Category: imidazoles-derivatives

Lambert, Alexander published the artcileUltrasensitive Detection of Bacterial Protein Toxins on Patterned Microarray via Surface Plasmon Resonance Imaging with Signal Amplification by Conjugate Nanoparticle Clusters, Quality Control of 359860-27-8, the publication is ACS Sensors (2018), 3(9), 1639-1646, database is CAplus and MEDLINE.

Sensitive detection and monitoring of biol. interactions in a high throughput, multiplexed array format has numerous advantages. We report here a method to enhance detection sensitivity in surface plasmon resonance (SPR) spectroscopy and SPR imaging via the effect of accumulation of conjugated nanoparticles of varying sizes. Bacterial cholera toxin (CT) was chosen for the demonstration of enhanced immunoassay by SPR. After immobilization of CT on a gold surface, specific recognition is achieved by biotinylated anti-CT. The signal is amplified by the attachment of biotinylated 20nm AuNP via streptavidin bridge, followed by attachment of 5nm streptavidin-functionalized Fe3O4NP to the AuNP-biotin surface. The continuous surface binding of two differently-sized conjugated nanoparticles effectively increase their packing d. on surface; significantly improve SPR detection sensitivity, allowing quant. measurement of CT at very low concentration The dense packing of conjugated nanoparticles on the surface was confirmed by at. force microscopy characterization. SPR imaging of the immunoassay for high-throughput anal. utilized an Au-well microarray that attenuated the background resonance interference on the resulting images. A calibration curve of conjugated nanoparticle binding signal amplification for CT detection based on surface coverage has been obtained that shows a correlation in a range from 6.31 × 10-16 to 2.51 × 10-13 mol/cm2 with the limit of detection of 5.01 × 10-16 mol/cm2. The absolute quantity of detection limit using SPR imaging was 0.25 fmol. The versatile nanoparticles and biotin-streptavidin interaction used here should allow adaptation of this enhancement method to many other systems that include DNA, RNA, peptides, and carbohydrates, opening new avenues for ultrasensitive anal. of biomols.

ACS Sensors published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chang, Jinyu published the artcilePreparation of 5-methyl-3,5-dipropyl-2-pyrazoline catalyzed by chloroaluminate ionic liquids, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Structure (2022), 132539, database is CAplus.

5-Methyl-3,5-dipropyl-2-pyrazoline is an intermediate for the preparation of new high energy fuels. In this paper, chloroaluminate ionic liquids ([Bmim]Cl-xAlCl₃, x = 1, 1.2, 1.4, 1.6, 1.8, 2.0) were applied as green catalysts for the synthesis of 5-methyl-3,5-dipropyl-2-pyrazoline through the intramol. cyclization reaction of 2-pentyl ketazine. The effects of temperature, acidity and dosage of ionic liquids on the cyclization reaction were studied in detail and the highest catalytic performance was under the conditions as 110°, [Bmim]Cl-1.6AlCl₃ and 10% of 2-pentyl ketazine. With the theor. simulations, the possible catalytic mechanism was proposed as the hydrogen-like interaction between Al ([Bmim]⁺AlCl₄^–) and N1 atoms, which increases the charge of N2 atoms, thereby improving its nucleophilicity and further making it undergo intramol. addition reaction with Me. This study will provide guidance for the green preparation of 5-methyl-3,5-dipropyl-2-pyrazoline.

Journal of Molecular Structure published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Peng, Jinsong published the artcileCopper-catalyzed intramolecular C-N bond formation: a straightforward synthesis of benzimidazole derivatives in water, Product Details of C19H14N2, the publication is Journal of Organic Chemistry (2011), 76(2), 716-719, database is CAplus and MEDLINE.

A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramol. N-arylation providing the benzimidazole ring system. With Cu₂O (5 mol %) as the catalyst, DMEDA (10 mol %) as the ligand, and K₂CO₃ as the base, this protocol was applied to synthesize a small library of benzimidazoles, e.g., I in high yields. Remarkably, the reaction was exclusively carried out in water, rendering the methodol. highly valuable from both environmental and economical points of view.

Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Product Details of C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Arimoto, Masahiro published the artcileSemisynthetic β-lactam antibiotics. IV. Synthesis and antibacterial activity of 7β-[2-(hetero aromatic methoxyimino)-2-(2-aminothiazol-4-yl)acetamido]cephalosporins, Product Details of C5H8N2O, the publication is Journal of Antibiotics (1988), 41(12), 1795-811, database is CAplus and MEDLINE.

Title compounds I [R = OAc, 1-methyl-5-tetrazolylthio, (un)substituted pyridinium, 1-methylpyrrolidinium, pyridazinium; R¹ = (un)substituted imidazol-4-yl, 1,2,3-triazol-4-yl, pyridazin-3-yl, pyrimidin-4-yl, pyrazinyl] were synthesized and bacteriol. evaluated. Several I showed exceptional in vitro activity. The most active derivative, I (R = pyridinium, R¹ = imidazol-4-yl), was the most evenly balanced with respect to activity against Gram-pos. and Gran-neg. bacteria. Furthermore, I (R = pyridinium, R¹ = imidazol-4-yl) was stable to various types of β-lactamases and had high affinities for penicillin binding protein-3 and -1Bs of both Escherichia coli and Pseudomonas aeruginosa.

Journal of Antibiotics published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Product Details of C5H8N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Kyung-Bok published the artcileSurface modification of poly(glycolic acid) (PGA) for biomedical applications, Related Products of imidazoles-derivatives, the publication is Journal of Pharmaceutical Sciences (2003), 92(5), 933-937, database is CAplus and MEDLINE.

The immobilization of biol. ligands (such as biotin and peptides) onto biodegradable polymer surfaces, including poly(glycolic acid) (PGA) sutures, is complicated by the absence of functional groups on the polymer backbone. We demonstrate a method for overcoming this problem, by attaching (+)-biotinyl-3,6,9-trioxaundecanediamine to the surface of PGA sutures, which immobilizes the ligand through an amide bond between amine (ligands) and carboxylic acid groups (surface-hydrolyzed PGA sutures). Fluorescence microscopy was used to verify the attachment of the biotin ligand to the surface of the PGA suture after a complexation with fluorescein-conjugated streptavidin. The strategy can be generalized to surface modifications of other biodegradable aliphatic polyesters, which would improve the properties of the polymers in biomedical applications such as active targeting of drugs based on ligand-attached, polymeric drug delivery systems.

Journal of Pharmaceutical Sciences published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sun, Qiao published the artcileCobalt-catalyzed C(sp²)-H/C(sp³)-H coupling via directed C-H activation and 1,5-hydrogen atom transfer, Synthetic Route of 258278-25-0, the publication is Organic Chemistry Frontiers (2018), 5(4), 582-585, database is CAplus.

The regioselective synthesis of 1-[2-[(benzylamino)methyl]phenyl]ethanones such as I [R = H, 3-Cl, 4-Ph, etc.; R¹ = Me, n-Pr; R² = Et, n-Bu; R¹R² = (CH₂)₃, (CH₂)₄, (CH₂)₅, etc.] via cobalt-catalyzed C(sp²)-H/C(sp³)-H cross-coupling reaction between various (E)-aryl imines and 2-bromobenzyl-protected secondary amines was reported. Promoted by a combination of a cobalt-N-heterocyclic carbene catalyst and Grignard reagent, the reaction was allowed for the introduction of α-aminoalkyl groups into the ortho position of the imine at a mild temperature The cobalt catalyst was proposed to play key roles in two distinct modes of C-H cleavage, i.e., directed C-H metalation and 1,5-hydrogen atom transfer.

Organic Chemistry Frontiers published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C7H5Cl2NO, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yu, Dan published the artcileCuO nanoparticle-catalyzed diaminations for synthesis of benzimidazole derivatives, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Applied Organometallic Chemistry (2016), 30(8), 695-698, database is CAplus.

Copper oxide nanoparticles were applied as an efficient catalyst for the formation of C-N bonds. They can catalyze diaminations for the regiospecific synthesis of 1,2-disubstituted benzimidazoles from 1,2-dihaloarenes and N-arylamidines. The best performance was achieved using CuO nanoparticles with average diameter of 6.5 nm. In addition, the catalyst can be recycled and reused without any significant decrease in catalytic activity.

Applied Organometallic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C9H5ClO2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kim, Jina published the artcileIdentification of selective ERRγ inverse agonists, Product Details of C7H7BN2O2, the publication is Molecules (2016), 21(1), 80/1-80/16, database is CAplus and MEDLINE.

GSK5182 (4) is currently one of the lead compounds for the development of estrogen-related receptor gamma (ERR) inverse agonists. Here, we report the design, synthesis, pharmacol. and in vitro absorption, distribution, metabolism, excretion, toxicity (ADMET) properties of a series of compounds related to 4. Starting from 4, a series of analogs were structurally modified and their ERR inverse agonist activity was measured. A key pharmacophore feature of this novel class of ligands is the introduction of a heterocyclic group for A-ring substitution in the core scaffold. Among the tested compounds, several of them are potent ERR inverse agonists as determined by binding and functional assays. The most promising compound, 15g, had excellent binding selectivity over related subtypes (IC50 = 0.44, >10, >10, and 10 μM at the ERR, ERRγ, ERR∝, and ERβ subtypes, resp.). Compound 15g also resulted in 95% transcriptional repression at a concentration of 10 _M, while still maintaining an acceptable in vitro ADMET profile. This novel class of ERR inverse agonists shows promise in the development of drugs targeting ERR-related diseases.

Molecules published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, Product Details of C7H7BN2O2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Slade, Peter G. published the artcileProteins Modified by the Lipid Peroxidation Aldehyde 9,12-Dioxo-10(E)-dodecenoic Acid in MCF7 Breast Cancer Cells, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Chemical Research in Toxicology (2010), 23(3), 557-567, database is CAplus and MEDLINE.

The hydroperoxide of linoleic acid (13-HPODE) degrades to 9,12-dioxo-10(E)-dodecenoic acid (DODE), which readily modifies proteins. This study identified the major proteins in MCF7 cells modified by DODE. To reduce false positives, three methods were used to identify DODE-modified proteins. First, cells were treated with a synthetically biotinylated 13-HPODE (13-HPODE-biotin). Modified proteins were enriched by NeutrAvidin affinity and identified by two-dimensional liquid chromatog.-tandem mass spectrometry (2D LC-MS/MS). Second, cells were treated with native 13-HPODE. Protein carbonyls were biotinylated with an aldehyde reactive probe, and modified proteins were enriched by NeutrAvidin affinity and identified by 2D LC-MS/MS. Third, using a newly developed DODE antibody, DODE-modified proteins were located by 2D SDS-PAGE and Western blot and identified by in-gel digestion and LC-MS/MS. Anal. of the proteins characterized by all three methods revealed a significant overlap and identified 32 primary proteins modified by DODE in MCF7 cells. These results demonstrated the feasibility for the cellular formation of DODE protein-carbonyl adducts that may be future indicators of oxidative stress.

Chemical Research in Toxicology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C8H11NO, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Guebitz, G. published the artcileThe TAS procedure in pharmaceutical analysis, HPLC of Formula: 2508-72-7, the publication is Scientia Pharmaceutica (1976), 44(1), 23-8, database is CAplus.

In the TAS (a thermomicro, thin-layer chromatog.) procedure, an unknown is mixed with a substance to facilitate its volatilization and heated in a special oven. The vapors are condensed on a chromatog. plate, separated, and identified. A table is given for 50 single and 6 combination pharmaceuticals listing the volatilizing substance, chromatog. solvent, method of visualization, and Rf factor.

Scientia Pharmaceutica published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem