Category: imidazoles-derivatives

Zhang, Bing published the artcileElectrocatalytic water-splitting for the controllable and sustainable synthesis of deuterated chemicals, Application In Synthesis of 2622-67-5, the publication is Science Bulletin (2021), 66(6), 562-569, database is CAplus.

Tandem water electrolysis for the transformation of universal feedstock to value-added chems. integrated with hydrogen generation and in situ utilization is a promising approach to address the economic challenges of electrochem. hydrogen evolution and storage. Herein, we present the controllable electrocatalytic deuteration of halides using inexpensive and reusable heavy water (D₂O) as a D-source for the preparation of valuable D-labeled chems. and pharmaceuticals under mild conditions. This electrochem. deuteration method with high efficiency and selectivity furnishes a series of D-labeled chems. and pharmaceuticals in high yields with excellent D-incorporation. The reaction efficiency and selectivity, i.e., the precise substitution of deuterium atoms at different halogen positions, can be tuned by varying the applied voltages. The results show the great potential of green and economical electrocatalytic methods for producing value-added fine chems. in addition to hydrogen evolution.

Science Bulletin published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C7H13BrSi, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Feng, Zi-Wei published the artcileStructural dependence on the property of chiral stationary phases derived from chitosan bis(arylcarbamate)-(amide)s, Application of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Carbohydrate Polymers (2017), 301-309, database is CAplus and MEDLINE.

The goal of present study was to study the structural dependence of chitosan derivatives on enantioseparation and mobile phase tolerance of the corresponding chiral packing materials for liquid chromatog. Hence, a series of chitosan bis(arylcarbamate)-(n-pentyl amide)s and the related chiral stationary phases (CSPs) were prepared from chitosans with different mol. weights Because of the H-bond formed via CH₃-π interaction, the CSP bearing Me substituent exhibited higher tolerance than the ones bearing dichloro substituents. The CSP derived from the chitosan bis(3,5-dichlorophenylcarbamate)-(n-pentyl amide) with a higher mol. weight possessed high tolerance to mobile phases, whereas the enantioseparation capability of this CSP was not as good as that of the one prepared from the chitosan derivative with a lower mol. weight Therefore, enantioseparation capability and mobile phase tolerance have to be counterbalanced in designing chiral selectors for the CSPs derived from chitosan bis(arylcarbamate)-(amide)s.

Carbohydrate Polymers published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Application of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lane, Thomas J. published the artcileMetal binding of the benzimidazoles, Related Products of imidazoles-derivatives, the publication is Journal of the American Chemical Society (1960), 2994-7, database is CAplus.

The acid dissociation constants were determined potentiometrically for benzimidazole (I), 2-methylbenzimidazole (II), and 2-ethyl-benzimidazole in solutions of ionic strength 0.16M (NaNO₃) at 4 ± 1, 25 ± 0.1, and 35 ± 0.1°. The enthalpy changes ΔH⁰ were 8.7, 9.8, and 9.3 kcal./mole for the resp. compounds Formation constants were determined for Cu(II) with I by the Bjerrum potentiometric method in solutions of the same ionic strength at the 3 temperatures An upper limit was found for the value of the formation constant of Cu(II) with II at 4°. The formation constants for Cd with I and II were determined by a polarographic method in 50% aqueous EtOH at 25 ± 0.1°. The benzene portion of I appears to hinder coördination with Cu(II). Formation constants for Cu(II) with 2-(hydroxymethyl)benzimidazole and 1-methyl-2-(hydroxymethyl)benzimidazole show that the unsaturated N is the active site in the substituted I.

Journal of the American Chemical Society published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Smith, Leon M. II published the artcileNovel phenylalanine derived diamides as Factor XIa inhibitors, Application In Synthesis of 13682-33-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(2), 472-478, database is CAplus and MEDLINE.

The synthesis, structural activity relationships (SAR), and selectivity profile of a potent series of phenylalanine diamide FXIa inhibitors will be discussed. Exploration of P1 prime and P2 prime groups led to the discovery of compounds with high FXIa affinity, good potency in our clotting assay (aPPT), and high selectivity against a panel of relevant serine proteases as exemplified by compound (I). Compound I demonstrated good in vivo efficacy (EC₅₀ = 2.8 μM) in the rabbit elec. induced carotid arterial thrombosis model (ECAT).

Bioorganic & Medicinal Chemistry Letters published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C10H9NO4S, Application In Synthesis of 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Algul, Oztekin published the artcileSynthesis, characterization and genotoxicity of platinum(II) complexes with substituted benzimidazole ligands, Application In Synthesis of 7467-35-8, the publication is Turkish Journal of Chemistry (2005), 29(6), 607-615, database is CAplus.

Five cis-[Pt(II)Cl₂L_n] complexes with substituted benzimidazole ligands (n = 2, L = 2-ethyl-, 2-benzyl-, 2-phenoxymethyl-, 1-methyl-2-phenyl-benzimidazole; n = 1, L = 1-methyl-2-hydroxymethylbenzimidazole) were synthesized and characterized by elemental anal., and IR and ¹H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds

Turkish Journal of Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Gang-Jian published the artcileNi/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides, Related Products of imidazoles-derivatives, the publication is Tetrahedron Letters (2019), 60(46), 151260, database is CAplus.

A simple and convenient method was developed for the Ni/NHC-catalyzed cross-coupling of Me sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides RS(O)NR¹R² [R = Me, c-hexyl, 4-MeC₆H₄, etc.; R¹ = Et, CH₂CH=CH₂, Bn, etc.; R² = H, Me, Et, etc.; R¹R² = (CH₂)₄, (CH₂)₂O(CH₂)₂, (CH₂)₂S(CH₂)₂, etc.] in moderate to good yields. The method provided the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility.

Tetrahedron Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hamamoto, Hiroshi published the artcileSerum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus, SDS of cas: 359860-27-8, the publication is Nature Communications (2021), 12(1), 6364, database is CAplus and MEDLINE.

Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. For unclear reasons, the antibacterial activity of lysocin E in a mouse systemic infection model is higher than expected from in vitro results, and the in vitro activity is enhanced by addition of bovine serum. Here, we confirm that serum from various species, including humans, increases lysocin E antimicrobial activity, and identify apolipoprotein A-I (ApoA-I) as an enhancing factor. ApoA-I increases the antibacterial activity of lysocin E when added in vitro, and the antibiotic displays reduced activity in ApoA-I gene knockout mice. Binding of ApoA-I to lysocin E is enhanced by lipid II, a cell-wall synthesis precursor found in the bacterial membrane. Thus, the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins and microbial components.

Nature Communications published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Das, Rajesh published the artcileStrategic design of a bifunctional Ag(I)-grafted NHC-MOF for efficient chemical fixation of CO₂ from a dilute gas under ambient conditions, Synthetic Route of 258278-25-0, the publication is Inorganic Chemistry Frontiers (2022), 9(11), 2583-2593, database is CAplus.

The chem. fixation of carbon dioxide into valuable products constitutes a promising step toward reducing the atm. CO₂ concentration Consequently, herein we report the strategic design of a bifunctional catalyst by grafting catalytically active Ag(I) ions onto N-heterocyclic carbene (NHC) sites in a MOF for efficient chem. fixation of CO₂ from a dilute gas to oxazolidinones, bio-relevant commodity chems. Indeed, Ag(I)@MOF-NHC demonstrated excellent catalytic activity for efficient fixation of CO₂ from a dilute gas (CO₂ : N₂ = 13 : 87%) with alkynes to afford valuable chems., oxazolidinones, under RT and atm. pressure (balloon) conditions. The superior activity of the Ag(I) anchored MOF over the individual (AgNO₃ and MOF-NHC) components has been ascribed to the synergistic effect between the CO₂-philic NHC and alkynophilic Ag(I) sites exposed in the 1D channels of the MOF. Furthermore, the Ag(I) anchored MOF showed high recyclability without significant loss of catalytic activity and structural rigidity. Overall, this is a unique demonstration of the utilization of dilute CO₂ under environmentally friendly mild conditions and can pave the way for the development of efficient catalytic systems for sustainable utilization of CO₂ from dilute gases.

Inorganic Chemistry Frontiers published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Park, Tae Jung published the artcileAlignment of SWNTs by protein-ligand interaction of functionalized magnetic particles under low magnetic fields, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Journal of Nanoscience and Nanotechnology (2011), 11(5), 4540-4545, database is CAplus and MEDLINE.

A simple method to controllably align single-walled CNTs (SWNTs) by magnetic particles embedded with superparamagnetic iron oxide as an accelerator under the magnetic field was developed. The functionalization of SWNTs using biotin, interacted with streptavidin-coupled magnetic particles (micro-to-nano in diameter), and layer-by-layer assembly were performed for the alignment of a particular direction onto the clean Si and the Au substrate at very low magnetic forces (0.02-0.89 T) at room temperature The successful alignment of the SWNTs with multi-layer film was observed by SEM and TEM. By changing the orientation and location of the substrates, crossed-networks of SWNTs-magnetic particle complex could easily be fabricated. It is suggested that this approach, which consists of a combination of biol. interaction among streptavidin-biotin and magnetite particles, should be useful for lateral orientation of individual SWNTs with controllable direction.

Journal of Nanoscience and Nanotechnology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sung, Daekyung published the artcileFacile Method for Selective Immobilization of Biomolecules on Plastic Surfaces, HPLC of Formula: 359860-27-8, the publication is Langmuir (2009), 25(19), 11289-11294, database is CAplus and MEDLINE.

A key aspect of biochip and biosensor preparation is optimizing surface attachment of biomols. Here, the authors report a facile approach for selectively immobilizing biomols. on amphiphilic polymer-coated plastic surfaces with anti-biofouling properties. To modify plastic surfaces, the authors synthesized two types of random copolymers by radical polymerization, which consisted of three parts: an anchoring group; a PEG component, which acted as a repellent of nonspecific biomols.; and a functional group, to which biomols. were conjugated. Dodecyl- and benzyl-based copolymers were highly soluble in water, presumably due to the presence of multiple PEG groups, and could easily coat the model plastic surface (polystyrene) in an aqueous environment. The antibiofouling property of each polymer-coated plastic surface was examined by measuring the extent of nonspecific protein adsorption using bovine serum albumin (BSA). Both polymer-coated plastic surfaces showed a very low level of BSA adsorption relative to that of an uncoated plastic surface (control). Finally, the authors showed that streptavidin and antibodies, as representative biomols., could be selectively immobilized on the polymer-coated plastic surfaces imprinted with biotin and protein A, resp., by microcontact printing, exhibiting an intense signal with low background.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C9H11BO4, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem