Category: imidazoles-derivatives

Hu, Xiao published the artcileDetermination of S-omeprazole sodium and the related substances by RP-HPLC, Product Details of C17H18N3NaO3S, the publication is Zhongguo Yaofang (2009), 20(22), 1744-1746, database is CAplus.

The aim of this paper is to establish an RP-HPLC method for content determination of S-omeprazole sodium and its related substances. The separation of S-omeprazole sodium and the related substances was carried out on a Phenomenex Luna C₁V8 column, and the mobile phase consisted of methanol-0.033 mol/L^-1 ammonium dihydrogen phosphate-triethylamine. The detection wavelength was 302 nm, the flow rate was 1.0 mL/min^-1, the column temperature was 25°, and the sample size was 20 μL. The linear range of omeprazole sodium was 10-500 mg/L^-1 (r = 0.9997). The average recovery rate was 100.27% (RSD = 0.74%). The average content of the related substances in samples was 0.42%. This method is simple, accurate, specific, and applicable for content determination of S-omeprazole sodium and its related substances.

Zhongguo Yaofang published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Product Details of C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ebisu, Keitaro published the artcileN-Terminal Specific Point-Immobilization of Active Proteins by the One-Pot NEXT-A Method, Quality Control of 359860-27-8, the publication is ChemBioChem (2009), 10(15), 2460-2464, database is CAplus and MEDLINE.

The authors earlier combined L/F-transferase-mediated functionalization with tRNA-aminoacylation using engineered aminoacyl-tRNA synthetase (ARS) in the same test tube and named the whole method NEXT-A (N-terminal extension of protein by transferase and aminoacyl-tRNA synthetase). Here, the authors report a practical method that combines the NEXT-A reaction and noncatalytic 1,3-dipolar cycloaddition for immobilizing any kind of active protein onto supports with an ordered orientation. Typically, a sugar-binding protein (lectin EW29Ch) was successfully immobilized onto an acrylamide-based gel. The authors monitored stoichiometry of the reaction during the immobilization. The lectin-immobilized gel was subjected to frontal affinity chromatog. and sugar-lectin interactions on the gel were measured. Direct immobilization of a target protein in a cell lysate without purification was also demonstrated.

ChemBioChem published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Quality Control of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Amer, M. M. published the artcileModified nitroprusside colorimetric determination of antazoline salts in some pharmaceutical preparation, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Pharmazie (1974), 29(5), 354-5, database is CAplus and MEDLINE.

The nitroprusside method of Slack and Mader (1957) was improved by using 80 mg H3BO3 in place of NaHCO3 (to alter pH) and adding 4 ml EtOH to give a red color instead of the violet, measurable at 540 nm, the color being maximum at 1 min and stable for 12 hr. The method is superior to that of BP 1968 and USP XV, since ephedrine and 19 other substances tested did not interfere with the reaction but naphazoline, Zn2+, and phentolamine did,. Recovery by this method ranged between 100.6.+-.0.23% to 102.3.+-.1.2%. Determinations were made against a standard curve for 0.1-1. mg of the corresponding antazoline salt.

Pharmazie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Safety of N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Elterman, V. A. published the artcileFeatures of aluminum electrodeposition from 1,3-dialkylimidazolium chloride chloroaluminate ionic liquids, Formula: C8H15ClN2, the publication is Journal of Molecular Liquids (2022), 118693, database is CAplus.

The mechanism of aluminum electrodeposition from acidic 1-butyl-3-methylimidazolium chloride chloroaluminate ionic liquids ([BMIm]Cl ILs) is studied over a wide range of the molar ratio of AlCl₃ to [BMIm]Cl (N) at 30°C. The findings for AlCl₃-[BMIm]Cl and AlCl₃-1-ethyl-3-methylimidazolium chloride ([EMIm]Cl) are analyzed and compared in order to identify dependences common for 1,3-dialkylimidazolium chloride ILs. Limiting currents were detected on the cathodic polarization curves at the aluminum | ionic liquid interface. Limiting currents are caused by the Al₂Cl^–₇ anions diffusion to the electrode surface. The limiting c.d. values for AlCl₃-[BMIm]Cl are lower (i_lim, 1.1 ≤ N leq 2.0 = 1.17 – 12.36 mA•cm^-2) than for AlCl₃-[EMIm]Cl (i_lim, 1.1 ≤ N leq 2.0 = 1.81 – 25.37 mA·cm^-2). It is shown that anion AlCl-4 can be reduced to metallic aluminum at cathodic overpotentials above 1.5 V. The diffusion coefficient of Al₂Cl-7 in AlCl₃-[BMIm]Cl (7.4•10-7 cm²•s^-1) is lower than in AlCl₃-[EMIm]Cl (9.3•10-7 cm²•s^-1) and is unaffected by aluminum chloride concentration in either system.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zeng, Run-Sheng published the artcileSynthesis of 1,2-diphenyl-1H-benzimidazole derivatives by an iodobenzene diacetate-mediated reaction of N,N’-diphenylbenzamidine derivatives, Category: imidazoles-derivatives, the publication is Youji Huaxue (2008), 28(3), 476-478, database is CAplus.

1,2-Phenyl-1H-benzimidazole derivatives were prepared by the reaction of iodobenzene diacetate with N,N’-diarybenzamidine derivatives in moderate yields at room temperature with simple manipulation. All the products were confirmed by ¹H NMR, ¹³C NMR, MS and IR spectra. A possible reaction mechanism was proposed.

Youji Huaxue published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C6H20Cl2N4, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Xiaochun published the artcileInkjet-Printed Bioassays for Direct Reading with a Multimode DVD/Blu-Ray Optical Drive, Synthetic Route of 359860-27-8, the publication is Analytical Chemistry (Washington, DC, United States) (2014), 86(18), 8922-8926, database is CAplus and MEDLINE.

Compact disk-based bioassays have been developed as novel point-of-care (POC) tools for various applications in chem. anal. and biomedical diagnosis. For the fabrication of assay disks, the surface patterning and sample introduction have been restricted to manual delivery that is unfavorable for on-demand high throughput medical screening. Herein, the authors have adapted a conventional inkjet printer to prepare bioassays on regular DVD-Rs and accomplished quant. anal. with a multimode DVD/Blu-Ray optical drive in conjunction with free disk diagnostic software. The feasibility and accuracy of this method have been demonstrated by the quant. anal. of inkjet-printed biotin-streptavidin binding assays on DVD, which serves as a trial system for other complex, medically relevant sandwich-format or competitive immunoassays.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

San Andres, M. P. published the artcileDetermination of antihistamines based on the formation of mixed aggregates with surfactants, Related Products of imidazoles-derivatives, the publication is Analyst (Cambridge, United Kingdom) (1998), 123(5), 1079-1084, database is CAplus.

The determination of antihistamines based on the measurement of the critical micelle concentration (CMC) of mixed sodium dodecyl sulfate (SDS)-antihistamine aggregates is proposed. The dye Coomassie Brilliant Blue G (CBBG) was used as a photometric probe (610 nm) for the rapid determination of CMCs. The micellar properties of the drugs permitted the determination of diphenhydramine, antazoline, tripelennamine, diphenylpyraline, and clemizole at the μM level, with detection limits from 0.1 to 0.7 μM. The proposed method surpasses in sensitivity the existing routine photometric methods used in the drug quality control and has detection limits similar to fluorimetric methods. The relative standard deviation for 6 μM diphenhydramine was 3.7%. The method was applied to the determination of these drugs in pharmaceutical preparations (solutions, capsules, creams, pills) which were analyzed directly after dissolution in distilled water.

Analyst (Cambridge, United Kingdom) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Thoma, K. published the artcileColloid association of antihistamines. Part 1. Relation between chemical structure and critical micelle formation concentration, Quality Control of 2508-72-7, the publication is Pharmaceutica Acta Helvetiae (1976), 51(3), 50-8, database is CAplus and MEDLINE.

Surface tensions were determined for 17 antihistamines in 0.5% aqueous solutions, and critical micelle concentrations ranging from 0.012 mole/l. (medrylamine maleate [60407-52-5]) to 0.185 mole/l. (Thenfadil [91-79-2]) were determined for all of these compounds and also for chlorphenamine-HCl [56343-98-7] in 0.9% saline. Cryoscopic, spectrophotometric, tensiometric, potentiometric, and conductometric methods were used to determine the critical micelle concentrations, and the results and ease of use were compared. The unsubstituted ethylenediamine, propylamine, and ethanolamine derivatives, Pyribenzamine [91-81-6], Avil [3269-83-8], and Benadryl [147-24-0], had similar critical micelle concentrations These concentrations decreased on phenyl group substitution in the order Me > Cl > Br.

Pharmaceutica Acta Helvetiae published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C10H15ClO3S, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Behravesh, Esfandiar published the artcileQuantification of ligand surface concentration of bulk-modified biomimetic hydrogels, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Biomaterials (2003), 24(24), 4365-4374, database is CAplus and MEDLINE.

This study describes a method for the quantification of active ligand surface concentration for bulk-modified hydrogels. Two poly(propylene fumarate-co-ethylene glycol) (P(PF-co-EG)) block copolymers were synthesized with terminal poly(ethylene glycol) (PEG) chains of number average mol. weight 1960 and 5190 g/mol. Hydrogels were synthesized with bulk-modified biotin as a model ligand, making use of a PEG spacer arm with a mol. weight of 3400 g/mol. Bulk concentration of biotin was calculated from the initial concentration of biotin, sol fraction, equilibrium water content, and relative incorporation of the polymers to the hydrogel. Surface concentration of biotin bulk-modified hydrogels was quantified with an enzyme linked immunosorbent assay using mouse monoclonal anti-biotin antibody (IgG), horseradish peroxidase-conjugated anti-mouse IgG, and a chemiluminescent substrate. The larger size of the IgG relative to the mesh size of the hydrogels allowed for the quantification of the active biotin at the surface of the hydrogels. Luminescent imaging was used to qual. show the isolation of the horseradish peroxidase-conjugated antibodies to the surface of the bulk-modified hydrogel. The active biotin ligands at the surface of hydrogels synthesized with terminal PEG chains of 1960 g/mol were at the top 7.2 nm while for those synthesized with terminal PEG chains of 5190 g/mol were at the top 4.4 nm of the bulk-modified hydrogel. The relationship between bulk ligand concentration and the active ligand concentration at the surface was dependent on the hydrogel composition The relative magnitude of the PEG spacer arm of the ligand compared to the PEG block length of the copolymer affected the surface availability of the ligand. The results suggest that steric hindrances caused by mobile PEG chains of the copolymer of mol. weight greater than that of the PEG spacer arm contributed to the decreased surface concentration of ligand. This work relates the bulk concentration of a ligand to its surface concentration, an important parameter for the adhesion, migration, and function of anchorage dependent cells.

Biomaterials published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cruz, Thais R. published the artcileNew dmso-ruthenium catalysts bearing N-heterocyclic carbene ligands for the ring-opening metathesis of norbornene, Synthetic Route of 258278-25-0, the publication is New Journal of Chemistry (2019), 43(16), 6220-6227, database is CAplus.

Novel DMSO Ru(II) complexes of N-heterocyclic carbenes [RuCl₂(S-DMSO)₂(SIMes)] (1), [RuCl₂(S-DMSO)₂(IMes)], (2) [RuCl₂(S-DMSO)₂(SIDip)] (3), and [RuCl₂(S-DMSO)₂(IDip)] (4) were successfully synthesized. The complexes 1–4 were characterized by elemental anal., FTIR, UV-visible, ¹H and ¹³C NMR, and computational studies. The polynorbornene (polyNBE) syntheses via ROMP using the complexes 1–4 as pre-catalysts in the presence of Et diazoacetate (EDA) were evaluated under different [EDA]/[Ru] and [NBE]/[Ru] ratios, temperatures (25 and 50°) and times (5-60 min). Quant. yields of polyNBEs using [NBE]/[EDA]/[Ru] = 5000/28/1 for 10 min at 25° were obtained. The order of magnitude of 10⁵ g mol^-1 for M_n and PDI values ranging from 1.2 to 3.5 were measured by SEC. A study combining exptl. data and computational calculations was performed to elucidate the mechanism of ROMP of NBE mediated by the complexes 1–4 as pre-catalysts. The proposed mechanism suggests the occurrence of a dissociative reaction of the complexes 1–4, losing a DMSO ligand as the 1st step, resulting in a 14-electron species, which reacts with EDA to form the metal-carbene, followed by discoordination of the 2nd DMSO mol. for coordination of NBE.

New Journal of Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem