Category: imidazoles-derivatives

Sanghavi, N. M. published the artcileEstimation of antazoline hydrochloride in tablets of antazoline hydrochloride, Related Products of imidazoles-derivatives, the publication is Indian Journal of Pharmacy (1974), 36(6), 137-8, database is CAplus.

The method of estimation of antazoline-HCl [2508-72-7] in tablets was based on the formation of a stable yellow nitroso derivative with NaNO2 solution in the presence of dilute HCl which shows maximum absorption at 412 mμ. A graph of optical d. against concentration gave a straight line over a concentration range of 10 μg/ml to 50 μg/ml showing that the reaction was in compliance with Beer’s Law. Known amounts of antazoline-HCl were added to known amounts of previously analyzed samples of antazoline-HCl and analyzed again by the proposed method. The percentage recovery was 98.6. The proposed method was found to be satisfactory within a narrow range of ± 2%. It was also found that other antihistamines like chlorpheniramine [132-22-9], dimenhydrinate [523-87-5], diphenhydramine [58-73-1] did not interfere. Excipients like starch [9005-25-8], gum arabic [9000-01-5], magnesium stearate [557-04-0], etc. did not interfere while paracetamol [103-90-2], phenylephrine-HCl [61-76-7] interfered.

Indian Journal of Pharmacy published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yang, Qi published the artcileA simple phenylation of heteroaromatic compounds using diphenyliodonium triflate, Category: imidazoles-derivatives, the publication is Research on Chemical Intermediates (2012), 38(7), 1335-1340, database is CAplus.

2-Ph heteroaromatic arenes I (Y = S, NH, NMe, NC₆H₅, O; X = CH, N) were prepared by phenylation of heteroaromatic compounds with diphenyliodonium trifluoromethanesulfonate as oxidant in the presence of 5 mol% Pd(OAc)₂ catalyst under mild reaction conditions (THF, 60°, 24 h). The proposed reaction mechanism was studied by HPLC.

Research on Chemical Intermediates published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C8H8O3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Prakash, Sekar published the artcileRhenium(I)-Catalyzed ortho-C-H Addition to Bicyclic Alkenes, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Chemistry – An Asian Journal (2018), 13(13), 1664-1668, database is CAplus and MEDLINE.

Hydroarylation of bicyclic alkenes was developed using a low-valent Re^I-catalyzed, directing group-assisted C-H bond activation strategy. The addition of sodium acetate significantly improves the reaction efficiency; moreover, bicyclic alkenes such as 7-oxa and aza benzonorbornadienes worked efficiently under this reaction condition. Preliminary mechanistic studies suggest that, after the alkene insertion, the rhenacycle preferentially undergoes protonolysis rather than reductive elimination.

Chemistry – An Asian Journal published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chan, Pak published the artcileCompatibility of ceftobiprole medocaril with selected drugs during simulated Y-site administration, Formula: C17H18N3NaO3S, the publication is American Journal of Health-System Pharmacy (2008), 65(16), 1545-1551, database is CAplus and MEDLINE.

Purpose: The phys. compatibility of the new cephalosporin ceftobiprole medocaril with 70 other drugs during simulated Y-site injection was studied. Methods: Ceftobiprole was reconstituted with sterile water for injection. Dilutions of ceftobiprole 2 mg/mL (as ceftobiprole medocaril 2.67 mg/mL) were prepared in 5% dextrose injection, 0.9% sodium chloride injection, and lactated Ringer’s injection. For testing compatibility with the other drugs, a 5-mL sample of the ceftobiprole 2-mg/mL admixtures was combined with a 5-mL sample of the other drug either undiluted or diluted with one of the three vehicles. Each combination was prepared in duplicate, switching the order of drug addition, and kept at room temperature At intervals up to four hours after preparation, samples were examined visually and with the aid of a Tyndall beam and measured with a turbidimeter and a particle sizer and counter. Compatibility with propofol was evaluated by checking for emulsion separation and particles after centrifugation. Results: In all three vehicles, ceftobiprole was compatible with 31 other drugs and incompatible with 32. With 7 drugs, compatibility was dependent on the vehicle used. Signs of incompatibility included the presence of visible and subvisible particles, haze, and turbidity. No incompatibilities were related to the order of mixing. Conclusion: Of the 70 drugs evaluated for compatibility with ceftobiprole 2 mg/mL (as medocaril) in 5% dextrose injection, 0.9% sodium chloride injection, and lactated Ringer’s injection, 31 were found to be compatible and 32 were found to be incompatible in all three of the infusion solutions For 7 of the drugs, compatibility was dependent on which infusion solution was used. Ceftobiprole medocaril should not be simultaneously administered via a Y site with drugs with which it was shown to be incompatible.

American Journal of Health-System Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Formula: C17H18N3NaO3S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nanda, Tanmayee published the artcilePalladium-Catalyzed C-C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides, Formula: C27H39ClN2, the publication is Journal of Organic Chemistry (2021), 86(3), 2682-2695, database is CAplus and MEDLINE.

Strain-driven palladium/N-heterocyclic carbene-catalyzed C-C bond activation of diphenylcyclopropenone (DPC) was explored for one-step access to trisubstituted α,β-unsaturated esters and amides. The designed transformation worked under mild conditions providing exclusively a single stereoisomer. Mechanistic studies support the oxidative addition of the C-C bond of cyclopropenone to in-situ-generated Pd(0) intermediate. Vinylic hydrogen in the product was proved that it is coming from phenol/aniline through deuterium-labeling studies. Late-stage functionalization of bioactive mols. such as procaine, estrone, and hymecromone demonstrated the robustness of this protocol.

Journal of Organic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sharma, Mahendra K. published the artcileCrystalline Divinyldiarsenes and Cleavage of the As:As Bond, Formula: C27H39ClN2, the publication is Chemistry – A European Journal (2019), 25(35), 8249-8253, database is CAplus and MEDLINE.

The first divinyldiarsenes [{(NHC)C(Ph)}As]₂ (NHC=IPr 3 a, SIPr 3 b; IPr=C{(NAr)CH}₂; SIPr=C{(NAr)CH₂}₂; Ar=2,6-iPr₂C₆H₃) are reported. Compounds 3 a and 3 b were prepared by the reduction of corresponding chlorides {(NHC)C(Ph)}AsCl₂ (NHC=IPr 2 a, SIPr 2 b) with Mg. Calculations revealed a small HOMO-LUMO energy gap of 3.86 (3 a) and 4.24 eV (3 b). Treatment of 3 a with (Me₂S)AuCl led to the cleavage of the As:As bond to restore 2 a, which is expected to proceed via the diarsane [{(IPr)C(Ph)}AsCl]₂ (4). Remarkably, 4 as well as 2 a can be selectively accessed on treatment of 3 a with an appropriate amount of C₂Cl₆. Moreover, 3 a readily reacts with PhEEPh (E=Se or Te) at room temperature to give {(IPr)C(Ph)}As(EPh)₂ (E=Se 5 a; Te 5 b), revealing the cleavage of As:As and E-E bonds and the formation of As-E bonds. Such highly selective stepwise oxidation (3a â†?4 â†?2a) and bond metathesis (3a â†?5a,b) reactions are unprecedented in main-group chem.

Chemistry – A European Journal published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C9H22OSi, Formula: C27H39ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Konieczna, Lucyna published the artcileChemometric exploration of the dependencies between molecular modeling descriptors and analytical chemistry data of antihistaminic drugs, Synthetic Route of 2508-72-7, the publication is Journal of AOAC International (2012), 95(3), 713-723, database is CAplus and MEDLINE.

The relationships between exptl. and computational descriptors of antihistamine drugs were studied using principal component anal. (PCA). Empirical data came from UV and IR spectroscopic measurements. Nonempirical data, such as structural mol. descriptors, and chromatog. data, were obtained from HyperChem software. Another objective was to test whether the parameters used as independent variables (nonempirical and empirical-spectroscopic) could lead to attaining classification similar to that developed on the basis of the chromatog. parameters. To arrive at the answer to the question, a matrix of 18 × 49 data, including HPLC and UV and IR spectroscopic data, together with mol. modeling studies, was evaluated by the PCA method. The obtained clusters of drugs were consistent with the drugs’ chem. structure classification. Moreover, the PCA method applied to the HPLC retention data and structural descriptors allowed for classification of the drugs according to their pharmacol. properties; hence it may potentially help limit the number of biol. assays in the search for new drugs.

Journal of AOAC International published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tertov, B. A. published the artcileLithium and sodium derivatives of N-substituted 2-alkylbenzimidazoles, Application In Synthesis of 4760-35-4, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1986), 1073-7, database is CAplus.

The title compounds (I; R = Me, Ph; R¹ = H, Me, Et, R² = Li, Na) were prepared in 90-6% yields by metalation of I (R¹ = H) with R³Li or R³Na (R³ = Bu, Ph, naphthyl). The preparation of other derivatives by treating I (R² = Li, Na) with Ph₂CO, PrONO₂, aldehydes, and iodides was also discussed. Thus, treating I (R = Me, R¹ = H, R² = Na) with MeI gave the corresponding I (R² = Me).

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C8H5F3O2S, Application In Synthesis of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mock, Donald M. published the artcileBiotin-protein bond: instability and structural modification to provide stability for in vivo applications, SDS of cas: 359860-27-8, the publication is Methods in Molecular Biology (Totowa, NJ, United States) (2008), 209-220, database is CAplus and MEDLINE.

Biotinylation of proteins is a powerful tool for investigating biol. phenomenon, both in vitro and in vivo. Biotinylating reagents that form covalent bonds with several types of amino acid residues are com. available. However, most, if not all, of these com. available biotinylating agents produce biotin-protein bonds that are susceptible to cleavage in human plasma. Here, we describe the use of IgG as a model protein for evaluation of biotin-protein bond stability and for the investigation of the mechanism of biotin release. We also describe the synthesis of a biotin-protein bond that is stable in human plasma and a method for evaluation of that stability.

Methods in Molecular Biology (Totowa, NJ, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Khedaioui, Douriya published the artcilePolyethylene Aerogels with Combined Physical and Chemical Crosslinking: Improved Mechanical Resilience and Shape-Memory Properties, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Angewandte Chemie, International Edition (2019), 58(44), 15883-15889, database is CAplus and MEDLINE.

While the introduction of polymers into aerogels strongly enhances their toughness, truly elastic monolithic aerogels which restore their dimensions upon extensive compression are still challenging to synthesize. In this context hydrophobic semi-crystalline polymers with low glass transition temperatures, and combined stiffness and flexibility, have only recently attracted attention. Shown here is that polyethylene aerogels with a low d., and combined chem. crosslinking and high crystallinity, display high moduli and excellent mech. resilience. To maximize the crystallinity of these aerogels while maintaining a high crosslinking d., polyethylene networks with well-defined segments were synthesized by hydrosilylation crosslinking of telechelic, vinyl-functionalized oligomers obtained from catalyzed chain-growth polymerization Recoverable deformations both above and below the melting temperature of polyethylene affords remarkable shape-memory properties.

Angewandte Chemie, International Edition published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Application of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem