Category: imidazoles-derivatives

Study of 5(6)-hydroxybenzimidazole aminomethylation was written by Smirnov, L. D.;Kuznetsov, Yu. V.;Stolyarova, L. G.;Lezina, V. P.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1985.Reference of 101018-70-6 The following contents are mentioned in the article:

Treating benzimidazole I (R = Me, R¹ = R² = H) with N-(methoxymethyl)piperidine, -morpholine, and N,N,N‘,N‘-tetramethylmethylenediamine in alc. gave 92.7, 88.7, and 65.4% aminomethylated derivatives I (R = Me, R¹ = piperidinomethyl, morpholinomethyl, Me₂NCH₂; R² = H). Treating I (R-R² = H) with piperidine and paraformaldehyde under Mannich reaction conditions gave I (R = H, R¹ = piperidinomethyl, R² = H, piperidinomethyl). Analogously obtained was I (R = H, R¹ = R² = Me₂NCH₂). This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Reference of 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Thermal and kinetic studies of trialkylimidazolium salts was written by Fox, Douglas M.;Awad, Walid H.;Gilman, Jeffrey W.;Maupin, Paul H.;Trulove, Paul C.;De Long, Hugh C.. And the article was included in ACS Symposium Series in 2005.COA of Formula: C8H15F6N2P The following contents are mentioned in the article:

The thermal properties of trialkylimidazolium room temperature ionic liquids (RTILs) have been determined using a flash point apparatus and the technique of thermal gravimetric anal. (TGA). Using a Setaflash flash point analyzer, all the salts studied were found to have flash points above 200 °C. TGA was utilized to study the decomposition of imidazolium based RTILs. The effects of C-2 hydrogen substitution, structural isomerism, alkyl chain length, anion type, and purge gas type is discussed. The decomposition kinetics of 1,2-dimethyl-3-butylimidazolium hexafluorophosphate was investigated using TGA. The global kinetic model and TGA Arrhenius parameters have been determined by employing both constant heating rate and isothermal programs. This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1COA of Formula: C8H15F6N2P).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C8H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of simple ammonium ionic liquids and their application in the cracking of dialkoxypropanes was written by Wang, Congmin;Guo, Liping;Li, Haoran;Wang, Yong;Weng, Jianyang;Wu, Lianhai. And the article was included in Green Chemistry in 2006.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

Owing to the unique advantages of ionic liquids, the preparation and industrial application of ionic liquids have attracted considerable interest. Herein, a series of simple ammonium ionic liquids has been synthesized and characterized. These ionic liquids are air and water stable, easy to prepare from amine and acid, and relatively cheap. They have been used as catalysts and environmentally benign solvents for the cracking reactions of dialkoxypropanes, eliminating the need for volatile organic solvents and addnl. catalysts. The results clearly demonstrate that these ionic liquids can be easily separated and reused without losing their activity and quality. Furthermore, the conversion and selectivity obtained with this method are significantly increased in comparison with those reported in traditional organic solvents to date. These ionic liquids provide a good alternative way for the synthesis of alkoxypropenes. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Homoleptic tris-cyclometalated iridium(III) complexes with phenylimidazole ligands for highly efficient sky-blue OLEDs was written by Zhuang, Jinyong;Li, Wanfei;Wu, Weichen;Song, Minshun;Su, Wenming;Zhou, Ming;Cui, Zheng. And the article was included in New Journal of Chemistry in 2015.Application of 914306-50-6 The following contents are mentioned in the article:

As an extension of the authors’ previous study, three sky-blue homoleptic Ir(III) complexes 1-3 with F-free phenylimidazole ligands were synthesized and their photophys., electrochem. and thermal properties were studied. All the complexes showed high photoluminescence quantum yields ranging from 0.50 to 0.53. The introduction of a bulky iso-Pr group at the 2,6-position of N-Ph of the phenylimidazole ligands increases the quantum yield and the decomposition temperature of the IR(III) complexes. As the conjugated system of the ligand becomes larger, a very small bathochromic-shift of 1 nm was observed in complex 3 (475 nm) compared with complexes 1 (474 nm) and 2 (474 nm). All the OLED devices showed high current efficiencies of over 20 cd A^-1 at the luminance of 1000 cd m^-2. Devices incorporated with complexes 1-3 all showed longer lifetime in comparison with that of a FIrpic-based device. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Application of 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supramolecular Self-Sorting Networks using Hydrogen-Bonding Motifs was written by Coubrough, Heather M.;van der Lubbe, Stephanie C. C.;Hetherington, Kristina;Minard, Aisling;Pask, Christopher;Howard, Mark J.;Fonseca Guerra, Celia;Wilson, Andrew J.. And the article was included in Chemistry – A European Journal in 2019.Product Details of 1384100-95-1 The following contents are mentioned in the article:

A current objective in supramol. chem. is to mimic the transitions between complex self-sorted systems that represent a hallmark of regulatory function in nature. In this work, a self-sorting network, comprising linear hydrogen motifs, was created. Selecting six hydrogen-bonding motifs capable of both high-fidelity and promiscuous mol. recognition gave rise to a complex self-sorting system, which included motifs capable of both narcissistic and social self-sorting. Examination of the interactions between individual components, exptl. and computationally, provided a rationale for the product distribution during each phase of a cascade. This reasoning holds through up to five sequential additions of six building blocks, resulting in the construction of a biomimetic network in which the presence or absence of different components provides multiple unique pathways to distinct self-sorted configurations. This study involved multiple reactions and reactants, such as 4-(tert-Butyl)-1H-imidazol-2-amine hydrochloride (cas: 1384100-95-1Product Details of 1384100-95-1).

4-(tert-Butyl)-1H-imidazol-2-amine hydrochloride (cas: 1384100-95-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 1384100-95-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bortezomib in combination with fludarabine plus cyclophosphamide for patients with relapsed or refractory mantle-cell lymphoma: results of the LYM-4003 study was written by Wang, Xiao-Xiao;Gao, Yan;Jin, Jie;Cao, Jun-Ning;Feng, Ji-Feng;Wang, Hua-Qing;Zhang, Hui-Lai;Cai, Qing-Qing;Li, Zhi-Ming;Jiang, Wen-Qi;Huang, Hui-Qiang;on behalf of the Lymphoma Committee, Chinese Anti-Cancer Association. And the article was included in Annals of Hematology in 2021.SDS of cas: 16506-27-7 The following contents are mentioned in the article:

This study aimed to identify the maximum-tolerated dose (MTD) of cyclophosphamide when combined with bortezomib and fludarabine (B-FC) in a phase 1b trial, and to assess the efficacy and safety of this combination in a phase 2 trial in patients with relapsed or refractory MCL (rrMCL). Forty patients were enrolled between Apr. 8, 2011, and Oct. 10, 2015. The MTD of cyclophosphamide was identified to be 250 mg/m² days 1-2. At a median follow-up of 31.6 mo (13.5-47.4), among 32 patients in phase 2, 10 (31%) had a complete response and 13 (41%) had a partial response. The median progression-free survival was 21 mo (95% CI 7.3-34.7), and the median overall survival was 32.4 mo (95% CI 17.8-47.0). Grade 3-4 hematol. AEs included neutropenia (27%) and thrombocytopenia (39%). The B-FC regimen has satisfactory responses and manageable toxicities in rrMCL patients (ClinicalTrials.gov NCT01322776). This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of 5-hydroxymethylfurfural from cellulose degradation catalyzed by acidic ionic liquids was written by Fu, Nihong;Yuan, Yuguo;Wang, Jingyun;Zang, Shuliang. And the article was included in Huaxue Tongbao in 2016.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

In this study, imidazolium based acidic ionic liquids and CrCl₃·6H₂O were used to catalyze the hydrolysis of cellulose in ionic liquid 1-allyl-3-methylimidazolium chloride ([Amim]Cl) via microwave-assisted irradiation to prepare 5-hydroxymethylfurfural (5-HMF). The effects of the type and amount of catalysts, reaction temperature and time, amount of water on the degradation of cellulose were studied in details. The results indicated that [C₂mim]HSO₄ and CrCl₃·6H₂O were efficient catalysts for preparing 5-HMF. The cellulose could be completely converted with the highest total reducing sugars (TRS) yield of 87.22% and 5-HMF yield of 50% under the condition of n_MCC:n_Cr = 10:1, the mass of [C₂mim]HSO₄ = 0.02 g, and reaction temperature 160°C under microwave-assisted heating for 30 min. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Commentary: post-transplantation cyclophosphamide uniquely restrains alloreactive CD4+ T-cell proliferation and differentiation after murine MHC-haploidentical hematopoietic cell transplantation was written by Stokes, Jessica;Simpson, Richard J.;Katsanis, Emmanuel. And the article was included in Frontiers in Immunology in 2022.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Herein authors investigated whether post-transplant cyclophosphamide (PT-CY) is unique in protecting against graft-vs.-host disease (GvHD) by comparing it to multiple other ′′optimally dosed′â€?chemotherapeutics. They concluded that PT-CY was superior to all other agents in ameliorating both clin. and histopathol. GvHD. It discuss about post-transplantation cyclophosphamide which uniquely restrains alloreactive CD4+ T-cell proliferation and differentiation after murine MHC-haploidentical hematopoietic cell transplantation. Authors discuss on the use of post-transplant bendamustine (PT-BEN) as an alternative agent that could replace PT-CY. They demonstrated that PT-BEN was equally effective in preventing early GvHD and protecting against late GvHD, while enabling superior graft-vs.-leukemia (GvL), when compared to PT- CY in murine haploidentical bone marrow transplantation (haplo-BMT). This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study on synthesis of methyl oleate catalyzed by 1-alkyl-3-methylimidazolium hydrosulfate was written by Sun, Hua;Li, Shengqing;Chen, Hao;Liu, Junchao;Xue, Aifang;Liu, Hanlan. And the article was included in Wuhan Gongcheng Daxue Xuebao in 2009.Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

Five acidic ionic liquids with an hydrogen sulfate group were synthesized ([C_nMIm]HSO₄, n = 0, 2, 4, 6 and 8). Their acidity was studied. Their application in esterification utilizing oleic acid and methanol was explored. The exptl. results showed 1-hexyl-3-methyl-imidazolium hydrogen sulfate ([C₆MIm]HSO₄) was the best catalyst of acidic ionic liquid in esterification. Under optimal esterification conditions: n_(methanol):n_{(oleic acid)} = 2.5:1, m_{(oleic acid)}:m_{([C6MIm]HSO4)} = 1:0.08, temperature 90°C and time 14 h, mass fraction of fatty acid Me ester could reach more than 91%. The ionic liquids were stable and could be reused. Me oleate was separated from raw material easily, and even if ionic liquid was reused beyond 6 times, the conversion of esterification did not decrease. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancement of the selective enzymatic biotransformation of rutin to isoquercitrin using an ionic liquid as a co-solvent was written by Wang, Jun;Sun, Guo-Xia;Yu, Liang;Wu, Fu-An;Guo, Xi-Jie. And the article was included in Bioresource Technology in 2013.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

An ionic liquid (IL)-containing buffer system was first applied in the conversion of rutin to isoquercitrin. High substrate solubility was achieved to enhance the selectivity and efficiency of hesperidinase-catalyzed reaction. Ten ILs were selected as co-solvents to assist catalytic reactions in this biotransformation process. The transformed products of rutin were identified by LC-MS. The [Bmim][BF₄]-glycine-sodium hydroxide buffer (pH 9) (10:90, volume/volume) was found to be the best medium for the biotransformation of isoquercitrin from rutin with higher selectivity and efficiency. The reaction time was reduced by 0.33-fold while the conversion of rutin and the yield of isoquercitrin were increased by 1.67-fold and 2.33-fold. The results suggest that IL co-solvents have great potential to enhance the selectively enzymic hydrolysis of rutin for isoquercitrin production This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem