Category: imidazoles-derivatives

Kim, Dong-Ki’s team published research in Polymers for Advanced Technologies in 22 | CAS: 359860-27-8

Polymers for Advanced Technologies published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Kim, Dong-Ki published the artcileMicropatterning of proteins on ion beam-induced poly(acrylic acid)-grafted polyethylene film, SDS of cas: 359860-27-8, the publication is Polymers for Advanced Technologies (2011), 22(12), 1989-1992, database is CAplus.

Micropatterns of proteins were created by using patterned ion beam irradiation onto a polyethylene film and graft polymerization of acrylic acid. Acrylic acid was selectively graft polymerized on the irradiated regions. The results of the grafting study revealed that the optimum fluence to achieve the maximum grafting degree was 1 × 1015 ions/cm2. Biotin was covalently immobilized on the grafted regions of the polyethylene film. Protein patterning was achieved through specific binding of biotin and streptavidin. The resolved protein patterns with the maximum fluorescence intensity were achieved on the poly(acrylic acid) (PAA)-grafted polyethylene films prepared at the fluence of 1 × 1015 ions/cm2. This method can be used for patterning of various biomols. and for further biol. applications.

Polymers for Advanced Technologies published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dai, Yu-ting’s team published research in Fenxi Ceshi Jishu Yu Yiqi in 19 | CAS: 161796-78-7

Fenxi Ceshi Jishu Yu Yiqi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Dai, Yu-ting published the artcileMicroanalysis for flame atomic absorption spectroscopy in determination of high content sodium, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Fenxi Ceshi Jishu Yu Yiqi (2013), 19(1), 24-27, database is CAplus.

A new method using Flame Atomic Absorption Spectroscopy (FAAS) and Microanal. to determine high content sodium is developed. The developed method involves the choosing of suitable absorption line of sodium, the optimization of testing parameters and the evaluation of the linearity of the method. The linearity is 0-5 mg/L, the detection limit is 0.02 mg/L and the repeatability is 0.5% RSD. By comparing the measured sodium content with its truth value in some known organic and inorganic compounds, the absolute error is less than 0.3%, the relative error is less than 1%, and the recovery is 99.2%-100.6%.

Fenxi Ceshi Jishu Yu Yiqi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hosadurga, K. Keerthy’s team published research in PLoS One in 9 | CAS: 79047-41-9

PLoS One published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, SDS of cas: 79047-41-9.

Hosadurga, K. Keerthy published the artcileSynthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines, SDS of cas: 79047-41-9, the publication is PLoS One (2014), 9(9), e107118/1-e107118/11, 11 pp., database is CAplus and MEDLINE.

The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles I (R1 = 3-O2NC6H4, 4-BrC6H4, 1H-indol-3-yl, etc.) from alcs., malanonitrile and 2-naphthalenol is reported. Addnl. chromenecarbonitriles from resorcinol and 4-hydroxy-2-chromenones were also reported. These novel 2-amino-chromene-3-carbonitriles showed cytotoxicity in human acute myeloid leukemia (AML) cell lines. Compound I (R1 = 2,6-Cl2C6H3) was found to be the most bioactive, decreasing growth and increasing apoptosis of AML cells and moreover, it (at a concentration of 5 μM) increased the G2/M and sub-G1 (apoptosis) phases of AML cells and when the AML cells were treated with this compound it exhibited decreased levels of Bcl-2 and increased levels of caspase-9. In silico mol. interaction anal. showed that this compound shared a similar global binding motif with navitoclax (another small mol. that binds Bcl-2), however it occupies a smaller volume within the P2 hot spot of Bcl-2. The intermol. π-stacking interaction, direct electrostatic interactions, and docking energy predicted for I (R1 = 2,6-Cl2C6H3) in complex with Bcl-2 suggest a strong affinity of the complex, rendering it as a promising Bcl-2 inhibitor for evaluation as a new anticancer agent.

PLoS One published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, SDS of cas: 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jadhvar, Suresh C. et al. published their research in American Journal of PharmTech Research in 2015 | CAS: 478935-29-4

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 478935-29-4

Synthesis and evaluation of anticancer activity of some new 3-aminoalkylated indole derivatives was written by Jadhvar, Suresh C.;Kasraliker, Hanmant M.;Bhusare, Sudhakar R.. And the article was included in American Journal of PharmTech Research in 2015.Application of 478935-29-4 The following contents are mentioned in the article:

An effective and economical protocol was developed for the synthesis of 3-substituted indoles by one-pot three-component coupling reaction of a substituted salicylaldehyde, N-methylaniline and indole using [Hmim] HSO4 as a catalyst. All the synthesized derivatives were evaluated for inhibition of cancer cell. The initial assays indicated that some of the newly synthesized compounds displayed significantly good inhibition activities against human breast cancer cell (MCF7), cell lines compared with the control (Adriamysin), which might be developed as novel lead scaffold for potential anticancer agents. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yu, Dan et al. published their research in Gongye Cuihua in 2009 | CAS: 478935-29-4

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 478935-29-4

Synthesis of diethyl maleate catalyzed by acid functionalized ionic liquids was written by Yu, Dan;Guo, Hongyun. And the article was included in Gongye Cuihua in 2009.Reference of 478935-29-4 The following contents are mentioned in the article:

Di-Et maleate was obtained by a reaction of maleic anhydride and anhydrous ethanol in the presence of an ionic liquid [i.e., TEAPS sulfate, N,N,N-triethyl-3-sulfo-1-propanaminium sulfate (1:1)]. Factors influencing the product formation were confirmed and the above-mentioned Di-Et maleate [i.e., (2Z)-2-butenedioic acid 1,4-di-Et ester, 99% yield] was obtained under the following reaction conditions : n(maleic anhydride) : n(ethanol) = 1:4, dosage of ionic liquid = 20% (wt) of maleic anhydride, cyclohexane as water carrier, 115°, reflux and water segregation for 4 h. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Reference of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tay, Nicholas E. S. et al. published their research in Journal of the American Chemical Society in 2017 | CAS: 870837-70-0

4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Category: imidazoles-derivatives

Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis was written by Tay, Nicholas E. S.;Nicewicz, David A.. And the article was included in Journal of the American Chemical Society in 2017.Category: imidazoles-derivatives The following contents are mentioned in the article:

Nucleophilic aromatic substitution (SNAr) is a direct method for arene functionalization; however, it can be hampered by low reactivity of arene substrates and their availability. Herein we describe a cation radical-accelerated nucleophilic aromatic substitution using methoxy- and benzyloxy-groups as nucleofuges. In particular, lignin-derived aromatics containing guaiacol and veratrole motifs were competent substrates for functionalization. We also demonstrate an example of site-selective substitutive oxygenation with trifluoroethanol to afford the desired trifluoromethylaryl ether. This study involved multiple reactions and reactants, such as 4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0Category: imidazoles-derivatives).

4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gong, D. et al. published their research in Asian Journal of Chemistry in 2010 | CAS: 478935-29-4

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 478935-29-4

Regioselectivity for nitrochlorobenzene preparation over imidazolium ionic liquids media using nitric acid was written by Gong, D.;Peng, X.;Sun, Z.. And the article was included in Asian Journal of Chemistry in 2010.Related Products of 478935-29-4 The following contents are mentioned in the article:

Nitrochlorobenzene was regioselectively prepared over imidazolium ionic liquids media by using HNO3 as nitrating agent. A variety of ionic liquids, [Hmim]HSO4, [Hmim]NO3 and [Hmim]CF3CO2 (Hmim = 1-methylimidazolium) were prepared for the improvement of regioselectivity in preparation of mononitrochlobenzene isomers. A high amount of para isomer was achieved when employing [Hmim]HSO4. Ionic liquids were conveniently reused for five times by filtration with excellent yield of mono-nitration products and para-selectivity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Horwitz, Steven M. et al. published their research in Journal of the National Comprehensive Cancer Network in 2022 | CAS: 16506-27-7

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C16H21Cl2N3O2

T-cell lymphomas, version 2.2022 was written by Horwitz, Steven M.;Ansell, Stephen;Ai, Weiyun Z.;Barnes, Jeffrey;Barta, Stefan K.;Brammer, Jonathan;Clemens, Mark W.;Dogan, Ahmet;Foss, Francine;Ghione, Paola;Goodman, Aaron M.;Guitart, Joan;Halwani, Ahmad;Haverkos, Bradley M.;Hoppe, Richard T.;Jacobsen, Eric;Jagadeesh, Deepa;Jones, Allison;Kallam, Avyakta;Kim, Youn H.;Kumar, Kiran;Mehta-Shah, Neha;Olsen, Elise A.;Rajguru, Saurabh A.;Rozati, Sima;Said, Jonathan;Shaver, Aaron;Shea, Lauren;Shinohara, Michi M.;Sokol, Lubomir;Torres-Cabala, Carlos;Wilcox, Ryan;Wu, Peggy;Zain, Jasmine;Dwyer, Mary;Sundar, Hema. And the article was included in Journal of the National Comprehensive Cancer Network in 2022.Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoproliferative disorders arising from mature T cells, accounting for about 10% of non-Hodgkin lymphomas. PTCL-not otherwise specified is the most common subtype, followed by angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, anaplastic lymphoma kinase-pos., anaplastic large cell lymphoma, anaplastic lymphoma kinase-neg., and enteropathy-associated T-cell lymphoma. This discussion section focuses on the diagnosis and treatment of PTCLs as outlined in the NCCN Guidelines for T-Cell Lymphomas. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fraga-Dubreuil, Joan et al. published their research in Catalysis Communications in 2002 | CAS: 478935-29-4

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 478935-29-4

Catalyzed esterifications in room temperature ionic liquids with acidic counteranion as recyclable reaction media was written by Fraga-Dubreuil, Joan;Bourahla, Khadidja;Rahmouni, Mustapha;Bazureau, Jean Pierre;Hamelin, Jack. And the article was included in Catalysis Communications in 2002.Product Details of 478935-29-4 The following contents are mentioned in the article:

Esterification reactions of acetic acid, methoxyacetic acid and methylmalonic acid with neo-pentanol, hexanol, heptanol and decanol have been investigated in three ionic liquids with hydrogen sulfate, dihydrogen phosphate as counteranions and also two ionic liquids modified with HPF6 as catalyst. The nature of both the counteranion and cation influence the behavior of the catalyst. Good yields and high selectivities were obtained and all the produced esters could be easily recovered due to their immiscibility with the ionic liquid as green reaction medium. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Product Details of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Soh, Chai Hoon et al. published their research in Journal of Combinatorial Chemistry in 2008 | CAS: 160072-56-0

4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 160072-56-0

An Efficient and Expeditious Synthesis of Di- and Monosubstituted 2-Aminoimidazoles was written by Soh, Chai Hoon;Chui, Wai Keung;Lam, Yulin. And the article was included in Journal of Combinatorial Chemistry in 2008.Product Details of 160072-56-0 The following contents are mentioned in the article:

A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles. The two-step reaction involves the synthesis of N-(1H-imidazol-2-yl)acetamides from readily available α-haloketones and N-acetylguanidine, followed by deacetylation. Significant rate enhancement was observed for both steps of the protocol, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures. A representative set of di- and monosubstituted 2-aminoimidazoles was prepared using com. available parallel reactors. This study involved multiple reactions and reactants, such as 4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0Product Details of 160072-56-0).

4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 160072-56-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem