Category: imidazoles-derivatives

Jiao, Yan published the artcileA facile color-tuning strategy for constructing a library of Ir(III) complexes with fine-tuned phosphorescence from bluish green to red using a synergetic substituent effect of -OCH₃ and -CN at only the C-ring of CN̂ ligand, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2016), 4(19), 4269-4277, database is CAplus.

By simply grafting a -CN group and/or a -OCH₃ group onto the meta- and/or para-site of the C-ring, a series of Ir(III) complexes bearing a similar mol. platform of bis(1,2-diphenyl-1H-benzimidazolato-N,C^2′)iridium(III)(acetylacetonate), but showing fine-tuned phosphorescence covering nearly the whole window of the visible spectrum with a wide color-tuning range of 109 nm was acquired. With the help of DFT calculations, it was revealed that if the C-related arene moiety of the CN̂ ligand (C-ring) contributes substantially to both the HOMO and LUMO of an Ir(III) complex, the concurrent introduction of an electron-donating -OCH₃ and an electron-withdrawing -CN groups on the C-ring at the meta- and para-sites relative to the Ir atom may lead to a favorable synergetic substituent effect on the color-tuning direction. This may represent a facile yet effective mol. design strategy for Ir(III) complexes with a desirous emission color. A bluish green organic light-emitting diode (OLED) based on one of the objective complexes displayed a maximum current efficiency of 62.1 cd A^-1, an external quantum efficiency of 19.8%, and a brightness of 48 040 cd m^-2, implying that high-performance red and blue OLED phosphors as well as libraries of Ir(III) complexes bearing similar mol. platforms may be developed through this -OCH₃ and -CN synergetic substitution strategy.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yu, Yong published the artcileSynthesis of sodium esomeprazole, SDS of cas: 161796-78-7, the publication is Huaxue Yanjiu Yu Yingyong (2014), 26(4), 591-595, database is CAplus.

Esomeprazole sodium was synthesized through asym. oxidation reaction, and the synthesis process route was optimized. The ufiprazole was prepared firstly, which was then oxidized to form esomeprazole. Finally, the esomeprazole sodium was prepared by reaction of esomeprazole with sodium hydroxide. The overall yield was 57.2%. The structures of target compounds were characterized by IR, ¹H NMR and MS.

Huaxue Yanjiu Yu Yingyong published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C19H21N3O3S, SDS of cas: 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yao, Wei-Wei published the artcileNi-catalyzed hydroaminoalkylation of alkynes with amines, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Nature Communications (2021), 12(1), 3800, database is CAplus and MEDLINE.

Here, a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes RCCR¹ (R = Me, n-Bu, Ph, 4-methoxyphenyl, etc.; R¹ = Me, i-Pr, TMS, 4-ethylphenyl, etc.) with N-sulfonyl amines R²CH₂NHR³ (R² = pentyl, cyclohexyl, Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R³ = Ms, Ts, [2,4,6-tris(propan-2-yl)phenyl]sulfonyl, etc.), providing a series of allylic amines R²CH(NHR³)C(=CHR¹)(R) in up to 94% yield was reported. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy₃) effectively promote the reaction.

Nature Communications published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C5H11NO2S, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Shizhuo published the artcileExperimental and theoretical study on the catalytic degradation of lignin by temperature-responsive deep eutectic solvents, COA of Formula: C8H15ClN2, the publication is Industrial Crops and Products (2022), 114430, database is CAplus.

Lignin is a renewable biomass resource with excellent application potential; however, the extremely complex structure of lignin renders it difficult to effectively degrade and use. In this context, it is necessary to identify a catalyst that can be easily recovered to increase the lignin degradation rate. In this paper, two temperature-responsive deep eutectic solvents (TRDESs), which can form homogeneous phases with reactants at a high temperature and sep. from the reaction system at low temperature, were designed to catalyze lignin degradation Based on the |HOMO-LUMO| gap, [Bmim]Cl and ChCl, which have a high catalytic activity, were selected from 22 deep eutectic solvents (DESs). [Bmim]Cl-EDTA (mole ratio = 1:1) was obtained by combining [Bmim]Cl and EDTA. ChCl-SA (mole ratio = 1:1) was obtained by combining ChCl and salicylic acid (SA). Results of COSMO-SAC modeling calculations and solubility experiments indicated that TRDESs can respond to temperature Specifically, these solvents can form a homogeneous phase with the reactants at high temperatures, thereby increasing the number and uniformity of the reaction sites. Moreover, the solvents can be separated from the reaction system at low temperature, which enables efficient recycling of the catalyst. Results of lignin degradation experiments indicated that the catalytic performance of [Bmim]Cl-EDTA is higher than that of the other DESs: the degradation rate of lignin is 83.63%, and the catalyst exhibits a satisfactory catalytic effect even after multiple cycles.

Industrial Crops and Products published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C7H6Cl2, COA of Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chopra, Radhika published the artcileDevelopment of a supramolecular ensemble of an AIEE active hexaphenylbenzene derivative and Ag@Cu₂O core-shell NPs: an efficient photocatalytic system for C-H activation, Formula: C19H14N2, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(66), 10179-10182, database is CAplus and MEDLINE.

A supramol. ensemble having Ag@Cu₂O core-shell nanoparticles stabilized by aggregates of a hexaphenylbenzene derivative has been developed which exhibits excellent photocatalytic efficiency in reactions involving preparation of imidazole and benzimidazole derivatives via C-H activation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verma, Raman K. published the artcileHeterocyclyl linked anilines and benzaldehydes as precursors for biologically significant new chemical entities, Computed Properties of 4760-35-4, the publication is Journal of Chemical Sciences (Bangalore, India) (2012), 124(5), 1063-1069, database is CAplus.

Syntheses of benzaldehydes and anilines, linked at the para position with an alkoxy ether linkage to 3 crucial heterocycles, namely benzimidazole, indole, and acridone, were reported. Representative procedures for the preparation of 1,3-diester, 2,4-thiazolidinedione, and α-bromopropanoic acid ester derivatives in case of benzimidazole, and a 1,3-diester and 2,4-thiazolidinedione derivative in case of indole-based precursors were optimized, and the said compounds were successfully synthesized.

Journal of Chemical Sciences (Bangalore, India) published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C25H47NO8, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verma, Raman K. published the artcileHeterocyclyl linked anilines and benzaldehydes as precursors for biologically significant new chemical entities, Related Products of imidazoles-derivatives, the publication is Journal of Chemical Sciences (Bangalore, India) (2012), 124(5), 1063-1069, database is CAplus.

Syntheses of benzaldehydes and anilines, linked at the para position with an alkoxy ether linkage to 3 crucial heterocycles, namely benzimidazole, indole, and acridone, were reported. Representative procedures for the preparation of 1,3-diester, 2,4-thiazolidinedione, and α-bromopropanoic acid ester derivatives in case of benzimidazole, and a 1,3-diester and 2,4-thiazolidinedione derivative in case of indole-based precursors were optimized, and the said compounds were successfully synthesized.

Journal of Chemical Sciences (Bangalore, India) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H4F6O, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jiang, Li-Ping published the artcileThe dominance of sulfate over two organic ligands in the solvothermal assembly of an undecanuclear cobaltous cluster: crystallography and mass spectrometry, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Dalton Transactions (2020), 49(48), 17683-17688, database is CAplus and MEDLINE.

An unexpected dominance of the coordination affinity of the sulfate anion over those of two organic chelating ligands, (1-methyl-1H-benzo[d]imidazol-2-yl)methanol (Hmbm) and pyridin-2-ylmethanamine (pma), was observed during the study of the solvothermal assembly of [Co₁₁(mbm)₆(pma)₂(SO₄)₈(H₂O)₆(CH₃OH)₆]·5CH₃OH (1), from CoSO₄·7H₂O at 100°C in methanol. ESI-MS of solutions at different periods of the assembly reveal a hierarchical sequence, [Co₁] → [Co₂] → [Co₃] → [Co₄] → [Co₅] → [Co₉], where the lower nuclearity species are richer in Co²⁺ and SO₄^2- before the inclusion of more mbm ligands at the last step. Its crystal structure consists of an almost sym. wheel of nine cobalt atoms, [Co₉(mbm)₆(SO₄)₈(H₂O)₆] in edge-sharing octahedral coordination arranged in triangles with two peripheral dangling [Co(pma)(CH₃OH)₃]. The sulfate ions exhibit three different coordination modes, two in μ₆-, two in μ₃– and four as μ₂-bridging. Its thermal, optical and magnetic properties are also reported.

Dalton Transactions published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Oh, Sangmi published the artcileIdentification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities, Quality Control of 13682-33-2, the publication is ACS Medicinal Chemistry Letters (2021), 12(4), 563-571, database is CAplus and MEDLINE.

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.

ACS Medicinal Chemistry Letters published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, Quality Control of 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Wei-Jie published the artcileHofmann-MOF derived nanoball assembled by FeNi alloy confined in carbon nanotubes as a magnetic catalyst for activating peroxydisulfate to degrade an ionic liquid, Computed Properties of 79917-90-1, the publication is Separation and Purification Technology (2022), 120945, database is CAplus.

As ionic liquids (ILs) are increasingly consumed, release of ILs into water environment has posed risks to aquatic ecol. due to their toxicities. Since 1-Butyl-3-methylimidazolium chloride (BMIMCl) represents the most typical IL, development of useful techniques to eliminate BMIM from water is urgent and critical While SO^•-₄-based oxidation processes are useful for degrading BMIM, very few studies have been conducted using peroxydisulfate (PDS), and almost no studies exist for developing heterogeneous activation of PDS to degrade BMIM. Thus, the aim of this study is to develop a useful heterogeneous catalyst for the first time to activate PDS for degrading BMIM in water. Herein, a special catalyst is developed from a unique Hofmann-type MOF ([Fe]pyrazine[Ni(CN)₄]) through carbonization to afford a nanoball assembled from carbon nanotubes (CNTs) with confinement of FeNi alloy nanoparticles. Such a FeNi@CNT (i.e., FeNiC) nanoball exhibits many advantageous features, including embedment of effective metals (Fe and Ni), strong magnetism, protection of FeNi by CNT, synergy of FeNi and CNT, and unique interwoven assembled structures, making FeNiC a promising heterogeneous catalyst for activating PDS to degrade BMIM. FeNiC is proven to exhibit a much higher catalytic activity (RSE = 0.0388) than Fe₃O₄ for PDS activation (RSE = 0.0155). FeNiC/PDS also shows a lower activation energy (i.e., 40.4 kJ/mol) for BMIM degradation then other reported values, revealing promising advantages of FeNiC. The activation mechanism as well as degradation pathway of BMIM degradation by FeNiC/PDS is also investigated here through theor. DFT calculations and exptl. evidences to provide valuable insights into degradation behaviors of BMIM using Hofmann MOF-derived catalysts.

Separation and Purification Technology published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem