Category: imidazoles-derivatives

Effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia patients and indirect comparison with rituximab-bendamustine: Results of study on 486 cases outside clinical trials was written by Morabito, Fortunato;Tripepi, Giovanni;Del Poeta, Giovanni;Mauro, Francesca Romana;Reda, Gianluigi;Sportoletti, Paolo;Laurenti, Luca;Coscia, Marta;Herishanu, Yair;Bossio, Sabrina;Varettoni, Marzia;Murru, Roberta;Chiarenza, Annalisa;Visentin, Andrea;Condoluci, Adalgisa;Moia, Riccardo;Pietrasanta, Daniela;Loseto, Giacomo;Consoli, Ugo;Scortechini, Ilaria;Rossi, Francesca Maria;Zucchetto, Antonella;Al-Janazreh, Hamdi;Vigna, Ernesto;Martino, Enrica Antonia;Cassin, Ramona;D’Arrigo, Graziella;Galimberti, Sara;Rago, Angela;Angeletti, Ilaria;Biagi, Annalisa;Del Giudice, Ilaria;Bomben, Riccardo;Neri, Antonino;Fronza, Gilberto;Monti, Paola;Menichini, Paola;Olivieri, Jacopo;Cutrona, Giovanna;Rossi, Davide;Cuneo, Antonio;Di Raimondo, Francesco;Gaidano, Gianluca;Polliack, Aaron;Trentin, Livio;Foa, Robin;Ferrarini, Manlio;Gattei, Valter;Gentile, Massimo. And the article was included in American Journal of Hematology in 2021.SDS of cas: 16506-27-7 The following contents are mentioned in the article:

However, these biomarkers’ practical prognostic relevance in the era of new drugs remains an open issue. Results investigating the clin. impact of IB in the current clin. practice mainly focused so far on relapsedresistant (RR) patients. Here, we conducted a multicenter, retrospective study to ascertain the predictive and prognostic relevance of well-known biol. and clin. indicators in 165 patients treated with IB as first-line. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kinetics and mechanism of oxidation of Rabeprazole sodium by potassium permanganate in alkaline medium was written by Ramyashree, H.;Shastry, Vidyavati. And the article was included in International Journal of Current Research in Chemistry and Pharmaceutical Sciences in 2020.Application of 117976-90-6 The following contents are mentioned in the article:

The oxidation of Rabeprazole sodium by potassium permanganate has been studied by spectrophotometrically in the presence of alk. medium at 298 K at 525 nm. The oxidation kinetics was also studied by varying the ionic strength of the medium. The reaction was studied at different temperatures and products of oxidation were analyzed by LCMS. By the exptl. observations, rate law was derived and mechanism was suggested. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Improvement the activity and selectivity of Fenton system in the oxidation of alcohols was written by Yang, Guoqiang;Lin, Qiuxing;Hu, Xingbang;Wu, Youting;Zhang, Zhibing. And the article was included in Journal of Catalysts in 2014.Computed Properties of C10H20N2O4S The following contents are mentioned in the article:

The reactivity and selectivity of Fenton system (Fe2+/H2O2) were improved with N-hydroxyphthalimide (NHPI) as cocatalyst.The oxidation process of benzyl alc. to benzaldehyde has been studied. The reaction catalyzed by this new Fe2+/H2O2/NHPI system can be well performed under room temperature without adding any organic solvent. Besides, this catalyst system is effective for the oxidation of different alcs. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Computed Properties of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Computed Properties of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Transition-metal-free regioselective C-H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source was written by Li, Junxuan;Tang, Jiayi;Wu, Yuanheng;He, Qiuxing;Yu, Yue. And the article was included in RSC Advances in 2018.SDS of cas: 866135-66-2 The following contents are mentioned in the article:

A facile transition-metal-free regioselective halogenation of imidazo[1,2-a]pyridines using sodium chlorite/bromite as the halogen source is presented. The reaction has provided an efficient method for the formation of C-Cl or C-Br bonds to synthesize 3-chloro or 3-bromo-imidazo[1,2-a]pyridines which were then efficiently transformed into imidazo[1,2-a]pyridine core π-systems by Suzuki-Miyaura reactions. This study involved multiple reactions and reactants, such as 3-Bromo-8-methylimidazo[1,2-a]pyridine (cas: 866135-66-2SDS of cas: 866135-66-2).

3-Bromo-8-methylimidazo[1,2-a]pyridine (cas: 866135-66-2) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 866135-66-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was written by Zhou, Lin-bo;Lu, Meng-meng;Xing, Lei;Chen, Guo-liang. And the article was included in Jingxi Huagong Zhongjianti in 2015.Recommanded Product: 914306-50-6 The following contents are mentioned in the article:

The target compound 1-(2,6-diisopropylphenyl)-2-phenyl-1H-imidazole was prepared in overall yield of 47.69% starting from 2,6-diisopropyl aniline via acylation by benzoyl chloride, chlorination by phosphorus oxychloride, nucleophilic substitution by aminoacetaldehyde di-Et acetal and cyclization by phosphate. The structure of target compound was characterized by ¹H NMR and ESI-MS. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Recommanded Product: 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The discovery of fluazaindolizine: A new product for the control of plant parasitic nematodes was written by Lahm, George P.;Desaeger, Johan;Smith, Ben K.;Pahutski, Thomas F.;Rivera, Michel A.;Meloro, Tony;Kucharczyk, Roman;Lett, Renee M.;Daly, Anne;Smith, Brenton T.;Cordova, Daniel;Thoden, Tim;Wiles, John A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Quality Control of Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate The following contents are mentioned in the article:

Fluazaindolizine is a new highly effective and selective product for the control of plant parasitic nematodes. Specificity for nematodes coupled with absence of activity against the target sites of com. nematicides suggests that fluazaindolizine has a novel mode of action. The discovery, structure-activity development and biol. properties for this new class of nematicides are presented. This study involved multiple reactions and reactants, such as Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (cas: 353258-31-8Quality Control of Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate).

Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate (cas: 353258-31-8) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Quality Control of Ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Acid-induced chemoselective arylthiolations of electron-rich arenes in ionic liquids from sodium arylsulfinates: the reducibility of halide anions in [Hmim]Br was written by Xu, Zhu-bing;Lu, Guo-ping;Cai, Chun. And the article was included in Organic & Biomolecular Chemistry in 2017.Related Products of 478935-29-4 The following contents are mentioned in the article:

An acid-induced protocol for the chemoselective arylthiolations of electron-rich arenes in ionic liquids from sodium arylsulfinates is introduced. The chem., in which [Hmim]Br (heaxylmethylimidazolium bromide) is used as both a solvent and a reducer, provides several advantages including odorless and simple operation, inexpensive reagents, recyclable solvents and gram-scale synthesis. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

How I treat and prevent venous thrombotic complications in patients with lymphoma was written by Schmidt, Robert A.;Lee, Agnes Y. Y.. And the article was included in Blood in 2022.Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Venous thromboembolism (VTE) is a common complication occurring in 5% to 10% of patients with lymphoma. As the complexity of lymphoma management has increased with novel therapies, so too has the treatment of VTE. Therapeutic options for the treatment of cancer-associated VTE have expanded from only warfarin and low-mol.-weight heparins (LMWHs) to include the direct oral anticoagulants (DOACs) apixaban, edoxaban and rivaroxaban. There have been no head-to-head trials comparing different DOACs in this setting, and randomized trials comparing a DOAC with LMWH dalteparin differ in trial design and results. Drug-drug interactions, drug-specific side effects, and patient selection are important considerations when prescribing anticoagulant therapy. In all patients, the relative risks of thrombosis and bleeding, the availability of the anticoagulant, and the life expectancy of the patient are vital elements in selecting the most appropriate anticoagulant (which can vary over time) for the individual patient. We describe the intricacies and challenges of treating thrombotic complications in patients with lymphoma with an emphasis on evidence and guideline-based care. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Coordination Frameworks based on 3,5-Bis(imidazole-1-yl)pyridine and Aromatic Dicarboxylate Ligands: Synthesis, Crystal Structures, and Photoluminescent Properties was written by Xu, Jiakun;Sun, Xiaochun;Yang, Lirong;Yan, Xincheng;Bi, Caifeng;Sun, Mi. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2014.Name: 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Three metal coordination polymers [Zn(bdc)(L)(H₂O)]n (1), [Co(pta)(L)(H₂O)₂]n (2), and [Cd(tda)(L)(H₂O)]n (3) [H₂bdc = 1,2-benzene dicarboxylate acid, H₂pta = terephthalic acid, H₂tda = 2, 5-thiophenedicarboxylic acid, L = 3,5-bis(imidazole-1-yl)pyridine] were synthesized and structurally characterized by IR spectroscopy, elemental anal., x-ray powder diffraction, and X-ray single crystal diffraction. Complex 1 shows a three-dimensional (3D) structure with cco topol. with the symbol 6⁵路8, whereas complex 2 features a 3-dimensional structure with cds topol. with the symbol 6⁵路8. Complex 3 has a 2-dimensional network constructed by the cadmium atoms bridged through the ligands tda and L. Their x-ray powder diffraction patterns were compared with the simulated ones. Also, their luminescent properties were studied in the solid state at room temperature, and the thermogravimetric analyses were carried out to study the thermal stability of the 3-dimensional networks. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Name: 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Atmospheric-pressure cold plasma for fabrication of anatase-rutile mixed TiO₂ with the assistance of ionic liquid was written by Zhang, Xiuling;Zhang, Lijuan;Li, Yanchun;Di, Lanbo. And the article was included in Catalysis Today in 2015.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:

An atm.-pressure dielec. barrier discharge (DBD) gas-liquid cold plasma was employed to synthesize TiO₂ nanoparticles in an aqueous solution, with the assistance of nine imidazolium-based ionic liquids and using air as working gas. X-ray diffraction, N₂ adsorption-desorption measurements, and transmission electron microscopy were used to characterize the samples. The results showed that the samples prepared by the DBD gas-liquid cold plasma were anatase-rutile mixed TiO₂ with mesoporous structures. The effects of the cations, anions, and the amount of the ionic liquids on the structure of the TiO₂ samples were investigated, and the corresponding mechanism of actions were analyzed. The photocatalytic activity of the TiO₂ photocatalysts was evaluated by photodegradation of Methylene blue. The TiO₂ prepared with the assistance of 0.2 mL 1-ethyl-3-methylimidazolium tetrafluoroborate in Ti precursor solution exhibited the highest photocatalytic activity. Atm.-pressure DBD cold plasma was found to be a fast, simple, and environmentally friendly method for fabricating mixed-phase TiO₂. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem