Category: imidazoles-derivatives

Diverse architectures and luminescence properties of three low-dimensional Zn(II)/Cd(II) coordination polymers based on a pyridine-imidazole ligand was written by Wang, Ji-Ping;Su, Bin;Li, Jin-Hua;Wang, Guo-Ming. And the article was included in Inorganic Chemistry Communications in 2018.COA of Formula: C11H9N5 The following contents are mentioned in the article:

Based on a rigid ligand 3,5-bis(imidazole-1-yl)pyridine (bip), three new low-dimensional Zn(II)/Cd(II) coordination polymers Zn(bip)Cl₂ (1), Zn(bip)Cl₂ (2) and [Cd(bip)(p-bdc)_0.5(NO₃)(H₂O)路H₂O]_n (3) (p-H₂bdc = 1,4-benzenedicarboxylic acid) have been successfully obtained. Compounds 1 and 2 both feature zero-dimensional (0D) structures, whose asym. units are the same. The weak 蟺-蟺 stacking arrangement in 1 and 2 is significantly different in mol. orientation, resulting in two entirely different three-dimensional (3D) supramol. structures. Compound 3 was characterized as an infinite one-dimensional (1D) chain structure formed by the linkage of Cd₂(bip)₂ units and linear p-bdc^2- ligands, and is further extended into a 3D supramol. architecture via weak 蟺-蟺 stacking interactions. It can be observed by careful investigation of the two structures that different packing modes in 1 and 2 can afford different networks. The photoluminescence of compounds 1–3 has been investigated in the solid state at ambient temperature This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6COA of Formula: C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.COA of Formula: C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A comparative study of chiral separation of proton pump inhibitors by supercritical fluid chromatography and high-performance liquid chromatography was written by Raja, Rupak;Alam, Syed Dilshad;Srisath, Vikas;Jain, Arvind Kumar;ALOthman, Zeid A.;Mohammed, Abdallah A. A.;Islam, Mohammad Ataul;Bhatt, Tahir;Ali, Imran. And the article was included in Journal of Separation Science in 2022.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

A comparative study of chiral separation of pantoprazole and rabeprazole is carried out using supercritical fluid chromatog. and high-performance liquid chromatog. The columns used were Chiralpak IA and Chiralpak IE. The best mobile phase in supercritical fluid chromatog. was carbon dioxide-0.2% triethylamine in methanol (60:40) and 0.1% triethylamine in n-hexane-ethanol (50:50) in high-performance liquid chromatog. For supercritical fluid chromatog., values of the retention factor of pantoprazole enantiomers were 3.97 and 4.88. These values for rabeprazole enantiomers were 6.10 and 7.52. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.23 and 1.23 and 2.20 and 3.36, resp. Similarly, for high-performance liquid chromatog., the values of retention factor for enantiomers of pantoprazole were 4.02 and 7.32. These values for rabeprazole enantiomers were 5.32 and 7.88, resp. The values of separation and resolution factor for pantoprazole and rabeprazole were 1.82 and 1.48 and 9.22 and 6.58, resp. A comparison was carried out, which confirmed supercritical fluid chromatog. as the best method due to its fastness, eco-friendly, and inexpensiveness. The reported methods are effective, efficient, and reproducible and may be used to sep. and identify pantoprazole and rabeprazole in any unknown samples. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of cellulosic Ag-nanocomposites using an ionic liquid was written by Tayyab, Zuhra;Safi, Sher Zaman;Rahim, Abdur;Khan, Amir Sada;Sharif, Faiza;Khan, Zia Ul Haq;Rehman, Fozia;Ullah, Zahoor;Iqbal, Jibran;Muhammad, Nawshad. And the article was included in Journal of Biomaterials Science, Polymer Edition in 2019.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:

Cellulose-based nanocomposites have gained much attention due to their remarkable biol. properties such as biodegradability, biocompatibility, and low toxicity. In this research work, 1-h-3-methylimidazolium hydrogen sulfate ionic liquid was employed as an efficient solvent for preparation of cellulosic Ag-nanocomposites (CRC/AgNPs composite) from Neem plant. Ionic liquid plays a dual role in obtaining cellulose-rich compound (CRC; removing lignin and hemicellulose components) and plant’s extract (phenolic compounds such as flavonoids, tannins, etc.) that reduces the AgNO₃ into AgNPs for preparation of CRC/AgNPs composite. The prepared CRC/AgNPs composite was characterized using XRD, FTIR and SEM techniques. The XRD and FTIR spectral anal. showed the characteristic peaks assigned to cellulosic constituent and AgNPs. SEM anal. revealed the particles in the range from 26 to 56 nm. The CRC/AgNPs composite was evaluated for its antibacterial and mech. properties. The antibacterial activity against S. aureus and E. coli for CRC/AgNPs composite was observed in comparison to CRC. Cell viability and morphol. were performed on MC3T3-E1 cells which showed no as such toxicity for the prepared CRC/AgNPs composite. Moreover, the addition of CRC/AgNPs composite as a filler increased the compression strength of polymeric materials. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and in vitro evaluation of rabeprazole sodium delayed release tablets was written by K., Bhavani;L., Matsyagiri. And the article was included in World Journal of Pharmaceutical Research in 2019.HPLC of Formula: 117976-90-6 The following contents are mentioned in the article:

The main objective of this research work was to formulate and evaluate the delayed release tablets of rabeprazole sodium, an anti ulcer drug like peptic ulcer and duodenal ulcer. Rabeprazole was classI proton pump inhibitor to gain FDA approval. Rabeprazole sodium delayed release tablets were prepared by direct compression technique and dry granulation method. All the Excipients are tested for compatibility with drug, which revealed that there was no phys. and chem. interaction occurred. During film coating Appearance, average weight, hardness, thickness, disintegration and during film coating appearance of film coating, Average weight of film coating tablet, disintegration time and during enteric coating appearance and average weight of enteric coated tablets acid resistance this parameters were performed like wt variation test, hardness, friability, disintegration time. Among all formulations, formulation F12 was found to be best of all the formulations showing drug release matching the innovator product so to that formulation all the quality control tests were done for conformation. Stability study is carried out for 3 mo at 25掳C; 60% RH: and 40掳C; 75% RH, according to ICH guidelines. The effect of these variables on drug release also studied. The in vitro drug release studied was performed in the disintegration apparatus This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6HPLC of Formula: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.HPLC of Formula: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation of immediate release tablets of Rabeprazole sodium by using tablet in tablet technology was written by Firoz, Syed. Gouse;Amaragiri Lakshmi, N.;Vasantha Kumari, B.;Swapnamadhuri, P.;Sudha Rani, S.;Karthik, S.. And the article was included in Indo American Journal of Pharmaceutical Sciences in 2021.HPLC of Formula: 117976-90-6 The following contents are mentioned in the article:

Rabeprazole provided effective control of gastric acid in patients with symptoms of gastroesophageal reflux. The present work was carried out to improve the therapeutic efficacy of Rabeprazole by expediting its onset of action. Rabeprazole is unstable in acidic environment which requires the drug in immediate release tablet to be delivered in an alk. environment to enhance the in vivo stability of Rabeprazole. The tablets were prepared by using Tablet-in-Tablet technol., in which the drug was present as inner core and the buffer as the outer layer. A total of four inner core formulations were prepared by direct compression method and evaluated for their phys. parameters. Outer core formulation was prepared using wet granulation method. A total of six tablets in tablet formulations were prepared using A4 as the best inner core formulation depending upon its disintegration time. The prepared tablets were film coated by using Insta moist shield film coating material, to protect the formulation from moisture absorbance. All the six formulations were evaluated and Batch F6 was selected as best formulation and compared with the reference product. The developed tablets were found to be superior to the existing immediate release formulations by providing macro pH environment instead of micro pH ambience with less buffer content. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6HPLC of Formula: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prognostic impact of rapid reduction of involved free light chains in multiple myeloma patients under first-line treatment with Bendamustine, Prednisone, and Bortezomib (BPV) was written by Holzhey, Tanja;Poenisch, Wolfram;Wang, Song-Yau;Holzvogt, Madlen;Holzvogt, Bruno;Andrea, Marc;Zehrfeld, Thomas;Hammerschmidt, Doreen;Hoffmann, Franz Albert;Becker, Cornelia;Schwarzer, Andreas;Schwarz, Maik;Schoenfelder-Fricke, Uta;Edelmann, Thomas;Braunert, Leanthe;Franke, Georg-Nikolaus;Jentzsch, Madlen;Schwind, Sebastian;Bill, Markus;Grimm, Juliane;Remane, Yvonne;Platzbecker, Uwe;Scholz, Markus. And the article was included in Journal of Cancer Research and Clinical Oncology in 2021.Electric Literature of C16H21Cl2N3O2 The following contents are mentioned in the article:

Light chain involvement is observed in almost every patient (pt) with newly diagnosed multiple myeloma (MM). Owing to a relatively short half-life, rapid reduction in the involved free light chain (iFLC) is of potential prognostic value. This retrospective anal. included 92 pts with newly diagnosed MM treated with bendamustine, prednisone, and bortezomib (BPV). After a median number of two (range 1-5) BPV cycles, the majority of pts (n = 86; 93%) responded with either sCR (n = 21), CR (n = 1), nCR (n = 25), VGPR (n = 20), or PR (n = 19). PFS and OS at 48 mo were 39% and 67%, resp. At baseline, 79 out of 92 pts (86%) had iFLC levels above the upper standard level and an abnormal ratio of involved to uninvolved free light chain 鈮?8. In a subgroup anal. of these pts, we evaluated the prognostic importance of an early reduction of the iFLC during the first two BPV cycles. A reduction 鈮?50% of the iFLC on day 8 of the first cycle was observed in 31 of 69 pts. These pts had a significantly better median PFS of 49 mo as compared to 20 mo in 38 pts with a lower iFLC reduction (p = 0.002). In contrast, OS did not differ significantly with a 48 mo survival of 77% vs 69% (p > 0.05). These results indicate that a rapid decrease in the iFLC on day 8 is an early prognostic marker for newly diagnosed MM pts undergoing BPV treatment. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Electric Literature of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand based 3D-QSAR model, pharmacophore, molecular docking and ADME to identify potential fibroblast growth factor receptor 1 inhibitors was written by Huang, Lu;Wu, Xulong;Fu, Xiaoli;Wang, Haoxiang;Tang, Biao;Xiao, Yirong;Zhou, Caixia;Zhao, Zhiqiao;Wan, Yujun;Chen, Hui;Tang, Zizhong;Yao, Huipeng;Shan, Zhi;Bu, Tongliang. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Application of 117976-90-6 The following contents are mentioned in the article:

The FGF/FGFR system may affect tumor cells and stromal microenvironment through autocrine and paracrine stimulation, thereby significantly promoting oncogene transformation and tumor growth. Abnormal expression of FGFR1 in cells is considered to be the main cause of tumorigenesis and a potential target for the treatment of cancer. In this study, a combination of structure-based drug carriers and mol. docking-based virtual screening was used to screen new potential FGFR1 inhibitors. Forty eight known inhibitors were collected to establish 3 D-QSAR models and pharmacophore models, investigate the relationship between the activity and conformation of compounds, and verify the efficiency of pharmacophore. In Accelrys Discovery Studio 2016, the ZINC database was filtered by Lipinski鈥瞫 Rule of Five and SMART鈥瞫 filtration. Then, Hypo01 was used for virtual screening of ZINC database. Compounds with predicted activity values less than 1 渭M were molecularly docked with FGFR1 protein crystals, the docking results were observed, and the interaction between compounds and targets was studied. The absorption, distribution, metabolism and excretion (ADME) and toxicity of potential inhibitors were studied, and a compound with new structural scaffolds were obtained. It could be further studied to explore their better therapeutic effects. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Three d¹⁰ coordination polymers assembled from 3,5-bis(imidazole-1-yl)pyridine and different polycarboxylates: Syntheses, structures and luminescence properties was written by Pan, Jie;Zhang, Di;Xue, Zhen-Zhen;Wei, Li;Han, Song-De;Wang, Guo-Ming. And the article was included in Solid State Sciences in 2017.Electric Literature of C11H9N5 The following contents are mentioned in the article:

Three novel Zn(II)/Cd(II) coordination polymers, [Cd₂(bip)₂(m-bdc)₂(H₂O)₂路3H₂O]_n (1), [Zn₂(bip)₂(p-bdc)₂路2.5H₂O]_n (2) and [Zn(bip) (p-bdc)路3H₂O]_n (3), where bip = 3,5-bis(imidazole-1-yl)pyridine, m-H₂bdc = 1,3-benzenedicarboxylic acid, p-H₂bdc = 1,4-benzenedicarboxylic acid, have been successfully synthesized under solvothermal conditions. The linkage of different ligands with Cd(II) ions in compound 1 affords a (3,5)-connected layer. Furthermore, 2D鈫?D parallel polycatenation occurs wherein the layers are polycatenated with the adjacent two parallel layers to form a 3D framework. In 2 and 3, the polycarboxylates act as pillars to combine the metal-bip chains, yielding the layered structures. These 2D networks are extended to the final 3D supramol. architectures by 蟺-蟺 stacking interactions. The results show that bip can act as a versatile building block for the construction of various coordination polymers. Moreover, the fluorescent properties of 1–3 in the solid state at room temperature have been investigated. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Electric Literature of C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Green synthesis of monolithic column incorporated with graphene oxide using room temperature ionic liquid and eutectic solvents for capillary electrochromatography was written by Li, Xin-Xin;Zhang, Li-Shun;Wang, Chao;Huang, Yan-Ping;Liu, Zhao-Sheng. And the article was included in Talanta in 2018.Recommanded Product: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

A hybrid monolith incorporated with graphene oxide (GO) was prepared in the first time with binary green porogens of deep eutectic solvents (DESs) and room temperature ionic liquids (RTILs). GO was modified with 3-(trimethoxysilyl) propylmethacrylate (纬-MPS), and the resultant GO-MPS can be incorporated into poly(methacrylic acid-co-butylmethacrylate-coethylene glycol dimethacrylate) monoliths covalently. A hybrid monolithic column with high permeability and homogeneity can be achieved due to good dispersion of GO-MPS in the green solvents. The GO-MPS incorporated monolith was characterized by TEM, SEM, TGA and nitrogen adsorption tests. The separation of small organic mols. of alkylphenones and alkylbenzenes was used to evaluate the performance of GO-MPS grafted monolith. The GO-MPS grafted monolith displayed the maximum column efficiency of 147,000 plates/m, about twice higher than the GO-free monolith. In addition, all of the retention and selectivity of small mols. of alkylphenones and alkylbenzenes increased due to the addition of GO-MPS. The use of DESs and RTILs is a powerful approach for the preparation of GO incorporated polymer monoliths. The monolith was further applied to the separation of tryptic digests from bovine serum albumin, and the result indicated its potential in the anal. of some complex samples. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Recommanded Product: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Isomeric Effect on the anticancer Behavior of two Zinc(II) complexes based on 3,5-bis(1-imidazolyl)pyridine: Experimental and Theoretical Approach was written by Zhu, Mingchang;Song, Da;Liu, Ning;Wang, Kehua;Su, Junqi;Xiong, Meng;Zhang, Xi;Xu, Yuang;Gao, Enjun. And the article was included in Applied Organometallic Chemistry in 2019.Name: 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Two isomeric Zinc(II) complexes constructed by 3,5-bis(1-imidazolyl)pyridine has been synthesized and characterized by single crystal x-ray diffraction, elemental analyses and IR spectroscopy. The binding mode and ability of complex 1–2 with CT-DNA were studied by UV and fluorescence spectra. The intrinsic binding constant K_b (K_b1 = 2.305 脳 10⁴ M^-1, K_b2 = 3.095 脳 10⁴ M^-1) and the observed association constant K_obs (K_obs1 = 1.523*10⁶ M^-1, K_obs2 = 2.057*10⁶ M^-1) indicated that the insertion ability of complex 2 with CT-DNA is stronger than complex 1. Gel electrophoresis showed that complexes have a good ability to hydrolyze cleavage pBR322 plasmid DNA. The cytotoxicity and apoptosis studies showed that complexes exhibited excellent cytotoxic activity against HeLa cells, especially complex 2 had better growth inhibition than Cisplatin. Mol. docking study simulated the binding model of complexes with DNA (PDB:4av1), showing an imidazole plane of complex 2 can be inserted into a DNA base pair in relative parallel. Both complexes can be used as potential anticancer agents. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Name: 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem