Category: imidazoles-derivatives

Topcu, Mehmet Ali published the artcileGold Leaching from Copper Anode Slime with 1-Butly-3-Methyl Imidazolium Chloride, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is JOM (2022), 74(5), 2120-2128, database is CAplus.

The aim of this study was to realize gold leaching from copper anode slime (CAS) with ionic liquid treatment. A novel medium, 1-Bu -3-methyl-imidazolium chloride (BmimCl), was used as the leaching reagent. The effects of ionic liquid concentration, temperature, time ,and solid/liquid ratio (S/L) on the leaching efficiency were investigated by Taguchi optimization and ANOVA methods. The results showed that 61.20% of gold leaching efficiency was achieved from CAS, under the optimum leaching conditions which were determined as %80 ionic liquid concentration, 50°C temperature, 1 h time and 1/20 g/mL solid/liquid ratio. The statistical results of the experiments revealed that the effects of each parameter on the gold leaching with BmimCl were in the following order: temperature > time > solid/liquid ratio > ionic liquid concentration

JOM published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C6H12O2, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Talsi, Evgenii P. published the artcileIsoinversion Behavior in the Enantioselective Oxidations of Pyridylmethylthiobenzimidazoles to Chiral Proton Pump Inhibitors on Titanium Salalen Complexes, Formula: C17H18N3NaO3S, the publication is ACS Catalysis (2015), 5(8), 4673-4679, database is CAplus.

The oxidation of two pyridylmethylthiobenzimidazoles to proton pump inhibitors (S)-omeprazole and (R)-lansoprazole, and to their enantiomers, with H₂O₂ is achieved by using chiral titanium salalen complexes as catalysts. The latter ensure high enantioselectivities (up to 96% ee) and efficiencies (TN 200-300), with high sulfoxide yields (up to >96%). The oxidation enantioselectivities vary with temperature in a nonmonotonic manner, demonstrating isoinversion behavior. Maximum enantioselectivity is attained at 273···283 K, which temperature region may be recommended for preparative oxidations Kinetic peculiarities and the oxidation mechanism are discussed.

ACS Catalysis published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C8H11BO2, Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Noumir, A. published the artcileModeling of Isobaric Vapor-Liquid Equilibrium Data for Ionic Liquid-Containing Ternary Systems, HPLC of Formula: 79917-90-1, the publication is Russian Journal of Physical Chemistry A (2022), 96(1), 27-35, database is CAplus.

The object of this work focuses, on the one hand, on the development of the Wilson model for electrolytes, temperature-dependent parameters, and, on the other, tests the model and its accuracy in the prediction of ternary VLE data from few exptl. data points. The exptl. data reported in the literature are used to determine the model parameters proposed in this work for the ethanol-water binary system. The obtained interaction parameters are then used for the correlation and prediction of VLE data for five ternary systems composed of ethanol, water and different ionic liquids with different percentages at atm. pressure (101.32 kPa). We have made the prediction of ternary VLE data, ionic liquid-containing ternary systems, from temperature-dependent binary interaction parameters, adjusted by using some ternary VLE data coupled with binary VLE data. The obtained results are in good agreement with the data reported in the literature.

Russian Journal of Physical Chemistry A published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Keni, Shubham published the artcileBenzimidazole: a propitious scaffold with multifarious therapeutic potential, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is European Journal of Biomedical and Pharmaceutical Sciences (2018), 5(11), 483-488, database is CAplus.

A review is presented on the antibacterial, antifungal, antiviral, antiinflammatory, antihypertensive activity of benzimidazole derivatives as drug. Most of the drugs and pharmacol. active moieties possess heterocyclic ring structure and presence of hetero atoms or groupings evinces privileged specificities in their pharmacol. targets. Among the heterocyclic compounds, benzimidazole has emerged as cardinal construction motif, which plays pivotal role in drug development. Benzimidazole scaffold is known to possess some prime pharmacol. activities like anti- mycobacterial, antimicrobial, anti-viral, antioxidant, antiinflammatory, antihypertensive, etc. This broad spectrum of biol. and biochem. activities was further assisted by the synthetic flexibility of benzimidazole, which permits development of large no of structurally diverse derivatives Therefore, it is necessary to compile the latest information along with earlier information to understand present status of benzimidazole nucleus in drug discovery. In the present review, various derivatives of benzimidazole possessing anti-mycobacterial, antimicrobial, analgesic and antiinflammatory potential are brought into limelight and their activity was elucidated in accordance with structure activity relation studies.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sergievskii, A. V. published the artcileReactions of methyl 4-aminofurazan-3-carboximidate with nitrogen-containing nucleophiles, Synthetic Route of 332026-86-5, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2001), 37(5), 717-720, database is CAplus.

Me 4-aminofurazan-3-carboximidate reacts with aromatic amines and hydrazines to give the corresponding amidines and amidrazones. The reaction of the title compound with o-phenylenediamine yields 3-amino-4-(2-benzimidazoyl)furazan, and with acylhydrazines N²-acyl-4-aminofurazan-3-carbohydrazides are formed. The latter undergo thermal intramol. cyclization with formation of 3-amino-4-(1,2,4-triazol-3-yl)furazan derivatives containing various substituents in position 5 of the triazole ring.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 332026-86-5. 332026-86-5 belongs to imidazoles-derivatives, auxiliary class Oxadiazole,Amine,Benzimidazole, name is 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, and the molecular formula is C10H14O, Synthetic Route of 332026-86-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Shasha published the artcileMerging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening, HPLC of Formula: 913835-63-9, the publication is ACS Catalysis (2022), 12(5), 3201-3210, database is CAplus.

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields.

ACS Catalysis published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, HPLC of Formula: 913835-63-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Vidic, Jasmina published the artcileGold Surface Functionalization and Patterning for Specific Immobilization of Olfactory Receptors Carried by Nanosomes, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Analytical Chemistry (Washington, DC, United States) (2007), 79(9), 3280-3290, database is CAplus and MEDLINE.

There is substantial interest in engineering solid supports to achieve functional immobilization of membrane receptors both for investigation of their biol. function and for the development of novel biosensors. Three simple and practical strategies for immobilization of a human olfactory receptor carried by nanosomes are presented. The basis of the functionalization of solid gold surfaces is a self-assembled monolayer (SAM) containing biotinyl groups. Biotinyl groups are subsequently used to attach neutravidin and then biotinylated monoclonal antibody directed against the receptor to allow its specific grafting. Surface plasmon resonance technique is implemented for real-time monitoring of step-by-step surface functionalization and, in addition, for testing the functional response of immobilized olfactory receptors. The authors show that OR1740 is functional when immobilized via a tag attached to its C-terminus, but not via its N-terminus. Finally, the authors demonstrate that gold surfaces can be patterned by the SAMs tested using microcontact printing. AFM images of immobilized nanosomes onto a patterned surface suggest that small nanosomes flatten and fuse into larger vesicles but do not merge into a continuous layer. The whole study emphasizes the outstanding performances of the BAT/PEGAT SAM, which could be useful for developing on-a-chip sensor formats for membrane receptor investigations and use.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C10H10O2, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dutt, Manesh Chandra published the artcileUse of ninhydrin as a spray reagent for the detection of some basic drugs on thin-layer chromatograms, HPLC of Formula: 2508-72-7, the publication is Journal of Chromatography (1980), 195(1), 133-8, database is CAplus.

In a study aimed at exploring the potential of ninhydrin [485-47-2] to produce colored spots on thin-layer chromatog. plates, a wide variety of colors, on a white background, were produced by 52 of the 56 bases studied. In most instances different colors were produced at each of the selected temperatures (80, 120, and 160°), e.g., with amphetamine sulfate [60-13-9] the colors produced were pink-violet, grey-brown, and red-brown, resp. The response of the compounds to this method varied from 20 μg at room temperature to 1 μg at 160°.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, HPLC of Formula: 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dutt, Manesh Chandra published the artcileIdentification of basic drugs by the thin-layer chromatographic profiles of their ninhydrin complexes, Synthetic Route of 2508-72-7, the publication is Journal of Chromatography (1981), 206(2), 267-77, database is CAplus.

Fifty-two common basic drugs produce various colors when spotted with ninhydrin [485-47-2] on plastic thin-layer plates and heated. When the plate is then developed in a suitable solvent each of the colored spots separates into a variety of addnl. colored spots and patches, the number of which depends on the temperature of heating. The relative intensity and spatial arrangement form a profile that is highly characteristic of the compounds The formation of such profiles was investigated at 100 and 160°C.

Journal of Chromatography published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Narla, Divya published the artcileSimultaneous estimation of aceclofenac and esomeprazole sodium in bulk by RP-HPLC, COA of Formula: C17H18N3NaO3S, the publication is American Journal of PharmTech Research (2016), 6(2), 493-502, database is CAplus.

A simple, accurate, precise and specific RP-HPLC method has been developed for the simultaneous estimation of Aceclofenac and Esomeprazole Sodium in bulk. Chromatog. anal. was carried out on C18 column (250mm × 4.6mm, 5μm). Mobile phase used is a homogenous mixture of ACN: Methanol in the ratio of 50:50 volume/volume The detection was carried out at 285nm. The retention times were found to be 3.00 and 4.41 min for Aceclofenac and Esomeprazole Na resp. Both the drugs showed linearity in the range of 30 – 70mcg/mL. The correlation coefficient was found to be 0.99 and 0.992 for Aceclofenac and Esomeprazole Na resp. The developed method was validated as per ICH guidelines.

American Journal of PharmTech Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, COA of Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem