE.

Click chem. was applied to polymeric nanobrushes presenting azide groups at the terminal. Specifically, the non-biofouling oligoethylene glycol Me ether methacrylate film was functionalized to achieve maximized biospecific interactions between surface-attached ligands and target mols. with PEG as an inert background.

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Zee-Won published the artcileSingle cell array of biotinylated cells using surface functionalization and microcontact printing, Category: imidazoles-derivatives, the publication is Chemistry Letters (2005), 34(5), 648-649, database is CAplus.

This paper describes a versatile method for generating single cell arrays on a glass substrate, which could be applicable to any arbitrary cell types, by a combination of surface functionalization, biotinylation of cells, and microcontact printing (μCP).

Chemistry Letters published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Park, Sangjin published the artcileDual Functional, Polymeric Self-Assembled Monolayers as a Facile Platform for Construction of Patterns of Biomolecules, Formula: C18H34N4O5S, the publication is Langmuir (2007), 23(22), 10902-10905, database is CAplus and MEDLINE.

The authors report a facile approach to the construction of patterns of biomols. based on polymeric self-assembled monolayers (pSAMs) that possess dual functions: “bio-reactive (post-functionalizable)” and “bio-inert (anti-biofouling)” properties. To prepare pSAMs on Si/SiO₂ wafers were new random copolymers synthesized by radical polymerization of poly(ethylene glycol) Me ether methacrylate (PEGMA), 3-(trimethoxysilyl)propyl methacrylate (TMSMA), and N-acryloxysuccinimide (NAS), and referred to as poly(TMSMA-r-PEGMA-r-NAS). Poly(TMSMA-r-PEGMA-r-NAS) was designed to play triple roles: “surface-reactive”, “bio-reactive”, and “bio-inert” ones. The pSAMs of poly(TMSMA-r-PEGMA-r-NAS) were formed on Si/SiO₂ wafers with 1 h incubation of the substrates in the polymer solution, which showed approx. a 1 nm-thick film as measured by ellipsometry. After the formation of the pSAMs, the feasibility of the pSAMs as a dual functional surface (bio-inert and bio-reactive properties) was examined The ability of the pSAMs to block nonspecific adsorption of proteins was evaluated against bovine serum albumin as a model protein. High-resolution N(1s) XPS anal. on the protein adsorption revealed that significant reduction up to âˆ?7% was observed compared to the unmodified Si/SiO₂ wafer. In addition, micropatterns of streptavidin with high signal-to-noise ratios were achieved using microcontact printing (μCP) of NH₂-bearing biotin onto the pSAMs of poly(TMSMA-r-PEGMA-r-NAS) on glass slides, which suggests that other biomols. could also be efficiently immobilized onto the pSAMs with high specificity while minimizing nonspecific adsorption. The surface d. of both bio-reactive and anti-biofouling functionality could be tailored by simply changing initial feed ratios of each monomer in the polymer synthesis:different molar ratios of the bio-reactive group (NAS: 33%, 20%, and 10%, resp.) were employed. When micropatterns of streptavidin were constructed, the pSAMs with 33% NAS moiety showed the highest immobilization of the protein. Taken together, the present dual functional, random copolymers may have warrant applications in the field of biosensors and biochips.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Im, Jaewan published the artcileStructural characteristics and thermal properties of regenerated cellulose, hemicellulose and lignin after being dissolved in ionic liquids, SDS of cas: 79917-90-1, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2022), 365-375, database is CAplus.

This study investigated the use of ionic liquids such as 1-butyl-3-methylimidazolium chloride, 4-butyl-4-Me morpholinium chloride, 1-butyl-1-methylpiperidinium chloride, and 1,3-dimethylimidazolium methylphosphite to dissolve cellulose, hemicellulose, and lignin biomass, as alternatives to highly toxic organic solvents. The biomass treated with the ionic liquids is characterized by SEM, X-ray diffraction, thermogravimetric anal., and Fourier-transform IR spectroscopy. The X-ray diffraction results revealed that most of the biomass treated with ionic liquids had low crystallinity after treatment with the ionic liquids Thermogravimetric anal. confirmed that the pyrolysis temperature of the biomass treated with the ionic liquid decreased. However, it was found that the pyrolysis temperature of the biomass was increased again after the ionic liquid was washed with an antisolvent. This result was interpreted using Fourier-transform IR spectroscopy to show that the O-H hydrogen bonding of cellulose was restored. The exptl. results from this study can help provide a better understanding of the biomass regeneration mechanism of ionic liquids and increase the applicability of biomass in various fields.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sarker, Aniruddha published the artcileResidue Monitoring and Risk Assessment of Cyazofamid and Its Metabolite in Korean Cabbage Under Greenhouse Conditions, Product Details of C11H8ClN3, the publication is Bulletin of Environmental Contamination and Toxicology (2020), 105(4), 595-601, database is CAplus and MEDLINE.

The residual characteristics and risk assessment with respect to cyazofamid and its metabolite 4-chloro-5-p-tolylimidazole-2-carbonitrile were monitored in case of Korean cabbage at different preharvest intervals during a greenhouse trial. The 0.02 kg a.i/ha of cyazofamid was sprayed twice on seven-day intervals (i.e., on day 0, 7, 14, and 21 before harvest). The liquid chromatog.-tandem mass spectrometry anal. was used to monitor the residual amount of fungicide. The matrix-matched calibration curves with respect to the cyazofamid in Korean cabbage exhibited good linearity (R2 �0.999) and acceptable recoveries of 84.1%-114.9%. The biol. half-life of cyazofamid in Korean cabbage was 3.18 days. During the treatment, the preharvest residue of cyazofamid in Korean cabbage 14 days before harvest (0.80 mg/kg) was lower than that specified by the MFDS-MRL (Ministry of Food and Drug Safety-Maximum Residue Limit, 2.0 mg/kg) and should be recommended as the safe preharvest-interval application limit. The hazard quotient showed low toxicity (70.58%) during the risk assessment study of cyazofamid.

Bulletin of Environmental Contamination and Toxicology published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Sang Hyun published the artcileThe Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids, Formula: C16H23F6N3O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2005), 3469-3471, database is CAplus and MEDLINE.

The Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids were determined by the intrinsic viscosity method and their dependencies on the length of the alkyl group analyzed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C16H23F6N3O2, Formula: C16H23F6N3O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem