Category: imidazoles-derivatives

Concentration-dependent apparent partition coefficients of ionic liquids possessing ethyl- and bi-sulphate anions was written by Jain, Preeti;Kumar, Anil. And the article was included in Physical Chemistry Chemical Physics in 2016.Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

This study deals with the concentration dependent apparent partition coefficients log P of the Et and bisulfate-based ionic liquids It is observed that the bisulfate-based ionic liquids show different behavior with respect to concentration as compared to Et sulfate-based ionic liquids It is significant and useful anal. for the further implementation of alkyl sulfate based ionic liquids as solvents in extraction processes. The log P values of the Et sulfate-based ionic liquids were noted to vary linearly with the concentration of the ionic liquid, whereas a flip-flop trend with the concentration for the log P values of the bisulfate-based ionic liquids was observed due to the difference in hydrogen bond accepting basicity and possibility of aggregate formation of these anions. The 蟺-蟺 interactions between the imidazolium and pyridinium rings were seen to affect the log P values. The alkyl chain length of anions was also observed to influence the log P values. The hydrophobicity of ionic liquid changes with the alkyl chain in the anion in the order; [HSO₄]^– < [EtSO₄]^– < [BuSO₄]^–. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrochemical determination of anticancer drug Bendamustine and its interaction with double strand DNA in the absence and presence of quercetin was written by Erol, Aylin;Akpinar, Fatma;Muti, Mihrican. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2021.Synthetic Route of C16H21Cl2N3O2 The following contents are mentioned in the article:

Studies based on drug-DNA interactions, especially anticancer drug-DNA interactions, are of great importance for the method development. It is thought that single-use electrodes, which give fast, cheap and reproducible results, will make a great contribution to the chip technol. for the development of individual patient anal. in the future. It is known that antioxidants reduce carcinogenesis caused by oxidative stress with their radical scavenging effects. Literature shows that quercetin (QRCT) exhibits anticancer activity by preventing oxidative cell damage as an effective radical scavenger. In this study, Bendamustine (BND), an anticancer drug, which is used in different blood cancer types, was electrochem. determined and the toxicity degree was calculated by examining the interaction of the drug with DNA in the absence and presence of QRCT, which is the first examination in the literature. Limit of detection and quantification for BND was calculated as 6.0 and 20.0渭g/mL resp. by using the equation I = 0.029 x CBND+ 1.197, (R2 = 0.997). We found that QRCT prevents the interaction between BND and DNA because of its strong interaction with DNA. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Synthetic Route of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lipase-catalyzed synthesis of caffeic acid phenethyl ester in ionic liquids: effect of specific ions and reaction parameters was written by Wang, Jun;Li, Jing;Zhang, Leixia;Gu, Shuangshuang;Wu, Fuan. And the article was included in Chinese Journal of Chemical Engineering in 2013.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

Caffeic acid phenethyl ester (CAPE) is a rare, naturally occurring phenolic food additive. This work systematically reported fundamental data on conversion of caffeic acid (CA), yield of CAPE, and reactive selectivity during the lipase-catalyzed esterification process of CA and phenylethanol (PE) in ionic liquids (ILs). Sixteen ILs were selected as the reaction media, and the relative lipase-catalyzed synthesis properties of CAPE were measured in an effort to enhance the yield of CAPE with high selectivity. The results indicated that ILs containing weakly coordinating anions and cations with adequate alkyl chain length improved the synthesis of CAPE. [Emim][Tf₂N] was selected as the optimal reaction media. The optimal parameters were as follows by response surface methodol. (RSM): reaction temperature, 84.0; mass ratio of Novozym 435 to CA, 14:1; and molar ratio of PE to CA, 16:1. The highest reactive selectivity of CAPE catalyzed by Novozym 435 in [Emim][Tf₂N] reached 64.55% (CA conversion 98.76% and CAPE yield 63.75%, resp.). Thus, lipase-catalyzed esterification in ILs is a promising method suitable for CAPE production This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Novel potassium-competitive acid blocker, tegoprazan, protects against colitis by improving gut barrier function was written by Son, Mijeong;Park, I. Seul;Kim, Soochan;Ma, Hyun Woo;Kim, Ji Hyung;Kim, Tae Il;Kim, Won Ho;Han, Jaeyong;Kim, Seung Won;Cheon, Jae Hee. And the article was included in Frontiers in Immunology in 2022.Computed Properties of C18H20N3NaO3S The following contents are mentioned in the article:

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by prolonged inflammation of the gastrointestinal tract. IBD can result from gut barrier dysfunction, altered gut microbiota, and abnormal intestinal immunity induced by environmental factors in genetically susceptible individuals. Proton pump inhibitors (PPIs) such as rabeprazole are frequently employed for gastric acid inhibition. However, long-term PPI administration can alter the intestinal microbiome composition, possibly worsening IBD severity. The present study revealed that tegoprazan, a potassiumcompetitive acid blocker, significantly improved colitis in mice and enhanced the intestinal epithelial barrier function. Tegoprazan alleviated gut microbiota dysbiosis and enhanced the growth of Bacteroides vulgatus. In turn, B. vulgatus alleviated intestinal inflammation by inhibiting epithelial adhesion of pathogenic bacteria. Unlike rabeprazole, tegoprazan did not induce gut dysbiosis. Our findings provide novel insights into the potential role of tegoprazan as an intestinal protectant for IBD and as a therapeutic agent for gastric acid-related diseases. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Computed Properties of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Computed Properties of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effects of [HMIM]HSO₄ and [OMIM]HSO₄ on the electrodeposition of zinc from sulfate electrolytes was written by Zhang, Qibo;Hua, Yixin. And the article was included in Journal of Applied Electrochemistry in 2009.Category: imidazoles-derivatives The following contents are mentioned in the article:

The effects of the organic additives 1-hexyl-3-methylimidazolium hydrogen sulfate ([HMIM]HSO₄) and 1-octyl-3-methylimidazolium hydrogen sulfate ([OMIM]HSO₄) on current efficiency (CE), power consumption (PC), polarization behavior of the cathode, deposit morphol., and crystallog. orientation during electrodeposition of Zn from acidic sulfate solution were studied. The results were compared with those of a common industrial additive, gum arabic. Addition of these additives increases current efficiency, decreases power consumption, and improves the surface morphol. at lower concentrations Both the additives showed similar polarization behavior to gum arabic and the extent of polarization was in the order: Gum arabic > [OMIM]HSO₄ > [HMIM]HSO₄. The nature of the electrode reactions was studied through measurements of Tafel slopes, transfer coefficients, and exchange current densities. Data obtained from x-ray diffractograms revealed that the presence of any of these additives did not change the structure of the electrodeposited Zn but affected the crystallog. orientation of the crystal planes. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Category: imidazoles-derivatives).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Management of Waldenstrom’s macroglobulinemia on the basis of cytogenetic abnormality was written by Sekiguchi, Naohiro. And the article was included in Ketsueki Naika in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Indeed, in the last decade, the mol. pathogenesis of WM, such as chromosomal abnormalities, gene mutations, and signal transduction, has progressed rapidly, and new drugs, including BTK inhibitors, have been vigorously developed. While there are reports indicating that searching for chromosomal/genetic abnormalities at the time of diagnosis is highly significant in predicting the response rate and long-term prognosis in the therapeutic intervention of WM, in Japan, it is difficult to say that such searches are sufficiently performed in routine clin. practice. At present, there are no high-evidence-level clin. practice guidelines or prognostic models based on chromosomal/genetic abnormalities. It is hoped that in the next 10 years established a stratification of clin. practice based on chromosomal/genetic abnormalities in WM. In this article, the author like to explain the chromosomal/genetic abnormalities that can be detected by WM, and also discuss the prognostic significance of chromosomal/genetic abnormalities, proposed treatment algorithms based on chromosomal/genetic abnormalities, and issues, including my personal views. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A highly efficient chemiluminescence system based on an enhancing effect of Ag nanoclusters/graphene quantum dots mixture for ultrasensitive detection of rabeprazole was written by Yousfefzadeh, Ashraf;Abolhasani, Jafar;Hassanzadeh, Javad;Somi, Mohammad Hossein. And the article was included in Analytical Sciences in 2019.Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Herein, an efficient chemiluminescence (CL) reaction with a high emission intensity is reported based on a synergistic improving effect of silver nanoclusters (AgNCs) and graphene quantum dots (GQDs). First, the syntheses of AgNCs and GQDs were simply performed by the chem. reducing ofAgNO₃ and a thermal treatment of glucose, resp. After the characterization steps, the beneficial behavior of the prepared nanomaterial was investigated in CL systems. The oxidation reaction of KMnO₄-rhodamine B produced weak CL emission. However, the presence of AgNCs and GQDs led to a synergetic enhancing effect, and thus higher emission was obtained. A possible mechanism was investigated for this effect using absorption and fluorescence experiments Furthermore, rabeprazole showed a relatively selective enhancing impact on the CL emission. The CL intensity was linearly increased in the rabeprazole concentration range of 4 – 133 ng mL^-1 with a detection limit (3Sb/m) of 1.1 ng mL^-1. The developed CL method was utilized for the measurement of Rbp in biol. samples with acceptable precision and accuracy. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Quality Control of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Effect of cation alkyl chain length on liquid-liquid equilibria of {ionic liquids + thiophene + heptane}: COSMO-RS prediction and experimental verification was written by Song, Zhen;Zhang, Jingjing;Zeng, Qian;Cheng, Hongye;Chen, Lifang;Qi, Zhiwen. And the article was included in Fluid Phase Equilibria in 2016.Related Products of 478935-29-4 The following contents are mentioned in the article:

When selecting ionic liquid (IL) as solvent for extraction processes, the cation alkyl chain length is an important structural variation, while research particularly concerning its effect is lacking. In this work, the effect of cation alkyl chain length on the liquid-liquid equilibrium of {IL + thiophene + heptane}, an example for extractive desulfurization, was systematically investigated. The COSMO-RS model was employed to calculate the distributional coefficient (尾^{鈭?/sup>) and selectivity (S鈭?/sup>) at infinite dilution for thiophene of the combinations of 17 cations and 63 anions. Two different anion-dependent tendencies of the 尾鈭?/sup> with increasing the cation alkyl chain length were identified and analyzed by COSMO-RS theory. To verify the scarcely-reported decreasing 尾鈭?/sup> with longer cation alkyl chain, acetate ([OAc]–) was selected as representative and liquid-liquid equilibrium {[C_nMIM][OAc] + thiophene + heptane} (n = 2, 4, 6, 8) were exptl. determined, which validate the anion-dependency and demonstrate the highest extraction performance of [C₂MIM][OAc]. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).}

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Persistent viral shedding of severe acute respiratory syndrome coronavirus 2 after treatment with bendamustine and rituximab: A case report was written by Arai, Tatsuya;Mukai, Satoru;Kazama, Ryo;Ogawa, Yoshihiko;Nishida, Koji;Hatanaka, Kazuo;Gohma, Iwao. And the article was included in Journal of Infection and Chemotherapy in 2022.Related Products of 16506-27-7 The following contents are mentioned in the article:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is detectable in nasopharyngeal specimens for up to 12-20 days regardless of the presence of chronic diseases in patients. A case of prolonged SARS-CoV-2 infection that lasted for more than eight weeks was reported. The patient had persistent lymphopenia after receiving six cycles of bendamustine and rituximab (BR) therapy for follicular lymphoma; the last chemotherapy session was completed nine months before admission. The first nasopharyngeal specimen (NPS) for the SARS-CoV-2 polymerase chain reaction assay tested pos. for the N501Y variant five weeks before admission. The patient”s general and respiratory conditions gradually worsened; therefore admitted in the hospital, and the same SARS-CoV-2 variant was subsequently identified on admission. Treatment for coronavirus disease was initiated, and the patien’s condition improved; however, the NPS tested pos. on day 15. The patient was discharged on day 28 and was instructed to isolate at home for a month. Hence, possible prolonged SARS-CoV-2 shedding should be considered in patients who receive BR therapy. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Related Products of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design was written by Sanders, Marijn P. A.;Roumen, Luc;van der Horst, Eelke;Lane, J. Robert;Vischer, Henry F.;van Offenbeek, Jody;de Vries, Henk;Verhoeven, Stefan;Chow, Ken Y.;Verkaar, Folkert;Beukers, Margot W.;McGuire, Ross;Leurs, Rob;Ijzerman, Adriaan P.;de Vlieg, Jacob;de Esch, Iwan J. P.;Zaman, Guido J. R.;Klomp, Jan P. G.;Bender, Andreas;de Graaf, Chris. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 101018-70-6 The following contents are mentioned in the article:

We present the systematic prospective evaluation of a protein-based and a ligand-based virtual screening platform against a set of three G-protein-coupled receptors (GPCRs): the 尾-2 adrenoreceptor (ADRB2), the adenosine A_2A receptor (AA2AR), and the sphingosine 1-phosphate receptor (S1PR1). Novel bioactive compounds were identified using a consensus scoring procedure combining ligand-based (frequent substructure ranking) and structure-based (Snooker) tools, and all 900 selected compounds were screened against all three receptors. A striking number of ligands showed affinity/activity for GPCRs other than the intended target, which could be partly attributed to the fuzziness and overlap of protein-based pharmacophore models. Surprisingly, the phosphodiesterase 5 (PDE5) inhibitor sildenafil was found to possess submicromolar affinity for AA2AR. Overall, this is one of the first published prospective chemogenomics studies that demonstrate the identification of novel cross-pharmacol. between unrelated protein targets. The lessons learned from this study can be used to guide future virtual ligand design efforts. This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Recommanded Product: 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem