Category: imidazoles-derivatives

CD5 expression in marginal zone lymphoma predicts differential response to rituximab or bendamustine/rituximab was written by Hsu, Andrew;Kurt, Habibe;Zayac, Adam S.;Olszewski, Adam J.. And the article was included in Leukemia & Lymphoma in 2022.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

We examined outcomes of 244 patients with marginal zone lymphoma (MZL) diagnosed in 2010-2020, of which 25 (10%) expressed CD5. CD5 expression was present in 22% of splenic, 8% of nodal, and 5% of extranodal MZL, and showed frequent blood/bone marrow involvement, elevated lactate dehydrogenase, and TP53 deletions. CD5 expression was not associated with progression-free or overall survival, but it conferred a significantly higher risk of histol. transformation (22% vs. 4% at 5 years, p = 0.002). Among patients receiving first-line rituximab monotherapy, CD5 expression was associated with lower response rate (30% vs. 77%, p = 0.006), PFS (25% vs. 45% at 3 years, p = 0.003) and OS (44% vs. 77%, p = 0.010), whereas CD5 status did not significantly affect outcomes of patients receiving bendamustine with rituximab (P for interaction = 0.012 for progression-free survival). CD5-pos. MZL may have a propensity to leukemic dissemination, histol. transformation, and may derive benefit from first-line bendamustine/rituximab rather than rituximab alone. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Near-infrared phosphorescence emission of Zn(II) coordination polymer based on 3,5-bis(1-imidazoly)pyridine: Syntheses, structure and photoelectron performance was written by Lu, Xiao-Min;Zhai, Zhi-Min;Liu, Xin-Yi;Li, Fei-Fei;Yang, Xiao-Gang;Li, Jin-Yao;Guo, Yu-Ming;Ma, Lu-Fang. And the article was included in Journal of Solid State Chemistry in 2019.Application of 1374155-84-6 The following contents are mentioned in the article:

Long wavelength of near IR (NIR) room temperature phosphorescence (RTP) emission is a kind of highly desirable materials. With the self-assembly reaction of D-A-D type semi-rigid 3,5-bis(1-imidazoly)pyridine (BMP) organic ligand and Zn(II) ions, one ionic coordination polymer (CP) {[Zn_0.5(BMP)(H₂O)]·(NO₃)} (1) was synthesized and characterized. The as-synthesized 1 exhibits highly prolonged phosphorescence lifetime >6000 times as long as that of the pristine BMP phosphor ligand. Theory calculation indicates that NO₃^– counterions highly affect the electronic structure and energy levels of the cationic CP host. By a facile anionic exchange, Eosin Y (EY) dye guest encapsulated into the CP host can significantly tune the phosphorescence color from yellow to rare example of near IR emission through an efficient phosphorescence energy transfer. The optoelectronic performance of 1 and EY@1 also were studied. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Application of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acetone-soluble cellulose acetate extracted from waste blended fabrics via ionic liquid catalyzed acetylation was written by Sun, Xunwen;Lu, Canhui;Zhang, Wei;Tian, Dong;Zhang, Xinxing. And the article was included in Carbohydrate Polymers in 2013.Category: imidazoles-derivatives The following contents are mentioned in the article:

Isolation of cellulose from waste polyester/cotton blended fabrics (WBFs) is a bottleneck for recycling and exploiting waste textiles. The objective of this study was to provide a new environmental-friendly and efficient approach for extracting cellulose derivatives and polyester from WBFs. A Bronsted acidic ionic liquid (IL) N-methyl-imidazolium bisulfate, [Hmim]HSO₄, was used as a novel catalyst for acetylation of cellulose rather than a solvent with the aim to overcome low isolation efficiency associated with the very high viscosity and relatively high costs of ILs. The extraction yield of acetone-soluble cellulose acetate (CA) was 49.3%, which corresponded to a conversion of 84.5% of the cellulose in the original WBFs; meanwhile, 96.2% of the original poly(ethylene terephthalate) (PET) was recovered. The extracted CA was characterized by ¹H NMR, FTIR, XRD and TGA anal., and the results indicated that high purity acetone-soluble CA and carbohydrate-free PET could be isolated in this manner from WBFs. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Category: imidazoles-derivatives).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview was written by Dash, Ranjeet Prasad;Rais, Rana;Srinivas, Nuggehally R.. And the article was included in Xenobiotica in 2018.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:

A review. Proton pump inhibitors have been extensively used for the treatment of ailments due to increased gastric acid secretion such as peptic ulcers, gastroesophageal reflux disease, etc. There are several approved drugs in the proton pump inhibitor class with the latest entries representing single enantiomer drugs of the previously approved racemic drugs. Despite having a high degree of structural resemblance, rabeprazole, was shown to possess some unique differentiation from other drugs in the class. One of the key distinguishing features of rabeprazole was related to the lesser involvement of polymorphic metabolism in its pharmacokinetic disposition. The review was aimed to provide pharmacokinetic data of rabeprazole from several clin. studies including drug-drug interaction studies where rabeprazole was either a perpetrator drug or victim drug. Addnl. perspectives on therapy considerations due to the unique metabolic disposition of rabeprazole including the possible issues related to chirality were provided. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rituximab in combination with adapted-dose of ifosfamide and etoposide as salvage treatment in elderly refractory/relapsed diffuse large B-cell lymphoma patients non-candidate for high dose therapy: a retrospective study was written by Aussedat, Guillaume;Maucort-Boulch, Delphine;Rey, Philippe;Safar, Violaine;Karlin, Lionel;Elsensohn, Mad Helenie;Bachy, Emmanuel;Lebras, Laure;Favier, Bertrand;Vantard, Nicolas;Ghergus, Dana;Golfier, Camille;Sesques, Pierre;Lazareth, Anne;Lequeu, Helene;Ferrant, Emmanuelle;Salles, Gilles;Nicolas-Virelizier, Emmanuelle;Ghesquieres, Herve. And the article was included in Leukemia & Lymphoma in 2022.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

We retrospectively reviewed for 72 relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) patients ineligible for autologous stem-cell transplantation (ASCT) treated between 2004 and 2017, efficacy and safety profile of rituximab (375 mg/m²) in combination with etoposide (300 mg/m²) and ifosfamide (1500 mg/m²) at 2, 3, or 4-wk intervals. Median age was 79 years (range, 64-92). The median number of previous line was 1 (range 1-8). Patients received a median of six cycles (1-12). Fourteen patients (19%) presented partial and 14 complete responses (19%). Among the 369 cycles, nine patients developed febrile neutropenia (13%), 14 a grade 3-4 neutropenia (19%), 7 a grade 3-4 thrombocytopenia (10%) without grade 3-4 non-hematol. toxicity. With a median follow up of 7.8 mo, the median progression-free survival, overall survival, and duration of response were 4.4 mo, 9.4 mo, and 12 mo, resp. This regimen represents a therapeutic option in R/R DLBCL patients ineligible to ASCT. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of ethyl 2-chloropropionate catalyzed by acidic imidazolium ionic liquids was written by Zhou, Xiansi;Liu, Jiabin;Luo, Wenfeng;Zhang, Yiwen;Song, Hang. And the article was included in Huaxue Yanjiu Yu Yingyong in 2011.Formula: C10H20N2O4S The following contents are mentioned in the article:

The synthesis of Et 2-chloropropanoate in acidic imidazolium ionic liquids was studied. Four imidazolium ionic liquids were prepared and employed as catalysts in the esterification. Their acidities were measured by Hammett method and the acidity-catalytic activity relationship was investigated. [Hmim]HSO₄ was found to be the most efficient catalyst. The effects of reaction time, reaction temperature, the molar ratio of alc. to acid, the amount of ILs on the yield of Et 2-chloropropanoate were investigated. The optimum esterification conditions were obtained: reaction time was 2h, n(2-chloropropanoic acid):n(IL):n(ethanol)=1:1:2 and reaction temperature was 90°C. The yield of Et 2-chloropropanoate was 85.5% and the purity of product detected by GC was 99% under the optimum conditions. Even if the catalyst was repeatedly used for 5 times, the catalytic activity maintains stable. The reusability of the IL was excellent and it could be reused for 5 times without obviously catalytic activity decrease. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Comparable Ionicity of the Solutions of Aprotic and Protic Ionic Liquids by Anion Substitution was written by Jain, Preeti;Kumar, Anil. And the article was included in Journal of Solution Chemistry in 2017.Computed Properties of C10H20N2O4S The following contents are mentioned in the article:

Temperature dependent molar conductances and fluidities of bisulfate and Et sulfate anion-based ionic liquids were measured. The extent of dissociation of the ionic liquids was estimated from the Walden plot in term of ionicity. The ionicity mainly depends on the magnitude of Coulombic forces, altered by the anion’s Lewis basicity. Aqueous solutions of aprotic ionic liquids, in general, possesses ionicity in the range of ≈70-99%. This article reveals that the substitution of the anion by bisulfate and ethylsulfate reduces the ionicity of aqueous solution of these ionic liquids to the range of 10-37%. This is very close to that exhibited by some of the protic ionic liquids and phosphonium based ionic liquids with sweetner anions. The concentration dependent molar conductance of these ionic liquids has been fitted to Mahiuddin and Ismail’s equation. To our surprise, the molar conductances of bisulfate-based aprotic ionic liquids are remarkably high, even though these ionic liquids possess lower ionicity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Computed Properties of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Repurposing of pharmaceutical drugs by high-throughput approach for antihypertensive activity as inhibitors of angiotensin-converting enzyme (ACE) using HPLC-ESI-MS/MS method was written by Bhatti, Muhammad Salman;Asiri, Yahya Ibrahim;Uddin, Jalal;El-Seedi, Hesham R.;Musharraf, Syed Ghulam. And the article was included in Arabian Journal of Chemistry in 2021.Electric Literature of C18H20N3NaO3S The following contents are mentioned in the article:

Angiotensin-converting enzyme (ACE) plays an important role in regulating blood pressure in the body by converting angiotensin-I into angiotensin-II. It is the basic component of Renin angiotensin aldosterone system (RAAS), imbalance of RAAS may leads to many cardiovascular and renal diseases. There are many marketed available drugs for the inhibition of ACE, but prolonged use of some drugs may cause the progressive side effects. Repurposing of existing drugs can be a way to find new inhibitors of ACE. In this study, a high-throughput and sensitive method of HPLC-ESI-QqQ-MS with good reproducibility (%RSD < 9.98) and linearity (R2 = 0.999) was used to investigate the 77 com. drugs for their inhibitory potential as antihypertensive drugs. Among these drugs, 41 drugs were found active and 36 of them showed moderate to good inhibition with lowest IC₅₀ = 272 μM. This study showed that different pharmaceutical drugs can also be used as ACE inhibitor after necessary clin. trials or validation. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Electric Literature of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New topological Zn metal organic frameworks as multi-responsive fluorescent sensing materials for detecting Fe³⁺, Cr₂O^2-₇, CrO^2-₄ and tetracycline in aqueous system was written by Fan, Chuanbin;Xu, Cungang;Zhu, Bin;Wang, Lulu;Zong, Ziao;Wu, Ruixue;Zhang, Xia;Fan, Yuhua. And the article was included in Journal of Solid State Chemistry in 2021.Computed Properties of C11H9N5 The following contents are mentioned in the article:

Three new Zn metal organic frameworks (Zn-MOFs), {[Zn₂(L)[H (1,4-bmib)]]·1.5(H₂O)}_n (1), {[Zn₂(HL) (3,5-bip)₂]·(H₂O)}_n (2), and {[Zn₂(HL) (4,4′-bbibp)₂]·4(H₂O)}_n (3), have been first synthesized based on a flexible H₅L ligand with ether functional group (C-O-C) and successfully characterized (semi-flexible H₅L = 3,5-bis(3,5-dicarboxylphenoxy)benzoic acid, flexible 1,4-bmib = 1,4-bis(2-methylimidazol-1-yl)butane, rigid 3,5-bip = 3,5-bis(1-imidazolyl)pyridine, and rigid 4,4′-bbibp = 4,4′-bis(benzoimidazo-1-ly)biphenyl). Zn-MOFs 1-3 are unique topol. networks. As multi-responsive fluorescent sensing materials of 1 and 3, they show excellent response and sensitivity for Fe³⁺, CrO^2-₄ and Cr₂O^2-₇, and tetracycline (TC) in aqueous system. The quenching mechanism is also investigated in detail. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Computed Properties of C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Computed Properties of C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient synthesis of biodiesel catalyzed by CF₃SO₃H-functionalized ionic liquids: experimental design and study with response surface methodology was written by Zhang, Hui;Li, Yuqi;Lu, Zexiang;Wu, Mei;Shi, Ronghui;Chen, Lihui. And the article was included in Reaction Kinetics, Mechanisms and Catalysis in 2017.Quality Control of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

Five SO₃H and CF₃SO₃H-functionalized ionic liquids (ILs) with different acidity were synthesized. The catalytic performances of various ILs were evaluated for producing biodiesel in the esterification reaction and the yield of biodiesel increased with the increase of ILs’ acid strength. [Bsmim]CF₃SO₃ was found to be a highly-efficient catalyst for increasing the biodiesel yield due to its greatly enhanced Bronsted acidity, and it was also an environmental friendly solvent for its good recyclability and hydrophilicity. The exptl. design and study were carried out by using the response surface methodol. (RSM) for optimizing the production process. The optimum biodiesel yield of nearly 99% was achieved at the conditions that the catalyst amount of 11%, the molar ratio of methanol to oleic acid of 9:1, the reaction time of 3 h and the reaction temperature of 62 °C were used. In addition, the catalyst showed an excellent reusability. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Quality Control of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem