Category: imidazoles-derivatives

Incidence of Pneumocystis jirovecii pneumonia utilizing a polymerase chain reaction-based diagnosis in patients receiving bendamustine was written by Rice, Mikhaila L.;Barreto, Jason N.;Thompson, Carrie A.;Mara, Kristin C.;Tosh, Pritish K.;Limper, Andrew H.. And the article was included in Cancer Medicine in 2021.SDS of cas: 16506-27-7 The following contents are mentioned in the article:

Our objective was to determine the cumulative incidence of PJP diagnosed by single copy target, non-nested PCR in patients receiving bendamustine. Patients were evaluated for PJP from initiation of bendamustine through 9 mo after the last administration. The cumulative incidence of PJP was estimated using the Aalen-Johansen method. Cox proportional hazard models were used to demonstrate the strength of association between the independent variables and PJP risk. This single-center, retrospective cohort included 486 adult patients receiving bendamustine from 1 Jan. 2006 through 1 August 2019. Most patients received bendamustine-based combination therapy (n = 461, 94.9%), and 225 (46.3%) patients completed six cycles. Rituximab was the most common concurrent agent (n = 431, 88.7%). The cumulative incidence of PJP was 1.7% (95% CI 0.8%-3.3%, at maximum follow-up of 2.5 years), after the start of bendamustine (n = 8 PJP events overall). Prior stem cell transplant, prior chemotherapy within 1 yr of bendamustine, and lack of concurrent chemotherapy were associated with the development of PJP in univariate analyses. Anti-Pneumocystis prophylaxis was not significantly associated with a reduction in PJP compared to no prophylaxis (HR 0.37, 95% CI (0.05, 3.04), p = 0.36). This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.SDS of cas: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A randomized phase 3 study of ixazomib-dexamethasone versus physician’s choice in relapsed or refractory AL amyloidosis was written by Dispenzieri, Angela;Kastritis, Efstathios;Wechalekar, Ashutosh D.;Schonland, Stefan O.;Kim, Kihyun;Sanchorawala, Vaishali;Landau, Heather J.;Kwok, Fiona;Suzuki, Kenshi;Comenzo, Raymond L.;Berg, Deborah;Liu, Guohui;Kumar, Arun;Faller, Douglas V.;Merlini, Giampaolo. And the article was included in Leukemia in 2022.Recommanded Product: 16506-27-7 The following contents are mentioned in the article:

In the first phase 3 study in relapsed/refractory AL amyloidosis (TOURMALINE-AL1 NCT01659658), 168 patients with relapsed/refractory AL amyloidosis after 1-2 prior lines were randomized to ixazomib (4 mg, days 1, 8, 15) plus dexamethasone (20 mg, days 1, 8, 15, 22; n = 85) or physicians choice (dexamethasone 卤 melphalan, cyclophosphamide, thalidomide, or lenalidomide; n = 83) in 28-day cycles until progression or toxicity. Primary endpoints were hematol. response rate and 2-yr vital organ deterioration or mortality rate. Only the first primary endpoint was formally tested at this interim anal. Best hematol. response rate was 53% with ixazomib-dexamethasone vs 51% with physicians choice (p = 0.76). Complete response rate was 26 vs 18% (p = 0.22). Median time to vital organ deterioration or mortality was 34.8 vs 26.1 mo (hazard ratio 0.53; 95% CI, 0.32-0.87; p = 0.01). Median treatment duration was 11.7 vs 5.0 mo. Adverse events of clin. importance included diarrhea (34 vs 30%), rash (33 vs 20%), cardiac arrhythmias (26 vs 15%), nausea (24 vs 14%). Despite not meeting the first primary endpoint, all time-to-event data favored ixazomib-dexamethasone. These results are clin. relevant to this relapsed/refractory patient population with no approved treatment options. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Survival, causes of death, and the prognostic role of comorbidities in chronic lymphocytic leukemia in the pre-ibrutinib era: A population-based study was written by Steingrimsson, Vilhjalmur;Lund, Sigrun H.;Dickman, Paul W.;Weibull, Caroline E.;Bjorkholm, Magnus;Landgren, Ola;Kristinsson, Sigurdur Y.. And the article was included in European Journal of Haematology in 2022.Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

To evaluate temporal trends in survival and causes of death in patients with chronic lymphocytic leukemia (CLL) in a nationwide study. The cohort consisted of 13,009 Swedish CLL patients diagnosed 1982-2013. Relative survival (RS) and excess mortality rate ratios (EMRR) with 95% confidence intervals (95% CIs) were estimated using flexible parametric survival models. Cause-specific hazard ratios (HRs) were estimated for the linear effect of 10-yr increase in year of diagnosis. The excess mortality decreased comparing 2003-2013 to 1982-1992 (EMRR = 0.53, 95% CI 0.48-0.58). The 5-yr RS increased between 1982 and 2012 for patients >51 years at diagnosis and improved for patients 鈮?1 years after 2002. The rate of CLL-specific deaths decreased over time (HR = 0.78, 95% CI 0.75-0.81). Compared to patients with no comorbidity, patients with 1 and 2+ Charlson Comorbidity Index points had HR = 1.35 (95% CI 1.25-1.45) and HR = 1.47 (95% CI 1.37-1.57) for CLL-related mortality, resp. Survival in CLL patients improved in the era of chemoimmunotherapy, and this was largely explained by reduced CLL-related mortality. The increased rate of CLL-related mortality in patients with comorbidities emphasizes the importance of the newer and better tolerated targeted therapy. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Searching for an optimal therapy for H pylori eradication: High-dose proton-pump inhibitor dual therapy with amoxicillin vs. standard triple therapy for 14 days was written by Hwong-Ruey Leow, Alex;Chang, Jo-Ven;Goh, Khean-Lee. And the article was included in Helicobacter in 2020.Formula: C18H20N3NaO3S The following contents are mentioned in the article:

Background & Aims : We compared a high-dose dual therapy (HDDT) with rabeprazole and amoxicillin and compared it with a standard triple therapy (STT) with rabeprazole, amoxicillin, and clarithromycin for 2 wk for H pylori eradication in treatment naive patients. Methods : H pylori-pos. patients were randomly assigned to either a rabeparzole (Pariet) 20 mg b.i.d., amoxicillin (Ospamox) 1 g b.i.d. and clarithromycin (Klacid) 500 mg b.i.d. for 14 days or rabeprazole (Pariet) 20 mg q.i.d., amoxicillin (Ospamox) 1 g q.i.d. also for 14 days. Eradication was tested for by the C¹³-UBT at least 4 wk after the completion of therapy. Results : H pylori was eradicated in 86.2% of patients (81/94) (95% CI: 77.8-91.7) in the STT group compared with 92.8% (90/97) (95% CI: 85.9-96.5) in the HDDT group on ITT anal. On PP anal., H pylori was eradicated in 91.0% of patients (81/89) (95% CI: 83.3-95.4) in the STT group compared with 93.8% (90/96) (95% CI: 87.0-97.1) in the HDDT group. Side effects were few although many patients in the STT arm complained of bitter taste. The HDDT arm was well tolerated by patients. Conclusions : The HDDT gave a high eradication rate comparable to the STT for 2 wk and was a well-tolerated regimen for H pylori eradication. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Formula: C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two Mn^II, Cu^II complexes derived from 3,5-bis(1-imidazolyl)pyridine: Synthesis, DNA binding, Molecular docking and cytotoxicity studies was written by Zhu, Mingchang;Liu, Jiaxing;Su, Junqi;Meng, Bo;Feng, Yunhui;Jia, Bing;Peng, Tingting;Qi, Zhenzhen;Gao, Enjun. And the article was included in Applied Organometallic Chemistry in 2019.COA of Formula: C11H9N5 The following contents are mentioned in the article:

Two complexes [MnL₂(H₂O)₂]路2ClO₄ (complex 1) and [CuL(H₂O)₃]路2NO₃ (complex 2) (L = 3,5-bis(1-imidazolyl)pyridine) were designed and synthesized. The structures of the complexes were characterized by x-ray crystallog., elemental analyses, and IR spectra. The interaction capacity of the complexes with calf thymus DNA was studied by UV and fluorescence spectroscopy. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR322 plasmid DNA. Efficient binding properties of DNA were established by UV-visible, fluorescence, and gel electrophoresis. The intrinsic binding constants (K_b) are 0.1524 and 0.1041 for complexes 1 and 2, resp. The two complexes exhibited a higher cytotoxicity against HeLa cell lines and lower cytotoxicity toward normal cell lines. Flow cytometry demonstrated the cancer cell inhibitory rate of the two complexes. Computer-aided mol. docking studies were performed to visualize the binding mode of the drug candidate at the mol. level. Complex 1 exhibited a significant higher cancer cell inhibitory rate than cisplatin and other complexes. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6COA of Formula: C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Four structural diversity MOF-photocatalysts readily prepared for the degradation of the methyl violet dye under UV-visible light was written by Lu, Lu;Wang, Jun;Shi, Chuncheng;Sun, Yanchun;Wu, Weiping;Pan, Ying;Muddassir, Mohd.. And the article was included in New Journal of Chemistry in 2021.Application of 1374155-84-6 The following contents are mentioned in the article:

Four new metal-organic frameworks based on transition metals, namely [Mn₂(渭₂-H₂O)₂(H₂L)₂(CH₃CN)₂] (1), [Mn(L)_0.5 phen)路_0.5H₂O] (2), [Co(H₂O)₂(L)_0.5(bip)路H₂O] (3) and [Co₂(L)(bb)₂路HbbBr] (4), where (H₄L = 5,5鈥?(1,4-phenylenebis(methyleneoxy))diisophthalic acid, bip = 3,5-bis(1-imidazoly)pyridine, phen = 1,10-phenanthroline, bb = 4,4鈥?bis(imidazolyl)biphenyl), have been successfully synthesized under solvothermal conditions. 1 showed a 2D layer featuring a polythreaded network with alternate left-and right-handed 21 helical chains. 2 possessed a 1D [Mn(H₂L)]n chain that was further expanded into a 2D layer through O-H路路路O hydrogen bonds. 3 exhibited a 3D threefold interpenetrating network with a point symbol of (64路82)(66)2. 4 had a 3D 3-fold interpenetrated motif with 2-nodal 4,4-c connectivity. The photocatalytic results demonstrated that all of them could exhibit efficient photocatalytic abilities towards the degradation of methyl violet (MV) under UV irradiation The mechanism of the photocatalytic performance was explored and discussed. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Application of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vonoprazan is Superior to Rabeprazole for Healing Endoscopic Submucosal Dissection: Induced Ulcers was written by Yamasaki, Akira;Yoshio, Toshiyuki;Muramatsu, Yusuke;Horiuchi, Yusuke;Ishiyama, Akiyoshi;Hirasawa, Toshiaki;Tsuchida, Tomohiro;Sasaki, Yutaka;Fujisaki, Junko. And the article was included in Digestion in 2018.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

Background and Aims: Endoscopic submucosal dissection (ESD) is a well-established minimally invasive treatment for early gastric cancer. To heal ESD-induced ulcers, we commonly prescribe proton pump inhibitors (PPIs). Vonoprazan is our new choice, which is reported to have a stronger and longer acid inhibitory effect than existing PPIs. Here, we aimed to evaluate the efficacy of vonoprazan for healing ESD-induced ulcers compared with rabeprazole. Methods: We reviewed 190 patients who underwent ESD before and after we switched the acid secretion inhibitor from rabeprazole to vonoprazan. We evaluated scarring and reduction rates at 4 wk after ESD. Results: Scarring rates were not different between vonoprazan and rabeprazole (31.7 vs. 18.9%; p = 0.07). However, for ulcers 鈮?5 mm, vonoprazan was superior to rabeprazole (42.2 vs. 19.2%; p < 0.05). Reduction rates were superior for vonoprazan compared with rabeprazole (93.0 vs. 90.4%; p < 0.05). In multivariate anal., vonoprazan was superior to rabeprazole for ulcer scarring (OR 2.21; p < 0.05), and ulcer location in the lower-third of the stomach had higher risk of incomplete scarring (OR 0.37; p < 0.05). Conclusion: Vonoprazan was superior to rabeprazole for healing ESD-induced ulcers. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Determination of hexafluorophosphate by ion chromatography with direct conductivity detection was written by Yang, Ling;Yu, Hong;Li, Siwen. And the article was included in Fenxi Ceshi Xuebao in 2009.COA of Formula: C8H15F6N2P The following contents are mentioned in the article:

A method was developed for the determination of hexafluorophosphate by ion chromatog. coupled with direct conductivity detection. The separation of analytes was performed on a Shim-pack IC-A3 anion-exchange column using benzoic acid as an eluent. The influences of the type, concentration and pH value of eluent, and column temperature on retention time of hexafluorophosphate were investigated. The optimized chromatog. conditions for determination of hexafluorophosphate were using 1.0 M benzoic acid with pH 7.5 as eluent with column temperature of 40掳 and flow rate of 1.0 mL/min. Under the optimal conditions, hexafluorophosphate could be separated in 12 min. A good linear relationship was obtained between chromatog. peak area and concentration of hexafluorophosphate in the range of 20.0-200.0 mg/L. The detection limit(S/N=2) of hexafluorophosphate was 9.2 mg/L. The RSDs (n=5) for retention time and peak area were 0.2% and 0.6%, resp. The method has been applied in the determination of hexafluorophosphate in ionic liquids The spiked recoveries of hexafluorophosphate were in 98-100%. The good linearity and the repeatability of the method could meet the requirements of quant. anal. of hexafluorophosphate in ionic liquids This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1COA of Formula: C8H15F6N2P).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C8H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Physical properties of 1-alkyl-3-methylimidazolium hydrogen sulfate was written by Sun, Hua;Li, Shengqing;Chen, Hao;Liu, Junchao;Liu, Hanlan. And the article was included in Huaxue Yanjiu in 2008.Product Details of 478935-29-4 The following contents are mentioned in the article:

Five ionic liquids, namely, 1-alkyl-3-methylimidazolium hydrogen sulfate ([C_nMIm]HSO₄; alkyl = Et, Bu, hexyl, octyl) were synthesized and characterized by NMR and FT-IR spectra. The phys. properties including solubility, d., viscosity, thermostability, conductivity, pK_a were measured. The results showed that the alkyl chain length had the most dramatic effect on phys. properties. The d. of [CnMIm] HSO₄ decreased with increasing length of alkyl in imidazole. Viscosities were correlated with the length of the alkyl chain in imidazole and the viscosity of [C₄MIm]HSO₄ was the lowest( 16.359*10^-3Pa路s). Because of the effect of hydrogen bonds and Van Der Waals forces, the pK_a of [C₆MIm]HSO₄ was the lowest (0.695). The limiting molar conductivity of [CnMIm]HSPO₄ was greater than that of KCl and the limiting molar conductivity of [C₄MIm]HSO₄ had the highest value. Solubility depended on the polarity of solvents and the compounds were easily dissolved in higher polarity solvents. These imidazolium compounds were stable at temperatures lower than 240掳 and behaved as Newtonian fluids. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Product Details of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach was written by Fang, Mike;Richardson, Brian;Cameron, Cheryl M.;Dazard, Jean-Eudes;Cameron, Mark J.. And the article was included in BMC Bioinformatics in 2021.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

In this study, we demonstrate that our modified Gene Set Enrichment Anal. (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enrichment that emphasizes biol. directionality of drug-derived gene sets. We detail our dpGSEA method and show its effectiveness in detecting specific perturbation of drugs in independent public datasets by confirming fluvastatin, paclitaxel, and rosiglitazone perturbation in gastroenteropancreatic neuroendocrine tumor cells. In drug discovery experiments, we found that dpGSEA was able to detect phenotypically relevant drug targets in previously published differentially expressed genes of CD4+T regulatory cells from immune responders and non-responders to antiviral therapy in HIV-infected individuals, such as those involved with virion replication, cell cycle dysfunction, and mitochondrial dysfunction. dpGSEA is publicly available at https://github.com/sxf296/drug_targeting. DpGSEA is an approach that uniquely enriches on drug-defined gene sets while considering directionality of gene modulation. We recommend dpGSEA as an exploratory tool to screen for possible drug targeting mols. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem