Category: imidazoles-derivatives

Computation of liquid-liquid equilibrium of organic-ionic liquid systems using NRTL, UNIQUAC and NRTL-NRF models was written by Haghtalab, Ali;Paraj, Aliakbar. And the article was included in Journal of Molecular Liquids in 2012.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

Ionic liquids (ILs) with their limitless combination of cations and anions can offer an optimal solvent for a specific purpose especially separation processes. Among ionic liquids, alkyl-sulfate derivatives are the most promising ILs to be applied in industrial processes. The present work investigates liquid-liquid equilibrium phase behavior of 12-ILs comprising sulfate-based anions. Computation of liquid-liquid equilibrium for 36 ternary systems is carried out using three local composition models, namely non-random two liquid (NRTL), non-random two liquid non-random factor (NRTL-NRF) and universal quasi chem. (UNIQUAC) activity coefficient models. All the interaction parameters of the three models are regressed using an optimization program based on Simplex method of Nelder and Mead. Comparison of the results is expressed by root mean square deviation (rmsd) between the exptl. and calculated compositions It is demonstrated that the NRTL-NRF model presents very good satisfactory results with rmsd values of about 1.05 so that this model is highly appropriate to calculate thermodn. properties of ionic liquid solutions This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Phase 1 Study Evaluating Pharmacokinetics and Tolerability of Ofatumumab Combined With Bendamustine in Patients With Indolent B-Cell Non-Hodgkin鈥瞫 Lymphoma was written by Forero-Torres, Andres;Chandler, Jason Claud;Iyer, Swaminathan P.;Kanate, Abraham S.;Quinlan, Michelle;Hoever, Petra;Izquierdo, Miguel;Davis, Jaclyn;Madan, Sumit. And the article was included in Clinical Pharmacology in Drug Development in 2022.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

The pharmacokinetics (PK) and safety of ofatumumab and bendamustine alone and in combination were evaluated in patients with treatment-naive or relapsed indolent B-cell non-Hodgkin lymphoma (iNHL). Patients were randomly assigned to ofatumumab and bendamustine or ofatumumab alone. Ofatumumab PK concentration profiles and parameters were similar, alone or in combination with bendamustine. A decrease of 14% in the maximum observed plasma concentration (C_max) and 15% in the area under the plasma concentration-time curve (AUC) from time 0 to the last measurable concentration sampling time (AUC_last) was observed for ofatumumab coadministered with bendamustine, which was not considered clin. relevant. Bendamustine PK concentration profiles and parameters were similar with or without ofatumumab. The most frequent treatment-related adverse event was infusion-related reaction in 53% in the combination arm and 47% in the ofatumumab arm. No relevant drug-drug interaction was observed between ofatumumab and bendamustine. Ofatumumab alone or in combination with bendamustine had a manageable safety profile. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

LocoMMotion: a prospective, non-interventional, multinational study of real-life current standards of care in patients with relapsed and/or refractory multiple myeloma was written by Mateos, Maria-Victoria;Weisel, Katja;De Stefano, Valerio;Goldschmidt, Hartmut;Delforge, Michel;Mohty, Mohamad;Cavo, Michele;Vij, Ravi;Lindsey-Hill, Joanne;Dytfeld, Dominik;Angelucci, Emanuele;Perrot, Aurore;Benjamin, Reuben;van de Donk, Niels W. C. J.;Ocio, Enrique M.;Scheid, Christof;Gay, Francesca;Roeloffzen, Wilfried;Rodriguez-Otero, Paula;Broijl, Annemiek;Potamianou, Anna;Sakabedoyan, Caline;Semerjian, Maria;Keim, Sofia;Strulev, Vadim;Schecter, Jordan M.;Vogel, Martin;Wapenaar, Robert;Nesheiwat, Tonia;San-Miguel, Jesus;Sonneveld, Pieter;Einsele, Hermann;Moreau, Philippe. And the article was included in Leukemia in 2022.HPLC of Formula: 16506-27-7 The following contents are mentioned in the article:

Despite treatment advances, patients with multiple myeloma (MM) often progress through standard drug classes including proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), and anti-CD38 monoclonal antibodies (mAbs). LocoMMotion (ClinicalTrials.gov identifier: NCT04035226) is the first prospective study of real-life standard of care (SOC) in triple-class exposed (received at least a PI, IMiD, and anti-CD38 mAb) patients with relapsed/refractory MM (RRMM). Patients (N = 248; ECOG performance status of 0-1, 鈮? prior lines of therapy or double refractory to a PI and IMiD) were treated with median 4.0 (range, 1-20) cycles of SOC therapy. Overall response rate was 29.8% (95% CI: 24.2-36.0). Median progression-free survival (PFS) and median overall survival (OS) were 4.6 (95% CI: 3.9-5.6) and 12.4 mo (95% CI: 10.3-NE). Treatment-emergent adverse events (TEAEs) were reported in 83.5% of patients (52.8% grade 3/4). Altogether, 107 deaths occurred, due to progressive disease (n = 74), TEAEs (n = 19), and other reasons (n = 14). The 92 varied regimens utilized demonstrate a lack of clear SOC for heavily pretreated, triple-class exposed patients with RRMM in real-world practice and result in poor outcomes. This supports a need for new treatments with novel mechanisms of action. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7HPLC of Formula: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Electrochemical properties of imidazolium salt electrolytes for electrochemical capacitor applications was written by McEwen, Alan B.;Ngo, Elen L.;LeCompte, Karen;Goldman, Jay L.. And the article was included in Journal of the Electrochemical Society in 1999.Product Details of 157310-73-1 The following contents are mentioned in the article:

The specific ionic conductivity, dynamic viscosity, and electrochem. stability of several imidazolium salts are reported as neat ionic liquids and their solutions in several organic solvents. The temperature dependence of conductivity and viscosity are analyzed for 1-ethyl-3-methylimidazolium (EMI⁺) and 1,2-dimethyl-3-n-propylimidazolium (DMPI⁺) salts, and the influence of bis(trifluoromethylsulfonyl)imide (Im^–), bis(perfluoroethylsulfonyl)imide (Beti^–), hexafluoroarsenate (AsF₆^–), hexafluorophosphate (PF₆^–), and tetrafluoroborate (BF₄^–) on these properties are discussed. These imidazolium salts make possible electrolytes with high concentration (>3 M), high room temperature conductivity (up to 60 mS/cm), and a wide window of stability (>4 V at 20 VA/cm²). Differential scanning calorimetric results confirm a large glass phase for the ionic liquids, with substantial (>80掳) supercooling. Thermal gravimetric results indicate the imidazolium salts with Im^– and Beti^– anions to be thermally more stable than the Li salt analogs. The Vogel-Tammann-Fulcher interpretation accurately describes the conductivity temperature dependence. This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1Product Details of 157310-73-1).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Product Details of 157310-73-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chitosan/heparin blends in ionic liquid produce polyelectrolyte complexes that quickly adsorb citrate-capped silver nanoparticles, forming bactericidal composites was written by Souza, Paulo R.;Vilsinski, Bruno H.;de Oliveira, Ariel C.;Berton, Sharise B. R.;Nunes, Catia S.;Kipper, Matt J.;Schrekker, Henri S.;Martins, Alessandro F.;Muniz, Edvani C.. And the article was included in Journal of Molecular Liquids in 2021.Formula: C10H20N2O4S The following contents are mentioned in the article:

We present chitosan (CHT)/heparin (HP) polyelectrolyte complexes (PECs) that quickly adsorb citrate-capped silver nanoparticles (AgNPs). CHT/HP blends in ionic liquid ([HMIm][HSO4]) form durable PECs after precipitation in water. CHT/HP PECs have pos. Zeta potentials (higher than +20 mV). They adsorb citrate-capped AgNPs (Zeta potential of – 12.25 mV) synthesized from Turkevichs method. PEC/AgNPs composites are characterized by spectroscopic, thermal, and microscopy analyses. AgNPs on the PEC surfaces are confirmed by transmission electron microscopy. PECs adsorb AgNPs from aqueous suspensions, achieving 鈮?95% of removal (17.18渭g of AgNPs per mg of PEC) after only 10 min. The pseudo-second-order kinetic model adjusted well to the exptl. data. The PECs release approx. 11.80渭g/mg Ag+ (66%) compared to the initial adsorbed AgNPs content (17.18渭g/mg) after 7200 min at pH 2.0. The PECs present low swelling degrees (between 130 and 150%), supporting high stability in water. PEC/AgNPs composites promote significant bactericidal activity toward Staphylococcus aureus and Escherichia coli between 0.25 and 0.5 mg/mL. This study shows a new strategy to create hybrid polysaccharide/AgNPs composites. PECs can stabilize the AgNPs and release Ag+ ions, supporting antimicrobial materials. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

New ionic liquid-based preparative method for diosgenin from Rhizoma dioscoreae nipponicae was written by Yan, Wang;Ji, Luo;Hang, Song;Shun, Yao. And the article was included in Pharmacognosy Magazine in 2013.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

Background: Rhizoma dioscoreae nipponicae is a perennial herb and its roots have been widely used in Traditional Chinese Medicine (TCM). Objective: To develop and optimize the extraction and hydrolysis technol. of diosgenin from Rhizoma dioscoreae nipponicae. Materials and Methods: 1-methyt-3-(3-sulfopropyl)-imidazolium hydrogen sulfate ([PSMIM]HSO₄), as a kind of functional ionic liquid, replaced inorganic acid, and was used in a one-step ultrasonic extraction and hydrolysis for the preparation of diosgenin (the aglycon of dioscin and an important precursor chem. in the pharmaceutical industry) from Rhizoma dioscoreae nipponicae, for the first time. The effects of various factors were evaluated. The obtained product was studied using high performance liquid chromatog. (HPLC). Results: About 6.35 mg of diosgenin could be obtained from 2.0 g of raw material. Reusability and recycling of the ionic liquid were validated with fairly good results. The ionic liquid solution was reused four times, and the final extraction efficiency only decreased by 5%. Conclusion: In virtue of the obvious advantages of the green extraction and catalytic solvent, with further study, it is believed that this new one-step preparative method promises to replace the traditional methods. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Leaching of metals from printed circuit boards using ionic liquids was written by Barrueto, Yahaira;Hernandez, Pia;Jimenez, Yecid;Morales, Jaime. And the article was included in Journal of Material Cycles and Waste Management in 2021.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

The rise in the electronics industry has impacted the environment through the large volumes of waste that are improperly disposed of and the growing demand for precious and rare metals from natural sources. Leaching of copper, cobalt, gold, and silver from printed circuit boards of waste cellular phone has been carried out using imidazolium cation-based ionic liquids (ILs). For the studied metals, the obtaining of selective leaching obtained is reported for the first time, where acidic ionic liquids ([Bmim]HSO₄ and [Hmim]HSO₄) leached copper and cobalt, while basic ionic liquids ([Bmim]Cl and [Bmim]Br) extracted gold and silver. The effect of temperature has been studied by testing at 60 and 80掳C, where the highest extraction was obtained at the lowest temperature The concentration of the ionic liquid was also studied through a test without ionic liquid and then varying from 20 to 60%, where at higher concentration the extraction is more efficient ratifying the use of ionic liquids as leaching solutions for metals. Ionic liquids have demonstrated the ability to leach metal ions as the primary reagent in the leaching solution The following extraction percentages were obtained for each metal: 86.2% copper, 99.5% cobalt, 40.8% gold, and 44.6% silver. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cost drivers associated with diffuse large B-cell lymphoma (DLBCL) in Japan: A structural equation model (SEM) analysis was written by Tsutsue, Saaya;Makita, Shinichi;Yi, Jingbo;Crawford, Bruce. And the article was included in PLoS One in 2022.Electric Literature of C16H21Cl2N3O2 The following contents are mentioned in the article:

Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin’s lymphoma of increasing prevalence in Japan. However, patients with relapsed or refractory disease to first line treatment (rrDLBCL) have been found to shoulder greater economic burden and have poor survival with subsequent lines of therapy. The relative impact of individual patient attributes on total medical cost among patients with rrDLBCL receiving second or third line (2L/3L) therapy was assessed. Structural equation modeling was used to identify potential cost drivers of total medical costs incurred by treatment and procedures in a Japanese retrospective claims database. From the database, rrDLBCL patients on 2L or 3L of treatment were grouped into resp. cohorts. The mean [median] (SD) total medical cost of care for the 2L cohort was 73,296.40 [58,223.11] (58,409.79) US dollars (USD) and 75,238.35 [60,477.31] (59,583.66) USD for the 3L cohort. The largest total effect on medical cost in both cohorts was length of hospital stay (LOS) (尾: 0.750 [95%CI: 0.728, 0.772] vs 尾: 0.762 [95%CI: 0.729, 0.794]). Length of hospital stay and potential heart disease complications due to line of treatment were the primary drivers of total cost for patients who had received at least 2L or 3L therapy for rrDLBCL. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Electric Literature of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Electric Literature of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Favorable outcomes of allogeneic hematopoietic stem cell transplantation with fludarabine-bendamustine conditioning and posttransplantation cyclophosphamide in classical Hodgkin lymphoma was written by Beynarovich, Anastasia;Lepik, Kirill;Mikhailova, Natalia;Borzenkova, Evgenia;Volkov, Nikita;Moiseev, Ivan;Zalyalov, Yuri;Kondakova, Elena;Kozlov, Andrey;Stelmakh, Lilia;Pirogova, Olga;Zubarovskaya, Lyudmila;Kulagin, Alexander;Afanasyev, Boris. And the article was included in International Journal of Hematology in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for patients with relapsed and refractory classic Hodgkin lymphoma (rrHL). However, the optimal conditioning regimen and GVHD prophylaxis for rrHL remain undetermined The aim of this study was to investigate outcomes of allo-HSCT with a fludarabine plus bendamustine (FluBe) conditioning regimen and GVHD prophylaxis with posttransplantation cyclophosphamide (PTCY) in patients with rrHL. Allo-HSCT results in 58 adult patients with rrHL were analyzed retrospectively. Three-year overall survival and event-free survival were 81% (95% CI 65-91) and 55% (95% CI 38-72), resp. The cumulative incidence of relapse (CIR) at 3 years was 33% (95% CI 13-51). The cumulative incidence of aGVHD grade II-IV and severe aGVHD grade III-IV was 36% (95% CI 22-48) and 22% (95% CI 9-33), resp. The cumulative incidence of cGVHD was 32% (95% CI 17-45), including moderate or severe cGVHD in 17% (95% CI 4-28). Patients who developed aGVHD after allo-HSCT had significantly lower CIR (24% vs 49%, p = 0.004). The use of PBSC as a graft source also significantly reduced CIR (4% vs 61%, p = 0.002). FluBe-PTCY allo-HSCT facilitates favorable outcomes, low toxicity, and mortality in rrHL. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Immune response to COVID-19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T-cell response was written by Ramasamy, Karthik;Sadler, Ross;Jeans, Sally;Weeden, Paul;Varghese, Sherin;Turner, Alison;Larham, Jemma;Gray, Nathanael;Carty, Oluremi;Barrett, Joe;Bowcock, Stella;Oppermann, Udo;Cook, Gordon;Kyriakou, Chara;Drayson, Mark;Basu, Supratik;Moore, Sally;McDonald, Sarah;Gooding, Sarah;Javaid, Muhammad K.. And the article was included in British Journal of Haematology in 2022.COA of Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Myeloma patients frequently respond poorly to bacterial and viral vaccination. A few studies have reported poor humoral immune responses in myeloma patients to COVID-19 vaccination. Using a prospective study of myeloma patients in the UK Rudy study cohort, we assessed humoral and interferon gamma release assay (IGRA) cellular immune responses to COVID-19 vaccination post second COVID-19 vaccine administration. We report data from 214 adults with myeloma (n = 204) or smoldering myeloma (n = 10) who provided blood samples at least three weeks after second vaccine dose. Pos. Anti-spike antibody levels (> 50 iu/mL) were detected in 189/203 (92.7%), pos. IGRA responses were seen in 97/158 (61.4%) myeloma patients. Only 10/158 (6.3%) patients were identified to have both a neg. IGRA and neg. anti-spike protein antibody response. In all, 95/158 (60.1%) patients produced pos. results for both anti-spike protein serol. and IGRA. After adjusting for disease severity and myeloma therapy, poor humoral immune response was predicted by male gender. Predictors of poor IGRA included anti-CD38/anti-BCMA (B-cell maturation antigen) therapy and Pfizer-BioNTech vaccination. Further work is required to understand the clin. significance of divergent cellular response to vaccination. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7COA of Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.COA of Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem