Category: imidazoles-derivatives

Buehlmayer, Peter published the artcileNonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives, Product Details of C8H13ClN2O, the publication is Journal of Medicinal Chemistry (1991), 34(10), 3105-14, database is CAplus and MEDLINE.

(Tetrazolylnaphthalenylmethyl)imidazoles I (R = Cl, R¹ = CH₂OH, R² = 1,2-Q, imidazole ring position = 5, 6, 7; R = CH₂OH, R¹ = Cl, R² = 2-Q, imidazole ring position = 6) and (naphthalenylmethyl)imidazoles II (R = Cl, R¹ = CH₂OH, R³ = CO₂H, 2-tetrazolyl, R⁴ = H, Me; R = CH₂OH, R¹ = Cl, R³ = CO₂H, 2-tetrazolyl, R⁴ = H, Me) were prepared and examined as angiotensin II receptor antagonists and as inhibitors of angiotensin II induced contraction of rabbit aortic rings. Thus, 5-methylnaphthalen-1-ylcarbonitrile was brominated to the 5-(bromomethyl) derivative which reacted with 2-butyl-4(5)-chloro-5(4)-(hydroxymethyl)imidazole to give I (R = Cl, R¹ = CH₂OH, R² = 1-cyano, imidazole ring position = 5) II. II was treated with Bu₃SnN₃ in xylene to give I (R = Cl, R¹ = CH₂OH, R² = 2-Q, imidazole ring position = 6; R = CH₂OH, R¹ = Cl, R² = 2-Q, imidazole ring position = 6) were the most potent of the compounds tested.

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Product Details of C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Van Gyseghem, E. published the artcileDetermining orthogonal and similar chromatographic systems from the injection of mixtures in liquid chromatography-diode array detection and the interpretation of correlation coefficients color maps, Product Details of C17H20ClN3, the publication is Journal of Chromatography A (2004), 1026(1-2), 117-128, database is CAplus and MEDLINE.

Generic orthogonal chromatog. systems might be helpful tools as potential starting points in the development of methods to sep. impurities and the active substance in drugs with unknown impurity profiles. The orthogonality of 38 chromatog. systems was evaluated from weighted-average-linkage dendrograms and color maps, both based on the correlation coefficients between the retention factors on the different systems. On each chromatog. system, 68 drug substances were injected as mixtures of three or four components to increase the throughput. The (overlapping) peaks were identified and resolved with a peak purity algorithm, orthogonal projection approach (OPA). The visualization techniques applied allowed a simple evaluation of orthogonal and (groups of) similar systems.

Journal of Chromatography A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C7H16Cl2Si, Product Details of C17H20ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Qian published the artcileIonic liquid decorated MXene/Poly (N-isopropylacrylamide) composite hydrogel with high strength, chemical stability and strong adsorption, Application In Synthesis of 258278-25-0, the publication is Chemosphere (2022), 303(S), 135083, database is CAplus and MEDLINE.

Organic phenolic pollutants in industrial wastewater cause severe environmental pollution and physiol. damage. Poly (N-isopropylacrylamide) (PNIPAM) hydrogels generally have poor mech. strength and are also intrinsically frangible, limiting their widespread applications in wastewater treatment. Combining them with 2-dimensional materials can also only improve the mech. properties of hydrogels. Here, we report a high-strength, chem. stability and strong adsorption MXene/poly (N-isopropylacrylamide) (PNIPAM) thermosensitive composite hydrogel for efficient removal of phenolic pollutants from industrial wastewater. Ionic liquids (ILs) were grafted onto the surface of MXenes and introduced into NIPAM monomer solution to obtain composite hydrogels by in-situ polymerization for improved mech. strength and adsorption capacity of the composite hydrogel. Compared with the MXene/PNIPAM composite hydrogel, the introduction of ILs simultaneously improves the mech. and adsorption properties of the composite hydrogel. The ILs bind to the surface of MXene flakes through electrostatic interactions, which improved the thermal stability and oxidation resistance of MXenes while maintaining its good dispersion. Using 1-Ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF4) modified MXene (MXene-EMIMBF4) did not change significantly were observed after aging for 45 days. As-prepared composite hydrogels demonstrated excellent mech. properties, reusability, and high adsorption capacity for p-Nitrophenol (4-NP). The MXene-EMIMBF4/PNIPAM hydrogel could recover after ten 95% strain compression cycles under the synergistic effect of chem. bonding and electrostatic attraction. Its maximum adsorption capacity for 4-NP was 200.29 mg g^-1 at room temperature, and the adsorption capacity maintained at �0% of its initial value after five adsorption cycles, which was related to the introduction of EMIMBF4 to form a denser network structure. The adsorption data followed the pseudo-second-order kinetics and Freundlich models.

Chemosphere published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C11H11BFNO4, Application In Synthesis of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Jian-Tao published the artcileTwo-dimensional array Debye ring diffraction protein recognition sensing, Formula: C18H34N4O5S, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(56), 6337-6339, database is CAplus and MEDLINE.

We attach 2-D colloidal arrays onto the surface of hydrogels containing biotin. The hydrogel volume shrinks with increasing concentrations of avidin due to the formation of avidin-biotin crosslinks. This causes the Debye diffraction ring diameter to increase, and the 2-D diffraction wavelength to blue-shift.

Chemical Communications (Cambridge, United Kingdom) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C12H25Br, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Verhoest, Patrick R. published the artcileDiscovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920)(I) for the Treatment of Schizophrenia, Product Details of C9H10N2O, the publication is Journal of Medicinal Chemistry (2009), 52(16), 5188-5196, database is CAplus and MEDLINE.

By utilizing structure-based drug design (SBDD) knowledge, a novel class of phosphodiesterase (PDE) 10A inhibitors was identified. The structure-based drug design efforts identified a unique “selectivity pocket” for PDE10A inhibitors, and interactions within this pocket allowed the design of highly selective and potent PDE10A inhibitors. Further optimization of brain penetration and drug-like properties led to the discovery of 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) (I). This PDE10A inhibitor is the first reported clin. entry for this mechanism in the treatment of schizophrenia.

Journal of Medicinal Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C11H22N2O4, Product Details of C9H10N2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kapale, Suraj S. published the artcileA sustainable approach towards the three-component synthesis of unsubstituted 1H-imidazoles in the water at ambient conditions, Quality Control of 13682-33-2, the publication is Journal of Asian Natural Products Research (2021), 23(7), 712-716, database is CAplus and MEDLINE.

A green protocol for the synthesis of imidazoles I [R = Ph, 4-BrC₆H₄, 2-furyl, etc.; R¹ = R² = H, Ph] was demonstrated. The reaction was realized using com. available lipase enzyme, porcine pancreas lipase (PPL) in water. The reaction conditions were selective and mild which helped to tolerate a wide variety of functional groups to gave desired products I in good chem. yields.

Journal of Asian Natural Products Research published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, Quality Control of 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Manyar, Haresh G. published the artcileThe green catalytic oxidation of alcohols in water by using highly efficient manganosilicate molecular sieves, Category: imidazoles-derivatives, the publication is Green Chemistry (2006), 8(4), 344-348, database is CAplus.

An efficient and green catalytic protocol for the oxidation of alcs. to the corresponding aldehydes is based on use of manganosilicate mol. sieves as efficient heterogeneous catalyst in aqueous conditions and peroxydisulfate as oxidant. The advantageous feature of this oxidation methodol. is the efficiency and selectivity on heterocyclic and aliphatic alcs. The manganosilicate was prepared through a facile complexation procedure leading to uniform mesoporous cubic structure devoid of extra-framework bulk manganese oxide species.

Green Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chen, Wei published the artcileOne-pot synthesis of 1,2-diphenyl-1H-imidazole derivatives catalyzed by CuI, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Huaxue Shiji (2011), 33(7), 603-606, database is CAplus.

A new strategy for one step synthesis of 1,2-diphenyl-1H-imidazole derivatives, using CuI to catalyze the C-N and C-C coupling reaction, was described. This method is economical, cost efficient, and harmless. Structures of the products were characterized by ¹H-NMR, ¹³C-NMR, MS spectra and elemental anal.

Huaxue Shiji published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Safety of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Rubing published the artcileStructure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Journal of Medicinal Chemistry (2015), 58(11), 4713-4726, database is CAplus and MEDLINE.

Forty-three 1,5-diheteroaryl-1,4-pentadien-3-ones were designed as potential curcumin mimics, structurally featuring a central five-carbon dienone linker and two identical nitrogen-containing aromatic rings. They were synthesized using a Horner-Wadsworth-Emmons reaction as the critical step and evaluated for their cytotoxicity and antiproliferative activities toward both androgen-insensitive and androgen-sensitive prostate cancer cell lines and an aggressive cervical cancer cell line. Most of the synthesized compounds showed distinctly better in vitro potency than curcumin in the four cancer cell lines. The structure-activity data acquired from the study validated (1E,4E)-1,5-diheteroaryl-1,4-pentadien-3-ones as an excellent scaffold for in-depth development for clin. treatment of prostate and cervical cancers. 1-Alkyl-1H-imidazol-2-yl, ortho pyridyl, 1-alkyl-1H-benzo[d]imidazole-2-yl, 4-bromo-1-methyl-1H-pyrazol-3-yl, thiazol-2-yl, and 2-methyl-4-(trifluoromethyl)thiazol-5-yl were identified as optimal heteroaromatic rings for the promising in vitro potency. (1E,4E)-1,5-Bis(2-methyl-4-(trifluoromethyl)thiazol-5-yl)penta-1,4-dien-3-one, featuring thiazole rings and trifluoromethyl groups, was established as the optimal lead compound because of its good in vitro potency and attractive in vivo pharmacokinetic profiles.

Journal of Medicinal Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C5H8N2O2, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sun, Manman published the artcileOne-pot synthesis of 1,2-diphenyl-1H-benzo[d]imidazole derivatives by a Pd-catalyzed N-arylation and Cu-catalyzed C-H functionalization/C-N bond formation process, Application In Synthesis of 2622-67-5, the publication is RSC Advances (2014), 4(88), 47373-47376, database is CAplus.

A one-pot synthesis of 1,2-diaryl-1H-benzo[d]imidazole derivatives starting from N-arylbenzamidines and iodobenzenes or bromobenzenes was introduced. The process consisted of a Pd-catalyzed N-arylation and a Cu-catalyzed C-H functionalization/C-N bond formation.

RSC Advances published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C25H23NO4, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem