Category: imidazoles-derivatives

Use of Aromatic Ionic Liquids in the Reduction of Surface Phenomena of Crude Oil-Water System and their Synergism with Brine was written by Sakthivel, Sivabalan;Velusamy, Sugirtha;Gardas, Ramesh L.;Sangwai, Jitendra S.. And the article was included in Industrial & Engineering Chemistry Research in 2015.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

Enhanced oil recovery is governed primarily by the role of interfacial tension between crude oil and water. Interfacial tension (IFT) of the crude oil-water system is one of the vital factors in the anal. of the capillary forces affecting trapped oil within the reservoir rocks. High salinity and temperature of the reservoirs tend to make researchers search for new surfactants to lower the interfacial tension in crude oil-water systems. The current study hopes to create a move toward solving the above problem through the use of aromatic ionic liquids (ILs) based on imidazolium as the cation and various anions such as [Cl]^–, [Br]^–, [BF₄]^–, [H₂PO₄]^–, [HSO₄]^–, and [PF₆]^– in different concentrations This work involves the study of the effect of concentration, temperature, time, and brine on the fate of surface tension (SFT) of water and interfacial tension of crude oil-water systems. The present study also addresses the trend in the elec. conductivity of ILs in water along with the effect of temperature and concentration of ILs. The study reveals that these ILs are effective in reducing the SFT and IFT of water and crude oil-water systems at high salinity and temperature conditions. In the IFT measurements, a linear decrement with increase in temperature is observed for crude oil-water in the presence of ILs. The interfacial tension of the various imidazolium-based ionic liquids with the crude oil-water system has been measured as a function of temperature by means of the Wilhelmy plate method. The influence of the nature of cation and anion of ionic liquids and of the chain length on the cationic head of the ILs on interfacial tension is also discussed in detail. At increased salinity conditions, unlike classical surfactants, these ILs are found to be more successful. Enhanced efficiency of the drop in IFT using NaCl and IL mixture has been confirmed by measuring the IFT between crude oil and the aqueous solution of IL. The synergism of salt and IL mixture on the reduction of IFT has been observed This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rituximab concentration varies in patients with different lymphoma subtypes and correlates with clinical outcome was written by Liu, Shu;Wang, Zhao;Chen, Rongxin;Wang, Xueding;Fang, Xiaojie;Chen, Zhuojia;Guan, Shaoxing;Liu, Tao;Lin, Tongyu;Huang, Min;Huang, He. And the article was included in Frontiers in Pharmacology in 2022.Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Individual variations in concentrations of rituximab in different B cell non-Hodgkin’s lymphoma subtypes and their relevance to efficacy were still unclear. From 2016 to 2021, a prospective clin. trial was conducted, and 510 samples with 6 uncommon subtypes of B-cell lymphoma were enrolled to examine the pharmacokinetic behavior of rituximab and its impact on clin. outcomes, including complete response (CR), progression-free survival (PFS) and overall survival (OS). Considerable variability was observed in the rituximab trough concentration in the first cycle (C1-trough, 1.16-55.52μg/mL) in patients with different lymphoma subtypes. Patients with “double-hit” lymphoma (4.01 ± 0.77μg/mL) or mantle cell lymphoma (MCL; 15.65 ± 16.45μg/mL) had much lower C1-trough and worse outcomes. Great individual variation in the C1-trough existed among patients with mucosa-associated lymphoma (MALT), and the high C1-trough observed in patients treated with the RB regimen was associated with a better response than was obtained with R-CHOP (38.41 ± 14.13μg/mL vs 15.49 ± 8.80μg/mL, p = 0.0029). Despite the high aggressiveness of the cancer, Burkitt lymphoma patients receiving intensive chemotherapy had the highest C1-trough (28.85 ± 9.35μg/mL) and maintained longterm PFS. The C1-trough in patients with mixed, unclassifiable B-cell lymphoma was close to 20μg/mL, and these patients had acceptable outcomes. Overall, a low rituximab C1-trough was associated with adverse consequences, including persistent progression, early recurrence and a short OS, however, some high-risk factors appeared to be balanced by the presence of a high C1-trough. Basal levels of circulating CD19+ lymphocytes differed between and within patients with diverse lymphoma subtypes and were neg. correlated with C1-trough. Therefore, the traditional doses of rituximab are inadequate for patients with “double-hit” lymphoma and MCL. Increasing the initial rituximab dose according to the disease, high-risk factors and even the baseline CD19+ lymphocyte count will be new methods to optimize therapeutic regimens for patients with different lymphoma subtypes. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

T cell defects: new insights into the primary resistance factor to CD19/CD22 cocktail CAR T-cell immunotherapy in diffuse large B-cell lymphoma was written by Wang, Jiachen;Shen, Kefeng;Mu, Wei;Li, Weigang;Zhang, Meilan;Zhang, Wei;Li, Zhe;Ge, Tong;Zhu, Zhoujie;Zhang, Shangkun;Chen, Caixia;Xing, Shugang;Zhu, Li;Chen, Liting;Wang, Na;Huang, Liang;Li, Dengju;Xiao, Min;Zhou, Jianfeng. And the article was included in Frontiers in Immunology in 2022.COA of Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Despite impressive progress, a significant portion of patients still experience primary or secondary resistance to chimeric antigen receptor (CAR) T-cell immunotherapy for relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). The mechanism of primary resistance involves T-cell extrinsic and intrinsic dysfunction. In the present study, a total of 135 patients of DLBCL treated with murine CD19/CD22 cocktail CAR T-therapy were assessed retrospectively. Based on four criteria (maximal expansion of the transgene/CAR-pos. T-cell levels post-infusion [Cmax], initial persistence of the transgene by the CAR transgene level at +3 mo [Tlast], CD19+ B-cell levels [B-cell recovery], and the initial response to CAR T-cell therapy), 48 patients were included in the research and divided into two groups (a T-normal group [n = 22] and a T-defect [n = 26] group). According to univariate and multivariate regression analyses, higher lactate dehydrogenase (LDH) levels before leukapheresis (hazard ratio (HR) = 1.922; p = 0.045) and lower cytokine release syndrome (CRS) grade after CAR T-cell infusion (HR = 0.150; p = 0.026) were independent risk factors of T-cell dysfunction. Moreover, using whole-exon sequencing, we found that germline variants in 47 genes were significantly enriched in the T-defect group compared to the T-normal group (96% vs. 41%; p<0.0001), these genes consisted of CAR structure genes (n = 3), T-cell signal 1 to signal 3 genes (n = 13), T cell immune regulation- and checkpoint-related genes (n = 9), cytokine- and chemokine-related genes (n = 13), and T-cell metabolism-related genes (n = 9). Heterozygous germline UNC13D mutations had the highest intergroup differences (26.9% vs. 0%; p = 0.008). Compound heterozygous CX3CR1I249/M280 variants, referred to as pathogenic and risk factors according to the ClinVar database, were enriched in the T-defect group (3 of 26). In summary, the clin. characteristics and T-cell immunodeficiency genetic features may help explain the underlying mechanism of treatment primary resistance and provide novel insights into CAR T-cell immunotherapy. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7COA of Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.COA of Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bendamustine versus chlorambucil in treatment of chronic lymphocytic leukaemia in China: a randomized, open-label, parallel-controlled, phase III clinical trial was written by Zhou, Daobin;Xu, Wei;Ma, Hongbing;Zhao, Chunting;Hu, Yu;Zhao, Yaozhong;Wu, Depei;Zhao, Xielan;He, Yanjuan;Yan, Jinsong;Wang, Chunsen;Meng, Fanyi;Jin, Jie;Zhang, Xiaohong;Yu, Kang;Hu, Jianda;Lv, Yue. And the article was included in Investigational New Drugs in 2022.Recommanded Product: 16506-27-7 The following contents are mentioned in the article:

Chronic lymphoblastic leukemia (CLL) is the most common adult leukemia and mainly affects the elderly. Chemoimmunotherapy still has a role in the standard frontline therapy for specific population. However, the clin. activity of bendamustine has not been investigated in unfit Chinese patients with CLL. To compare the efficacy and safety of bendamustine vs. chlorambucil for untreated Chinese patients with Binet stage B/C CLL. Methods. In this multi-center, randomized, open-label, parallel-controlled, phase III trial, patients with previously untreated CLL were enrolled and randomly assigned (1:1) to receive bendamustine or chlorambucil. The primary endpoint was the objective response rate. Secondary endpoints included progression-free survival, the duration of response, and overall survival. Adverse events were recorded to evaluate safety. Of 158 screened patients, 147 were enrolled and randomly allocated to receive bendamustine (n = 72) or chlorambucil (n = 75). After a median follow-up of 25.6 mo (IQR 12.5-27.7), 69.0% (95% CI, 56.9-79.5) of bendamustine-treated patients achieved objective response and 37.0% (95% CI, 26.0-49.1) of chlorambucil with a difference of 32.0% (95%CI: 16.6-47.5), demonstrating the superiority of bendamustine to chlorambucil (p < 0.001). The median progression-free survival was longer for bendamustine (16.5 mo; 95% CI, 11.3-24.7) vs. chlorambucil (9.6 mo; 95% CI, 8.7-11.8; p < 0.001). A longer median duration of response was seen in those receiving bendamustine (19.2 mo; 95% CI, 11.8-29.1) than chlorambucil (10.7 mo; 95% CI, 5.6-13.6; p = 0.0018). Median overall survival was not reached in either group. Overall survival at 18 mo was 88% for bendamustine vs. 85% for chlorambucil. Most common adverse events in both groups were neutropenia and thrombocytopenia. In untreated Chinese patients with Binet stage B/C CLL, bendamustine induced the better objective response and resulted in longer progression-free survival than chlorambucil. Overall, these results validate the role of bendamustine as an effective and safe first-line therapy in this population. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Influence of the calcination temperature and ionic liquid used during synthesis procedure on the physical and electrochemical properties of Ti/(RuO₂)_0.8-(Sb₂O₄)_0.2 anodes was written by Santos, Marcel O.;Santos, Gessica V.;Mattedi, Silvana;Griza, Sandro;Eguiluz, Katlin I. B.;Salazar-Banda, Giancarlo R.. And the article was included in Journal of Electroanalytical Chemistry in 2018.Formula: C10H20N2O4S The following contents are mentioned in the article:

The development of synthesis methods to produce efficient anodes for wastewater treatment systems is an important industrial issue. Here, we describe the synthesis and the phys. and electrochem. characterization of Ti/(RuO₂)_0.8-(Sb₂O₄)_0.2 anodes prepared by thermal decomposition The electrodes were prepared using three calcination temperatures (500, 550 and 600 °C) and using 2-hydroxyethylammonium acetate (2HEAA) and methyl-imidazolium hydrogensulfate ((HMIM)HSO₄) ionic liquids (IL) as solvents for the precursors solutions Both ionic liquids used were characterized in terms of water content and viscosity. The 2HEAA IL is almost 10 times more viscous than the (HMIM)HSO₄ IL. The anodes developed were electrochem. characterized by cyclic voltammetry, morphol. factor, electrochem. impedance spectroscopy and accelerated service lifetime tests. The electrodes synthesized using the 2HEAA IL have superior electrocatalytic properties and electrochem. stability than those made using the (HMIM)HSO₄ IL. In addition, the anodes made using the 2HEAA IL as solvent have more homogenous surfaces and higher crystallinity degree than those made using the (HMIM)HSO₄ IL. Among the studied calcination temperatures, combining 550 °C and the 2HEAA IL results in more compact and rough electrode surfaces with the highest electroactive areas and electrochem. stability. Thus, the temperature of 550 °C is suitable for the synthesis of mixed metal oxide (MMO) anodes. The electrodes synthesized using the 2HEAA IL are more efficient in the electrochem. oxidation of the Reactive Yellow 186 dye than those made using the (HMIM)HSO₄ IL. Consequently, the viscosity of the IL used has great influence on the performance of the synthesized anodes. In addition, the high viscosity of the 2HEAA IL results in a lower number of calcinations steps to produce the anodes and, hence, lower production cost. Viscous ionic liquids are therefore promising for the production of MMO anodes via thermal decomposition methods. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem