Category: imidazoles-derivatives

Dindar, Cigdem K. published the artcileThe Development of Spectrophotometric and Validated Stability- Indicating RP-HPLC Methods for Simultaneous Determination of Ephedrine HCL, Naphazoline HCL, Antazoline HCL, and Chlorobutanol in Pharmaceutical Pomade Form, Synthetic Route of 2508-72-7, the publication is Combinatorial Chemistry & High Throughput Screening (2020), 23(10), 1090-1099, database is CAplus and MEDLINE.

Allergic rhinitis, acute nasal congestion and sinusitis are one of the most common health problems and have a major effect on the quality of life. Several medications are used to improve the symptoms of such diseases in humans. Pharmaceutical pomade form containing Ephedrine (EPD) HCl, Naphazoline (NPZ) HCl, Antazoline (ANT) HCl, and Chlorobutanol (CLO) is one of them. Objective: For these reasons, this study includes the development of spectrophotometric and chromatog. methods for the determination of EPD HCl, NPZ HCl, ANT HCl, and CLO active agents in the pharmaceutical pomade. Method: In the spectrophotometric method, third-order derivative of the amplitudes at 218 nm n=5 and the first-order derivative of the amplitudes 254 nm n=13 was selected for the determination of EPD, ANT, resp. while NPZ was determined by the second derivative at 234 nm and n=21. Colorimetric detection was applied for assay anal. of CLO at 540 nm. Furthermore, a reverse phase high performance liquid chromatog. (RP- HPLC) method has been developed and optimized by using Agilent Zorbax Eclipse XDB C18 (75 mm x 3.0 mm, 3.5μm) column. The column temperature was 40°C, binary gradient elution was used and the mobile phase consisted of 15 mM phosphate buffer in distilled water (pH 3.0) and methanol, and the flow rate was 0.6 mL min^-1 and the UV detector was detected at 210 nm. The linear operating range was obtained as 11.97-70, 0.59-3, 2.79-30, and 2.92-200μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO resp. The LOD values were found to be 3.95, 0.19, 0.92 and 0.96μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in the spectrophotometric method, resp. The linear ranges in the RP-HPLC method were 8.2-24.36μg mL^-1, 0.083 – 0.75μg/mL, 2.01-7.5μg mL^-1 and 2.89-24.4μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO, resp. The LOD values in the validation studies were 2.7, 0.025, 0.66 and 0.86μg mL^-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in RP-HPLC method resp. Conclusion: The results of the spectrophotometric and chromatog. methods were compared and no differences were found between the two methods.

Combinatorial Chemistry & High Throughput Screening published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ren, Xi published the artcileMetabolic glycan labeling and chemoselective functionalization of native biomaterials, Related Products of imidazoles-derivatives, the publication is Biomaterials (2018), 127-134, database is CAplus and MEDLINE.

Decellularized native extracellular matrix (ECM) biomaterials are widely used in tissue engineering and have reached clin. application as biomesh implants. To enhance their regenerative properties and postimplantation performance, ECM biomaterials could be functionalized via immobilization of bioactive mols. To facilitate ECM functionalization, we developed a metabolic glycan labeling approach using physiol. pathways to covalently incorporate click-reactive azide ligands into the native ECM of a wide variety of rodent tissues and organs in vivo, and into the ECM of isolated rodent and porcine lungs cultured ex vivo. The incorporated azides within the ECM were preserved after decellularization and served as chemoselective ligands for subsequent bioconjugation via click chem. As proof of principle, we generated alkyne-modified heparin, immobilized it onto azide-incorporated acellular lungs, and demonstrated its bioactivity by Antithrombin III immobilization and Factor Xa inhibition. The herein reported metabolic glycan labeling approach represents a novel platform technol. for manufacturing click-reactive native ECM biomaterials, thereby enabling efficient and chemoselective functionalization of these materials to facilitate tissue regeneration and repair.

Biomaterials published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ge, Mengmeng published the artcileInsight into the dual effect of water on lignin dissolution in ionic liquids, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is International Journal of Biological Macromolecules (2022), 178-184, database is CAplus and MEDLINE.

The dual regulation of water on lignin in ionic liquids was studied at the mol. level by mol. dynamics simulation. The simulation results show that a small amount of water will destroy the ion association in ionic liquids, i.e., it will produce more free anions and cations. The free ions around lignin are conducive to the dissolution of lignin. On the contrary, excess water will seriously solvate anions and cations. By changing the number of lignin clusters, it is more intuitive to observe that the dissolution of lignin in ILs containing a small amount of water is stronger than that in pure IL, however, the dissolution ability of lignin is reduced after adding a large amount of water in ILs. It is concluded that with the increase of water content, water changes from co-solvent to anti-solvent in the dissolution process. This study provides ideas for the design of IL-water system for economic pretreatment of biomass.

International Journal of Biological Macromolecules published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yu, Ke published the artcileIonic liquids screening for lignin dissolution: COSMO-RS simulations and experimental characterization, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Liquids (2022), 118007, database is CAplus.

As the second most abundant terrestrial polymer, lignin has emerged as a major sustainable source for the production of fuels, chems., and materials. However, efficient screening of solvents for lignin dissolving faces great challenges. In this work, COSMO-RS was used to screen 3886 ionic liquids (ILs) composed of 58 cations and 67 anions, to find out the most effective ones for lignin dissolving by considering the critical items of logarithmic infinite dilution activity coefficient (lnγ^{âˆ?/sup>) and σ-profiles. The substantial improvement of lignin dissolution was achieved in [PMpyrr][OAc] IL by both simulations and experiments validations. Moreover, it was found that the anions dominate the dissolution process and the strongly polar anions exhibit better dissolution ability. Furthermore, the underlying mechanism originated from the hydrogen bond (H-bond) between ILs and lignin was also revealed and systemically analyzed from donor and acceptor ability, indicating that high lignin solubility is reached in the ILs with stronger ability to form H-bond acceptors. This work leads to possible ways toward developing more selective and efficient lignin dissolution methods based on solvent properties.}

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C7H9BO3, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xu, Cheng published the artcileSynthesis and characterization of fungicide cyazofamid, HPLC of Formula: 120118-14-1, the publication is Yingyong Huagong (2009), 38(7), 1076-1077, 1083, database is CAplus.

Cyazofamid was prepared with 4-methylacetophenone as starting material by bromization, cyclization, dehydration-chlorination and sulfonicate. The content of cyazofamid was 93.5%, and the total yield was over 35%.

Yingyong Huagong published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C8H6BrClO, HPLC of Formula: 120118-14-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Heller, William T. published the artcileImpact of Two Water-Miscible Ionic Liquids on the Temperature-Dependent Self-Assembly of the (EO)₆-(PO)₃₄-(EO)₆ Block Copolymer, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is ACS Omega (2022), 7(23), 19474-19483, database is CAplus and MEDLINE.

There are many studies on the self-assembly of triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) copolymers in aqueous solution These polymers display a rich phase diagram as a function of block length, concentration, temperature, and additives. Here, we present a small-angle neutron scattering study of the impact of two water-miscible ionic liquids, 1-butyl-3-methylimidazolium chloride ([C₄C₁mim][Cl]) and 1-butyl-3-methylpyrrolidinium chloride ([C₄C₁pyrr][Cl]), on the temperature-dependent self-assembly of (EO)₆-(PO)₃₄-(EO)₆, also known as L62 Pluronic, in aqueous solution Both ionic liquids depress the temperatures of the various structural transitions that take place, but ([C₄C₁pyrr][Cl]) has a stronger effect. The structures that the triblock copolymer self-assembles into do not dramatically change nor do they significantly change the series of structures that the system transitions through as a function of temperature relative to the various transition temperatures

ACS Omega published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sinha, Hemant K. published the artcileAcidity constants of 2-(hydroxymethyl)benzimidazole, Formula: C9H10N2O, the publication is Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical (1986), 25A(12), 1092-6, database is CAplus.

The effects of solvents and pH on the spectral characteristics of 2-(hydroxymethyl)benzimidazole indicate that methylene group in between hydroxy and benzimidazole ring interferes in their direct interaction and thus each chromophore behaves independently. PH studies on 2-(hydroxymethyl)-1-methylbenzimidazole as well as on the compound devoid of 1-Me substituent demonstrate that the monoanion is formed by the deprotonation of imino group rather than the hydroxy group. Proton-induced fluorescence quenching of monocation is observed in moderate solutions

Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C65H82N2O18S2, Formula: C9H10N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yue, Kun published the artcileComparison between Ab Initio Molecular Dynamics and OPLS-Based Force Fields for Ionic Liquid Solvent Organization, Computed Properties of 79917-90-1, the publication is Journal of Physical Chemistry B (2022), 126(21), 3908-3919, database is CAplus and MEDLINE.

OPLS-based force fields (FFs) have been shown to provide accurate bulk-phase properties for a wide variety of imidazolium-based ionic liquids (ILs). However, the ability of OPLS to reproduce an IL solvent structure is not as well-validated given the relative lack of high-level theor. or exptl. data available for comparison. In this study, ab initio mol. dynamics (AIMD) simulations were performed for three widely used ILs: the 1-butyl-3-methylimidazolium cation with chloride, tetrafluoroborate, or hexafluorophosphate anions, i.e., [BMIM][Cl], [BMIM][BF₄], and [BMIM][PF₆], resp., as a basis for further assessment of two unique IL FFs: the ±0.8 charge-scaled OPLS-2009IL FF and the OPLS-VSIL FF. The OPLS-2009IL FF employs a traditional all-atom functional form, whereas the OPLS-VSIL FF was developed using a virtual site that offloads neg. charge to inside the plane of the ring with careful attention given to reproducing hydrogen bonding. Detailed comparisons between AIMD and the OPLS FFs were made based on radial distribution functions (RDFs), combined distribution functions (CDFs), and spatial distribution functions (SDFs) to examine cation-anion interactions and π⁺-π⁺ stacking between the imidazolium rings. While both FFs were able to correctly capture the general solvent structure of these popular ILs, the OPLS-VSIL FF quant. reproduced interaction distances more accurately. In addition, this work provides further insights into the different short- and long-range structure patterns of these popular ILs.

Journal of Physical Chemistry B published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C26H26N4O7, Computed Properties of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bezzubov, Stanislav I. published the artcileTuning the photophysical and electrochemical properties of iridium(III) 2-aryl-1-phenylbenzimidazole complexes, Computed Properties of 2622-67-5, the publication is Inorganica Chimica Acta (2014), 22-30, database is CAplus.

Heteroleptic bis-cyclometalated Ir(III) complexes, [Ir(cpbi)₂(H₂dcbpy)][PF₆] (1), [Ir(pbi)₂(H₂dcbpy)][PF₆] (2), and [Ir(mpbi)₂(H₂dcbpy)][PF₆] (3), where pbi = 1,2-diphenylbenzimidazole, cpbi = 2-(4-chlorophenyl)-1-phenylbenzimidazole, mpbi = 2-(3,4-dimethoxyphenyl)-1-phenylbenzimidazole, and H₂dcbpy = 2,2′-bipyridine-4,4′-dicarboxylic acid were synthesized and characterized by elemental anal., ¹H, ³¹P NMR, and high resolution mass-spectra. The mol. structure of complex 3 was determined from single-crystal x-ray anal. The complexes exhibit absorption up to 550 nm with molar absorptivities of 2500 M^-1 cm^-1. They have strong luminescence in broad yellow-to-red region in solutions at room temperature While chloro-substituent (complex 1) causes a little hypsochromic shift of the absorption maxima compared to unsubstituted 2, introduction of two methoxy-groups (complex 3) gives rise to a bathochromic shift of âˆ?00 nm. A.C. voltammetry studies of the complexes indicates reversible oxidation and reduction potentials. Calculated excited state oxidation potentials for 1–3 are neg. enough to efficiently inject electrons into the conduction band of TiO₂ (E_F â‰?-0.5 V). Thus, from the electrochem. point of view, all the complexes, especially 3, are good candidates for operation in DSSC as dyes.

Inorganica Chimica Acta published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Computed Properties of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bezzubov, Stanislav I. published the artcile(2-Benzoyl-1-phenylethenolato-κ²O,O’)bis[2-(1-phenyl-1H-benzimidazol-2-yl)phenyl-κC¹]iridium(III) dichloromethane disolvate, Synthetic Route of 2622-67-5, the publication is IUCrData (2016), 1(12), x161915, database is CAplus.

The authors present here synthesis and crystal structure of a neutral Ir^III complex, [Ir(C₁₉H₁₃N₂)₂(C₁₅H₁₁O₂)]·2CH₂Cl₂ or [Ir(CN̂)₂OÔ]·2CH₂Cl₂, where CN̂ is 1,2-diphenyl-1H-benzimidazole and OÔ is 2-benzoyl-1-phenylethenolate. The coordination sphere of the Ir^III atom, located on a 2-fold rotation axis, is that of a slightly distorted C₂N₂O₂ octahedron, with the N atoms in a trans configuration. In the crystal, complex mols. assemble through weak C-H···π interactions in the range 2.699(3)-2.892(3) Å. The solvent CH₂Cl₂ mols. reside in channels aligned along the a axis and are connected to the complex mols. by C-H···O interactions.

IUCrData published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Synthetic Route of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem