Category: imidazoles-derivatives

Li, Hui published the artcileSynthesis, characterization and electrophosphorescent properties of mononuclear platinum(II) complexes based on 2-phenylbenzoimidazole derivatives, Computed Properties of 2622-67-5, the publication is Journal of Organometallic Chemistry (2009), 694(17), 2777-2785, database is CAplus.

The rational design, synthesis and characterization of five phosphorescent Pt complexes [(CÑ)Pt(acac)] [Hacac = acetylacetone, HCÑ = 1-methyl-2-(4-fluorophenyl)benzoimidazole (H-FMBI), 1-methyl-2-phenylbenzoimidazole (H-MBI), 1,2-diphenyl-benzoimidazole (H-PBI), 1-(4-(3,6-di-t-butylcarbazol-9-yl))phenyl-2-phenylbenzoimidazole (t-BuCz-H-PBI), and 1-(4-(3,6-di-(3,6-di-t-butyl-carbazol-9-yl))carbazol-9-yl)phenyl-2-phenylbenzoimidazole (t-BuCzCz-H-PBI)] are discussed. The crystal structure of (MBI)Pt(acac) shows a nearly ideal square planar geometry around the Pt atom and weak intermol. interactions with π-π spacing of 3.55 Å. All of the complexes emit green phosphorescence from the metal-to-ligand charge-transfer (MLCT) excited state with high quantum efficiency (0.08-0.17) at room temperature A multilayer organic light-emitting diode (OLED) with (MBI)Pt(acac) as phosphorescent dopant was fabricated using the method of high-vacuum thermal evaporation, which gives a maximum brightness, luminous and power efficiency of 13,605 cd/m², 15.1 cd/A and 4.3 lm/W, resp. In contrast, a comparable performance can be achieved in the solution-processed OLED based on (t-BuCzPBI)Pt(acac) with a peak brightness, luminous and power efficiency of 13,606 cd/m², 17.5 cd/A and 8.4 lm/W, resp. The better device efficiency results from the good square plane of the central Pt coordination unit and the inhibition of aggregates due to bulky and rigid t-butylcarbazole dendrons.

Journal of Organometallic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Computed Properties of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Cao, Hong-Tao published the artcileA sulfur-free iridium(III) complex for highly selective and multi-signaling mercury(II)-chemosensors, COA of Formula: C19H14N2, the publication is Dalton Transactions (2015), 44(46), 19997-20003, database is CAplus and MEDLINE.

A sulfur-free iridium(III) complex (pbi)₂Ir(mtpy) (1) was successfully prepared and adopted as a Hg(II)-chemosensor with high selectivity and sensitivity. Multi-signaling responses towards Hg(II) ions were observed by UV-vis absorption, phosphorescence and electrochem. measurements. With addition of Hg(II) ions, complex 1 presented quenched emission in its phosphorescence spectrum and the detection limit was as low as 2.5 × 10^-7 M. Addnl., its redox peak currents showed a broad linear relationship with the concentration of Hg(II) ions ranging from 0 to 500 μM, which was beneficial for the quant. detection. Based on the ¹H NMR and ESI-MS analyses, the probing mechanism was tentatively supposed to be the Hg²⁺-induced changes in the local environment of complex 1. Such a response process was useful for achieving simple and effective detection of Hg(II) ions as well as developing more chemosensors.

Dalton Transactions published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, COA of Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Huang, Liurong published the artcileStructural and functional properties of collagen from tilapia scales pretreated by heat-assisted ionic liquids, Quality Control of 79917-90-1, the publication is Journal of Applied Polymer Science (2022), 139(14), 51903, database is CAplus.

This paper explores the structural and functional properties of collagen from tilapia scales pretreated by heat-assisted ionic liquids (ILs). Results show that the solubility of collagen was significantly influenced by the type and concentration of ILs. With the increase of IL concentration, a remarkable decrease in solubility of collagen was seen. Fluorescence spectra show that heat and IL pretreatments induced the exposure of chromophores. Changes in sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that subunits of collagen regenerated from most of the IL solvent systems were not destroyed. The functional properties of regenerated collagen were evaluated by gel strength, viscosity, water-binding capacity, and emulsifying capacity. Results show that all heat-assisted ILs pretreatments improved the gel strength and viscosity, and the highest gel strength and viscosity were both obtained in the collagen pretreated by heat-assisted [EMIM]Cl. Heat-assisted [BMIM]BF₄ pretreatment exhibited the lowest water-binding capacity. Heat-assisted [BDMIM]Cl pretreatment indicated superior effect on improving emulsifying capacity than other pretreatments due to its ability to break most of the hydrogen bonds in collagen mols., resulting in the formation of new re-aggregates with higher solubility and more hydrophobic groups.

Journal of Applied Polymer Science published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Quality Control of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lo, Pui Kin Tony published the artcileNickel(II)-Catalyzed Synthesis of Sulfinates from Aryl and Heteroaryl Boronic Acids and the Sulfur Dioxide Surrogate DABSO, Recommanded Product: Imidazo[1,2-a]pyridine-6-boronic acid, the publication is ACS Catalysis (2019), 9(12), 10668-10673, database is CAplus.

A redox-neutral Ni(II)-catalyzed sulfination of readily available aryl and heteroaryl boronic acids is reported. Using the combination of com. available, air-stable NiBr₂·(glyme), a com. available phenanthroline ligand and DABSO, boronic acids are efficiently converted to the corresponding sulfinate salts, which can be further elaborated to valuable sulfonyl-containing groups, including sulfones, sulfonamides, sulfonyl fluorides, and sulfonate esters. The catalyst loading can be reduced to 2.5 mol % on a gram scale. This practically simple protocol tolerates an unprecedented range of pharmaceutically relevant and electron-poor (hetero)aryl boronic acids, allowing the direct synthesis of active pharmaceutical ingredients.

ACS Catalysis published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, Recommanded Product: Imidazo[1,2-a]pyridine-6-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Qi published the artcileHighly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection, Application In Synthesis of 332026-86-5, the publication is Journal of Medicinal Chemistry (2021), 64(10), 6856-6876, database is CAplus and MEDLINE.

Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for Alzheimer’s disease (AD) because of its compensation capacity to hydrolyze acetylcholine (ACh) and its close association with Aβ deposit. Here, we identified S06-1011 (hBChE IC₅₀ = 16 nM) and S06-1031 (hBChE IC₅₀ = 25 nM) as highly effective and selective BChE inhibitors, which were proved to be safe and long-acting. Candidate compounds exhibited neuroprotective effects and the ability to improve cognition in scopolamine- and Aβ_1-42 peptide-induced cognitive deficit models. The best candidate S06-1011 increased the level of ghrelin, a substrate of BChE, which can function as improving the mental mood appetite. The weight gain of the S06-1011-treated group remarkably increased. Hence, BChE inhibition not only plays a protective role against dementia but also exerts a great effect on treating and nursing care.

Journal of Medicinal Chemistry published new progress about 332026-86-5. 332026-86-5 belongs to imidazoles-derivatives, auxiliary class Oxadiazole,Amine,Benzimidazole, name is 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, and the molecular formula is C9H7N5O, Application In Synthesis of 332026-86-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Xing published the artcileSynthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi, Related Products of imidazoles-derivatives, the publication is Molecules (2016), 21(11), 1574/1-1574/14, database is CAplus and MEDLINE.

A series of benzimidazole phenylhydrazone derivatives I (R¹ = H, CH₃, Cl; R² = H, CH₃; R³ = 2,4-F₂, 3,5-Cl₂, 2,6-Cl₂, etc.) was synthesized. The structure of I (R¹ = H; R² = H; R² = 2-F) was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound I (R¹ = H; R² = H; R² = 2,4-F₂) exhibited significant inhibitory activity against R. solani and M. oryzae with the EC₅₀ values of 1.20 and 1.85 μg/mL, resp. In vivo testing demonstrated that I (R¹ = H; R² = H; R² = 2,4-F₂) could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound I (R¹ = H; R² = H; R² = 2,4-F₂) with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Molecules published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C13H10O3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Ying published the artcileDetection of Membrane-Binding Proteins by Surface Plasmon Resonance with an All-Aqueous Amplification Scheme, Formula: C18H34N4O5S, the publication is Analytical Chemistry (Washington, DC, United States) (2012), 84(7), 3179-3186, database is CAplus and MEDLINE.

The authors report here a surface plasmon resonance (SPR) method for detection of cell membrane binding proteins with high degree signal amplification carried out in an all-aqueous condition. Ultrahigh detection sensitivity was achieved for a membrane-based biosensing interface through the use of functional gold nanoparticles (AuNP) in combination with in situ atom transfer radical polymerization (ATRP) reaction. Fusion of phosphatidylcholine vesicles on a calcinated SPR gold chip established a supported bilayer membrane in which cell receptor monosialoganglioside GM1 was embedded for capture of bacterial cholera toxin (CT). The surface-bound CT was recognized with biotinylated anti-CT, which was linked to the biotin-AuNP through an avidin bridge. The biotin-AuNP surface was functionalized with ATRP initiator that triggers localized growth of poly(hydroxyl-Et methacrylate) (PHEMA) brush, contributing to marked SPR signal enhancement and quant. measurement of CT at very low concentrations The resulting polymer film has been characterized by optical and at. force microscopy. A calibration curve for CT detection has been obtained displaying a response range from 6.3 × 10^-16 to 6.3 × 10^-8 M with a detection limit of 160 aM (equivalent to âˆ?500 mols. in 100 μL sample solution). Sensitive detection of biomols. in complex medium has been conducted with CT-spiked serum, and the detection limit can be effectively improved by 6 orders of magnitude compared to direct measurement in serum. The combined AuNP/ATRP method reported here opens new avenues for ultrasensitive detection of proteins on delicate sensor interfaces constructed by lipid membranes or cell membrane mimics.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Bong Soo published the artcileFunctionalization of Poly(oligo(ethylene glycol) methacrylate) Films on Gold and Si/SiO₂ for Immobilization of Proteins and Cells: SPR and QCM Studies, Synthetic Route of 359860-27-8, the publication is Biomacromolecules (2007), 8(12), 3922-3929, database is CAplus and MEDLINE.

Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) (pOEGMA) with various thicknesses were formed on gold and Si/SiO₂ substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester – an initiator of atom transfer radical polymerization (ATRP) – and surface-initiated ATRP. After the formation of the pOEGMA films, terminal hydroxyl groups of side chains divergent from the methacrylate backbones were activated with N,N’-disuccinimidyl carbonate (DSC), and the DSC-activated pOEGMA films were reacted with (+)-biotinyl-3,6,9-trioxaundecanediamine (Biotin-NH₂) to form biotinylated pOEGMA films. By surface plasmon resonance experiments with the target protein (streptavidin) and model proteins (fibrinogen and lysozyme), the authors verified that the resulting films showed the enhanced signal-to-noise ratio (âˆ?0-fold enhancement) for the biospecific binding of streptavidin compared with the biotinylated substrate prepared from carboxylic acid-terminated SAMs. Quartz crystal microbalance measurements were also carried out to obtain the surface coverage of streptavidin and fibrinogen adsorbed onto the biotinylated pOEGMA films with various thicknesses and to investigate the effect of film thicknesses on the biospecific binding of streptavidin. Both the binding capacity of streptavidin and the signal-to-noise ratio of streptavidin/fibrinogen were saturated at the 20 nm thick pOEGMA film. In addition, to demonstrate a wide applicability of the pOEGMA films, the authors constructed micropatterns of streptavidin and cells by microcontact-printing biotin-NH₂ and poly-L-lysine onto the DSC-activated pOEGMA films, resp.

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Artemenko, M. V. published the artcileComplexing in the nickel nitrate-1-methyl-2-hydroxymethylbenzimidazole-methanol system, Synthetic Route of 7467-35-8, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1971), 37(9), 859-62, database is CAplus.

The spectra of MeOH solutions of Ni(NO3)2 and 1-methyl-2-hydroxy-methylbenzimidazole (I) of varying concentrations were analyzed for their gaussian components. The frequencies 26,500, 16,250, 14,250, and 9500 cm-1 were assigned to 3 I.Ni(NO3)2 and 25,500, 15,250, and 13,250 cm-1 to I.Ni(NO3)2. The instability constant of 3 I.Ni(NO3)2 is 4.2 × 10-3. The magnetic moment is 2.76 ± 0.07 μB, and the paramagnetic Curie point is 53°K. The spectra of the complex as a solid and in solution are analogous and indicate an octahedral structure.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Synthetic Route of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Duncia, John V. published the artcileThe discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (1990), 33(5), 1312-29, database is CAplus and MEDLINE.

A new class of potent antihypertensives, e.g., N-benzylimidazoles, I (R = CH₂CO₂H, CH₂OH, CH₂OMe, CH₂CO₂H, CH₂CO₂Me; R¹ = NO₂, NH₂, CO₂H, CH₂CO₂H, OMe, etc.) has been discovered that exert their effect through blockade of the angiotensin II (AII) receptor. Most AII antagonists reported so far are peptide mimics of the endogenous vasoconstrictor octapeptide angiotensin II. I are nonpeptides and therefore constitute a new class of potent AII receptor antagonists. Based on the overlap of a conformation of AII with literature lead compound I (R = CH₂CO₂H R¹ = H)(II) a hypothesis was developed suggesting the need for an addnl. acidic functionality to increase the lead’s potency. The substitution of an addnl. carboxylic acid resulted in a 10-fold increase in binding affinity observed for diacid I (R = CH₂CO₂H, R¹ = CO₂H). The binding affinities for subsequent compounds were eventually increased 1000-fold over that of II through a systematic SAR study. A structure-affinity relationship showed the presence of four key elements for good activity: an addnl. Ph ring at the N-benzyl para position of the benzylimidazole nucleus, an acidic functionality at the ortho-position of the terminal aromatic ring, a lipophilic side chain at the imidazole 2-position of three to five carbon atoms in length, and a group at the imidazole 5-position capable of hydrogen bonding. The synthesis as well as the pharmacol. activity of the compounds in this new series of AII receptor antagonists are presented.

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem