Category: imidazoles-derivatives

Maji, Ankur published the artcileWell-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Journal of Organic Chemistry (2022), 87(13), 8351-8367, database is CAplus and MEDLINE.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shevtsova, I. I. published the artcileCoordination compounds of copper salts and silver salts with some benzimidazole and benzothiazole derivatives and their antimicrobic properties, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Antibiotiki (Kiev) (1970), 44-8, database is CAplus.

Among 26 coordination compounds studied, 2 complexes of AgNO3 with 2-methylbenzothiazole and 2-(hydroxymethyl)benzothiazole had a high antiinfusorial activity. The action of all compounds on Paramecium caudatum is shown. Four of the complexes prevented mold growth on grains.

Antibiotiki (Kiev) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C7H8BClO2, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Donne-Op den Kelder, G. M. published the artcileQSAR studies on mifentidine and related compounds, Synthetic Route of 13682-33-2, the publication is Quantitative Structure-Activity Relationships (1988), 7(2), 60-71, database is CAplus.

The MNDO semiempirical SCF-MO method was used to calculate charge distributions of a series of histamine H₂-receptor antagonists. The investigated compounds concerned mifentidine analogs, RC₆H₄N:CHNHR¹-4, (R = heterocyclics; R¹ = Me, Et, iso-Pr, Pr). A correlation was found between H₂-antagonistic activity as determined by inhibition of specific [³H]-tiotidine binding to the H₂ receptors of a guinea pig cortex preparation, and the net at. charges of 2 of the atoms in the heterocycle. The binding capacity of the ligand mol. to the receptor was enhanced when the electronic population of atom and the pos. charge on the proton were higher. Assuming that the difference between both charges might effectively serve as a valuable substitute for the H bond-forming capacity of the X-H group, the conclusion can be drawn that this property of the heterocycle plays an important role in the interaction process of the ligand with its H₂-receptor. The obtained regression equation(s) suggest that the monocation (formamidine moiety protonated) is the species related to pharmacol. activity.

Quantitative Structure-Activity Relationships published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, Synthetic Route of 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bakthavatchalam, Balaji published the artcileComparative evaluation on the thermal properties and stability of MWCNT nanofluid with conventional surfactants and ionic liquid, Product Details of C8H15ClN2, the publication is Journal of Thermal Analysis and Calorimetry (2022), 147(1), 393-408, database is CAplus.

Conventional surfactants such as CTAB (cetrimonium bromide), SDS (sodium dodecyl sulfate), SDBS (sodium dodecyl sulfonate) are combined with nanofluids to improve the stability and thermal conductivity of nanofluids. These nanofluids are mainly used for heat transfer applications where heating and cooling are usual courses of action which result in surfactants producing foams and polluting the heat transfer media, affecting the total system performance. Besides, the common surfactant mols. that augment the thermal resistance between the nanoparticles and base fluid also affect the thermophys. properties of the nanofluid. In this paper, [Bmim][Cl] (1-butyl-3-methylimidazolium chloride), a high purity ionic liquid (IL) with higher thermal stability was used to provide a comparative study on the stability and thermal properties with that of the conventional surfactants (CTAB, SDS, SDBS) on multiwalled carbon nanotubes (MWCNT)/propylene glycol (PG) nanofluid. The transient hot-wire based KD2-Pro and zeta potential results demonstrated that the inclusion of ionic liquid improved the thermal conductivity and stability of the formulated nanofluid. However, much like the conventional surfactants, the strong electrostatic repulsive force created by the ionic liquid was found to decrease when the temperature is increased. The outcome demonstrated the most extreme thermal conductivity upgrade of 33.7% at 303 K and maximum dispersion stability of more than one month without any aggregation for the nanofluid containing ionic liquid

Journal of Thermal Analysis and Calorimetry published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Product Details of C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kaboudin, Babak published the artcileA novel and facile route for the synthesis of medetomidine as the α₂-adrenoceptor agonist, HPLC of Formula: 1021949-47-2, the publication is Journal of the Iranian Chemical Society (2017), 14(8), 1735-1739, database is CAplus.

Herein, a novel and facile method for the synthesis of (+/-)-4(5)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole (medetomidine) in a good yield in five steps is reported. The method involves Wittig olefination of the phenylimidazolylketone, followed by a hydrogenation. The Wittig alkenylation reaction provides a convenient step for the synthesis of medetomidine without requiring methylation and dehydration steps, which are problematic processes in the previous methods.

Journal of the Iranian Chemical Society published new progress about 1021949-47-2. 1021949-47-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alkenyl,Benzene, name is 5-(1-(2,3-Dimethylphenyl)vinyl)-1H-imidazole, and the molecular formula is C13H14N2, HPLC of Formula: 1021949-47-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Yoa Jun published the artcileA practical synthesis of 2-butyl-4(5)-chloro-5(4)-hydroxymethyl-1H-imidazole, COA of Formula: C8H13ClN2O, the publication is Synthetic Communications (1993), 23(18), 2623-30, database is CAplus.

A practical process for the synthesis of 2-butyl-4-hydroxymethylimidazole (I, R = H) followed by silylation-chlorination-desilylation to provide chloroimidazole I (R = Cl) in an overall 71% yield has been developed.

Synthetic Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C5H10O2S, COA of Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tanaka, Fujie published the artcileDevelopment of a Small Peptide Tag for Covalent Labeling of Proteins, Category: imidazoles-derivatives, the publication is Bioconjugate Chemistry (2007), 18(4), 1318-1324, database is CAplus and MEDLINE.

A 21-mer peptide that can be used to covalently introduce synthetic mols. into proteins has been developed. Phage-displayed peptide libraries were subjected to reaction-based selection with 1,3-diketones. The peptide was further evolved by addition of a randomized region and reselection for improved binding. The resulting 21-mer peptide had a reactive amino group that formed an enaminone with 1,3-diketone and was used as a tag for labeling of maltose binding protein. Using this peptide tag and 1,3-diketone derivatives, a variety of mols. such as reporter probes and functionalities may be covalently introduced into proteins of interest.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C3H7NO2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia-Alvarez, Ana C. published the artcileSelf-assembled nickel cubanes as oxygen evolution catalysts, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(69), 8608-8611, database is CAplus and MEDLINE.

Ni₄O₄ cubanes [(μ₃-L¹O)NiCl(MeOH)]₄ and [(μ₃-L²O)NiCl(H₂O)]₄ (L¹OH = 1-H-2-benzimidazolylmethanol, L²OH = 1-methyl-2-benzimidazolylmethanol) self-assemble from com. available 1-H- and 1-methyl-2-benzimidazolylmethanol and NiCl₂·6H₂O in high yields under mild conditions. Both complexes were characterised spectroscopically and by X-ray crystallog. The cubanes oxidise water electrocatalytically to dioxygen at neutral pH in aqueous potassium phosphate buffer solutions

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Luo, Ching-Zong published the artcileRh^III-catalyzed C-H activation: a versatile route towards various polycyclic pyridinium salts, Quality Control of 2622-67-5, the publication is Chemistry – A European Journal (2013), 19(42), 14181-14186, database is CAplus and MEDLINE.

An efficient and convenient method for the synthesis of highly substituted polycyclic pyridinium salts from the reaction of various 2-aryl-pyridines and 2-aryl-sp²-nitrogen-atom-containing heterocycles with alkynes through rhodium(III)-catalyzed C-H activation and annulation under an O₂ atmosphere is described. A possible mechanism that involves the chelation-assisted C-H activation of the 2-aryl-pyridine substrate, insertion of the alkyne, and reductive elimination is proposed. This mechanism was supported by the isolation of a five-membered rhodacycle (I’). In addition, kinetic isotope studies were performed to understand the intimate reaction mechanism.

Chemistry – A European Journal published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Choi, Jae-Hak published the artcilePatterned immobilization of biomolecules by using ion irradiation-induced graft polymerization, Formula: C18H34N4O5S, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2009), 47(22), 6124-6134, database is CAplus.

A new method for biomol. patterning based on ion irradiation-induced graft polymerization was demonstrated in this study. Ion irradiation on a polymer surface resulted in the formation of active species, which was further used for surface-initiated graft polymerization of acrylic acid. The results of the grafting study revealed that the surface graft polymerization using 20 vol % of acrylic acid on the poly(tetrafluoroethylene) (PTFE) film irradiated at the fluence of 1 × 10¹⁵ ions/cm² for 12 h was the optimum graft polymerization condition to achieve the maximum grafting degree. The results of the fluorescence microscopy also revealed that the optimum fluence to achieve the maximum fluorescence intensity was 1 × 10¹⁵ ions/cm². The grafting of acrylic acid on the PTFE surfaces was confirmed by a fluorescence labeling method. The grafted PTFE films were used for the immobilization of amine-functionalized p-DNA, followed by hybridization with fluorescently tagged c-DNA. Biotin-amine was also immobilized on the acrylic acid grafted PTFE surfaces. Successful biotin-specific binding of streptavidin further confirmed the potential of this strategy for patterning of various biomols. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6124-6134, 2009.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem