Category: imidazoles-derivatives

Chen, Jiuyan published the artcileThe mechanisms involved into the inhibitory effects of ionic liquids chemistry on adsorption performance of ciprofloxacin onto inorganic minerals, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2022), 129422, database is CAplus.

The ionic liquids (ILs) can influence the adsorption of antibiotics on minerals but there was ambiguity about mechanisms. Herein, we demonstrated the adsorption characteristics of ciprofloxacin (CIP) onto ferrihydrite and montmorillonite by various soluble ILs. Five imidazolium-based ILs with different alkyl chain lengths ([C₂mim]Cl, [C₄mim]Cl, [C₆mim]Cl) and counteranions ([C₄mim][TOS] and [C₄mim][PF₆]) were employed. The results validated that ILs could suppress CIP adsorption on both minerals due to the adsorption site competition between cations and CIP mols., steric hindrance induced by long alkyl chains of ILs, and electrostatic interaction. Interestingly, the adsorption-inhibition effects of ILs were almost unchanged with the lengthening alkyl chain for ferrihydrite, which were ascribed to the comparable adsorption capacities of the three ILs on ferrihydrite. Whereas, the effects of ILs on CIP adsorption onto montmorillonite followed the order of [C₆mim]Cl > [C₄mim]Cl > [C₂mim]Cl owing to the adsorption site competition and steric hindrance effects on the ILs increased with the lengthening alkyl chain. Furthermore, the inhibitory effects of ILs on CIP adsorption onto both studied minerals were also dependent on the counteranions (kept the same cation ([C₄mim]+)) and in the following order of [C₄mim][PF₆] > [C₄mim][TOS] > [C₄mim]Cl, which was mainly ascribed to the differences of anions in the ion sizes and the binding affinities to minerals. Addnl., the extent of the inhibitory impact of [C₄mim][TOS] on CIP adsorption onto ferrihydrite declined with increasing solution pH from 5.0 to 9.0, which was attributed to the amounts of adsorbed [TOS]^– declined with increasing pH. Contrarily, for montmorillonite, the extent increased with increasing pH, owing to increase in adsorption site competition and steric effect at higher pH conditions. Our findings emphasize the significance of emerging contaminants in understanding the antibiotic environmental behavior in eco-environmental systems.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tang, Fan published the artcileThe dissipation of cyazofamid and its main metabolite in soil response oppositely to biochar application, Formula: C11H8ClN3, the publication is Chemosphere (2019), 26-35, database is CAplus and MEDLINE.

Biochars derived from rice straw (RS), corn straw (CS), chicken manure (CM) and tire rubber (TR) were applied to soil to investigate their effects on the dissipation of cyazofamid and its metabolite CCIM (4-chloro-5-p-tolylimidazole-2-carbonitrile), with high acute toxicity compared to cyazofamid. The enhancement of cyazofamid dissipation followed the order of CS > RS > CM, whereas TR depressed the cyazofamid dissipation. Adsorption, hydrolysis and microbial degradation were all involved in cyazofamid dissipation. CM and CS enhanced the contribution of biodegradation to cyazofamid dissipation, which might be related with the shifted microbial community. More importantly, CCIM residual was drastically increased by 8-15 times after biochar application, regardless of biochar type. In total, this study shed light on the issue of build-up of metabolites in biochar-amended soil, especially for metabolites having higher toxicities than parent compounds, providing new insights into potential risk of biochar application for soil remediation.

Chemosphere published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C17H37NO3, Formula: C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xia, Pin-si published the artcileDetermination of related substances in esomeprazole sodium for injection by RP-HPLC, Computed Properties of 161796-78-7, the publication is Zhongnan Yaoxue (2014), 12(11), 1131-1135, database is CAplus.

An RP-HPLC method to determine the related substances in esomeprazole sodium for injection was established. The determination was performed on a Inerstil ODS-3 column (150 mm×4.6 mm, 5 μm), with a mobile phase consisting of a mixture of acetonitrile and phosphate buffer (pH=7.4) and tetrabutylammonium hydrogen sulfate. The column temperature was 30°C at 1.0 mL·min^-1 and the detective wavelength was 280 nm. The related substances were completely separated from the main constituent. Impurity A and B were stable in 24 h under the condition of frozen dark, but impurity C was not stable. Omeprazole and impurity A, B and C had good linearity at 0.0633-2.1108 μg·mL^-1 (r=1.000), 0.1465-1.9538 μg·mL^-1 (r=1.000), 0.1587-1.9835 μg·mL^-1 (r=0.9999), 0.0576-3.8388 μg·mL^-1 (r=0.9996) resp. The recoveries were at 91%-105%, and RSDs were less than 5%, which could be meet the requirements. The method can be used for the quality control of esomeprazole sodium for injection.

Zhongnan Yaoxue published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C4H5BN2O2, Computed Properties of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chen, Tao published the artcileSynthesis of 4(5)-chloro-2-cyano-5(4)-(4-methylphenyl)imidazole, Product Details of C11H8ClN3, the publication is Huaxue Shiji (2015), 37(6), 571-573, database is CAplus.

Compound 4-chloro-2-cyano-5-(4-methylphenyl)imidazole was synthesized from 4-methylacetophenone. It started from oxidation using selenium dioxide and cyclization by hydroxylamine and glyoxal solution to give 4-hydro-5-(4-methylphenyl)-2-oxyiminomethylimidazole-3-oxide as the key intermediate. Then, the process was followed by dehydration and chlorination with thionyl chloride and N,N-dimethylformamide. The overall yield was 69.0% (based on 4′-methylacetophenone).

Huaxue Shiji published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C11H8ClN3, Product Details of C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Yue-mei published the artcileNew synthesis of fungicide cyazofamid, Synthetic Route of 120118-14-1, the publication is Nongyao (2015), 54(5), 324-326, database is CAplus.

Aims: This paper aims to report the new synthesis of fungicide cyazofamid. Methods: The compound was synthesized using 4-acetyltoluene as raw materials, through reactions of the oxidation, esterification, ammoniation, dehydration, chlorination and sulfonylation to obtain cyazofamid. And the paper mainly discussed the optimum process conditions for synthesizing substituted imidazole ring: reaction temperature is 85°C, reaction time is 10 h, ethanol as the solvent and n[2-oxo-2-(p-tolyl)acetaldehyde]:n[(NH₄)₂CO₄]:n[glyoxylic acid (50% water solution) ]:n(triethylamine) = 1:1.5:3:5. Results: The total yield was 37.0%. Conclusions: The process is simple, the reaction conditions are mild, all the intermediates are easy to be purified and identified.

Nongyao published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H6ClN, Synthetic Route of 120118-14-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhao, Panpan published the artcileA simple preparation method for rare-earth phosphate nano materials using an ionic liquid-driven supported liquid membrane system, Product Details of C16H23F6N3O2, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2017), 369-376, database is CAplus.

For the first time, our group has developed a novel, high-flux strategy for shape-controlled synthesis of rare earth nano-materials (CePO₄) using ionic liquid(IL)-driven supported liquid membrane (HVHP, DUPAPORE) system. The system contains three phases including a supply phase of rare earth ions, a feed phase of phosphates, and ionic liquid-driven supporting liquid membrane phase. The imidazolium IL-driven supported liquid membrane is promising for nano-synthetic reaction of CePO₄. The anion types of immersed imidazolium IL have a critical role in the formation rate of CePO₄ nano-materials. Moreover, the adding SO^2-₄ anion or adjustment of pH in supply phase containing Ce(III) ions could control effectively the morphol. of the CePO₄ nano-materials. The result can be regarded as a good example, the IL:[C₄mim][Tf₂N] -driven support liquid membrane systems can be used to prepare nano-wire and nano-sphere structures of CePO₄ with high efficiency and flux. Besides, the IL-driven supported liquid membrane can be cycled many times by using the back flush activation method.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 862731-66-6. 862731-66-6 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid, name is 1-octyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide, and the molecular formula is C10H10O3, Product Details of C16H23F6N3O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bai, Zheng-Wu published the artcileEvaluation and comparison of N-cycloalkylformylated chitosan bis(arylcarbamate)s as chiral selectors for enantioseparation, COA of Formula: C17H18N3NaO3S, the publication is New Journal of Chemistry (2017), 41(19), 10561-10567, database is CAplus.

To systematically study the structural dependence on the properties of N-cycloalkylformylated chitosan bis(arylcarbamate)s, 3,5-dimethylphenylcarbamates of N-cyclopropylformylated, N-cyclobutylformylated, N-cyclopentylformylated and N-cyclohexylformylated chitosans were prepared as chiral selectors. Since both the mol. weights of chitosan and the substituents at the 3- and 6-positions of the phenylcarbamates are identical, the influences of the substituent at the 2-position on the solvent tolerability and enantioseparation performance of the chiral selectors were specifically compared and discussed. The solvent tolerability and enantioseparation performances of the chiral selectors obviously differed with the variation of the substituent at the 2-position of the glucosamine skeleton. Although all the chiral selectors generally showed satisfactory tolerability in Et acetate and acetone, the chiral selector with a three-membered ring exhibited much more preferable tolerability against THF than the others with a four-, five- or six-membered ring. Enantioseparation results revealed that most of the chiral selectors exhibited powerful chiral recognition and enantioseparation abilities, and the chiral selector with a five-membered ring exhibited the best enantioseparation performance. The corresponding coated-type chiral stationary phases prepared from these chitosan-based chiral selectors were able to be complementary with each other and applied as promising chiral separation materials for enantiomeric separations

New Journal of Chemistry published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, COA of Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Ming published the artcileChemical reaction within a compact non-porous crystal containing molecular clusters without the loss of crystallinity, Safety of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Science (2017), 8(8), 5356-5361, database is CAplus and MEDLINE.

The very rare occurrence of a gas-solid chem. reaction has been found to take place on a mol. within a compact non-porous crystal without destroying its long-range structural order and retaining similar crystal structures when yellow crystals of Fe^II₄(mbm)₄Cl₄(MeOH)₄ were exposed to air to give black [Fe^III₄(mbm)₄Cl₄(OH)₄]·2H₂O. The latter cannot be synthesized directly. The original cluster underwent an exchange of methanol to hydroxide, an oxidation of Fe(II) to Fe(III), a change in stereochem. and hydration while the packing and space-group remained unaltered.

Chemical Science published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C6H6N2O, Safety of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhao, Wangdan published the artcileDetermination and Thermodynamic Modeling of Solid-Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol + Ethyl Acetate) Binary Solvent Mixtures, Product Details of C17H18N3NaO3S, the publication is Journal of Chemical & Engineering Data (2017), 62(7), 1965-1972, database is CAplus.

Esomeprazole sodium was a proton pump inhibitor (PPI) synthesized using omeprazole sulfide. In this paper, we used a static-analytic method to analyze the solubility of our own synthesis of esomeprazole sodium in Et acetate, acetonitrile, Me iso-Bu ketone, ethanol, methanol, and in the (ethanol + Et acetate) mixtures between 278.15 and 328.15 K. A group of thermodn. models were selected such as the Jouyban-Acree equation, the modified Apelblat equation, and CNIBS/R-K equations. All equations can be well applied and the modified Apelblat equations are relatively better. We determined the thermodn. properties of esomeprazole sodium using the van’t Hoff equation furthermore, including the entropy, Gibbs energy, and enthalpy.

Journal of Chemical & Engineering Data published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C15H21BO3, Product Details of C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hu, Xutao published the artcileElucidating the transition between CO₂ physisorption and chemisorption in 1,2,4-triazolate ionic liquids at a molecular level, HPLC of Formula: 79917-90-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 435(Part_2), 134956, database is CAplus.

Capture of CO₂ is a crucial process to achieve carbon neutrality. High-performance CO₂ capture involves both physi- and chemi-sorption, with a transition between them. However, the underlying mechanistic insights required to produce the methods to tune the transition are poorly understood. Here, we describe a series of 1,2,4-triazolate ionic liquids (TZ ILs) that capture > 0.7 mol CO₂ /mol TZ IL in a two-stage absorption process. Physi- and chemi-sorption were studied by spectroscopy using ¹³CO₂ and the transition between the two sorption modes has been identified. UV-Vis, FT-IR and NMR spectroscopy as well as d. and viscosity measurements demonstrate that physisorption is initially the dominant process whereas later chemisorption predominates. Based on the identification of key species combined with theor. modeling, a plausible mol.-level mechanism is proposed for the transition between the two sorption modes. These mechanistic insights enable the transition of CO₂ capture to be tuned.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem