Category: imidazoles-derivatives

Preparation of imidazolium ionic liquids and their catalytic activity in the synthesis of β-enaminones was written by Yin, Wanxiang;Li, Runsheng;Long, Yulin;Li, Ming;Yang, Jun. And the article was included in Jinan Daxue Xuebao, Ziran Kexue Yu Yixueban in 2010.Recommanded Product: 478935-29-4 The following contents are mentioned in the article:

A series of imidazolium ionic liquids ([Hmim]⁺) with different anions were prepared and the catalytic performance of these catalysts for the synthesis of β-enaminones were investigated. The results showed that these [Hmim]⁺-type ionic liquids exhibited excellent activity; [Hmim]BF₄ had the best catalytic performance and had a yield of 96% after 10 min. [Hmim]BF₄ as a catalyst has been used for the synthesis of different β-enaminones and most of the reactions can proceed smoothly. [Hmim]BF₄ was reused five times without considerable loss of activity and had a yield of 89% after 10 min reaction. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Recommanded Product: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development of pharmacists’ work support system using vibrational spectroscopy was written by Moriyama, Kei. And the article was included in Kagaku Kogyo in 2020.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:

This paper focuses on application of Raman spectroscopy in development of device for drug identification useful in prescription drug preparation process or consultation process with patients with pre-prescribed medicines. First, the authors developed a Raman spectra database of 210 common tablets, and then, 46 tablets were analyzed with Raman spectroscopy and collated with the database to obtain a quality index. Also, addnl. use of near-IR spectroscopy was investigated. The results showed that tablets can be identified non-destructively by measuring the Raman spectrum, and the accuracy was increased with the combinational use of near-IR spectra. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Clean synthesis of adipic acid by catalytic oxidation of cyclohexene in acidic ionic liquid was written by Wang, Xiaodan;Cui, Tianfang;Yu, Xiulan. And the article was included in Shenyang Huagong Daxue Xuebao in 2012.Related Products of 478935-29-4 The following contents are mentioned in the article:

Without any organic solvent and halide, oxidation of cyclohexene to adipic acid with aqueous 30% hydrogen peroxide catalyzed by tungstic acid/acidic ionic liquids was carried out. When the molar ratio of cyclohexene, tungstic acid, N-methylimidazolium hydrosulfate ([HMM]HSO₄) and hydrogen peroxide was 50:1:5:220 ([HMM]HSO₄, 10 mmol), the isolated yield of adipic acid could reach 90.5% for 7.5 h under reflux temperature Such yield was the same or better than that obtained from the present research. The catalyst was cheap, easily prepared and environment friendly, and it could be recycled easily with no loss of the activity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators was written by Bischoff, Francois;Berthelot, Didier;De Cleyn, Michel;MacDonald, Gregor;Minne, Garrett;Oehlrich, Daniel;Pieters, Serge;Surkyn, Michel;Trabanco, Andres A.;Tresadern, Gary;Van Brandt, Sven;Velter, Ingrid;Zaja, Mirko;Borghys, Herman;Masungi, Chantal;Mercken, Marc;Gijsen, Harrie J. M.. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 1194374-75-8 The following contents are mentioned in the article:

The design and the synthesis of several chem. subclasses of imidazole containing γ-secretase modulators (GSMs) is described. Conformational restriction of an aminopyridone into bicyclic pyridone isosteres has led to compounds with high in vitro and in vivo potency. This has resulted in the identification of benzimidazole I as a GSM with low nanomolar potency in vitro. In mouse, rat, and dog, this compound displayed the typical γ-secretase modulatory profile by lowering Aβ42 and Aβ40 levels combined with an especially pronounced increase in Aβ38 and Aβ37 levels while leaving the total levels of amyloid peptides unchanged. This study involved multiple reactions and reactants, such as 8-Bromo-2-methylimidazo[1,2-a]pyridine (cas: 1194374-75-8Recommanded Product: 1194374-75-8).

8-Bromo-2-methylimidazo[1,2-a]pyridine (cas: 1194374-75-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1194374-75-8

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brentuximab vedotin in combination with bendamustine in pediatric patients or young adults with relapsed or refractory Hodgkin lymphoma was written by Vinti, Luciana;Pagliara, Daria;Buffardi, Salvatore;Di Ruscio, Valentina;Stocchi, Francesca;Mariggio, Elena;Parasole, Rosanna;Di Matteo, Antonia;Petruzziello, Fara;Paganelli, Valeria;De Vito, Rita;Del Bufalo, Francesca;Strocchio, Luisa;Locatelli, Franco. And the article was included in Pediatric Blood & Cancer in 2022.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Although children and young adults with Hodgkin’s lymphoma usually have a favorable prognosis, patients with primary refractory disease and some subsets of relapsed patients still have a dismal outcome. Brentuximab vedotin (BV) in combination with bendamustine may represent a suitable salvage therapy; data on 32 patients aged less than 25 years were retrospectively analyzed. Patients received up to six cycles of treatment of BV 1.8 mg/kg on day 1 and bendamustine 90-120 mg/m² on days 2 and 3. At the end of treatment, the overall response rate was 81. The 3-yr overall and progression-free survivals are 78.1and 67, resp. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

ESR and polarography of nitro azoles. 4. Polarographic study of nitrobenzimidazoles was written by Lopyrev, V. A.;Larina, L. I.;Baumane, L.;Shibanova, E. F.;Gavars, R.;Ponomareva, S. M.;Vakul’skaya, T. I.;Stradins, J.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1984.Product Details of 93521-65-4 The following contents are mentioned in the article:

The 1st and 2nd polarog. half-wave potentials (E) of benzimidazoles I (R = NMe₂, NH₂, OMe, OEt, Me, H, Cl, etc.) were subjected to correlation anal. The effect of R on the 1st E values was exerted via the inductive and resonance mechanisms to approx. equal degrees; the effect of R on the 2nd E values was exerted primarily via the resonance mechanism. The calculation of a radical-stabilizing factor was discussed. The pK₂ values of I in MeCN range from 16.63 for I (R = cyano) to 23.40 for I (R = Me). This study involved multiple reactions and reactants, such as Methyl 5-Nitro-1H-benzimidazole-2-carboxylate (cas: 93521-65-4Product Details of 93521-65-4).

Methyl 5-Nitro-1H-benzimidazole-2-carboxylate (cas: 93521-65-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 93521-65-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Case report: unremitting COVID-19 pneumonia, viral shedding, and failure to develop anti-SARS-CoV-2 antibodies for more than 6 months in patient with mantle cell lymphoma treated with rituximab was written by Berktas, Bahadir M.;Koyuncu, Adem. And the article was included in American Journal of Tropical Medicine and Hygiene in 2022.Related Products of 16506-27-7 The following contents are mentioned in the article:

Severe cases of COVID-19 are being reported in patients with comorbidities and drug-induced immunosuppression. The risk seems to depend on the type of immunosuppressive agents used, and it is particularly high with rituximab because of its long-lasting effects. We report a 71-yr-old man with COVID-19, mantle cell lymphoma, and rituximab-associated immunodeficiency. His COVID-19 clin. course was severe, unremitting, prolonged, and with frequent acute exacerbations requiring hospitalization. Viral shedding and failure to develop anti-severe acute respiratory syndrome coronavirus 2 antibodies continued for at least 6 mo. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Related Products of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Fatal Breakthrough COVID-19 Case Following Bendamustine-Rituximab Therapy was written by Kamegai, Kohei;Iwamoto, Noriko;Togano, Tomiteru;Maeda, Kenji;Takamatsu, Yuki;Miyazato, Yusuke;Ishikane, Masahiro;Mizokami, Masashi;Sugiyama, Masaya;Iida, Shun;Miyamoto, Sho;Suzuki, Tadaki;Ohmagari, Norio. And the article was included in International Journal of Infectious Diseases in 2022.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Although mRNA vaccines are substantially effective toward SARS-CoV-2 infection, patients with hematol. malignancies are still prone to the virus. Herein, we report a fatal case of breakthrough SARS-CoV-2 Delta variant infection in a patient with mucosa-associated lymphoid tissue lymphoma with remission by bendamustine-rituximab (BR) therapy completed a year ago. The serol. study revealed impaired responsiveness toward vaccines and prolonged high viral load after infection. BR therapy seemingly induced an immune escape. Prevention and treatment strategies for such vulnerable patients should be clarified immediately. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 1,5-benzodiazepine derivatives catalyzed by acidic ionic liquid was written by Xu, Qiu-yan;Ji, Shun-jun;Gu, Da-gong. And the article was included in Hecheng Huaxue in 2005.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

A novel method was reported that 1,5-benzodiazepine derivatives were synthesized via the condensation of o-phenylenediamines with ketones using acidic ionic liquid and alc. as a catalyst system. Target compounds thus prepared included 2,3-Dihydro-2,2,4-trimethyl-1H-1,5-benzodiazepine, 2-ethyl-2,3-dihydro-2,3,4-trimethyl-1H-1,5-benzodiazepine, 2,3,9,10a-tetrahydrospiro[benzo[b]cyclopenta[e][1,4]diazepine-10(1H),1′-cyclopentane], etc. The ionic liquid used in this study was 1-he;yl-3-methyl-1H-imidazolium hydrogen sulfate. This catalyst system can be reused three times. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalytic synthesis of normal propyl cinnamate in acidic ionic liquid was written by Huang, Yanxian. And the article was included in Yingyong Huagong in 2012.Computed Properties of C10H20N2O4S The following contents are mentioned in the article:

Normal Pr cinnamate was synthesized with acidic ionic liquid[Hmim]HSO₄ as catalyst. The effects of molar ratio of acid/alc., reaction time and the catalyst amount of ionic liquid on the yield of Pr cinnamate were investigated and the optimal conditions were as follows: amount of cinnamic acid 1.48 g (0.01 mol), the molar ratio of acid to alc. 1:6, catalyst 2 mL, reaction time 5 h. The yield of the Pr cinnamate could reach 88.2%. The ionic liquid could be reused for 5 times without much lose in activities. The structure of Pr cinnamate was characterized by IR spectrum and chromatog./mass spectrometry. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Computed Properties of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Computed Properties of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem