Category: imidazoles-derivatives

Esterification of oleic acid in [Bmim]BF₄/[Hmim]HSO₄ + TX-100/cyclohexane ionic liquid microemulsion was written by Jiang, Dongyu;Chen, Li;Wang, Aili;Yan, Zongcheng. And the article was included in RSC Advances in 2014.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

Esterification of oleic acid was carried out in a 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄)/Triton X-100 + 1-hexyl-3-methylimidazolium hydrogen sulfate ([Hmim]HSO₄)/cyclohexane microemulsion. A pseudo ternary phase diagram of the designed systems was drawn to investigate the phase behavior of the microemulsion, with the surfactant [Hmim]HSO₄ acting as a catalyst. The effects of various reaction parameters were explored. The results showed that the maximum yield of lauryl oleate reaches 91.17% and its selectivity reaches 98.55% under optimum reaction conditions. The reaction was carried out with 8 wt% catalyst at 373 K for 6 h. The molar ratios of [Bmim]BF₄ to the surfactant and of oleic acid to lauryl alc. were 0.24 and 0.2, resp. Comparison reactions between different alcs. and oleic acid were also performed, and the results showed that long alkyl chain alcs. promote the reaction rate. UV-vis absorption spectra demonstrated that the generated water enters the [Bmim]BF₄ microdomain of the ionic liquid microemulsions. A possible mechanism of the reaction was also presented. All the results indicate that the [Bmim]BF₄/TX-100 + [Hmim]HSO₄/cyclohexane microemulsion is a very efficient catalyst system for esterification reactions. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zanubrutinib for treatment-naive and relapsed/refractory chronic lymphocytic leukaemia: long-term follow-up of the phase I/II AU-003 study was written by Cull, Gavin;Burger, Jan A.;Opat, Stephen;Gottlieb, David;Verner, Emma;Trotman, Judith;Marlton, Paula;Munoz, Javier;Johnston, Patrick;Simpson, David;Stern, Jennifer C.;Prathikanti, Radha;Wu, Kenneth;Novotny, William;Huang, Jane;Tam, Constantine S.. And the article was included in British Journal of Haematology in 2022.Product Details of 16506-27-7 The following contents are mentioned in the article:

Summary : The phase I/II AU-003 study in patients with treatment-naive (TN) or relapsed/refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma demonstrated that zanubrutinib therapy results in clin. meaningful and durable responses with acceptable safety and tolerability. We report updated safety and efficacy data for 123 patients with a median follow-up of 47路2 mo. Patients received zanubrutinib 160 mg twice daily (81 patients), 320 mg once daily (40), or 160 mg once daily (two). Discontinuations due to adverse events or disease progression were uncommon. The overall response rate (ORR) was 95路9% (TN, 100%; R/R, 95%) with 18路7% achieving complete response (CR). Ongoing response at 3 years was reported in 85路7%. The ORR in patients with del(17p)/tumor protein p53 mutation was 87路5% (CR 16路7%). The 2- and 3-yr progression-free survival estimates were 90% (TN, 90%; R/R, 91%) and 83% (TN, 81%; R/R, 83%) resp. The most reported Grade 鈮? adverse events were neutropenia (15路4%), pneumonia (9路8%), hypertension (8路9%) and anemia (6路5%). The annual incidence of atrial fibrillation, major hemorrhage, Grade 鈮? neutropenia and Grade 鈮? infection decreased over time. With a median follow-up of 鈭? years, responses remain clin. meaningful and durable and long-term tolerability to zanubrutinib therapy continues. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Product Details of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study was written by Kodama, Masaaki;Okimoto, Tadayoshi;Mizukami, Kazuhiro;Hirashita, Yuka;Wada, Yasuhiro;Fukuda, Masahide;Matsunari, Osamu;Okamoto, Kazuhisa;Ogawa, Ryo;Fukuda, Kensuke;Kudo, Yoko;Kawahara, Yoshinari;Murakami, Kazunari. And the article was included in Journal of Gastroenterology and Hepatology in 2021.Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Improvement of atrophic gastritis and intestinal metaplasia (IM) is considered to reduce the gastric cancer risk, but whether it can be achieved by H. pylori eradication (HPE) remains controversial. To evaluate the effect of HPE, we observed the gastric mucosa for up to17 years after HPE and sex differences in gastric mucosa. In total, 172 patients (94 males, 78 females) with HPE were enrolled. Annual histol. evaluations were performed for up to 17 years. The grades of mononuclear cells, neutrophils, atrophy, IM in the antrum and corpus were evaluated using the updated Sydney system. Pre-HPE period, atrophy had improved significantly 1 yr after HPE in the antrum (1.50 卤 0.75 vs. 1.21 卤 1.25, P < 0.01) and corpus (0.59 卤 0.75 vs. 0.18 卤 0.52, P < 0.05). IM showed no significant change during 17 years after HPE at either biopsy site. Atrophy scores did not differ significantly between males and females. IM scores were significantly higher in males than in females before eradication (antrum, 0.67 卤 0.94 vs. 0.44 卤 0.77, P = 0.003, corpus, 0.20 卤 0.62 vs. 0.047 卤 0.21, P = 0.0027) and at most observation timepoints. During 17 years after HPE, atrophy, but not IM, improved significantly at the greater curvatures of the antrum and corpus. IM was significantly more severe in males than in females. Careful follow-up after HPE based on sex differences in gastric mucosal characteristics is important. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer was written by Matsuoka, Hiroya;Ando, Koji;Swayze, Emma J.;Unan, Elizabeth C.;Mathew, Joseph;Hu, Quingjiang;Tsuda, Yasuo;Nakashima, Yuichiro;Saeki, Hiroshi;Oki, Eiji;Bharti, Ajit K.;Mori, Masaki. And the article was included in PLoS One in 2020.Reference of 117976-90-6 The following contents are mentioned in the article:

Irinotecan specifically targets topoisomerase I (topoI), and is used to treat various solid tumors, but only 13-32% of patients respond to the therapy. Now, it is understood that the rapid rate of topoI degradation in response to irinotecan causes irinotecan resistance. We have published that the deregulated DNA-PKcs kinase cascade ensures rapid degradation of topoI and is at the core of the drug resistance mechanism of topoI inhibitors, including irinotecan. We also identified CTD small phosphatase 1 (CTDSP1) (a nuclear phosphatase) as a primary upstream regulator of DNA-PKcs in response to topoI inhibitors. Previous reports showed that rabeprazole, a proton pump inhibitor (PPI) inhibits CTDSP1 activity. The purpose of this study was to confirm the effects of rabeprazole on CTDSP1 activity and its impact on irinotecan-based therapy in colon cancer. Using differentially expressing CTDSP1 cells, we demonstrated that CTDSP1 contributes to the irinotecan sensitivity by preventing topoI degradation Retrospective anal. of patients receiving irinotecan with or without rabeprazole has shown the effects of CTDSP1 on irinotecan response. These results indicate that CTDSP1 promotes sensitivity to irinotecan and rabeprazole prevents this effect, resulting in drug resistance. To ensure the best chance at effective treatment, rabeprazole may not be a suitable PPI for cancer patients treated with irinotecan. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Reference of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Reference of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rp-hplc method development and validation for simultaneous estimation of clidinium bromide, chlordiazepoxide, dicyclomine hcl and rabeprazole sodium in pharmaceutical dosage form was written by Khan, Ummekulsum;Luhar, Shailesh V.;Narkhede, Sachin B.. And the article was included in European Journal of Biomedical and Pharmaceutical Sciences in 2018.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:

A simple, rapid, economical, precise and accurate RP-HPLC method for simultaneous estimation of Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium has been developed. Method was studied by using Shimadzu 2010CHT, Chromatog. separation was achieved using ODS C18 RP column (250 mm 脳 4.6 mm i.d., 5渭m) kept at ambient temperature, using a mobile phase consisting a mixture of Phosphate buffer (pH 4.5): Acetonitrile (80:20 volume/volume) and pH adjusted with 0.5% orthophosphoric acid at a flow rate of 1.0 mL/min. The detection was made at 215 nm. Retention time was 3.12 min, 4.28 min and 6.97 min and 13.29 for Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium resp. Linear correlation was obtained between peak area and concentration in the range of 5-15 渭g/mL for Clidinium Bromide, 10-30 渭g/mL for Chlordiazepoxide, 20-60 渭g/mL for Dicyclomine HCl and Rabeprazole Sodium. The percentage recoveries of four drugs Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium were found to be 100.48-101.46 %, 98.87-101.75%,98.20-98.80% and 100.94-101.71 % resp. The % RSD value was less than 2, for intraday and interday precision. It can be successfully used for routine anal. of Clidinium Bromide, Chlordiazepoxide, Dicyclomine HCl and Rabeprazole Sodium in combined solid dosage form without any interference from common excipients and impurity. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of dimethyl succinate catalyzed by ionic liquids was written by Zhao, Dishun;Liu, Mengshuai;Xu, Zhice;Zhang, Juan;Zhang, Di;Fu, Jiangtao;Ren, Peibing. And the article was included in Huagong Xuebao (Chinese Edition) in 2012.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:

Seven kinds of ionic liquids, 1-hexyl-3-methylimidazolium hydrogensulfate ([Hmim]HSO₄), 1-butyl-3-methylimidazolium dihydrogen phosphate ([Bmim]H₂PO₄), 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]HSO₄), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄), 1-butylpyridinium hydrogen sulfate ([Bpy]HSO₄), 1-butylpyridinium dihydrogen phosphate ([Bpy]H₂PO₄), 1-ethylpyridinium hydrogen sulfate ([Epy]HSO₄), were designed and synthesized. The synthesis of di-Me succinate catalyzed by ionic liquids was studied for the first time. It was shown that [Epy]HSO₄ had the best catalytic performance, and optimal conditions for the synthesis of di-Me succinate were obtained, succinic acid and methanol molar ratio 1 : 3.0, amount of catalyst 5% (g/g) of succinic acid, reaction temperature 70掳C and reaction time 2 h. Under the optimal conditions, the yield of di-Me succinate was up to 91.83%, esterification rate was 96.32%. The catalyst was recycled 7 times without substantial decrease in activity. Moreover, compared to conventional industrial catalysts, ionic liquid catalyst had the superiority of smaller catalyst dosage, less byproduct, mild reaction conditions, high yield, and recycled catalyst usage. Finally, the mechanism of esterification catalyzed by ionic liquids was discussed. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Impact of rituximab on COVID-19 outcomes was written by Levavi, Hannah;Lancman, Guido;Gabrilove, Janice. And the article was included in Annals of Hematology in 2021.Reference of 16506-27-7 The following contents are mentioned in the article:

Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clin. outcomes from SARS-CoV-2 infection and development of COVID-19 antibodies, we conducted a retrospective study of adults across the Mount Sinai Health System diagnosed with COVID-19 who received rituximab for any indication from Feb. 2019 to Oct. 2020. Patients’ baseline characteristics, markers of disease severity, clin. outcomes, and antibody development were examined Of the 49 patients included in the anal., 63.2% required hospitalization for COVID-19, 24.5% required an ICU admission, and 32.7% died. Proximity of last rituximab infusion and COVID-19 diagnosis did not affect rates of hospitalization, admission to intensive care units or death. Over half (51.7%) of those whose antibodies were checked developed neutralizing anti-spike protein antibodies. The median time between rituximab administration and COVID-19 diagnosis was not significantly different between those who developed antibodies and those who did not (p = .323). Of the 14 patients with documented neg. COVID-19 antibody titers, 11 of them survived SARS-CoV-2 infection, indicating that development of neutralizing antibodies may not be necessary for recovery from COVID-19. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Reference of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Proton Pump Inhibitors and Bone Health: An Update Narrative Review was written by Lespessailles, Eric;Toumi, Hechmi. And the article was included in International Journal of Molecular Sciences in 2022.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Proton pump inhibitors (PPIs) are an antacid drug often used in acid-related disorders. They decrease acid secretion in the stomach by blocking an enzyme called H+/K+ ATPase which controls acid production Introduced to the market in 1989, their use has increased rapidly worldwide and they are now among the top 10 most prescribed drugs in the United States. As of 2015, the FDA has already approved six drugs of this class (omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole and rabeprazole). Recently, the risks and benefits of long-term PPI use were questioned and many studies indicated that their use should be carefully considered, especially in young patients, whose treatment with these drugs could last many years. Even greater concerns have been raised about a potential pos. association between PPIs and osteoporotic fracture risk including the hip, spine and wrist. Although based on observational studies, there is substantial evidence associating the long-term use of PPIs and fracture. This relationship is only partially admitted due to the lack of consistent effects of PPIs on bone mineral d. loss. Therefore, this narrative review aimed to discuss the recent findings pertaining to the risk of osteoporotic fracture associated with PPIs, in particular prolonged use, and to call for further research to elucidate the mechanisms associated with this bone fragility. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stereoselective pharmacokinetics of (R)-(+)- and (S)-(-)-rabeprazole in human using chiral LC-MS/MS after administration of rabeprazole sodium enteric-coated tablet was written by Sun, Lu-Ning;Shen, Yi-Wen;Ying, Yu-Wen;Li, Duo;Li, Teng-Fei;Zhang, Xue-Hui;Zhao, Ping;Ding, Li;Wang, Yong-Qing. And the article was included in Chirality in 2018.Recommanded Product: 117976-90-6 The following contents are mentioned in the article:

Rabeprazole is an effective proton pump inhibitor to treat acid-related diseases. To achieve the simultaneous determination of rabeprazole enantiomers in human plasma, a chiral LC-MS/MS method was developed and validated. Acetonitrile including 0.1% ammonium were used as protein precipitating agent. Analytes were separated within 8 min on a Chiralpak IC column (4.6 mm 脳 150 mm, 5 渭m). The mobile phase was 10 mM ammonium acetate including 0.2% acetic acid-acetonitrile (35:65, volume/volume). An API 4000 mass spectrometer was used as detector for the anal., and the multiple reactions monitoring transitions of m/z 360.1 鈫?242.2 and 346.1 鈫?198.1 were opted for quantifying rabeprazole enantiomers and internal standard Matrix effects were not apparent for each enantiomer and internal standard (esomeprazole), the calibration curves were linear over the concentration of 0.500 to 400 ng路mL^-1, the intra-run precisions were below 5.4%, the inter-run precisions were below 9.9%, and the accuracy was between -9.2% and 9.3%. There was no chiral inversion observed during sample storage, preparation procedure, and anal., demonstrating that analytes were stable in this study. This method was applied to the stereoselective pharmacokinetic study of (R)-(+)- and (S)-(-)-rabeprazole after oral administration of 10-mg rabeprazole sodium enteric-coated tablet in healthy Chinese subjects. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

X-ray diffraction studies of electrochemical graphite intercalation compounds of ionic liquids was written by Sutto, Thomas E.;Duncan, Teresa T.;Wong, Tiffany C.. And the article was included in Electrochimica Acta in 2009.Reference of 157310-73-1 The following contents are mentioned in the article:

Electrochem. intercalation studies are used to characterize ionic liquids composed of a variety of cationic and anionic species. Electrochem., the ionic liquids are characterized by cyclic voltammograms and charge-discharge experiments for the intercalation and de-intercalation of the various cationic and anionic species into graphite. X-ray structure anal. is also performed to determine the relation between the electrochem. behavior of the ionic liquids, and the formation of intercalated graphitic compounds Two different types of imidazolium cations are studied, specifically the di- and trisubstituted imidazolium. These cations are paired with the following anions: tetrafluoroborate, hexafluorophosphate, bis(trifluoromethanesulfonyl)imide, bis(perfluoroethanesulfonyl)imide, nitrate and H sulfate. Results indicate stronger intercalation chem. for the trisubstituted imidazoliums, correlating with the greater charge-discharge efficiencies found for these types of ionic liquids Many of the anions exhibit very poor charge-discharge efficiencies, correlating to very poorly formed graphite intercalates. The exception to this is the H sulfate intercalate, which had low charge-discharge efficiencies but formed a well defined graphite intercalate. Only the imide based anions exhibited both high charge-discharge efficiencies and the formation of a clearly defined graphite intercalate. This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1Reference of 157310-73-1).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 157310-73-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem