Category: imidazoles-derivatives

Synthesis of N-cyanoethyl-N-hydroxyethylaniline catalyzed by acidic ionic liquid was written by Guo, Hui;Yin, Yuanyuan;Zhang, Xueying;Zhuang, Yuwei;Cao, Jian;Zhang, Guobao. And the article was included in Yingyong Huaxue in 2020.Application of 478935-29-4 The following contents are mentioned in the article:

N-Cyanoethyl-N-hydroxyethylaniline is an important dye intermediate with a wide range of applications. A green and efficient protocol for the synthesis of N-cyanoethyl-N-hydroxyethylaniline by reaction of acrylonitrile and N-hydroxyethyl aniline with 1-butyl-3-methylimidazolium hydrogen sulfate ionic liquid ([Bmim]HSO₄) as a catalyst has been developed, eliminating inert-gas welding and complex operation of traditional methods. The effect of ionic liquid, the amount of ionic liquid, the ratio of substrates, temperature and time were investigated. The optimum reaction conditions were obtained as follow: [BMIM]HSO₄ 0.8 mmol, n (N-hydroxyethyl aniline):n (acrylonitrile) = 1:1.2, reaction time of 12 h, reaction temperature of 90°C. The acidic ionic liquid could be easily separated and reused for at least 5 times without significantly decrease in catalytic activity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Unexpected tandem reaction of new type Morita-Baylis-Hillman adducts promoted by [Hmim]HSO₄/NaNO₃ system was written by Zhong, Weihui;Wang, Guan;Chen, Kai. And the article was included in Heterocycles in 2012.Related Products of 478935-29-4 The following contents are mentioned in the article:

A tandem reaction of a new type of Baylis-Hillman adduct, such as R-C₆H₄CCl=CH(OH)C(CH₂)CO₂R¹ (R = 4-MeO, 4-NO₂, 4-Me, H, 4-F, 3-Cl; R¹ = Me, Et) was promoted by the ionic liquid 1-hexyl-3-methylimidazolium·HSO₄/NaNO₃ system and the unexpected products 6-aryl-2H-pyran-3-carboxylates and the corresponding imidazolium salts I (R = 4-NO₂, H, 3-Cl, 4-F, R¹ = Me; R = 4-NO₂, 4-F, R¹ = Et) were efficiently formed via rearrangement and substitution reactions. While mediated by 1-ethyl-3-methylimidazolium·HSO₄/NaNO₃ system, the key intermediates, nitrates II (R = 4-OMe, 4-F, R¹ = Me; R = 3-Cl, R¹ = Et) were isolated. A plausible mechanism for the transformation was given. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two- and three-dimensional hybrid zinc phosphites: syntheses, structures and photoluminescence properties was written by Han, Song-De;Zhang, Xiu-Rong;Pan, Jie;Mu, Ying;Li, Jin-Hua;Wang, Guo-Ming. And the article was included in Dalton Transactions in 2018.Synthetic Route of C11H9N5 The following contents are mentioned in the article:

Two zinc-phosphites modified by a rigid amine 3,5-bis(imidazole-1-yl)pyridine (BIP), [Zn₂(HPO₃)₂(BIP)]·H₂O (1) and [Zn₃(HPO₃)₃(BIP)(H₂O)]·H₂O (2), were solvothermally prepared Compound 1 possesses a zincophosphite layer decorated by BIP moieties via coordinating to intralayer Zn(II) ions. Compound 2 features a 3-dimensional frame with a pillar-layer structure, in which the organic BIP pillars the inorganic zincophosphite layer via coordinating to interlayer Zn(II) ions. The structural diversity from a 2-dimensional layer to a 3-dimensional frame was mainly attributable to the different bridging modes of BIP in the process of assembly. Their temperature-dependent photoluminescence properties also were studied. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Synthetic Route of C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brexucabtagene autoleucel therapy induces complete remission in a primary refractory blastoid mantle cell lymphoma with neurolymphomatosis was written by Khurana, Arushi;Dalland, Joanna C.;Young, Jason R.;Inwards, David J.;Paludo, Jonas. And the article was included in American Journal of Hematology in 2021.COA of Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

The ZUMA-2 trial, however, excluded patients with a possible requirement for urgent therapy due to ongoing or impending oncol. emergency (eg, tumor mass effect, tumor lysis syndrome), involvement of the central nervous system and required patients to be exposed to a Bruton tyrosine kinase (BTK) inhibitor. Interim PET/CT after three cycles of bendamustine and rituximab, showed a significant improvement in lymphadenopathy and skeletal lesions, however, with new lesions in the nasopharynx and right chest wall. The patient underwent brexu-cel therapy after lymphodepletion chemo but his course was complicated by cytokine release syndrome (CRS) on day +1 with a peak grade of one based on the ASTCT 2019 grading. This is the first report of a brexu-cel for MCL-associated NL and blastoid variant with complete remission at day +60 without added neurotoxicity. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7COA of Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dispersing of petroleum asphaltenes by acidic ionic liquid and determination by UV-visible spectroscopy was written by Nezhad, Eshagh Rezaee;Heidarizadeh, Fariba;Sajjadifar, Sami;Abbasi, Zahra. And the article was included in Journal of Petroleum Engineering in 2013.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

Nowadays, constructing a mechanism to prevent the aggregation petroleum asphaltenes by the use of new acidic ionic liquids has become of fundamental importance. In this research, 3-(2-carboxybenzoyl)-1-methyl-1H-imidazol-3-ium chloride ([CbMIM] [Cl]) and other ionic liquids such as [CbMIM]BF4, [HMIM]Cl, [BMIM]Br, and [HMIM]HSO4 were tested. It should be noted that during the experiment the presence of the acidic ionic liquid moiety enhanced interactions between asphaltenes and acidic ionic liquids and it greatly limited asphaltene aggregation. We considered parameters such as temperature, amount of dispersant, effect of water: toluene ratio, the stirring time and effects of other ionic liquids, and determination of concentration of petroleum asphaltenes after dispersing by acidic ionic liquid under various parameters using UV-Visible spectroscopy. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Improved post-ASCT survival of relapsed/refractory classical Hodgkin lymphoma patients in the era of novel agents was written by Shah, Harsh;Jang, Hyejeong;Singh, Paramveer;Kosti, Jorgena;Kin, Andrew;Alavi, Asif;Ratanatharathorn, Voravit;Ayash, Lois;Uberti, Joseph;Ramchandren, Radhakrishnan;Kim, Seongho;Deol, Abhinav. And the article was included in Leukemia & Lymphoma in 2022.Synthetic Route of C16H21Cl2N3O2 The following contents are mentioned in the article:

Utilization of novel agents such as brentuximab vedotin (BV) and check-point inhibitors (CI) has increased in patients with relapsed/refractory (r/r) classical Hodgkin Lymphoma (cHL). We conducted a retrospective study of 209 patients who had ASCT for r/r cHL at our institution and compared outcomes of those who had ASCT from 2010-2018 (cohort 2, n = 110) with those who had ASCT between 2000 and 2009 (cohort 1, n = 99). The median OS was 7.6 years for cohort 1 [HR 2.08; 95% CI 1.14-3.80; p = 0.017] and not reached for cohort 2; with 4-yr improved OS difference of 15% (80% vs 65%) in cohort 2 vs cohort 1. The median PFS of cohort 1 was 30 mo vs 39 mo for cohort 2[HR 1.24; 95% CI 0.82-1.88; p = 0.3]. This study highlights improved OS of r/r cHL patients who have received ASCT in the novel agent era due to the exposure to agents such as BV and CIs. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Synthetic Route of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Synthetic Route of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Polatuzumab vedotin combined with rituximab-bendamustine immediately before stem cell mobilization in relapsed diffuse large B-cell lymphoma was written by Takakuwa, Teruhito;Okayama, Yusuke;Nakamae, Hirohisa;Kuno, Masatomo;Makuuchi, Yosuke;Harada, Naonori;Okamura, Hiroshi;Nishimoto, Mitsutaka;Nakashima, Yasuhiro;Koh, Hideo;Hino, Masayuki. And the article was included in Annals of Hematology in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

A case of ASCT performed following Pola-BR therapy for relapsed diffuse large B-cell lymphoma was reported. A 32-yr-old previously healthy man presented to hospital complaining of gradually worsening back pain that had first developed 3 mo earlier. Computed tomog. revealed multiple masses in the left liver lobe, pancreatic body, and both kidneys, as well as multiple enlarged lymph nodes. Based on the above findings, DLBCL stage IV was diagnosed. After six courses of R-CHOP, complete response (CR) was achieved, but back pain reoccurred 1 mo following treatment conclusion. Since a partial response was achieved after the first course of Pola-BR treatment, stem cell collection (SCC) at the conclusion of the second course was planned. MEAM (ranimustine, etoposide, cytarabine, and melphalan) with ASCT was subsequently performed and CR was achieved. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of gossypol acetate with [HMIm]HSO₄ ionic liquid as catalyst was written by Dong, Shihong;Wang, Dan;Zhu, Mingyuan;Dai, Bin. And the article was included in Zhongguo Youzhi in 2012.Application of 478935-29-4 The following contents are mentioned in the article:

With Bronsted acidic ionic liquid [HMIm]HSO₄ as the catalyst, the synthesis of gossypol acetate was investigated. The effects of reaction conditions including temperature, reaction time, material ratio and amount of catalyst on the yield of the reaction were also investigated. The optimal reaction conditions were as follows: reaction temperature 10°C, volume ratio of gossypol to glacial acetic acid-[HMIm]HSO₄ 1:1.0, amount of catalyst 6%(based on the mass of glacial acetic acid) and reaction time 4 h. Under these conditions, the yield of gossypol acetate reached 93%. At the same time, the stability and acidity of ionic liquid([HMIm]HSO₄) were investigated using thermogravimetric anal. and UV spectroscopy detection. The ionic liquid [HMIm]HSO₄ had a stable catalytic activity even after 4 cycles. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Proton pump inhibitors versus Cryptococcus species: effects on in vitro susceptibility and melanin production was written by Brilhante, Raimunda S. N.;da Rocha, Maria G.;de Oliveira, Jonathas S.;Espana, Jaime D. A.;Pereira, Vandbergue S.;Castelo-Branco, Debora de S. C. M.;Pereira-Neto, Waldemiro de A.;Sidrim, Jose J. C.;Cordeiro, Rossana de A.;Rocha, Marcos F. G.. And the article was included in Future Microbiology in 2019.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Aim: This study aimed to evaluate the effects of proton pump inhibitors (PPIs) on growth and melanin production by Cryptococcus spp. Materials & methods: Min. inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole against Cryptococcus spp. were determined and the effect of PPIs on melanin production was evaluated, in the presence or absence of copper sulfate or glutathione. Results: PPIs showed MICs ranging from 125-1000μg/mL and decreased melanization by Cryptococcus cells. Addition of copper sulfate or glutathione restored melanogenesis of cells grown in the presence of PPIs. The presence of PPIs and glyphosate decreased copper sulfate toxicity (1 mM). Conclusion: PPIs inhibited melanogenesis of Cryptococcus spp., possibly by chelating copper or inhibiting copper ATPase transport. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dual functionality of amphiphilic 1-alkyl-3-methylimidazolium hydrogen sulfate ionic liquids: surfactants with catalytic function was written by Nowicki, Janusz;Luczak, Justyna;Stanczyk, Dorota. And the article was included in RSC Advances in 2016.Formula: C10H20N2O4S The following contents are mentioned in the article:

A series of amphiphilic 1-alkyl-3-methylimidazolium hydrogen sulfate ionic liquids were synthesized. Acidic hydrogen sulfate ionic liquids with the alkyl chains C6-C14 are characterized by good surface properties. Their surface properties (adsorption and micellization parameters, degree of ionization of micelles, Krafft temperatures and thermodn. parameters) were determined Synthesized ionic liquids were applied as a co-catalyst in an oxirane ring opening reaction in epoxidized fatty acid Me esters (FAME). Their co-catalytic activities were determined and discussed as a function of their structure and surface properties. It was found that the co-catalytic properties, both conversion and selectivity, of alkylimidazolium hydrogen sulfate ionic liquids noticeably depended on the alkyl chain lengths, and in consequence their properties. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem