Category: imidazoles-derivatives

Steck, Edgar A. published the artcileBenzimidazole derivatives, Computed Properties of 4760-35-4, the publication is Organic Preparations and Procedures International (1975), 7(1), 6-11, database is CAplus.

1-(Aminomethyl)benzimidazoles [I, R = Me, NR2 = 3-carbamoyl-1-piperidinyl, 3-(diethylcarbamoyl-1-piperidinyl, 4-(2-hydroxyethyl)-1-piperazinyl, 4-(ethoxycarbonyl)-1-piperazinyl, R1 = 5-Cl, 6Cl, or 5,6-Cl2] were prepared by Mannich reaction of the appropriate benzimidazole and amine; o-C6H4(NH2)2 or 4-chloro-o-phenylenediamine reacted with 2-deoxy-D-glucose in the presence of Cu(I) acetate to give the corresponding 2-(D-arabino-2,3,4,5-tetrahydroxypentyl)benzimidazole; 2-(chloromethyl)-1-methyl-2-benzimidazole was treated with piperazine and tropine to give 1,4-bis(1-methyl-2-benzimidazolylmethyl)piperazine and 8-(1-methyl-2-benzimidazolyl)methyltropinium chloride resp.

Organic Preparations and Procedures International published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C6H17NO3Si, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Remillard, David published the artcileDegradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands, COA of Formula: C18H34N4O5S, the publication is Angewandte Chemie, International Edition (2017), 56(21), 5738-5743, database is CAplus and MEDLINE.

The bromodomain-containing protein BRD9, a subunit of the human BAF (SWI/SNF) nucleosome remodeling complex, has emerged as an attractive therapeutic target in cancer. Despite the development of chem. probes targeting the BRD9 bromodomain, there is a limited understanding of BRD9 function beyond acetyl-lysine recognition. We have therefore created the first BRD9-directed chem. degraders, through iterative design and testing of heterobifunctional ligands that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex. Degraders of BRD9 exhibit markedly enhanced potency compared to parental ligands (10- to 100-fold). Parallel study of degraders with divergent BRD9-binding chemotypes in models of acute myeloid leukemia resolves bromodomain polypharmacol. in this emerging drug class. Together, these findings reveal the tractability of non-BET bromodomain containing proteins to chem. degradation, and highlight lead compound dBRD9 as a tool for the study of BRD9.

Angewandte Chemie, International Edition published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, COA of Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Remillard, David published the artcileDual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is ACS Medicinal Chemistry Letters (2019), 10(10), 1443-1449, database is CAplus and MEDLINE.

Recent reports have highlighted the dual bromodomains of TAF1 (TAF1(1,2)) as synergistic with BET inhibition in cellular cancer models, engendering interest in TAF/BET polypharmacol. Here, we examine structure activity relationships within the BI-2536 PLK1 kinase inhibitor scaffold, previously reported to bind BRD4. We examine binding by this ligand to TAF1(2) and apply structure guided design strategies to discriminate binding to both the PLK1 kinase and BRD4(1) bromodomain while retaining activity on TAF1(2). Through this effort we discover potent dual inhibitors of TAF1(2)/BRD4(1), as well as biased derivatives showing marked TAF1 selectivity. We resolve X-ray crystallog. data sets to examine the mechanisms of the observed TAF1 selectivity and to provide a resource for further development of this scaffold.

ACS Medicinal Chemistry Letters published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marszall, Michal Piotr published the artcileReduction of silanophilic interactions in liquid chromatography with the use of ionic liquids, Synthetic Route of 2508-72-7, the publication is Analytica Chimica Acta (2005), 547(2), 172-178, database is CAplus.

A suppression of silanophilic interactions by the selected ionic liquids added to the mobile phase in thin-layer chromatog. (TLC) and HPLC is reported. Acetonitrile was used as the eluent, alone or with various concentrations of water and phosphoric buffer pH 3. Selectivity of the normal (NP) and the reversed (RP) stationary phase material was examined using proton-acceptor basic drugs analytes. The ionic liquids studied appeared to significantly affect analyte retention in NP-TLC, RP-TLC and RP-HPLC systems tested. Consequently, the increased separation selectivity was attained. Due to ionic liquid additives to eluent even analytes could be chromatographed, which were not eluted from the silica-based stationary phase materials with 100% of acetonitrile in the mobile phase. Addition of ionic liquid already in very small concentration (0.5%, volume/volume) could reduce the amount of acetonitrile used during the optimization of basic analytes separations in TLC and HPLC systems. Also, the influence of temperature on the separation of basic analytes was demonstrated and considered in practical HPLC method development.

Analytica Chimica Acta published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marszall, Michal Piotr published the artcileEvaluation of the silanol-suppressing potency of ionic liquids, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Separation Science (2006), 29(8), 1138-1145, database is CAplus and MEDLINE.

Recently, increasing attention was paid to the use of ionic liquids for HPLC and capillary electrophoresis. The silanol-suppressing potency of ionic liquids was evaluated by HPLC using the two-retention site model proposed previously by Nahum and Horvath. The binding constant, K_A, in that approach was demonstrated to reliably reflect the ability of the ionic liquids to block the silanols of the silica support material of the stationary phase. The determinations were carried out for ionic liquids of the 1-alkyl-3-methylimidazolium group using basic drugs as the test analytes. Comparison of ionic liquids with standard mobile phase additives such as triethylamine showed the former to possess advantages as silanol suppressors in HPLC. The main advantage of the method is that it provides a simple and fast determination of the silanol complex stability, which allowed comparison of the suppressing efficiency of several ionic liquids

Journal of Separation Science published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yun, Tae Gwang published the artcileIon-permselective conducting polymer-based electrokinetic generators with maximized utility of green water, HPLC of Formula: 79917-90-1, the publication is Nano Energy (2022), 106946, database is CAplus.

Hydro-elec. technol. has gathered much attention by the virtue of water as the energy source. However, the low energy d. of this technol. severely limits its practical use. Here, we demonstrate a PEDOT:PSS-based transpiration-driven electrokinetic power generator (p-TEPG) that enables the utilization of a wider variety of real-world water resources for maximizing energy generation efficiencies. In addition to the conventional elec. double layer on the material surface, the p-TEPG builds an addnl. p.d. in the polymer matrix by the selective penetration of cations into the matrix that contains sulfonate functional groups. p-TEPG exhibits 80-250% higher energy d. than carbon-based TEPG at the same resistance. Moreover, seawater produced enhanced volumetric energy/power densities (34.36 mJ cm^-3 and 44.70μW cm^-3) and areal energy/power densities (410μJ cm^-2 and 0.45μW cm^-2), resp., compared to DI water on a single p-TEPG device, which is sufficient to charge elec. energy storage systems and directly operate low-powered electronic.

Nano Energy published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C7H13BrSi, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Rasoolzadeh, Ali published the artcileA thermodynamic framework for determination of gas hydrate stability conditions and water activity in ionic liquid aqueous solution, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Liquids (2022), 118358, database is CAplus.

The formation of gas hydrates in pipelines and plugging of the gas flow path are a major cause of operating expenses, safety issues, pressure drop, and fatal accidents. Therefore, the inhibition of gas hydrate formation is of paramount importance. The utilization of a new class of inhibitors such as ionic liquids (ILs) is currently of great interest. In this regard, adjusting water activity in the inhibitor blend (water + IL) is a vital factor. Several models have been developed to calculate the activity of water in the presence of IL(s). The major disadvantage of these models is their correlative basis. This study aimed to propose a rigorous predictive model for the calculation of water activity in the presence of IL(s), which would then be applied in the prediction of the gas hydrate stability conditions. The model is made up of a mol. term (the short-range interactions from Free-Volume-Flory-Huggins (FVFH) activity model) as well as a contribution from ionic interactions as a result of IL(s) dissociation in water (the long-range electrostatic interactions from the extended Debye-Huckel (EDH) model). The overall absolute temperature deviation and the average absolute relative deviation percent in the calculated gas (methane and carbon dioxide) hydrate dissociation temperatures for the whole databank (500 data points including 37 ILs) were found to be 0.61 K and 0.22%, resp. This proves the superiority of the model over the previous correlative-basis ones. Finally, it is concluded that the higher temperature, the higher the IL(s) concentration, and the lower IL(s) mol. weight(s) result in larger model deviations.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xu, Yida published the artcileIon Channel Mimetic Chronopotentiometric Polymeric Membrane Ion Sensor for Surface-Confined Protein Detection, Related Products of imidazoles-derivatives, the publication is Langmuir (2009), 25(1), 568-573, database is CAplus and MEDLINE.

The operation of ion channel sensors is mimicked with functionalized polymeric membrane electrodes, using a surface confined affinity reaction to impede the electrochem. imposed ion transfer kinetics of a marker ion. A membrane surface biotinylated by covalent attachment to the polymeric backbone is used here to bind to the protein avidin as a model system. The results indicate that the protein accumulates on the ion-selective membrane surface, partially blocking the current-induced ion transfer across the membrane/aqueous sample interface, and subsequently decreases the potential jump in the so-called super-Nernstian step that is characteristic of a surface depletion of the marker ion. The findings suggest that such a potential drop could be utilized to measure the concentration of protein in the sample. Because the sensitivity of protein sensing is dependent on the effective blocking of the active surface area, it can be improved with a hydrophilic nanopore membrane applied on top of the biotinylated ion-selective membrane surface. On the basis of cyclic voltammetry characterization, the nanoporous membrane electrodes can indeed be understood as a recessed nanoelectrode array. The results show that the measuring range for protein sensing on nanopore electrodes is shifted to lower concentrations by more than 1 order of magnitude, which is explained with the reduction of surface area by the nanopore membrane and the related more effective hemispherical diffusion pattern.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C14H12N2S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Beillard, Audrey published the artcileMechanochemistry for facilitated access to N,N-diaryl NHC metal complexes, Related Products of imidazoles-derivatives, the publication is New Journal of Chemistry (2017), 41(3), 1057-1063, database is CAplus.

A user-friendly and solvent-free mechanosynthetic strategy allowed light-sensitive Ag(I) complexes featuring N,N-diaryl N-heterocyclic carbenes (NHC), including challenging and sterically hindered ligands, to be yielded efficiently. The 1st transmetalations using ball-milling to obtain Pd and Cu NHC complexes were performed. A convenient 1-pot two-step metalation/transmetalation procedure was also realized.

New Journal of Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Borges, Mariana S. published the artcileEvaluation of residual biomass produced in Cerrado Tocantinense as potential raw biomass for biorefinery, HPLC of Formula: 79917-90-1, the publication is Biomass Conversion and Biorefinery (2022), 12(8), 3055-3066, database is CAplus.

Furanic compounds such as 5-hydroxymethylfurfural (HMF) and furfural (FF) obtained from biomass have emerged as important industrial chem. platforms. In this sense, the present study aimed to evaluate the economical use of crude biomass of rice husk (RH), cupuacu peel (CP), and pequi peel (PP) to obtain furanic compounds such as HMF and FF, using the ionic liquid 1-butyl-3-methylimidazolium chloride ([BMIM][Cl]) and the catalyst chromium(III) chloride hexahydrate (CrCl₃.6H₂O). The results of the anal. showed that biomasses have potential for use in biorefineries; however, the most promising among those is the RH, due to the significant content of holocellulose. The optimization of hydrolysis through the methodol. developed by Dunning and Dallas (1949) made it possible to obtain significant levels of glucose (14.28%), xylose (3.81%), and arabinose (0.93%). The obtained products were analyzed by Fourier transform IR spectrophotometry (FT-IR) and high-performance liquid chromatog. (HPLC). The best yields for RH obtained were 1.92% (HMF) and 2.89% (FF). From the results obtained, it can be concluded that the RH has a good capacity for producing value-added compounds in biorefineries.

Biomass Conversion and Biorefinery published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem