Category: imidazoles-derivatives

Kankate, Rani S. published the artcileSynthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives, HPLC of Formula: 7467-35-8, the publication is Oriental Journal of Chemistry (2014), 30(4), 1855-1863, database is CAplus.

A series of [(benzimidazolylalkyl)piperazinyl]phenylmethanone derivatives I [R¹ = H, Cl, R² = H, Me, Et, R³ = H, Me, Ph] was synthesized by microwave irradiation and evaluated for in vitro antifungal activity using ketoconazole as the standard Among the tested compounds, benzimidazole derivatives with an N-1 Me, a C2 asym. center and C5 chlorine substitution showed good antifungal activity against the C. albicans strain using the turbidimetric method.

Oriental Journal of Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileMicrowave assisted synthesis, antifungal evaluation and molecular docking of benzimidazole derivatives, Application In Synthesis of 7467-35-8, the publication is Pharma Chemica (2014), 6(6), 396-405/1-396-405/10, 10 pp., database is CAplus.

A novel series of benzimidazole derivatives, carrying biphenyl carbonyl piperazine moiety based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14 α-demethylase (CYP51) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro antifungal activity against Candida albicans revealed activity for many compounds as comparable to that of ketoconazole.

Pharma Chemica published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jares-Erijman, E. published the artcileImaging quantum dots switched on and off by photochromic fluorescence resonance energy transfer (pcFRET), Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Molecular Crystals and Liquid Crystals (2005), 257-265, database is CAplus.

The reversible modulation of the emission of CdSe/ZnS semiconductor nanocrystals (quantum dots) was achieved by binding photochromic diheteroarylethenes and switchable acceptors for fluorescence resonance energy transfer. A biotinylated diheteroarylethene derivative was bound to quantum dots bearing conjugated streptavidin, leading to an intensity decrease as a consequence of energy transfer to the closed form of the acceptor. Interconversion between the open and closed forms by irradiation with 365 and 546 nm light enabled deactivation and activation, resp., of the FRET process with a corresponding modulation of quantum dot emission, observed both in solution and by sequential wide-field imaging.

Molecular Crystals and Liquid Crystals published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kurdziel, K. published the artcileCoordination properties of 4(5)-hydroxymethylimidazole and 4(5)-hydroxymethyl-5(4)-methylimidazole towards cobalt(II) ions, Safety of (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Journal of Coordination Chemistry (2007), 60(8), 877-889, database is CAplus.

Two new complexes of imidazole alcs., 4-hydroxymethylimidazole (4-CH₂OHim) and 4-hydroxymethyl-5-methylimidazole (4-CH₂OH-5-CH₃i.m.), with Co(II), [CoL₂(H₂O)₂](NO₃)₂ were obtained. These compounds were characterized through single x-ray diffraction studies, spectroscopic (IR, far-IR, UV-visible-NIR) and magnetic measurements. The hydroxymethylimidazole ligands are bidentate, coordinating the heterocyclic ring through pyridine-like N atoms and the O atom of the hydroxymethyl group (chromophore CoN₂O₄). The Co(II) coordination polyhedra are distorted octahedrons, with the equatorial plane defined by the 4-CH₂OHim (or 4-CH2OH-5-CH₃i.m.) bidentate ligands and two H₂O mols. occupying axial (trans) positions. Formation of successive Co(II) complexes with 4-CH₂OH-5-CH₃i.m. in aqueous solution was followed quant. by potentiometry.

Journal of Coordination Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Safety of (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Borcard, Francoise published the artcileCovalent Cell Surface Functionalization of Human Fetal Osteoblasts for Tissue Engineering, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Bioconjugate Chemistry (2011), 22(7), 1422-1432, database is CAplus and MEDLINE.

The chem. functionalization of cell-surface proteins of human primary fetal bone cells with hydrophilic bioorthogonal intermediates was investigated. Toward this goal, chem. pathways were developed for click reaction-mediated coupling of alkyne derivatives with cellular azido-expressing proteins. The incorporation via a tetraethylene glycol linker of a dipeptide and a reporter biotin allowed the proof of concept for the introduction of cell-specific peptide ligands and allowed us to follow the reaction in living cells. Tuning the conditions of the click reaction resulted in chem. functionalization of living human fetal osteoblasts with excellent cell survival.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Yoa Jun published the artcileA practical synthesis of 2-butyl-4(5)-chloro-5(4)-hydroxymethyl-1H-imidazole, COA of Formula: C8H13ClN2O, the publication is Synthetic Communications (1993), 23(18), 2623-30, database is CAplus.

A practical process for the synthesis of 2-butyl-4-hydroxymethylimidazole (I, R = H) followed by silylation-chlorination-desilylation to provide chloroimidazole I (R = Cl) in an overall 71% yield has been developed.

Synthetic Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C5H10O2S, COA of Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tanaka, Fujie published the artcileDevelopment of a Small Peptide Tag for Covalent Labeling of Proteins, Category: imidazoles-derivatives, the publication is Bioconjugate Chemistry (2007), 18(4), 1318-1324, database is CAplus and MEDLINE.

A 21-mer peptide that can be used to covalently introduce synthetic mols. into proteins has been developed. Phage-displayed peptide libraries were subjected to reaction-based selection with 1,3-diketones. The peptide was further evolved by addition of a randomized region and reselection for improved binding. The resulting 21-mer peptide had a reactive amino group that formed an enaminone with 1,3-diketone and was used as a tag for labeling of maltose binding protein. Using this peptide tag and 1,3-diketone derivatives, a variety of mols. such as reporter probes and functionalities may be covalently introduced into proteins of interest.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C3H7NO2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia-Alvarez, Ana C. published the artcileSelf-assembled nickel cubanes as oxygen evolution catalysts, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(69), 8608-8611, database is CAplus and MEDLINE.

Ni₄O₄ cubanes [(μ₃-L¹O)NiCl(MeOH)]₄ and [(μ₃-L²O)NiCl(H₂O)]₄ (L¹OH = 1-H-2-benzimidazolylmethanol, L²OH = 1-methyl-2-benzimidazolylmethanol) self-assemble from com. available 1-H- and 1-methyl-2-benzimidazolylmethanol and NiCl₂·6H₂O in high yields under mild conditions. Both complexes were characterised spectroscopically and by X-ray crystallog. The cubanes oxidise water electrocatalytically to dioxygen at neutral pH in aqueous potassium phosphate buffer solutions

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Luo, Ching-Zong published the artcileRh^III-catalyzed C-H activation: a versatile route towards various polycyclic pyridinium salts, Quality Control of 2622-67-5, the publication is Chemistry – A European Journal (2013), 19(42), 14181-14186, database is CAplus and MEDLINE.

An efficient and convenient method for the synthesis of highly substituted polycyclic pyridinium salts from the reaction of various 2-aryl-pyridines and 2-aryl-sp²-nitrogen-atom-containing heterocycles with alkynes through rhodium(III)-catalyzed C-H activation and annulation under an O₂ atmosphere is described. A possible mechanism that involves the chelation-assisted C-H activation of the 2-aryl-pyridine substrate, insertion of the alkyne, and reductive elimination is proposed. This mechanism was supported by the isolation of a five-membered rhodacycle (I’). In addition, kinetic isotope studies were performed to understand the intimate reaction mechanism.

Chemistry – A European Journal published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Choi, Jae-Hak published the artcilePatterned immobilization of biomolecules by using ion irradiation-induced graft polymerization, Formula: C18H34N4O5S, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2009), 47(22), 6124-6134, database is CAplus.

A new method for biomol. patterning based on ion irradiation-induced graft polymerization was demonstrated in this study. Ion irradiation on a polymer surface resulted in the formation of active species, which was further used for surface-initiated graft polymerization of acrylic acid. The results of the grafting study revealed that the surface graft polymerization using 20 vol % of acrylic acid on the poly(tetrafluoroethylene) (PTFE) film irradiated at the fluence of 1 × 10¹⁵ ions/cm² for 12 h was the optimum graft polymerization condition to achieve the maximum grafting degree. The results of the fluorescence microscopy also revealed that the optimum fluence to achieve the maximum fluorescence intensity was 1 × 10¹⁵ ions/cm². The grafting of acrylic acid on the PTFE surfaces was confirmed by a fluorescence labeling method. The grafted PTFE films were used for the immobilization of amine-functionalized p-DNA, followed by hybridization with fluorescently tagged c-DNA. Biotin-amine was also immobilized on the acrylic acid grafted PTFE surfaces. Successful biotin-specific binding of streptavidin further confirmed the potential of this strategy for patterning of various biomols. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6124-6134, 2009.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem