Category: imidazoles-derivatives

Stawowczyk, Adolf published the artcileTriethanolamine stearate compatibility with some drugs in emulsion ointments, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Farmacja Polska (1975), 31(2), 105-9, database is CAplus.

Benzalkanium bromide and Vioform [130-26-7] were the only 2 of the 12 drugs tested which were stable for the whole duration of the exptl. period in the presence of triethanolamine stearate [4568-28-9] in solutions and emulsion ointments. Sulfathiazole [72-14-0] was stable for 30 days in solutions, but became discolored within 20 days in ointment. Ointments of ethacridine lactate [1837-57-6] were stable for at least 6 months, and those of diphenhydramine-HCl [147-24-0], chloropyribenzamine-HCl [6170-42-9], and tripellennamine-HCl [154-69-8] for 30 days.

Farmacja Polska published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C3H3Br2ClO, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tewari, S. N. published the artcileDetection and determination of psychotropic drugs by thin layer chromatography and its application in toxicological analysis, Related Products of imidazoles-derivatives, the publication is Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriumsdiagnostik (1977), 116(11), 1123-9, database is CAplus.

The detection, identification, and determination of 22 tranquilizers in tissues by thin-layer chromatog. using 18 solvent systems and 6 chromogenic reagents is described. The tissues were homogenized, incubated at 100° in concentrated HCl and ether extracted through an acid-base cycle. Tissue distributions of promazine [58-40-2], chlorpromazine [50-53-3], thioridazine [50-52-2], and imipramine [50-49-7] in cases of human poisoning were determined using 2 solvent systems and chromogenic reagents.

Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriumsdiagnostik published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C12H23N3S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tulus, Semiha published the artcileSpectrophotometric determination of antazoline and its salts by using 1,1-diphenyl-2-picrylhydrazyl, Synthetic Route of 2508-72-7, the publication is Journal of Faculty of Pharmacy of Istanbul University (1975), 11(1), 38-43, database is CAplus.

A visible spectrophotometric determination of antazoline (I) [91-75-8] or its’ salts (I-HCl [2508-72-7], I-methanesulfonte [3131-32-6]) was given based on the diminishing violet color intensity of 1,1-diphenyl-2-picrylhydrazyl [1898-66-4] which reacted with some substances by hydrogen abstraction. The method was sensitive to 20-50 mcg doses.

Journal of Faculty of Pharmacy of Istanbul University published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C6H13NO2, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wiedmann, Jerome L. published the artcileTurfgrass dissipation of cyazofamid, Product Details of C11H8ClN3, the publication is ACS Symposium Series (2009), 97-109, database is CAplus.

Traditionally, the fate of pesticides applied to turf has been measured by a 120-day dissipation study to satisfy the United States Environmental Protection Agency (USEPA) data requirements. The focus of these studies has been to measure the rate of degradation of the active ingredient and its degradates as well as to assess the potential for leaching of each of these compounds into the soil. Historically, all grass clippings were left on the plot to recycle the residues. Recently, concern has also been raised about the loss of residues from the treated area via removal of the grass clippings during the mowing process. The fate of cyazofamid, a cyanoimidazole fungicide, used for Pythium control in turf was investigated with and without removal of clippings at sites in North Carolina and Virginia. Comparison of loss of cyazofamid by clipping removal to other mechanisms of dissipation indicates that for a pesticide such as cyazofamid, which has very short foliar and soil half-lives and which does not leach, the loss due to removal in the clippings is minimal (0.7-2.2%). Even with application rates of 1 lb a.i./A, dissipation of cyazofamid from turf was rapid (half-lives of 18 to 19 days). There was very little movement of either cyazofamid or its degradates into the soil. By 120 days after the last of three applications, 94-98.8% of the applied cyazofamid had degraded (primarily in the form of bound residues).

ACS Symposium Series published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C10H12F6N4O6PdS2, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Jin published the artcilePreparation and catalytic properties of the triphenylarsine and triphenylstibine-stabilized tri-heteroleptic NHC-Pd-allyl complexes, SDS of cas: 258278-25-0, the publication is Journal of Organometallic Chemistry (2019), 35-40, database is CAplus.

A series of triphenylarsine and triphenylstibine-stabilized tri-heteroleptic NHC-Pd-allyl complexes were synthesized and characterized. The solid-state structures of the complexes shown mononuclear carbene palladium complexes, in which, each palladium center was coordinated by an N-heterocyclic carbene, the η³-coordinated allyl moiety and an As or Sb donor. Further investigation of the Pd complexes as catalysts in Sonogashira coupling reaction was carried out and the obtained complexes exhibited good reactivities for aryl bromides.

Journal of Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C15H20O6, SDS of cas: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Jin published the artcile(N-heterocyclic carbene)PdCl(N-heterocyclic carboxylate) complexes: Synthesis and catalytic activities towards arylation of benzoxazoles with aryl halides, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Applied Organometallic Chemistry (2018), 32(7), n/a, database is CAplus.

A series of N-heterocyclic carboxylate-stabilized N-heterocyclic carbene palladium complexes has been synthesized and fully characterized. The solid-state structures indicate that each of the palladium centers is coordinated by an N-heterocyclic carbene, a chloride and a bidentate N,O-donor N-heterocyclic carboxylate ligand. The catalytic performance of the complexes was screened and the results revealed that the complexes exhibit moderate to high catalytic activities for the direct C-H bond arylation of benzoxazoles with aryl bromides.

Applied Organometallic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C15H12O8, Name: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Knight, Zachary A. published the artcileCyazofamid; pesticide tolerances, Category: imidazoles-derivatives, the publication is Federal Register (2009), 74(129), 32448-32453, database is CAplus.

Tolerances are established for combined residues of cyazofamid and its metabolite, CCIM, expressed as cyazofamid in or on fruiting vegetable group 8 (0.4 ppm) and okra (0.4 ppm). A tolerance of 1.5 ppm is established with regional restrictions in or on grape. The established grape import and tomato tolerances are removed, as a regional tolerance on grape and fruiting vegetable group tolerance replaces them. Interregional Research Project Number 4 (IR-4) requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA).

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C13H16O2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Micheli, Federico published the artcileCyazofamid; pesticide tolerances for emergency exemptions, Application In Synthesis of 120118-14-1, the publication is Federal Register (2012), 77(18), 4248-4252, database is CAplus.

Time-limited tolerances are established for residues of cyazofamid in or on basil, fresh (12 ppm) and dried (144 ppm). This action is in response to EPA’s granting of an emergency exemption under section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizing use of the pesticide on basil. This regulation establishes a maximum permissible level for residues of cyazofamid in or on these commodities. The time-limited tolerances expire on Dec. 31, 2014.

Federal Register published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C6H17NO3Si, Application In Synthesis of 120118-14-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Mengyan published the artcileIonic Liquid-Assisted Fast Synthesis of Carbon Dots with Strong Fluorescence and Their Tunable Multicolor Emission, Synthetic Route of 79917-90-1, the publication is Small (2022), 18(11), 2106683, database is CAplus and MEDLINE.

Conventional synthesis of carbon dots (CDs) mostly involves a hydrothermal or solvent-thermal reaction which needs relatively high temperature and pressure. In this work, ionic liquid is used to assist in fast synthesizing CDs with an ultrahigh photoluminescent quantum yield (98.5%) by heating at a low temperature (≤100°C) and at atm. pressure. In addition, through this approach, tunable multicolor emissive CDs can be successfully achieved and used for preparing high-performance white light-emitting diodes. Theor. computation proves that the activity of synthesis reaction can be significantly enhanced by ionic liquids D. functional theory calculation reveals that the size and graphite nitrogen ratios of CDs have an effect on bandgap reduction, resulting in a red shift of the emission, which is in good agreement with the exptl. results. This simple and promising approach for fast synthesis of tunable emissive CDs using ionic liquid affords the facilitation of CDs-based luminescent materials for fast manufacturing of functional devices.

Small published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Han, Wei published the artcileDetermination of residual solvents in esomeprazole sodium by headspace gas chromatography, Formula: C17H18N3NaO3S, the publication is Shenyang Yaoke Daxue Xuebao (2012), 29(4), 276-279, database is CAplus.

A method for determination of seven kinds of residual solvents in esomeprazole sodium by headspace gas chromatog. was developed. The residual solvents were separated on DB-624 (30 m × 530 μm, 3 μm) capillary chromatog. column using temperature programming. Nitrogen gas was used as carrier gas with FID as detector. There was a good linear relationship in the exptl. concentrations of ethanol, acetone, isopropanol, acetonitrile, dichloromethane, Me tert-Bu ether, toluene (r≳0.9990). The average recoveries were ranged from 89.7% to 104.6%. The limit of detection were 1.40, 0.39, 1.60, 1.10, 0.74, 0.04 and 0.16 mg·L^-1, resp. The method was sensitive, accurate and reproducible. It could be used for the detection of residual solvents in esomeprazole sodium.

Shenyang Yaoke Daxue Xuebao published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem