Category: imidazoles-derivatives

Ren, Fei published the artcileGreen synthesis of acetylated maize starch in different imidazolium carboxylate and choline carboxylate ionic liquids, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Carbohydrate Polymers (2022), 119353, database is CAplus and MEDLINE.

This work demonstrates that acetylated maize starches (AMS) with varied degree of substitution (DS, 0.26-2.63) was synthesized in ionic liquids (ILs) (imidazolium chloride, imidazolium carboxylate and choline carboxylate) at 85°C without catalyst. The DS of AMS and reaction efficiency increased with decreasing alkyl chain length of cations or anions, while decreased as the choline cation replaced the imidazolium cation and the chloride anion replaced the acetate anion. The AMS synthesized in imidazolium-based ILs exhibited much higher hydrophobicity and thermal stability than the native starch. Rheol. properties of ILs and ATR-FTIR anal. of acetic anhydride/ILs mixtures indicated that a shorter alkyl side chain or the combination of an imidazolium cation and an acetate anion gave ILs lower viscosities and weaker interactions between acetic anhydride mols., which favored the acetylation of starch. These findings provide insights into the design of green processes to modify starch and the application of acetylated starch.

Carbohydrate Polymers published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Qin, Xu-feng published the artcileDetection and control of impurities in esomeprazole sodium for injection, Synthetic Route of 161796-78-7, the publication is Shandong Huagong (2014), 43(3), 21-25, database is CAplus.

Objective: To establish a method to determine and confirm the structures of the impurities in esomeprazole sodium for injection. Method: HPLC method was adopted. The determination was performed on Agilent chromatog. (model: 1260, detector: G1315D), ZORBA EXTEND-C18 (250 mm × 3.0 mm, 5 μm) column was used. The flow rate was 1.0 mL·min^-1 with UV detective wavelength at 280 nm, the column temperature was 35°C, gradient elution; the structure was identified by NMR and mass spectrum. Results: The imparity peaks and esomeprazole sodium peak were effectively separated when the sample was forcedly destroyed, no matter change the proportion of mobile phase, column temperature, flow rate, or different chromatog. column models and manufacturers, the separation degree accords with regulation. Conclusion: The method has been developed and validated of the detection and control of impurities in esomeprazole sodium for injection, and the structures of impurities have been confirmed. This method is selective, specific, good durable. It is suitable for structure confirmation, detection and control of impurities in esomeprazole sodium for injection.

Shandong Huagong published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Synthetic Route of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wu, Hong published the artcileDiscovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma, COA of Formula: C18H34N4O5S, the publication is ACS Chemical Biology (2014), 9(5), 1086-1091, database is CAplus and MEDLINE.

BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. The authors have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and irreversible BTK kinase inhibitor, QL47, which covalently modifies Cys 481. QL47 inhibits BTK kinase activity with an IC₅₀ of 7 nM, inhibits autophosphorylation of BTK on Tyr 223 in cells with an EC₅₀ of 475 nM, and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr 759) with an EC₅₀ of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations

ACS Chemical Biology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H10F3NO3S2, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Ling-Yun published the artcileButterfly and chair clusters using N,O-chelating ligands: A combined crystallographic and mass spectrometric study, Quality Control of 7467-35-8, the publication is Applied Organometallic Chemistry (2020), 34(5), e5533, database is CAplus.

The organic ligand (1-methyl-1H-benzo[d]imidazol-2-yl)methanol (HL¹) was used to react with Cu(ClO₄)₂·6H₂O and triethylamine at 80°C to afford the complex [Cu₄(L¹)₆]·(ClO₄)₂·CH₃CN (1). Every four-coordinated Cu(II) ion is surrounded with NO₃ coordinated environment, and every five-coordinated Cu(II) ion is surrounded with N₂O₃ coordinated environment. Changing the metal salt to Zn(NO₃)₂·6H₂O, and after adding CH₃COONa, afforded the complex [Zn₄(L¹)₄(NO₃)₂(CH₃COO)₂] (2), in which every five-coordinated Zn(II) ion is surrounded with NO₄ coordinated environment. High-resolution electrospray ionization mass spectrometry results revealed that complex 1 broke into the most stable fragment [Cu₂(L¹)₃]⁺, and it also can assemble high nuclear peaks in solution For complex 2, it was found that the complex exhibited different component distribution in solution Not only were there substitutions between coordinated anions, but the high nuclear peaks could also be detected.

Applied Organometallic Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C8H11BO2, Quality Control of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Juan published the artcileSynthesis of substituted phenylcarbamates of N-cyclobutylformylated chitosan and their application as chiral selectors in enantioseparation, Application of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Analyst (Cambridge, United Kingdom) (2016), 141(14), 4470-4480, database is CAplus and MEDLINE.

The goal of this study was to develop new chiral stationary phases (CSPs) with high chiral recognition capability and high compatibility with the so-called nonstandard solvents. Seven new chitosan bis(phenylcarbamate)-(N-cyclobutylformamide) derivatives were synthesized from chitosan with high degree of deacetylation as a starting material. The corresponding chiral stationary phases (CSPs 1-7) were prepared with the chitosan derivatives as chiral selectors (CSs). The enantioseparation capability of CSPs 1-7 was evaluated by HPLC with nineteen analytes. In comparison with the CSPs of cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) and amylose tris(3,5-dimethylphenylcarbamate) (ADMPC), the prepared CSPs generally demonstrated excellent enantioseparation capability, particularly for the CSP derived from chitosan bis(3-chloro-4-methylphenylcarbamate)-(N-cyclobutylformamide). Also, the CSPs in the present study could sep. some analytes better, making them complementary for enantioseparations with the CSPs of CDMPC and ADMPC. The tolerability of the CSP with the best enantioseparation capability to organic solvents was studied. It could work in pure Et acetate, pure chloroform, and a normal phase containing 70% THF, which are prevented from enantioseparation by the coating type CSPs of CDMPC and ADMPC. As these chitosan derivatives were almost insoluble in most organic solvents, the corresponding CSPs can work in a wide range of mobile phases. The influence of the position and electron effects of Me and chloro groups introduced onto the CSs and the composition of mobile phases on enantioseparation is also discussed.

Analyst (Cambridge, United Kingdom) published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N2O6, Application of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Liling published the artcileExtraction and Determination of Protein from Edible Oil Using Aqueous Biphasic Systems of Ionic Liquids and Salts, Application In Synthesis of 79917-90-1, the publication is Food and Bioprocess Technology (2022), 15(1), 190-202, database is CAplus.

This study aimed to develop the extraction method of protein from edible oil for rapid detection. Firstly, aqueous biphasic systems (ABS) based on six hydrophilic ionic liquids (ILs) and three salts were developed and the phase diagram was drawn by turbidimetric point method. The binodal curves were fitted to the Merchuk equation. On this basis, the ABS composed of IL and salt were applied to extract protein from edible oil. The type of IL or salt, IL concentration, salt concentration, oil mass, extraction pH, and temperature on the extraction efficiency of protein from oil were investigated. The results showed that the optimum conditions for the extraction of protein from edible oil with ABS were as follows: 50% (w/v) K3PO4, 20% (w/v) [Bmim]Cl at 35°C, and pH 9.0. Under the optimal conditions, the protein extraction efficiency was almost 100%. Also, the extraction mechanism was studied and the main driving factors of protein extraction may be the hydrophobicity, electrostatic interaction, and salting-out between mols. Finally, the method was used to detect the com. edible oils from different sources. The results showed that the ABS could also be used to extract protein from other edible oils. In conclusion, the IL-based ABS method is simple and rapid for protein extraction from edible oil, and will highlight novel possibilities in the large-scale separation and purification of protein from oily solution

Food and Bioprocess Technology published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C38H74Cl2N2O4, Application In Synthesis of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Na published the artcileThe activity and molecular interaction of lysozyme in adding four ionic liquids aqueous solutions, Computed Properties of 79917-90-1, the publication is Journal of Molecular Liquids (2022), 118788, database is CAplus.

In this work, four hydrophilic ionic liquids (ILs, 1-butyl-3-methylimidazolium tetrafluoroborate ([C₄mim]BF₄), 1-butyl-3-methylimidazolium chloride ([C₄mim]Cl), 1-butyl-3-methylimidazolium bromide ([C₄mim]Br) and 1,3-dimethylimidazolium iodide ([dmim]I)) were selected to probe their effect on lysozyme activity and the mol. interaction in aqueous solutions Specifically, the effects of pH and concentration of ILs on lysozyme activity were investigated by using the spectrophotometric turbidity assay. The results demonstrated that the effect of ILs on lysozyme activity depended on the concentration of ILs. Fixing the pH at 6.85, lysozyme activity rose firstly and then reduced with the increase of concentration of four ILs, reaching the maximum at 75 mM. The UV-Vis spectra illustrated that the interaction between ILs and lysozyme was weak. The results of emission and synchronous fluorescence spectra indicated that ILs had a quenching effect on the fluorescence of lysozyme, and the quenching effect increased with the increasing concentration of ILs. Meanwhile, the fluorescent quenching mechanism of ILs on lysozyme was dynamic quenching, and ILs had significant effects on the tryptophan (Trp) residues Trp62 or Trp108 at the active site of lysozyme, which suggested that effects of ILs on lysozyme activity could be attributed to the conformational changes of lysozyme triggered by changes in the microenvironment surrounding Trp62 or Trp108.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ma, Xiong-Feng published the artcileLigand Effect on the Single-Molecule Magnetism of Tetranuclear Co(II) Cubane, SDS of cas: 7467-35-8, the publication is Inorganic Chemistry (2017), 56(24), 15178-15186, database is CAplus and MEDLINE.

A clear dependence on the ligand has been observed for the magnetic properties of a closely related series of Co(II) cubane structures, viz. [Co₄(mbm or bm)₄(ROH)₄Br₄] (1-MeOH, 1-EtOH, 2-MeOH, and 2-EtOH, where 1 = [Co₄(mbm)₄Br₄], 2 = [Co₄(bm)₄Br₄], bm = (1H-benzo[d]imidazol-2-yl)methanolate. and mbm = 1-Me-bm.). The [Co₄(OR)₄] cubane core consists of an octahedral Co^II center chelated by the alkoxide oxygen and imidazole nitrogen atoms from monoanionic bm or mbm and coordinated by methanol/alc. and bromine. Interestingly, electrospray ionization mass spectrometry (ESI-MS) indicates that 1-MeOH and 2-MeOH are unstable in methanol and transformed to the butterfly [Co₄L₆]²⁺ but that 1-EtOH and 2-EtOH are stable in ethanol. Their magnetic susceptibilities suggest ferromagnetic coupling between the nearest cobalt centers to give a theor. S = 4 × 3/2 ground state with considerable magneto-crystalline behavior. The packing and intermol. interactions appear to influence the geometry of the cubes and thus the anisotropy of cobalt, which leads to different blocking temperatures (T_B). Consequently, the compounds with mbm, 1-MeOH and 1-EtOH, exhibit T_B > 2 K as shown by the relaxation of magnetization in zero applied dc field where the barriers U_eff/k_B are resp. 27 and 21 K and relaxation times are τ₀ = 1.3 × 10^-9 and 9.7 × 10^-9 s. However, the compounds with bm, 2-MeOH and 2-EtOH, remain paramagnetic above 2 K and do not show nonlinear response of the ac susceptibilities. These findings reaffirm the subtle dependence of single-mol. magnetism on coordination geometry and intermol. interaction.

Inorganic Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, SDS of cas: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hu, Wei-Wen published the artcileVirus immobilization on biomaterial scaffolds through biotin-avidin interaction for improving bone regeneration, Quality Control of 359860-27-8, the publication is Journal of Tissue Engineering and Regenerative Medicine (2016), 10(2), E63-E72, database is CAplus and MEDLINE.

To spatially control therapeutic gene delivery for potential tissue engineering applications, a biotin-avidin interaction strategy was applied to immobilize viral vectors on biomaterial scaffolds. Both adenoviral vectors and gelatin sponges were biotinylated and avidin was applied to link them in a virus-biotin-avidin-biotin-material (VBABM) arrangement. The tethered viral particles were stably maintained within scaffolds and SEM images illustrated that viral particles were evenly distributed in three-dimensional (3D) gelatin sponges. An in vivo study demonstrated that transgene expression was restricted to the implant sites only and transduction efficiency was improved using this conjugation method. For an orthotopic bone regeneration model, adenovirus encoding BMP-2 (AdBMP2) was immobilized to gelatin sponges before implanting into critical-sized bone defects in rat calvaria. Compared to gelatin sponges with AdBMP2 loaded in a freely suspended form, the VBABM method enhanced gene transfer and bone regeneration was significantly improved. These results suggest that biotin-avidin immobilization of viral vectors to biomaterial scaffolds may be an effective strategy to facilitate tissue regeneration.

Journal of Tissue Engineering and Regenerative Medicine published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zinser, Caroline M. published the artcileTowards environmentally friendlier Suzuki-Miyaura reactions with precursors of Pd-NHC (NHC = N-heterocyclic carbene) complexes, HPLC of Formula: 258278-25-0, the publication is Green Chemistry (2018), 20(14), 3246-3252, database is CAplus.

The preparation of [NHC·H][Pd(η³-R-allyl)Cl₂] complexes is disclosed and represents a facile, atom-economical, environmentally friendly and rapid synthesis. These palladates are immediate synthetic precursors to the well-known [Pd(NHC)(η³-R-allyl)Cl] complexes. Their activation leading to catalytically relevant species has been studied in the Suzuki-Miyaura reaction. The need for an activation step prior to the catalysis was examined The reaction scope showcases its ease and breadth in terms of functional group tolerance. Electron-donating and electron-withdrawing aryl chlorides and bromides were coupled effectively as well as heteroatom-containing and sterically hindered aryl halides. The catalytic reaction was conducted in ethanol with a weak and inexpensive inorganic base.

Green Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C11H15N3O5, HPLC of Formula: 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem