Category: imidazoles-derivatives

Synthesis and proton NMR spectra of 2-heteroaryl-substituted imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines was written by Yutilov, Yu. M.;Shcherbina, L. I.;Efremenko, A. F.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1989.HPLC of Formula: 52538-09-7 The following contents are mentioned in the article:

The title compounds were prepared by oxidation of mixtures of 2,3- or 3,4-pyridinediamines with heterocycles containing an active Me group in the presence of S. Other methods involved cyclization of pyridinediamines with picoline N-oxides and 2-pyridinethiocarboxanilides and the intramol. oxidative cyclization of N⁴-(2-pyridylmethyl)-3,4-pyridinediamine. In most cases, the yield was â‰?0%. The NMR spectra of 2-pyridylimidazopyridines were examined This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7HPLC of Formula: 52538-09-7).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 52538-09-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxidation of benzylic alcohols to their corresponding carbonyl compounds using ceric ammonium nitrate (CAN)/bronsted acidic ionic liquid was written by Hajipour, A. R.;Khazdooz, L.;Ruoho, A. E.. And the article was included in Journal of the Iranian Chemical Society in 2011.Synthetic Route of C10H20N2O4S The following contents are mentioned in the article:

A chemoselective and efficient procedure for the oxidation of alcs. to the corresponding carbonyl compounds is reported using ceric ammonium nitrate in the presence of 3-hexyl-1-methylimidazolium hydrogen sulfate as Bronsted acidic ionic liquid ([Hmim]HSO₄) as the solvent under mild conditions. The use of non-toxic and inexpensive materials, straightforward procedure, short reaction times and good yields of the products are the major advantages of this method. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Synthetic Route of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Synthetic Route of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Biginelli reaction starting directly from alcohols was written by Garima;Srivastava, Vishnu P.;Yadav, Lal Dhar S.. And the article was included in Tetrahedron Letters in 2010.Computed Properties of C10H20N2O4S The following contents are mentioned in the article:

An efficient of one-pot oxidative access to 3,4-dihydropyrimidin-2-(1H)-ones directly from aromatic alcs. under mild conditions is reported. The protocol involves 1-methylimidazolium hydrogen sulfate [Hmim]HSO₄ catalyzed oxidation of aromatic alcs. to aromatic aldehydes with NaNO₃ followed by their cyclocondensation with 1,3-dicarbonyl compounds and urea in the same reaction vessel at 80 °C within 2-4 h to afford 3,4-dihydropyrimidin-2-(1H)-ones in 55-97% overall yields. Thus, the present work utilizing alcs. instead of aldehyde in Biginelli reaction is a valid and green alternative to the classical synthesis of 3,4-dihydropyrimidin-2-(1H)-ones. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Computed Properties of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Computed Properties of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of aethylparabenum catalyzed by task-specific acidic ionic liquid was written by Tan, Feng;Hu, Rong;Yang, Xue-jun;Li, Jun-yang. And the article was included in Xinan Minzu Daxue Xuebao, Ziran Kexueban in 2008.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

P-hydroxybenzoic acid and anhydrous ethanol are used to synthesize aethylparabenum with novel Bronsted activated [Hmim]HSO₄ as the catalyst. The influences of the reaction period, the mole ratio between alc. and acid, and the amount of ionic fluid on the ester yield were investigated. The optimized reaction condition is confirmed, according to which the reaction period should be 2.5 h, the mole ratio between alc. and acid should be 1:1.5, and the amount of ionic fluid should be 3 mL. Under this optimized condition, the ester yield could achieve 81.5%, and the ionic fluid could be used for 5 times repeatedly without any change of its catalytic efficiency. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Treatment strategy for relapsed/refractory mantle cell lymphoma was written by Ishizawa, Kenichi. And the article was included in Ketsueki Naika in 2021.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

A review. According to Japanese data, the median age of onset is around 60 years, and the male-female ratio is 2:1 or higher, which is more common among males. This paper discusses treatment strategy for relapsed/refractory mantle cell lymphoma. Mantle cell lymphoma, its treatment options such as immunochemotherapy, mol.-targeted drug, and cell therapy were discussed. Also, discusses medical treatment effect after the first recurrence in young people, Treatment policy and future prospects. Currently, the combination therapy of various mol.-targeted drugs is being investigated, but the development is progressing with the ibrutinib and venetoclax combination therapy. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

C-N-Cyclometalated Platinum(II) Complexes with Sterically Demanding 1,2-Diarylimidazole Ligands was written by Micksch, Maik;Tenne, Mario;Strassner, Thomas. And the article was included in Organometallics in 2014.Reference of 914306-50-6 The following contents are mentioned in the article:

Authors describe the synthesis, characterization, and photophys. properties of 12 neutral cyclometalated platinum(II) complexes with sterically demanding 1,2-diarylimidazole ligands and β-diketonate ancillary ligands. All complexes are photophys. active emitting in the blue-green to red region (490-590 nm) of the spectrum with quantum yields up to 58%, measured in poly(Me methacrylate) (PMMA) at room temperature The steric demand of the imidazole ligand as well as of the β-diketonate ligand shows a significant effect on the quantum yield but not on the emission wavelength. These can be tuned by changing the substituents at the C-2 Ph group of the imidazole ligand. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Reference of 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rabeprazole: A comprehensive profile. was written by Bakheit, Ahmed H;Al-Kahtani, Hamad M;Albraiki, Salem. And the article was included in Profiles of drug substances, excipients, and related methodology in 2021.Reference of 117976-90-6 The following contents are mentioned in the article:

Rabeprazole belongs to the class of anti-secretory drugs, with benzimidazoles substitution. These drugs induce gastric acid secretion through precise inhibition of the enzyme H⁺/K⁺-ATPase (acid or proton pump). This effect helps to treat and prevent conditions in which gastric acid directly aggravates symptoms such as duodenal and gastric ulcers. This chapter includes a comprehensive review of rabeprazole in terms of nomenclature, its physical-chemical properties, methods of preparation and ADME profiles. In addition, the chapter also includes a review of several methods for analysis of rebeprazole in its dosage forms and biological fluids. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Reference of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hydrothermal synthesis, crystal structures, and photoluminescent properties of two cadmium(II) coordination polymers derived from dicarboxylates and N-donor ligands was written by Xu, Jiakun;Sun, Xiaochun;Ju, Caixia;Yang, Lirong;Bi, Caifeng;Sun, Mi. And the article was included in Journal of Coordination Chemistry in 2013.Product Details of 1374155-84-6 The following contents are mentioned in the article:

Two metal coordination polymers, [Cd(ipa)(L₁)(H₂O)]_n (1) and [Cd(ipa)(L₂)]_n (2) [H₂ipa = isophthalic acid, L₁ = 3,5-bis(imidazol-1-yl)pyridine and L₂ = 3,5-bis(benzoimidazol-1-yl)pyridine], were synthesized and structurally characterized by IR, elemental anal., XRD, and x-ray single-crystal diffraction. Complex 1 shows a 2-fold cds topol. net and 2 features a 3-dimensional pcu topol. net. Luminescent properties of 1 and 2 were studied in the solid state at room temperature This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Product Details of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Product Details of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Indirect electrochemistry oxidation of alcohol to aldehyde in ionic liquid was written by Zhao, Xin-hua;Jiang, Xiao-min;Xie, Jiao. And the article was included in Guangzhou Huagong in 2013.Name: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

The indirect electrochem. oxidation of alc. could be carried out in the protonic ionic liquid methylimidazolium hydrogen sulfate with high selectivity-and current efficiency. The reaction consumed alc. and produced the corresponding aldehyde with the co-product of hydrogen gas in the electrochem. oxidation of alc. Further more, the corresponding carbonyl products could be separated from the electrolyte solution by the refluxing method, and the electrolyte solution could be recycled without apparent decrease in activity. Thus, this approach avoided the problematic by products and separation difficulty in the preparation of the short chain aliphatic aldehydes. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Name: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Name: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014 was written by Brodney, Michael A.;Auperin, David D.;Becker, Stacey L.;Bronk, Brian S.;Brown, Tracy M.;Coffman, Karen J.;Finley, James E.;Hicks, Carol D.;Karmilowicz, Michael J.;Lanz, Thomas A.;Liston, Dane;Liu, Xingrong;Martin, Barbara-Anne;Nelson, Robert B.;Nolan, Charles E.;Oborski, Christine E.;Parker, Christine P.;Richter, Karl E. G.;Pozdnyakov, Nikolay;Sahagan, Barbara G.;Schachter, Joel B.;Sokolowski, Sharon A.;Tate, Barbara;Wood, Douglas E.;Wood, Kathleen M.;Van Deusen, Jeffrey W.;Zhang, Lei. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate The following contents are mentioned in the article:

A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding Ph acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with robust central efficacy. The reduction of brain Aβ in guinea pigs in the absence of changes in B-cells suggested a potential therapeutic index with respect to APP processing compared with biomarkers of notch related toxicity. Optimization of the FTOC to plasma concentrations at the brain Aβ EC₅₀ lead to the identification of compound I (PF-3084014) which was selected for clin. development. This study involved multiple reactions and reactants, such as Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate).

Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Safety of Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem